Chen RH, Song F, Gan Y, Li TT, Ye L, et al. (2019) Autophagy and Transforming Growth Factor Beta1 in Renal Tubular Epithelia Cells. J Clin Nephrol Ren Care 5:043. doi. org/10.23937/2572-3286.1510043


© 2019 Chen RH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

REVIEW ARTICLE | OPEN ACCESSDOI: 10.23937/2572-3286.1510043

Autophagy and Transforming Growth Factor Beta1 in Renal Tubular Epithelia Cells

Rui Hong Chen1, Fen Song1, Yu Gan1, Ting Ting Li1, Lin Ye1, Wei Jing Liu1,2* and Hua-Feng Liu1*

1Institute of Nephrology, Guangdong Medical University, Zhanjiang, China

2Key Laboratory of Chinese Internal Medicine, Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China


Transforming growth factor beta1 (TGF-β1) is regarded as the important factor in many fibrotic kidney diseases. Autophagy is a vital mechanism which maintains intracellular homeostasis in eukaryotic cells and involves in various renal physiologic and pathological processes. Current studies indicate that autophagy in renal tubular epithelial cells serves as a renoprotective mechanism which modulates the course of diverse kidney disease. Thus, this review aims to show the possible linkage between TGF-β1 and autophagy in the renal tubular epithelial cells.