Moraes NS, Biassi TP, Mecabô G, Shinohara EMG, Cendoroglo MS, et al. (2019) Haemoglobin Level in Oldest Old with Active Aging: Analysis of a Brazilian Population. J Geriatr Med Gerontol 5:063.


© 2019 Moraes NS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/2469-5858/1510063

Haemoglobin Level in Oldest Old with Active Aging: Analysis of a Brazilian Population

Niele Silva de Moraes1,3*, Thais Priscila Biassi1, GrazielleMecabô1, Elvira Maria Guerra Shinohara2, Maysa Seabra Cendoroglo3, Thiago Xavier Carneiro1 and Maria Stella Figueiredo1

1Division of Hematology, Federal University of São Paulo, São Paulo, Brazil

2Department of Clinical Analysis and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil

3Division of Geriatric and Gerontology, Federal University of São Paulo, São Paulo, Brazil


The decline in haemoglobin (Hb) levels with advanced age is a widely known event. Nevertheless, it remains unclear whether this is a normal consequence of aging or a feature of age-related comorbidities. The World Health Organisation (WHO) definition of anaemia, although commonly used, was based on small epidemiological data and did not include individuals over 64-years-old. The aim of the present study is to evaluate haemoglobin levels and establish a reference range for a Brazilian population of the oldest old with active aging.

Patients and methods

This was a cross-sectional study of community-dwelling independent elderly aged 80 years or older in the city of São Paulo, Brazil. Patients were excluded if they were institutionalised, diagnosed with dementia, Parkinson's disease or current cancer, were undergoing dialysis or had been hospitalised in the last 3 months. Chronic diseases had to be under control. The reference range was calculated excluding patients with transferrin saturation below 16%, serum ferritin levels below 10 μg/L or eGFR < 30 ml/min/1.73 m2. Values were obtained according to recommendations of the International Federation of Clinical Chemistry (IFCC).


Of the 256 subjects included in this study, 182 (71%) were women, and the median age was 85-years-old (80-99). A total of 47 individuals met the exclusion criteria for statistical analysis. The median haemoglobin level was 13.9 g/dL in men and 13.3 g/dL in women. The calculated 0.95 reference range of haemoglobin concentration was 11.2-16.7 g/dL for men and 11.3-15.7 g/dL in women.


A lower threshold of haemoglobin was found for both men and women when compared to levels set by the WHO. Further studies must indicate the normal level of haemoglobin concentration in the elderly in the Brazilian population.