dos Santos SA, de Oliveira CL, Cortez PI, Rodrigues CSC (2018) Nutritional Status of Children and Adolescents with Sickle Cell Disease. J Nutri Med Diet Care 4:027.


© 2018 dos Santos SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

REVIEW ARTICLE | OPEN ACCESS DOI: 10.23937/2572-3278.1510027

Nutritional Status of Children and Adolescents with Sickle Cell Disease

Samara Agda dos Santos1*, Cecilia Lacroix de Oliveira2, Paulo Ivo Cortez3 and Cláudia dos Santos Cople Rodrigues2

1Specialist in Clinical Nutrition, Centro Universitário Central Paulista, Brazil

2Clinical Nutrition, State University of Rio de Janeiro, Brazil

3University Hospital Martagão Gesteira, Federal University of Rio de Janeiro, Brazil


Sickle cell disease (SCD) is a public health problem that interferes in the nutritional status of children and adolescents.


To describe of the nutritional status and identify the factors associated with the growth deficit or obesity of children and adolescents with sickle cell disease.


Critical analysis of originals articles published in Portuguese, English and Spanish in the electronic bases Medline, SciELO and LILACS with participants of 0 to 19 years old diagnosed with SCD.


We identified 37 articles that describe low weight, short stature and overweight or obesity prevalence ranging between 3 and 100%, 8.2% and 24.0%, 1.6% and 22.4%, respectively. The associated factors to the growth deficit were the increase of resting energy expenditure, the presence of low bone density, the high prevalence of low zinc and D-vitamin plasma concentration, the low consume of calcium and D-vitamin, vessel occlusion crises, increased need of transfusions and hormonal amendments presence.


Amendments by weight and stature were frequent; however, we note an adjustment once the presence of overweight and obesity already exists in this group. The blood transfusion, the zinc supplementation and the regular use of hydroxyurea has shown benefit in the growth of children and adolescents with sickle cell disease.