International Journal of

Immunology and ImmunotherapyISSN: 2378-3672

Early Online

 Open Access DOI:10.23937/2378-3672/1410035

Cancer Immunotherapy Therapeutic Manipulation of the CD8-HLA Class I Interaction: Potential and Challenges

P Savage

Article Type: REVIEW ARTICLE | First Published: February 23, 2019

The interaction between CD8 and HLA class I is largely monomorphic and of low affinity. Previous HLA mutation studies have indicated that manipulation of the affinity of this interaction can have dramatic biological effects. Reductions in CD8-HLA class I affinity can lead to inhibition of T cell mediated target cell killing, whilst modest affinity increases lead to enhanced target cell killing whilst retaining antigenic specificity. Here it is shown that target cells bearing a high affinity chim...

Volume 6
Issue 1