Folate Targeted Galactomannan Coated Iron Oxide Nanoparticles as a Nanocarrier for Targeted Drug Delivery of Capecitabine
Subha Veeramani, Kirubanandan Shanmugam and Renganathan Sahadevan
Article Type: Research Article | First Published: November 22, 2018
Iron oxide nanoparticle is the most promising nanoparticles (NPs) capable in Drug Delivery and targeting. Iron oxide nanoparticles were synthesized by green synthesis. Galactomannan, when attached to the surface of the nanoparticles, increases the biocompatibility of the nanoparticles. Folic acid (FA) is used as the ligand to target folate receptors, which are found abundant in cancer cells. FeNPs-GM-FA could target cancer cells when used as drug carriers. The synthesized iron oxide nanoparticle...
Silver Nanoparticles - Green Synthesis with Aq. Extract of Stems Ipomoea Pes-Caprae, Characterization, Antimicrobial and Anti-Cancer Potential
Subha Veeramani, Ernest Ravindran RS, Preethi Ramadoss, Cyrril Joseph, Kirubanandan Shanmugam and Renganathan S
Article Type: Research Article | First Published: October 10, 2018
Green synthesis is a novel process for the preparation of numerous metallic nanoparticle and provides a safer and eco-friendly process simultaneously achieving functionalization of nanoparticles with bioactive molecules in the plants extract. Green synthesis of silver nanoparticles (AgNPs) is performed using the aqueous extract of Ipomoea pes-caprae stems which acts as a bio-reducing agent. UV spectroscopic investigation confirms the formation of AgNPs by noticing the peak at 448 nm due to its s...
In Vitro Dissolution Studies on Naproxen-PVP Nanoformulations Show Enhanced Oral Bioavailability of Naproxen
Sandeep Patnaik, Aditya D Kurdekar, LA Avinash Chunduri, C Prathibha and K Venkataramaniah
Article Type: Research Article | First Published: October 08, 2018
Phase solubility behavior, physico-chemical characteristics, cytotoxicity, morphology and dissolution enhancement of Naproxen-PVP Nanoformulations have been studied. Drug-polymer ratios of 1:1, 1:2, 1:3, 1:4 for the poorly water-soluble drug, naproxen and the polymer PVP are prepared via wet milling using a conventional Retsch Planetary ball mill. The highest dissolution enhancement over that of the pure drug, 310% was achieved for the formulation ratio of 1:4. This ability of amphiphilic surfac...