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Editorial Letter  |   Volume 2, Issue 2

Headache Attributed to Obsessive Compulsive Disorder of Mastication

Mianwang He, Xiaolin Wang and Shengyuan Yu

A 51-years-old man who had developed severe phobia, anxiety since took illicit drugs twice 10 years ago, subsequently palpitation and shortness of breath appeared, having a continuous feeling that someone would attack him and he would die soon. Only mastication can partially relieve phobia and anxiety, and continuous involuntary mastication habit with left side teeth was developed. Anxiety and depression diagnosis was made by local clinic, but he didn't take the prescribed drugs.

PDF   |    Full Text | DOI: 10.23937/2469-5866/1510017

Original Article  |   Volume 2, Issue 2

Meta-analysis of Association between Helicobacter pylori Infection and Epilepsy

Gang Yao, Ping Wang, Xiang-Dan Luo and Ting-Min Yu

Despite recent research focus on the association between Helicobacter pylori (H. pylori) infection and epilepsy there is no consensus about the findings. To obtain a more comprehensive estimate of the association we conducted a meta-analysis to determine the prevalence of H. pylori infection in epilepsy patients and healthy controls. PubMed, EMBASE, Cochrane Library, Web of Science, Google Scholar and CINAHL were searched to identify eligible studies.

PDF   |    Full Text | DOI: 10.23937/2469-5866/1510016

Original Article  |   Volume 2, Issue 2

Hyperintentionality Hypothesis of Major Depression. Disordered Emotional and Cognitive Self-Observation in Tripartite Synapses and the Glial Networks

Bernhard J Mitterauer

Major depressive disorder is basically a disorder of the integration of distinct time periods generated in tripartite synapses and the astroglial networks. If the sequence of time periods is dysregulated, the patient does not only suffer from emotional impairment but also from cognitive deficits dependent on the brain region affected. Since the synaptic interactions operate on feedforward and feedback mechanisms, I speak of synaptic locations of self-observation in real time periods, information processing time periods and information integration time periods.

PDF   |    Full Text | DOI: 10.23937/2469-5866/1510015

Prospective Observational Study  |   Volume 2, Issue 2

Predictive Factors of Brain Death in Acute Neurocritical Patients Identified as Potential Organ Donors

Guixing Xu, Ping Xu, Jing Zhao, Zhiyong Guo and Xiaoshun He

In this prospective observational study, we collected clinical data of acute neurocritical patients with a potential progression to BD, who was admitted in the First Affiliated Hospital of Sun Yet-sen University from May 2015 to April 2016. Final endpoint was adjudicated brain death (BD). The clinical data were compared between patients who identified as BD within 7 days and those who identified beyond 7 days, the time of spontaneous respiratory arrest as start point. Neurological examination, laboratory and radiographic data before the BD, were recorded.

PDF   |    Full Text | DOI: 10.23937/2469-5866/1510014

Research Article  |   Volume 2, Issue 2

Maternal Undernutrition in Rats Affects Hippocampal Development through Inhibition of Neurogenin 1

Marquis L Jessie, Lili C Kudo, Nancy Vi, Kimbley Lau, Mina Desai, Michael G Ross and Stanislav L Karsten

Maternal undernutrition (UN) in rats inhibits neurologic development in offspring. To investigate these alterations we compared hippocampal global gene expression profiles of UN and control newborn pups. Whole transcriptome microarray analysis revealed significant changes in the expression of several genes including Neurogenin1 (Ngn1), a known neuro developmental regulatory factor. Expression of Ngn1 in the UN hippocampus was nearly 70% reduced. Western blot analysis using antibodies against Ngn1 protein, also showed more than a 50% decrease in the protein expression of Ngn1 in the hippocampus of UN newborn pups.

PDF   |    Full Text | DOI: 10.23937/2469-5866/1510013

Volume 2
Issue 2