International Journal of

Clinical Biostatistics and BiometricsISSN: 2469-5831


 Open Access DOI:10.23937/2469-5831/1510038

An Application of the Patient Rule-Induction Method to Detect Clinically Meaningful Subgroups from Failed Phase III Clinical Trials

Greg Dyson

Article Type: Original Article | First Published: June 28, 2021

Phase III superiority clinical trials have negative results (new treatment is not statistically better than standard of care) due to a number of factors, including patient and disease heterogeneity. However, even a treatment regime that fails to show population-level clinical improvement will have a subgroup of patients that attain a measurable clinical benefit. The goal of this paper is to modify the Patient Rule-Induction Method to identify statistically significant subgroups, defined by clini...

 Open Access DOI:10.23937/2469-5831/1510037

On the Comparison of Multiple Linear and Interval Regression Models of Apnea-Hypopnea Index in Patients with Obstructive Sleep Apnea Syndrome

Derviş Topuz and Adnan Karaibrahimoğlu

Article Type: Research Article | First Published: June 28, 2021

In the fuzzy regression models that are fitted by using fuzzy logic, every regression coefficient should be estimated at a certain level of a fuzziness tolerance because of dividing the error value into the coefficient. This study aims to compute the coefficient and deviation values of classical least squares (OLS) and fuzzy interval regression models on a sample data set and interpret them comparatively. There were totally 514 patients with OSAS (Obstructive Sleep Apnea Syndrome) who admitted t...

 Open Access DOI:10.23937/2469-5831/1510036

Comparison of Estimation Method in Diagnostic Meta-Analysis: An Application in Dentistry

Merve Parmaksiz, Hayal Boyacioğlu, Pelin Güneri and Nezaket Ezgi Özer

Article Type: Research Article | First Published: June 28, 2021

In this study, the objective was to compare different estimation methods in diagnostic meta-analysis. In this scope, DerSimonian and Laird (DL), Restricted Maximum Likelihood (REML), Sidik and Jonkman (SJ), Hedges and Olkin (HO), Maximum Likelihood (ML), Paule and Mandel (PM) estimation methods were examined. In the implementation part, effectiveness of Clinical Oral Examination (COE) in predicting the diagnosis of histological dysplasia or Oral Squamous Cell Carcinoma (OSCC) was studied. Meta a...

 Open Access DOI:10.23937/2469-5831/1510035

The Incidence of Tuberculosis in Brazil from 2001 to 2018: Use of Polynomial Regression Combined with a Stochastic Volatility Model

Jorge Alberto Achcar, Ricardo Puziol de Oliveira and Emerson Barili

Article Type: Original Article | First Published: April 21, 2021

Monthly tuberculosis (TB) counts from January 2001 to December 2018 showed an upward trend (data from SINAN - Information System for Notifiable Diseases). The increase in the incidence of TB in general is associated with an increase in the rate of extreme poverty, an increase in AIDS cases and other factors. Combining the polynomial linear regression and stochastic volatility models, the purpose of this study was to analyze monthly count data as well as the AIDS/TB, extreme poverty/TB and urban/...

 Open Access DOI:10.23937/2469-5831/1510034

Psychophysiological Differences in Patients with/without Schizophrenia: A Comparative Study

Theofilidis Antonis and Fountoulakis Konstantinos

Article Type: Original Article | First Published: April 09, 2021

Schizophrenia is a chronic and severe mental disorder affecting 20 million people worldwide. Characterized by distortions in thinking, perception, emotions, language, sense of self and behaviour. Differences in body mass index, weight and height, in patients with schizophrenia, mood disorders vs. normal controls. The study sample included 76 patients with unipolar depression, 16 patients with schizoaffective disorder, 122 patients with schizophrenia, and 78 patients with other mental disorders,...

 Open Access DOI:10.23937/2469-5831/1510033

Multiobjective Optimal Control of the COVID Virus Outbreak

Lakshmi Sridhar

Article Type: Research Article | First Published: January 20, 2021

The number of fatalities caused by the COVID virus is not only extremely high but also increasing at an alarming rate. The many strategies that are being used throughout the world, to control the pandemic, are being overwhelmed mercilessly by the global pandemic. In this paper three different optimization strategies are used to determine the best strategy that can minimize the damage. It is also demonstrated that for one value of the number of infected subjects two values of recovered and perish...

Volume 7
Issue 1