A Signal Detection Analysis of World Health Organization’s Pharmacovigilance Database
Article Type: Original Article | First Published: December 14, 2019
Pharmacovigilance is the primary method used to identify hazards associated with medicinal products. Using generalized likelihood ratio tests, we examed the adverse reaction signals of the drug class Monoamine oxidase inhibitors (MAOIs) from World Health Organization’s Pharmacovigilance Database. The proposed test procedure has the ability of detecting adverse reactions of multiple drugs simultaneously. Our findings sugggest there are 23 common Adverse reaction signals detected within this dru...
Child Mortality: A Comparative Study of Some Developing Countries in the World
Ilker Etikan, Ogunjesa Babatope, Kabiru Bala and Savas Ilgi
Article Type: Research Article | First Published: September 30, 2019
According to the United Nations Sustainable Development Goals, countries all over the world are expected to create a healthy living environment for the populace most especially the vulnerable population of which children are examples. Despite the reducing trend in the under-five mortality rate in some developing nations, some nations still have a high record of under-five mortality. This study adopted the use of a One-way Analysis of Variance (ANOVA) to evaluate any significant difference in the...
Partial Variable Selection and its Applications in Biostatistics
Jingwen Gu, Ao Yuan, Chunxiao Zhou, Leighton Chan and Ming T Tan
Article Type: Research Article | First Published: April 14, 2018
We propose and study a method for partial covariates selection, which only select the covariates with values fall in their effective ranges. The coefficients estimates based on the resulting data is more interpretable based on the effective covariates. This is in contrast to the existing method of variable selection, in which some variables are selected/deleted in whole. To test the validity of the partial variable selection, we extended the Wilks theorem to handle this case. Simulation studies ...