International Journal of

Clinical Biostatistics and BiometricsISSN: 2469-5831

Current Issue

 Open Access DOI:10.23937/2469-5831/1510026

The Basic Four Measures and their Derivates in Dichotomous Diagnostic Tests

Tadeusz R Ostrowski, MD and Tadeusz Ostrowski, PhD

Article Type: Original Article | First Published: June 05, 2020

The paper focuses on four basic statistics of dichotomous diagnostic tests, i.e. sensitivity, specificity, positive and negative predictive value, and some of their derivates, like Youden index and predictive summary index, and on further derivates of these derivates, i.e. Matthews correlation coefficient (or Yule phi), chi squared test and Cramer’s V coefficient. The paper contains also the necessary and sufficient conditions for a test to be invalid, to be uninformative and the necessary con...

 Open Access DOI:10.23937/2469-5831/1510025

Factors Influencing Resident Research: Evidence from a 10-Year Cohort

Adnan N Kiani, Babatunde Olaiya, Richard Berg and Ateeq Rehman

Article Type: Research Article | First Published: March 19, 2020

ACGME has put great emphasis on scholarly activity during residency, yet ACGME has not been able to identify gaps in achieving these goals. We possess longitudinal data for the last 10 years across our residency training programs. With this, we have identified missing gaps as well as propose interventions to address gaps. The research design employs utilizing a standardized research instrument (questionnaire), answered by every resident at the onset and completion of residency training. This que...

 Open Access DOI:10.23937/2469-5831/1510024

Nonparametric Method for Estimation of Controlled Correlations in Studies of VEGF-Hypoxia Relationship

Maxim S Kodryan, Anna V Kuznetsova, Luidmila L Klimenko, Aksana N Mazilina, Ivan V Baskakov and Oleg V Senko

Article Type: Research Article | First Published: March 04, 2020

It is known that vascular endothelial growth factor (VEGF) expression is a response to hypoxia. On the other hand hypoxia may be detected by oximetry parameters including venous CO-oximetry indices or corresponding partial pressures of O2 and CO2. However significant correlation ties between VEGF levels and oximetry parameters were not found in groups of patients with ischemic stroke and transient ischemic attack. At that some effect related to the relationship between VEGF and sO2 was observed ...

 Open Access DOI:10.23937/2469-5831/1510023

A Signal Detection Analysis of World Health Organization’s Pharmacovigilance Database

Yeqian Liu

Article Type: Original Article | First Published: December 14, 2019

Pharmacovigilance is the primary method used to identify hazards associated with medicinal products. Using generalized likelihood ratio tests, we examed the adverse reaction signals of the drug class Monoamine oxidase inhibitors (MAOIs) from World Health Organization’s Pharmacovigilance Database. The proposed test procedure has the ability of detecting adverse reactions of multiple drugs simultaneously. Our findings sugggest there are 23 common Adverse reaction signals detected within this dru...

 Open Access DOI:10.23937/2469-5831/1510022

Child Mortality: A Comparative Study of Some Developing Countries in the World

Ilker Etikan, Ogunjesa Babatope, Kabiru Bala and Savas Ilgi

Article Type: Research Article | First Published: September 30, 2019

According to the United Nations Sustainable Development Goals, countries all over the world are expected to create a healthy living environment for the populace most especially the vulnerable population of which children are examples. Despite the reducing trend in the under-five mortality rate in some developing nations, some nations still have a high record of under-five mortality. This study adopted the use of a One-way Analysis of Variance (ANOVA) to evaluate any significant difference in the...

 Open Access DOI:10.23937/2469-5831/1510018

Reassessing the Effectiveness of Right Heart Catheterization (RHC) in the Initial Care of Critically Ill Patients using Targeted Maximum Likelihood Estimation

Hai Zhu, Mary Akosile, Shuqin Zhang, Nils P Johnson, Dejian Lai and Hongjian Zhu

Article Type: Research Article | First Published: July 28, 2018

Right heart catheterization (RHC) is a well-established diagnostic tool for patients with congenital and acquired right heart disease and to actively monitor critically ill patients in the intensive care unit. Notably, previous randomized controlled trials and observational studies provide limited support for the clinical utilization of RHC in critically ill patients. However, traditional statistical methods incorporating propensity scores rely heavily on potentially invalid parametric assumptio...

 Open Access DOI:10.23937/2469-5831/1510017

Partial Variable Selection and its Applications in Biostatistics

Jingwen Gu, Ao Yuan, Chunxiao Zhou, Leighton Chan and Ming T Tan

Article Type: Research Article | First Published: April 14, 2018

We propose and study a method for partial covariates selection, which only select the covariates with values fall in their effective ranges. The coefficients estimates based on the resulting data is more interpretable based on the effective covariates. This is in contrast to the existing method of variable selection, in which some variables are selected/deleted in whole. To test the validity of the partial variable selection, we extended the Wilks theorem to handle this case. Simulation studies ...

 Open Access DOI:10.23937/2469-5831/1510016

Improved Wald Test for Equivalence Assessment of Analytical Biosimilarity

Yu-Ting Weng, Yi Tsong, Meiyu Shen and Chao Wang

Article Type: Research Article | First Published: March 15, 2018

The equivalence test in analytical similarity assessment uses a margin of 1.5 times of the standard deviation of a reference product. In the current practice, the standard deviation, estimated from study data, is considered as a fixed constantin the margin....

Volume 4
Issue 1