International Journal of

Clinical Biostatistics and BiometricsISSN: 2469-5831

Current Issue

 Open Access DOI:10.23937/2469-5831/1510023

A Signal Detection Analysis of World Health Organization’s Pharmacovigilance Database

Yeqian Liu

Article Type: Original Article | First Published: December 14, 2019

Pharmacovigilance is the primary method used to identify hazards associated with medicinal products. Using generalized likelihood ratio tests, we examed the adverse reaction signals of the drug class Monoamine oxidase inhibitors (MAOIs) from World Health Organization’s Pharmacovigilance Database. The proposed test procedure has the ability of detecting adverse reactions of multiple drugs simultaneously. Our findings sugggest there are 23 common Adverse reaction signals detected within this dru...

 Open Access DOI:10.23937/2469-5831/1510022

Child Mortality: A Comparative Study of Some Developing Countries in the World

Ilker Etikan, Ogunjesa Babatope, Kabiru Bala and Savas Ilgi

Article Type: Research Article | First Published: September 30, 2019

According to the United Nations Sustainable Development Goals, countries all over the world are expected to create a healthy living environment for the populace most especially the vulnerable population of which children are examples. Despite the reducing trend in the under-five mortality rate in some developing nations, some nations still have a high record of under-five mortality. This study adopted the use of a One-way Analysis of Variance (ANOVA) to evaluate any significant difference in the...

 Open Access DOI:10.23937/2469-5831/1510018

Reassessing the Effectiveness of Right Heart Catheterization (RHC) in the Initial Care of Critically Ill Patients using Targeted Maximum Likelihood Estimation

Hai Zhu, Mary Akosile, Shuqin Zhang, Nils P Johnson, Dejian Lai and Hongjian Zhu

Article Type: Research Article | First Published: July 28, 2018

Right heart catheterization (RHC) is a well-established diagnostic tool for patients with congenital and acquired right heart disease and to actively monitor critically ill patients in the intensive care unit. Notably, previous randomized controlled trials and observational studies provide limited support for the clinical utilization of RHC in critically ill patients. However, traditional statistical methods incorporating propensity scores rely heavily on potentially invalid parametric assumptio...

 Open Access DOI:10.23937/2469-5831/1510017

Partial Variable Selection and its Applications in Biostatistics

Jingwen Gu, Ao Yuan, Chunxiao Zhou, Leighton Chan and Ming T Tan

Article Type: Research Article | First Published: April 14, 2018

We propose and study a method for partial covariates selection, which only select the covariates with values fall in their effective ranges. The coefficients estimates based on the resulting data is more interpretable based on the effective covariates. This is in contrast to the existing method of variable selection, in which some variables are selected/deleted in whole. To test the validity of the partial variable selection, we extended the Wilks theorem to handle this case. Simulation studies ...

 Open Access DOI:10.23937/2469-5831/1510016

Improved Wald Test for Equivalence Assessment of Analytical Biosimilarity

Yu-Ting Weng, Yi Tsong, Meiyu Shen and Chao Wang

Article Type: Research Article | First Published: March 15, 2018

The equivalence test in analytical similarity assessment uses a margin of 1.5 times of the standard deviation of a reference product. In the current practice, the standard deviation, estimated from study data, is considered as a fixed constantin the margin....

Volume 4
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