International Journal of

Clinical Biostatistics and BiometricsISSN: 2469-5831

Current Issue

 Open Access DOI:10.23937/2469-5831/1510018

Reassessing the Effectiveness of Right Heart Catheterization (RHC) in the Initial Care of Critically Ill Patients using Targeted Maximum Likelihood Estimation

Hai Zhu, Mary Akosile, Shuqin Zhang, Nils P Johnson, Dejian Lai and Hongjian Zhu

Article Type: Research Article | First Published: July 28, 2018

Right heart catheterization (RHC) is a well-established diagnostic tool for patients with congenital and acquired right heart disease and to actively monitor critically ill patients in the intensive care unit. Notably, previous randomized controlled trials and observational studies provide limited support for the clinical utilization of RHC in critically ill patients. However, traditional statistical methods incorporating propensity scores rely heavily on potentially invalid parametric assumptio...

 Open Access DOI:10.23937/2469-5831/1510017

Partial Variable Selection and its Applications in Biostatistics

Jingwen Gu, Ao Yuan, Chunxiao Zhou, Leighton Chan and Ming T Tan

Article Type: Research Article | First Published: April 14, 2018

We propose and study a method for partial covariates selection, which only select the covariates with values fall in their effective ranges. The coefficients estimates based on the resulting data is more interpretable based on the effective covariates. This is in contrast to the existing method of variable selection, in which some variables are selected/deleted in whole. To test the validity of the partial variable selection, we extended the Wilks theorem to handle this case. Simulation studies ...

 Open Access DOI:10.23937/2469-5831/1510016

Improved Wald Test for Equivalence Assessment of Analytical Biosimilarity

Yu-Ting Weng, Yi Tsong, Meiyu Shen and Chao Wang

Article Type: Research Article | First Published: March 15, 2018

The equivalence test in analytical similarity assessment uses a margin of 1.5 times of the standard deviation of a reference product. In the current practice, the standard deviation, estimated from study data, is considered as a fixed constantin the margin....

Volume 4
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