A Combinatory Therapy Continuously Improves Memory in a Case of Probable Alzheimer's Disease with Head Trauma for Nearly Two Years
Jing Shi, Xuekai Zhang, Mingqing Wei, Jingnian Ni, Ting Li Mphil and Jinzhou Tian
Article Type: Case Report | First Published: December 05, 2016
Since the worldwide demographic ageing, prevalence of the most common cause of dementia in the elderly, Alzheimer's disease (AD), will increase dramatically. Although it has been intensively researched for many years, there are still limited treatments for AD. Currently approved pharmacotherapy is generally considered have symptom-relieving rather than disease processing modifying effects. Meanwhile, there are efficacy limits of such medicines, for example, donepezil efficacy starts to decline f...
Depression in Parkinson's Disease is Associated with a Serotoninergic System Change Secondary to Neuroinflammation
Ronise M Santiago, Maria ABF Vital, Marcelo D O Sato and Gustavo P Adam
Article Type: Research Report | First Published: December 03, 2016
Depression is a common psychiatric disorder in patients with Parkinson's disease (PD), being more prevalent in PD than in any other chronic disabling disease. Its cause, nevertheless, has not yet been elucidated. According to some authors, there is a decrease in serotonin (5-HT) levels compensatory to dopaminergic release impairment, but new evidence suggests that chronic inflammation may be a more likely etiogenic factor to depression. The inflammatory hypothesis states that depression is cause...
The Damaging Impact of Chronic Heart Failure on A Critical Interoreceptor and the Therapy for it
Robert S Fitzgerald
Article Type: Mini Overview | First Published: December 01, 2016
Congestive Heart Failure (CHF) is among the heart diseases which accounted for > 54% of deaths world-wide in 2013 in a World Health Organizations report. CHF patients most often have a more sensitized carotid body (CB) chemoreceptor than normal. CB neural output stimulates output from the sympathetic nervous system. Increased CB output in CHF has in animal models been attributed to a loss of shear stress on the luminal surfaces of the CBs' vascular endothelial cells....
Abnormal Plasticity and Epigenesis in Epileptic Seizures of an EL Mouse
Article Type: Rather Short Review | First Published: November 30, 2016
The EL mice were exposed to the natural proprioceptive sensory stimulation of tossing the animal into the air to provoke an epileptic seizure, which results from an increase in the excitability of the cortical neurons due to low activities of Glutamic acid decarboxylase (GAD) and Gamma-amino butyric acid (GABA). The seizures develop due to the abnormal plasticity and eventually occur spontaneously....