Eyisi CS, Onwuekwe IO, Eyisi IG, Ekenze O (2018) Rare and Hereditary Causes of Stroke-A Literature Review. Int J Neurodegener Dis 1:005.


© 2018 Eyisi CS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESS DOI: 10.23937/ijnd-2017/1710005

Rare and Hereditary Causes of Stroke-A Literature Review

Eyisi CS1*, Onwuekwe IO1, Eyisi IG2 and Ekenze O1

1Neurology Unit, Department of Medicine, College of Medicine, University of Nigeria Teaching Hospital, Nigeria

2Department of Community Medicine, College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Nigeria



Rare and hereditary diseases are important in causing stroke in children, younger patients and women [1]. These diseases have a world-wide prevalence, however they are not commonly diagnosed in Nigeria because of unavailability of gene mapping technologies. Notable exceptions include Moyamoya disease which commonly occur in Asian populations and Chronic Myelogenous Leukemia which causes stroke in the 7th and 8th decade, in contrast to other diseases that cause stroke in the 1st to 3rd decades [1].


The aim of this paper is to review several rare and hereditary causes of stroke.


A literature search of various database.


Stroke in young people have been linked to causes other than the conventional risk factors. In Africa, Sickle Cell Anemia is a leading cause [1]. International research consortium (MEGASTROKE) studying 520,000 individuals from around the world have identified about 22 new genetic risk factors for stroke [2].

There are currently about 32 independent genomic regions associated with stroke [2]. Other influences including hereditary causes have been associated with about 50% of strokes [2].