International Journal of

Neurodegenerative DisordersISSN: 2643-4539

Early Online

 Open Access DOI:10.23937/2643-4539/1710023

Dual‐Specificity Tyrosine Phosphorylation‐Regulated Kinase‐1A (DYRK1A), A Master Regulatory Protein Involved in Down Syndrome Brain Alterations and Mental Disability, A Key Contributor to Neurodegenerative Disorders of Alzheimer's Disease and A Potential Therapeutic Target

Mohammed Rachidi

Article Type: Research Article | First Published: July 04, 2022

Down syndrome (DS) is the most frequent genetic disease characterized by several neuropathological features including alteration in neurogenesis, mental disability, cognitive impairments, learning-memory deficits and early onset of Alzheimer’s disease (AD). Over expression of chromosome 21 genes, localized in Down Syndrome Critical Region (DSCR), is the main cause of DS neuropathological features. We studied herein one of DSCR genes, DYRK1A (Dual-Specificity Tyrosine-Phosphorylation-Regulated ...

 Open Access DOI:10.23937/2643-4539/1710022

Cognitive Decline in Parkinson's Disease: Theories and Implications for Rehabilitation

Katherine A Brown, PhD, CCC-SLP, CBIS, Dale KL Summers, MS, CCC-SLP and Kristie A Spencer, PhD, CCC-SLP

Article Type: Review Article | First Published: March 30, 2022

Cognitive changes in Parkinson’s disease (PD) can occur at any stage of the disease and have been shown to significantly impact well-being and life participation. The nature and pattern of cognitive decline in PD remains unclear due to the heterogeneity of symptoms and lack of a clear explanatory model. This review aims to draw attention to several theoretical models of cognitive decline in PD to deepen our understanding of the complex milieu of symptoms and begin to offer clinical implication...

Volume 5
Issue 1