A Review on Alzheimer Disease
Deeksha Kaloni and Abhishek Negi
Article Type: Review Article | First Published: September 18, 2019
Alzheimer is one of the most common causes of dementia that influence nerve cells in various parts of the brain. Pathologically it is caused because of intracellular neurofibrillary tangles and extracellular amyloidal protein and results in the deposition of plaques which obstruct the communication between the nerve cells resulting in this neurodegenerative disease. The genetic risk factor found to be associated with this disease is mutation in APP, PSEN1 and PSEN2 genes. Also, the diet and nutr...
Acute Cognitive Effects of Physical Activity for People who have Dementia
Jordan Elliott-King, Elizabeth Peel and Eef Hogervorst
Article Type: Original Article | First Published: August 01, 2019
Physical activity has the potential to improve cognition for those with dementia, as demonstrated by randomised controlled trials lasting at least 6 weeks. Research is yet to explore the acute cognitive effects of physical activity for people with dementia. Acute resistance physical activity with healthy late-middle aged individuals has been shown to facilitate general cognition, as well as benefit executive function specifically. This study therefore aimed to establish if people with dementia e...
Parkinson's Disease, Diabetes, Functional Decline and Cognitive Impairment: A Comparative Study of Elderly Mexican Americans and Non-Hispanic Whites
Peter L Heller, PhD, David F Briones, MD, James A Wilcox, MD, PhD and Jose Manuel de la Rosa, MD
Article Type: Research Article | First Published: July 11, 2019
We report logistic regression analyses findings from a community sample of elderly Mexican Americans and non-Hispanic whites demonstrating that degrees of associations between diabetes and PD with CImp persist after controlling for effects of functional decline. However, after adding effects of a number of control variables (including ethnicity) to the equation, association between diabetes and CImp is no longer significant. We suggest that these findings may well be an artifact of the high prev...
Identification of PSEN1 and PSEN2 Gene Variants and Clinical Findings with the Literature
Nadide Cemre Randa, Elçin Bora, Esra Ataman, Ozlem Oz, Gorsev Yener and Ayfer Ulgenalp
Article Type: Original Article | First Published: April 11, 2019
Alzheimer's disease is an age-related and irreversible disease and characterized progressively decline in cognitive functions such as memory, speech, executive functions and visual-spatial skills. Currently, there is no a simple and definitive diagnosis method for clinical management. It is possible to diagnose with 85-90% accuracy with clinical assesment and neuropsychological tests. The precisely-known risk factors associated with Alzheimer's disease are aging, family history, and the presence...