International Journal of

Neurodegenerative DisordersISSN: 2643-4539

Early Online

 Open Access DOI:10.23937/2643-4539/1710011

Endogenous Adaptation to Chronic Mild Hypoxia Shifts the Balance towards Anti-Inflammatory Milieu in Progressive Myelin Oligodendrocyte Glycoprotein Induced EAE

Nilufer Esen, Rakhi Sharma, James P Malleis and Paula Dore-Duffy, Ph.D

Article Type: Research Article | First Published: September 18, 2019

The mammalian brain depends on a continuous supply of oxygen and glucose to meet metabolic demand. Adaptive mechanisms allow brain cells to exist under conditions of moderately low oxygen when ‘idling’ or exposure to high altitude as well as elevated oxygen delivery when activated. Regulation involves numerous intrinsic and extrinsic adaptive mechanisms that serve to maintain metabolic homeostasis. Under conditions of chronic low oxygen (10%) endogenous changes in CNS angiodynamics help prom...

 Open Access DOI:10.23937/2643-4539/1710010

A Review on Alzheimer Disease

Deeksha Kaloni and Abhishek Negi

Article Type: Review Article | First Published: September 18, 2019

Alzheimer is one of the most common causes of dementia that influence nerve cells in various parts of the brain. Pathologically it is caused because of intracellular neurofibrillary tangles and extracellular amyloidal protein and results in the deposition of plaques which obstruct the communication between the nerve cells resulting in this neurodegenerative disease. The genetic risk factor found to be associated with this disease is mutation in APP, PSEN1 and PSEN2 genes. Also, the diet and nutr...

 Open Access DOI:10.23937/2643-4539/1710009

Acute Cognitive Effects of Physical Activity for People who have Dementia

Jordan Elliott-King, Elizabeth Peel and Eef Hogervorst

Article Type: Original Article | First Published: August 01, 2019

Physical activity has the potential to improve cognition for those with dementia, as demonstrated by randomised controlled trials lasting at least 6 weeks. Research is yet to explore the acute cognitive effects of physical activity for people with dementia. Acute resistance physical activity with healthy late-middle aged individuals has been shown to facilitate general cognition, as well as benefit executive function specifically. This study therefore aimed to establish if people with dementia e...

 Open Access DOI:10.23937/2643-4539/1710008

Parkinson's Disease, Diabetes, Functional Decline and Cognitive Impairment: A Comparative Study of Elderly Mexican Americans and Non-Hispanic Whites

Peter L Heller, PhD, David F Briones, MD, James A Wilcox, MD, PhD and Jose Manuel de la Rosa, MD

Article Type: Research Article | First Published: July 11, 2019

We report logistic regression analyses findings from a community sample of elderly Mexican Americans and non-Hispanic whites demonstrating that degrees of associations between diabetes and PD with CImp persist after controlling for effects of functional decline. However, after adding effects of a number of control variables (including ethnicity) to the equation, association between diabetes and CImp is no longer significant. We suggest that these findings may well be an artifact of the high prev...

 Open Access DOI:10.23937/IJND-2017/1710007

Identification of PSEN1 and PSEN2 Gene Variants and Clinical Findings with the Literature

Nadide Cemre Randa, Elçin Bora, Esra Ataman, Ozlem Oz, Gorsev Yener and Ayfer Ulgenalp

Article Type: Original Article | First Published: April 11, 2019

Alzheimer's disease is an age-related and irreversible disease and characterized progressively decline in cognitive functions such as memory, speech, executive functions and visual-spatial skills. Currently, there is no a simple and definitive diagnosis method for clinical management. It is possible to diagnose with 85-90% accuracy with clinical assesment and neuropsychological tests. The precisely-known risk factors associated with Alzheimer's disease are aging, family history, and the presence...

Volume 2
Issue 1