International Journal of Neurodegenerative Disorders is an open access peer-reviewed journal committed to promote the best standards of scientific discoveries and education. It covers all aspects of a range of conditions which primarily affect the neurons in the human brain. International Journal of Neurodegenerative Disorders publishes basic, clinical, and translational research.
International Journal of Neurodegenerative Disorders is newly launched journal which provide author benefits along with reliable copy rights policy. All the articles pass through a dual review process in which two independent review comments followed by editor's decision will be considered to publish the article. Editorial team ensures the maintenance of its standards by publishing the high quality, original and new advances in its field.
The journal welcome submissions in the form of original articles, research, reviews, cases, commentaries, reports, and short communications etc., covering the information on neurodegenerative disorders. The scope of the journal include but not limited to alzheimer's disease and other dementias, parkinson's disease and l.pd-related disorders, prion disease, motor neuron diseases, huntington's disease, spinocerebellar ataxia, spinal muscular atrophy, etc.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2643-4539/1710011
Nilufer Esen, Rakhi Sharma, James P Malleis and Paula Dore-Duffy, Ph.D
Article Type: Research Article | First Published: September 18, 2019
The mammalian brain depends on a continuous supply of oxygen and glucose to meet metabolic demand. Adaptive mechanisms allow brain cells to exist under conditions of moderately low oxygen when ‘idling’ or exposure to high altitude as well as elevated oxygen delivery when activated. Regulation involves numerous intrinsic and extrinsic adaptive mechanisms that serve to maintain metabolic homeostasis. Under conditions of chronic low oxygen (10%) endogenous changes in CNS angiodynamics help prom...
Open Access DOI:10.23937/2643-4539/1710010
Deeksha Kaloni and Abhishek Negi
Article Type: Review Article | First Published: September 18, 2019
Alzheimer is one of the most common causes of dementia that influence nerve cells in various parts of the brain. Pathologically it is caused because of intracellular neurofibrillary tangles and extracellular amyloidal protein and results in the deposition of plaques which obstruct the communication between the nerve cells resulting in this neurodegenerative disease. The genetic risk factor found to be associated with this disease is mutation in APP, PSEN1 and PSEN2 genes. Also, the diet and nutr...
Open Access DOI:10.23937/2643-4539/1710009
Jordan Elliott-King, Elizabeth Peel and Eef Hogervorst
Article Type: Original Article | First Published: August 01, 2019
Physical activity has the potential to improve cognition for those with dementia, as demonstrated by randomised controlled trials lasting at least 6 weeks. Research is yet to explore the acute cognitive effects of physical activity for people with dementia. Acute resistance physical activity with healthy late-middle aged individuals has been shown to facilitate general cognition, as well as benefit executive function specifically. This study therefore aimed to establish if people with dementia e...
Open Access DOI:10.23937/2643-4539/1710008
Peter L Heller, PhD, David F Briones, MD, James A Wilcox, MD, PhD and Jose Manuel de la Rosa, MD
Article Type: Research Article | First Published: July 11, 2019
We report logistic regression analyses findings from a community sample of elderly Mexican Americans and non-Hispanic whites demonstrating that degrees of associations between diabetes and PD with CImp persist after controlling for effects of functional decline. However, after adding effects of a number of control variables (including ethnicity) to the equation, association between diabetes and CImp is no longer significant. We suggest that these findings may well be an artifact of the high prev...
Open Access DOI:10.23937/IJND-2017/1710007
Nadide Cemre Randa, Elçin Bora, Esra Ataman, Ozlem Oz, Gorsev Yener and Ayfer Ulgenalp
Article Type: Original Article | First Published: April 11, 2019
Alzheimer's disease is an age-related and irreversible disease and characterized progressively decline in cognitive functions such as memory, speech, executive functions and visual-spatial skills. Currently, there is no a simple and definitive diagnosis method for clinical management. It is possible to diagnose with 85-90% accuracy with clinical assesment and neuropsychological tests. The precisely-known risk factors associated with Alzheimer's d...
Open Access DOI:10.23937/IJND-2017/1710006
Abhilasha Surampalli, Angele Nalbandian, Sandra Donkervoort, Manaswitha Khare, Annabel Wang, Rudolph Castellani, Hong Yin, Ana Rubio, Payal Patel, John Weiss, Tahseen Mozaffar and Virginia E Kimonis
Article Type: Case Report | First Published: December 19, 2018
Valosin Containing Protein (VCP) gene mutations have been reported in ~1-2% of familial amyotrophic lateral sclerosis (ALS). We report a case of clinically defined and neuropathologically confirmed ALS in a 48-year-old, emaciated female with a p.R155C (c.463 C > T) mutation in VCP gene. She presented with progressive generalized muscular weakness, weight loss, dyspnea on exertion, combined nasal and spastic dysarthria, positive jaw jerk and exagg...
Open Access DOI:10.23937/ijnd-2017/1710005
Eyisi CS, Onwuekwe IO, Eyisi IG and Ekenze O
Article Type: Research Article | First Published: November 19, 2018
A stroke is a Focal (or global) neurological impairment of sudden onset, lasting more than 24 hrs and usually from a vascular cause. Clinical presentation span through a myriad of motor deficits, sensory deficits, seizures, personality/behavioral anomalies, dementia, brainstem stroke syndromes and herniation syndromes. Traditionally stokes are classified as ischemic or hemorrhagic, the former more common than the latter in a ratio of 6:1. Conventional risk factors for stroke occurrence have al...
Open Access DOI:10.23937/IJND-2017/1710004
Jeffrey T Apter, Ivy A Billones and Kaylee White
Article Type: Case Report | First Published: November 16, 2018
A 69-year-old Caucasian female experienced multiple episodes of full-body tremors during the extension phase of the clinical study. The investigational drug was taken in the mornings. The patient reported that the AE started six months prior with episodes occurring 1-2 times per week eventually escalating almost daily and was more apparent during midnight hours and upon waking up. Further review of previous progress notes states that the patient denied the AE and even stated full compliance and ...
Open Access DOI:10.23937/ijnd-2017/1710003
David A Steenblock, Taruna Ikrar, Andrew S San Antonio, Elfi Wardaningsih and Masoud J Azizi
Article Type: Research Article | First Published: September 12, 2018
Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is a neurodegenerative and neuromuscular disorder characterized by a progressive death of motor neurons & motor paralysis that culminates in death, usually within 3-5 years of diagnosis from respiratory failure due to paralysis. Currently approved ALS therapies are not curative and fail to increase healthy lifespan. The worldwide prevalence of ALS is expected to increase by 69% over the ...
Open Access DOI:10.23937/ijnd-2017/1710002
Troy T Rohn and Jacob M Mack
Article Type: Research Article | First Published: February 23, 2018
Although harboring the Apolipoprotein E4 (APOE4) allele is a well-known risk factor in Alzheimer's disease (AD), whether a similar risk holds true for Parkinson's disease (PD) is currently not known. To investigate whether apoE pathology is present in PD, an immunohistochemical study was undertaken with fixed, human PD brain sections from the substantia nigra utilizing a recently characterized antibody that detects an amino-terminal fragment of a...
Open Access DOI:10.23937/ijnd-2017/1710001
Ammarah Y Soofi, Michelle E Kho, Vanina Dal Bello-Haas and Lori Letts
Article Type: Review Article | First Published: October 28, 2017
Many factors can affect a person's outlook on his/her life; rehabilitation interventions vary greatly and little is known about the effect of rehabilitation to maintain and/or enhance Quality of Life (QoL) in people with Amyotrophic Lateral Sclerosis (ALS)....
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