Kaloni D, Negi A (2019) A Review on Alzheimer Disease. Int J Neurodegener Dis 2:010.


© 2019 Kaloni D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Review Article | OPEN ACCESS DOI: 10.23937/2643-4539/1710010

A Review on Alzheimer Disease

Deeksha Kaloni1* and Abhishek Negi2

1School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, India

2Chungbuk National University, South Korea


Alzheimer is one of the most common causes of dementia that influence nerve cells in various parts of the brain. Pathologically it is caused because of intracellular neurofibrillary tangles and extracellular amyloidal protein and results in the deposition of plaques which obstruct the communication between the nerve cells resulting in this neurodegenerative disease. The genetic risk factor found to be associated with this disease is mutation in APP, PSEN1 and PSEN2 genes. Also, the diet and nutrition play quite an important role in the development as well as prevention of Alzheimer Disease. The biomarker used for the detection of the disease should be able to differentiate between different causes of dementia and should be able to detect it at early stage. Further the use of Induced pluripotent stem cells has proven to be an effective treatment for the cure of this disease. The objective of this review is to highlight about the pathway that lead to this disease and stem cell treatment of this disease.