International Journal of

Neurodegenerative DisordersISSN: 2643-4539

Current Issue

 Open Access DOI:10.23937/2643-4539/1710014

Predictors of Health-Related Quality of Life and Communicative Participation in Individuals with Dysarthria from Parkinson’s Disease

Kristie A Spencer, Clare Friedlander and Katherine A Brown

Article Type: Researc h Article | First Published: January 03, 2020

The motor and non-motor deficits of Parkinson’s disease (PD) can cause daily challenges and have been associated with reduced health-related quality of life (HrQoL). A number of variables have been consistently, though not unequivocally, identified as important in influencing overall HrQoL in individuals with PD, such as demographic factors, cognitive decline, and level of motor impairment. However, the presence and severity of dysarthria is often overlooked, despite the potentially adverse in...

 Open Access DOI:10.23937/2643-4539/1710013

Part Two: Habit and Customs, Obesity and Parkinson's Disease

Muslimat Kehinde Adebisi, Li Xuezhong, Ehianeta Teddy and Liuyi

Article Type: Review Article | First Published: October 21, 2019

Keyword used in searching for similar articles on PubMed were, Obesity, hyperlipidemia, Metabolic syndrome (MetS), Neurodegenerative disorders, Parkinson’s diseases (PD). Papers from 2014-2019 related were compiled. Cases at Zhenjiang First people’s hospital similar was compiled to draw conclusions. I evaluated the association between years of diagnosis (YOD) of PD and BMI for both male and female patients and compared to controlled groups. There was a statistically significance between YOD ...

 Open Access DOI:10.23937/2643-4539/1710012

Obesity may Increase the Prevalence of Parkinson’s Disease while Parkinson's may Reduce Obesity Index in Patients

Muslimat Kehinde Adebisi, Ehianeta Teddy, Mzee Said Abdulraman Salim, Liuyi, Abdul Nazif Mahmud, Aaron Gia Kanton and Abdullateef Taiye Mustapha

Article Type: Research Article | First Published: October 14, 2019

Currently Parkinson's disease is becoming more common among younger people of ages from 30-40 years. The incidence is higher among patients with higher BMI, some reports has it that Obesity is a risk factor for Parkinson’s disease while some reported that there is no relationship between obesity and Parkinson’s disease. Parkinson’s disease patient at the time of diagnosis has a above normal BMI but this goes below normal as the disease progresses. Therefore, it is important to explore the ...

 Open Access DOI:10.23937/IJND-2017/1710006

A Clinicopathologic Case Report of a Female with Valosin-Containing Protein (VCP) Gene Mutation Related Disease

Abhilasha Surampalli, Angele Nalbandian, Sandra Donkervoort, Manaswitha Khare, Annabel Wang, Rudolph Castellani, Hong Yin, Ana Rubio, Payal Patel, John Weiss, Tahseen Mozaffar and Virginia E Kimonis

Article Type: Case Report | First Published: December 19, 2018

Valosin Containing Protein (VCP) gene mutations have been reported in ~1-2% of familial amyotrophic lateral sclerosis (ALS). We report a case of clinically defined and neuropathologically confirmed ALS in a 48-year-old, emaciated female with a p.R155C (c.463 C > T) mutation in VCP gene. She presented with progressive generalized muscular weakness, weight loss, dyspnea on exertion, combined nasal and spastic dysarthria, positive jaw jerk and exaggerated gag reflex. Electrodiagnostic studies revea...

 Open Access DOI:10.23937/ijnd-2017/1710005

Rare and Hereditary Causes of Stroke-A Literature Review

Eyisi CS, Onwuekwe IO, Eyisi IG and Ekenze O

Article Type: Research Article | First Published: November 19, 2018

A stroke is a Focal (or global) neurological impairment of sudden onset, lasting more than 24 hrs and usually from a vascular cause. Clinical presentation span through a myriad of motor deficits, sensory deficits, seizures, personality/behavioral anomalies, dementia, brainstem stroke syndromes and herniation syndromes. Traditionally stokes are classified as ischemic or hemorrhagic, the former more common than the latter in a ratio of 6:1. Conventional risk factors for stroke occurrence have al...

 Open Access DOI:10.23937/IJND-2017/1710004

Multiple Episodes of Full-Body Tremors: An Unexpected Adverse Effect during an Alzheimer's Disease Investigational Drug Study

Jeffrey T Apter, Ivy A Billones and Kaylee White

Article Type: Case Report | First Published: November 16, 2018

A 69-year-old Caucasian female experienced multiple episodes of full-body tremors during the extension phase of the clinical study. The investigational drug was taken in the mornings. The patient reported that the AE started six months prior with episodes occurring 1-2 times per week eventually escalating almost daily and was more apparent during midnight hours and upon waking up. Further review of previous progress notes states that the patient denied the AE and even stated full compliance and ...

 Open Access DOI:10.23937/ijnd-2017/1710003

Amyotrophic Lateral Sclerosis (ALS) Linked to Intestinal Microbiota Dysbiosis & Systemic Microbial Infection in Human Patients: A Cross-Sectional Clinical Study

David A Steenblock, Taruna Ikrar, Andrew S San Antonio, Elfi Wardaningsih and Masoud J Azizi

Article Type: Research Article | First Published: September 12, 2018

Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is a neurodegenerative and neuromuscular disorder characterized by a progressive death of motor neurons & motor paralysis that culminates in death, usually within 3-5 years of diagnosis from respiratory failure due to paralysis. Currently approved ALS therapies are not curative and fail to increase healthy lifespan. The worldwide prevalence of ALS is expected to increase by 69% over the next 25 years, yet its etiology remains scientific...

 Open Access DOI:10.23937/ijnd-2017/1710002

Apolipoprotein E Fragmentation within Lewy Bodies of the Human Parkinson's Disease Brain

Troy T Rohn and Jacob M Mack

Article Type: Research Article | First Published: February 23, 2018

Although harboring the Apolipoprotein E4 (APOE4) allele is a well-known risk factor in Alzheimer's disease (AD), whether a similar risk holds true for Parkinson's disease (PD) is currently not known. To investigate whether apoE pathology is present in PD, an immunohistochemical study was undertaken with fixed, human PD brain sections from the substantia nigra utilizing a recently characterized antibody that detects an amino-terminal fragment of apoE. This antibody, termed the apoE cleavage fragm...

 Open Access DOI:10.23937/ijnd-2017/1710001

The Impact of Rehabilitation Interventions on Quality of Life in Individuals with Amyotrophic Lateral Sclerosis: A Systematic Review

Ammarah Y Soofi, Michelle E Kho, Vanina Dal Bello-Haas and Lori Letts

Article Type: Review Article | First Published: October 28, 2017

Many factors can affect a person's outlook on his/her life; rehabilitation interventions vary greatly and little is known about the effect of rehabilitation to maintain and/or enhance Quality of Life (QoL) in people with Amyotrophic Lateral Sclerosis (ALS)....

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