FRANZOI AEA, MONFREDINI NH, POPE LZB, dos REIS FI, TIRONI FA (2018) Cerebral Histoplasmosis in Non-Immunosuppressed Patient - Case Report. Int J Neurol Neurother 5:077.


© 2018 FRANZOI AEA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE REPORT | OPEN ACCESS DOI: 10.23937/2378-3001/1410077

Cerebral Histoplasmosis in Non-Immunosuppressed Patient - Case Report

André Eduardo de Almeida FRANZOI1*, Nayme Hechem MONFREDINI1, Leonora Zozula Blind POPE2, Felipe Ibiapina dos REIS3 and Fabio Antonio TIRONI2

1Medical Student at the University of Joinville Region, Brazil

2Pathologist at Hospital Dona Helena and Professor of Pathology at the University of Joinville Region, Brazil

3Neurologist at Dona Helena Hospital and Professor of Neurology at Joinville Region University, Brazil


Histoplasmosis is a disease caused by Histoplasma capsulatum var. capsulatum, which is endemic in Latin America. The manifestation of the disease in the central nervous system (CNS) is more frequent in immunosuppressed individuals with disseminated presentation. Pulmonary manifestations are usually the first symptoms. However, when neurological manifestations are the first clinical manifestations, the diagnosis becomes a challenge. The early diagnosis is fundamental in the final outcome of the patient. The objective is to report a case of difficult identification of cerebral histoplasmosis in a nonimmunosuppressed patient in Joinville, Brazil.