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© 2019 Bosqui LR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

REVIEW ARTICLE | OPEN ACCESSDOI: 10.23937/ijtd-2017/1710016

The Influence of Human T-Lymphotropic Virus 1 on Patients Coinfected by the Helminth Strongyloides stercoralis

Larissa Rodrigues Bosqui, Taylon Felipe Silva*, Raquel Arruda Sanfelice, Laís Fernanda Machado, Érika Caroline Steinle, Bianca Arranzato Bertasso, Marina Letícia Rezende Mantovani, Gabriela de Alcantara Dalevedo, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa, Wander Rogerio Pavanelli, Francine Nesello Melanda and Idessania Nazareth Costa

Department of Pathological Sciences, Laboratory of Parasitology of Neglected Diseases and Cancer, Londrina State University, Brazil


Strongyloides stercoralis is the helminth which causes strongyloidiasis, a neglected disease, with a global prevalence estimated at 60 million people infected, principally in tropical regions. The parasite’s proliferation occurs mainly in immunosuppressed hosts, in particular, patients carrying Human T-lymphotropic virus 1 (HTLV-1), which is responsible for the infection of cells of the immune system. As a result, we aimed to identify and discuss clinical and pathological aspects of infection by S. stercoralis in patients carrying HTLV-1. This is an exploratory study, of the literature review type. The search was undertaken in the PubMed, Scielo, Web of Science, Science Direct and Biblioteca Virtual emSaúde (BVS) databases in August 2016. The criteria for the inclusion of articles were: Language, published in the last 20 years, and to be relevant to the guiding question. After reading of the titles, 60 articles were excluded, and after reading of the abstracts, a further 70. Of the 56 articles remaining, 16 were excluded after reading the article in full. After analysis of the material, only 40 studies met the criteria established. The studies showed that this type of coinfection is found in the same specific population groups which are vulnerable to the diseases, as well as immunomodulation of the Th2 pattern, promoted by the presence of S. stercoralis and the difficulties related to the diagnosis of Strongyloidiasis. It is concluded that it is necessary to screen for HTLV-1in cases of infection by S. stercoralis, so as to initiate fast and efficient treatment against this coinfection.