International Journal of Tropical Diseases is an open access peer reviewed journal dealing with the infectious diseases that break out in hot, humid conditions, such as malaria, lymphatic filariasis, chagas disease, african trypanosomiasis, leishmaniasis, schistosomiasis, onchocerciasis, and dengue, etc. The journal is open in gathering high quality awareness among diseases thosefall in diverse group of communicable diseases that prevail in tropical and subtropical conditions.
Journal gathers original research, reviews, communications, letters, cases and short articles related to chagas disease, dengue, helminths, african trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, malaria, onchocerciasis, schistosomiasis, sexually transmitted infections, TB-HIV, TB, neglected tropical diseases, "exotic" diseases, prevention and treatment of tropical diseases, controlling tropical diseases, globalization and disease, etc. The journal includes recent advances in improving the understanding of disease and the safe and effective treatment of patients. Published articles are available online without any barriers to use and reuse under the terms of attribution license.
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Open Access DOI:10.23937/2643-461X/1710034
Gustavo Henrique Sumnienski Bertoldi, Rafael M Ronsoni, MD, MsC and Marcus Vinicius Magno Goncalves, MD, PhD
Article Type: Review Article | First Published: July 04, 2020
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a coronavirus strain, and its main way to get access to the cells is via the angiotensin converting enzyme (ACE2) and causes the Coronavirus Disease 2019 (COVID-19). ACE2 is an important enzyme in the pathogeneses of hypertension. For the treatment of hypertension, it is commonly used angiotensin II receptor blockers (ARBs) and angiotensin II converting enzyme inhibitors (ACEIs). It is clear that there is a lot of uncertainty an...
Open Access DOI:10.23937/2643-461X/1710033
Eliningaya J Kweka
Article Type: Commentary | First Published: June 19, 2020
Success in controlling malaria has been reported across the world mainly through the use of long-lasting insecticidal nets, indoor residual spray, and appropriate diagnosis and treatment. However, in the era of COVID-19, more attention has been shifted to cases and mortality caused by the SARS-CoV-2 virus, which are jeopardizing the continuity of efforts attained so far in malaria control. This commentary proposes alternatives to be adopted during the COVID-19 pandemic to maintain the attained m...
Open Access DOI:10.23937/2643-461X/1710032
Osvaldo Batista Rojas, MSc
Article Type: Research Article | First Published: June 04, 2020
An observational, descriptive and cross-sectional study was carried out; the universe of study was represented by all schoolchildren from six Primary Schools in Marianao during the period from August 2018 to January 2020 with the clinical and microbiological diagnosis of intestinal parasitosis and they were treated at Five Family Medical Offices. There was a predominance of the female sex for 51.4%. With greater predominance of the age group of 5 to 7 years for 33.8%, abdominal pain was the most...
Open Access DOI:10.23937/2643-461X/1710031
Marco Antonio Machado Schlindwein, Leticia Caroline Breis, Isabelle Pastor Bandeira, Rafael M Ronsoni, MD, MsC, Clizenaldo Torres, MD and Marcus Vinicius Magno Goncalves, MD, PhD
Article Type: Commentary | First Published: May 13, 2020
The emergence of SARS-CoV-2 is a challenge in the actual medical scenario. Besides the classical lung and respiratory disease, patients infected with the virus can present with cardiac injury, and pathogenic mechanisms point to direct infection of the heart. In this paper, we seek to show the correlation between cardiology and SARS-CoV-2 infection, especially with regard to myocarditis, which has been shown to be one of the complications in COVID-19. SARS-CoV-2 is the virus responsible for coron...
Open Access DOI:10.23937/2643-461X/1710030
Osvaldo Batista Rojas, MSc
Article Type: Research Article | First Published: April 24, 2020
To determine the association between the level of knowledge about intestinal parasitosis and preventive measures in mothers of parasitized schoolchildren between the ages of 5 and 11 years of the Marianao municipality in Havana in 2019. An observational, analytical, crosssectional study that included 195 mothers of schoolchildren between the ages of 5 and 11 years attended in the four Family Medical Offices of Marianao, Havana. Age, marital status, educational level, occupation, level of knowled...
Open Access DOI:10.23937/2643-461X/1710029
Shuaib Kayode Aremu, Kayode Rasaq Adewoye and Tayo Ibrahim
Article Type: Original article | First Published: April 08, 2020
The study was conducted in the Ear, Nose, and Throat (ENT) department of Federal Teaching Hospital Ido-Ekiti, which is a tertiary care hospital in Ekiti state, Nigeria. The study involved 275 patients above the age of 10, who presented in the ENT department over 5 years period and were clinically diagnosed cases of otomycosis. Certain patient demographics such as age, gender, and clinical presentations were recorded along with possible risk factors and clinically observed findings. Microbiologic...
Open Access DOI:10.23937/2643-461X/1710028
Osvaldo Batista Rojas, MSc
Article Type: Research article | First Published: February 20, 2020
An educational intervention study on intestinal parasitism was carried out in parents of parasitized children of Capitan San Luis de Marianao Elementary School, Havana in the period May 2018-2019, with the purpose of modifying the knowledge in these parents against some hygienic- sanitary aspects in order to reduce the incidence of disease through the application of a program of educational activities. Knowledge was determined through the use of a structured questionnaire. And social activities ...
Open Access DOI:10.23937/2643-461X/1710027
Monica Namayanja, Gloria Grace Akurut and George W Lubega
Article Type: Short Communication | First Published: February 08, 2020
Trypanosoma brucei brucei in mice, the experimental model of African Trypanosomiasis, is known to begin crossing the blood-brain barrier between 9-13 days post-infection, which is also considered the commencement of the late stage of the disease. A few recent reports however, reported traversal as early as two hours to a few days. In these reports laboratory strains were used thus this study sought to find out if this early brain invasion is phenomenon of laboratory strains or also field isolate...
Open Access DOI:10.23937/2643-461X/1710026
Anupam Brahma, MBBS, Prasit Kumar Ghosh, MD, Utpal Goswami, MD and Saswati Majumdar, MD
Article Type: Original Article | First Published: December 11, 2019
Dengue fever is one of the most important emerging infectious diseases constituting important contribution in global burden of disease. Platelet transfusion is required in the patients when they develop Dengue Hemorrhagic Fever (DHF) or thrombocytopenia below 20,000/ cu.mm without hemorrhage. Serial platelet counts are used to monitor the patients. In this study we investigated whether Mean Platelet Volume (MPV) could be used as a tool to predict development of significant thrombocytopenia, DHF ...
Open Access DOI:10.23937/2643-461X/1710025
Silvio J Krivokapich, Cinthia L Gonzalez Prous, Graciana M Gatti and Patricia A Arbusti
Article Type: Original Article | First Published: August 31, 2019
Early serological diagnosis of trichinellosis is affected by a long-term immunological "silent" period following infection. This emphasises the need for the development of sensitive diagnostic methods to be used when antibodies cannot be detected. In this study, we assessed the usefulness of three DNA sequences as a direct diagnosis method to detect early infection with Trichinella spiralis in peripheral blood by SYBR green real-time PCR using a murine model. Primers were designed from a nuclear...
Open Access DOI:10.23937/2643-461X/1710024
Osvaldo Batista Rojas, MSc
Article Type: Original Research | First Published: August 31, 2019
An intervention study was carried out, quasi-experimental, retro-prospective with the students of the Primary School "Hugo Camejo" and their parents in the period 2017-2019. The universe was constituted by 627 students and the sample by the 83 schoolchildren of 4th grade, with the objective of developing an intervention strategy to increase the level of knowledge about intestinal parasitosis. Reaching the following conclusions: Only half of the children before the intervention had adequate hygie...
Open Access DOI:10.23937/2643-461X/1710023
Danilo C Miguel and Danilo C Guarnier, DVM
Article Type: Mini Review | First Published: July 17, 2019
Leishmaniasis is a complex disease considered one of the most neglected tropical diseases of the world. The importance and role of domestic dogs and wild canids as a source of leishmaniasis infection is well recognized. The present mini-review discusses a series of epidemiological studies that reinforce the need to understand the role of reservoirs and vectors in the expansion of leishmaniasis to Brazilian urbanized areas, as Brazil is a country of continental dimensions and endemic for leishman...
Open Access DOI:10.23937/2643-461X/1710021
Juan Pablo Rodríguez Miranda
Article Type: Short Communication | First Published: May 30, 2019
The causal relationship between environmental pollution and specifically the lack of adequate environmental sanitation, in the context of the elimination of excreta and solid waste disposition on site guaranteed for this purpose, conceives a high risk in the proliferation of vectors and therefore proportional generation morbidity in diseases of a hydric nature that directly or indirectly affects the population....
Open Access DOI:10.23937/2643-461X/1710020
Maria Elena Villagran-Herrera, Manuel Sanchez-Moreno, Jose Alejandro Martinez-Ibarra, Ricardo Francisco Mercado-Curiel, Adriana Jheny Rodriguez-Mendez, Javier Avila-Morales, Maria del Carmen Aburto-Fernandez, Nicolas Camacho-Calderon and y Jose Antonio de Diego-Cabrera
Article Type: Research article | First Published: May 10, 2019
The acute phase of Chagas disease can occur at any age, however the pediatric population is usually the most affected (from one to 15 years), so it is very important to detect and treat it as soon as possible to try to eliminate the circulating parasite. The main objective of this research is to present the first seroepidemiological study of the infection by Trypanosoma cruzi, carried out to students of school age of both urban and rural primary schools in the State of Querétaro and at the same...
Open Access DOI:10.23937/IJTD-2017/1710019
Yohanna Jemimah, Oti Victor, Amuta Elizabeth, Philip Akpu and Anizoba Lynda
Article Type: Research article | First Published: April 04, 2019
Plasmodium falciparum infection remains a leading cause of global morbidity and mortality, causing about 3,000 daily deaths. This study intended to document the prevalence, and the associated factors of P. falciparum infection among febrile patients attending Federal the Medical Centre Keffi, Nigeria. After ethical clearance, 400 whole blood samples were collected from patients who gave informed consent and completed a self-structured questionnaire from July 2015 through January 2016. The blood ...
Open Access DOI:10.23937/ijtd-2017/1710018
Ileke Kayode David and Olabimi Isaac Omotayo
Article Type: Original Research | First Published: March 18, 2019
Female Anopheles mosquitoes are the vectors of human malaria. The use of chemical insecticides for vector control has hampered with environmental pollution and insect. This suggests the need for the development of more potent and environment-friendly insecticides for effective control of malaria. This research investigated the larvicidal, pupicidal and adulticidal activities of Chromolaena odorata and Vernonia amygdalina leaf extracts against....
Open Access DOI:10.23937/ijtd-2017/1710017
Afolabi Olajide Joseph, Ojo Babatunde David and Simon-Oke Iyabo Adepeju
Article Type: Original Article | First Published: March 13, 2019
Schistosomiasis is a parasitic disease transmitted by fresh water snail infected with the Schistosoma parasites. The disease is endemic in many parts of Asia, Africa, and South America affecting people who are unable to avoid contact with water, either because of their profession or because of lack of reliable source of safe water for drinking, washing and bathing. The study focused on the molluscicidal activities of the oil extracts of Tetrapleura tetraptera, Bridelia ferruginea and Azadirachta...
Open Access DOI:10.23937/ijtd-2017/1710016
Larissa Rodrigues Bosqui, Taylon Felipe Silva, Raquel Arruda Sanfelice, Lais Fernanda Machado, Erika Caroline Steinle, Bianca Arranzato Bertasso, Marina Leticia Rezende Mantovani, Gabriela de Alcantara Dalevedo, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa, Wander Rogerio Pavanelli, Francine Nesello Melanda and Idessania Nazareth Costa
Article Type: Review Article | First Published: February 09, 2019
Strongyloides stercoralis is the helminth which causes strongyloidiasis, a neglected disease, with a global prevalence estimated at 60 million people infected, principally in tropical regions. The parasite’s proliferation occurs mainly in immunosuppressed hosts, in particular, patients carrying Human T-lymphotropic virus 1 (HTLV-1), which is responsible for the infection of cells of the immune system. As a result, we aimed to identify and discuss clinical and pathological aspects of infection ...
Open Access DOI:10.23937/ijtd-2017/1710015
Sylvia Ortiz and Aldo Solari
Article Type: Review Article | First Published: February 06, 2019
Kinetoplastea Trypanosomatidae are unicellular flagellated parasites of different kind of hosts. They cause diseases in plants, animals and humans. These parasites are transmitted by insect vectors in a wide range of geographic areas. In this communication we review the interactions between trypanosomatid parasites, their hosts and thoughts about their impact on environmental health, especially in those regions where hosts are natural reserves of many species. The interactions of these parasites...
Open Access DOI:10.23937/ijtd-2017/1710014
Prevalence of Plasmodium Falciparum among Nigerians in Abuja and Central States: A Comparative Analysis of Sensitivity and Specificity Using Rapid Diagnostic Test and Microscopy as Tools in Management of Malaria
Peter Asaga Mac, Hussaini Fatima Asheadzi, Amuga Gideon, Prerna Thaker and Philomena Airiohuodion
Article Type: Research Article | First Published: January 30, 2019
A cross-sectional study of 403 consenting healthy individuals who came to National hospital, Abuja and Nasarawa State University hospital, Keffi for medical examination were recruited from April 2017 through July 2017. The socio-demographic charactersitics of each participant was obtained through oral consultation. Information collected included the sex, age, occupation and locality to which they belonged. The gold standard tool (microscopy) and RDTs were used to determine the prevalence of mala...
Open Access DOI:10.23937/ijtd-2017/1710013
Michelino Di Rosa and Lucia Malaguarnera
Article Type: Research Article | First Published: January 25, 2019
Over forty years of extensive research has not yet solved the complexity of Ebola pathogenesis leading to a continued need for a successful cure. This virus has evolved different strategies to counteract immune responses as they are unreceptive to a large portion of the known antiviral drugs and there is no valid treatment as to date for disease created by this pathogen. A plethora of evidences have revealed that monocytes/macrophage contribute significantly in viral pathogenesis....
Open Access DOI:10.23937/ijtd-2017/1710012
Juan Carlos Alava, Susana Alava and Juan Jose Alava
Article Type: Case Report | First Published: December 08, 2018
Strongyloides stercoralis is a common nematode causing intestinal parasitosis in the Ecuadorian population, but cases of lung infection by this helminth have not been documented in Ecuador. We document the first case of pulmonary strongyloidias is caused by S. stercoralis filariform larvae in a male patient from Manabí Province (Ecuador), showing clinical symptoms of terminal pulmonary syndrome. Previous to the decease of the patient, the larvae were identified by the direct smear method of a f...
Open Access DOI:10.23937/ijtd-2017/1710011
Ahmed Mohammed Al-hassan Ibrahim, Hafiz Hassan Shebeir Ahmed, Rehab AbdElgadir Adam, Ayman Ahmed and Arwa Elaagip
Article Type: Original Article | First Published: November 19, 2018
The housefly, Musca domestica, is a common household pest known to transmit human diseases like pathogenic bacteria, protozoa, metazoan, fungi and viruses. Apart from they are also responsible for transmitting intestinal parasites, which when outbreaks occur, could wreak havoc on both man and animals. The importance of house fly in disease transmission prompted this study to investigate the presence of intestinal parasites transmitted mechanically by houseflies that infested slaughterhouses in c...
Open Access DOI:10.23937/ijtd-2017/1710010
High Prevalence of Epilepsy in Onchocerciasis Endemic Communities of Ngie: Lack of Association with Taeniasis but Strong Indicators of Hereditary Factors and Characteristics of Onchocerciasis Associated Epilepsy Observed
Raphael Awah Abong, Fongoh Ayong Hassan, Tatsinkou Betrand Fossi, Peter Ndefon, Theresa Nkuo-Akenji, Samuel Wanji and Anong Damian Nota
Article Type: Original Article | First Published: November 12, 2018
Epilepsy, a neurological condition which affects individuals of all ages has been widely reported to be caused by parasitic, fungal, bacterial or viral infectious diseases of the Central Nervous System (CNS). Taenia solium infection otherwise known as neurocysticercosis in taeniasis endemic zones, Onchocerca volvulus infection in onchocerciasis meso/hyperendemic areas in Africa and other infectious agents have been highly incriminated in different parts of the world. Epilepsy remains an importan...
Open Access DOI:10.23937/ijtd-2017/1710009
Cavalcanti S, L Lerena V and Gomez C
Article Type: Case Report | First Published: October 27, 2018
Cardiovascular involvement by Leptospira is infrequent. However the statistics are under estimated. This paper reports a case of a 39 years old male, who works as a Marine and had traveled to a tropical endemic area for Leptospira in Peru. He was initially admitted with fever, headache and myalgias. He was diagnosed of Leptospirosis (Ig M positive and MAT positive) and malaria and receive specific treatment for both diseases (Doxycycline, Cloroquine, Primaquine). Ten days later he was readmitted...
Open Access DOI:10.23937/ijtd-2017/1710008
Titik Respati, Yudi Feriandi, Ermi Ndoen, Ardini Raksanegara, Heni Djuhaeni, Asep Sofyan and Pat Dale
Article Type: Original Article | First Published: October 12, 2018
Dengue Fever (DF) is a serious disease in Indonesia. The sustainability of a DF prevention program remains constrained despite continuing education programs and community participation efforts. Identifying the issues related to the cause of the disease is a major factor in its control. In this study we try to understand the complexity of the management of the disease. We apply an eco-health approach to explore DF management in Bandung city, West Java, an area of high DF incidence. A qualitative ...
Open Access DOI:10.23937/ijtd-2017/1710007
Delynn M Moss, Matthew T Whitney, Anna N Chard, Victoria Trinies, Seydou Doumbia, Christin H Goodman, Stevan Bullard, Ryan E Wiegand, Matthew C Freeman, Patrick J Lammie and Gwong-Jen Chang
Article Type: Research Article | First Published: October 11, 2018
We opportunistically included a chikungunya envelope 1 recombinant virus antigen (CHIKV E1), a dengue 2 virus-like protein (DENV-2 VLP), and a DENV-3 VLP in a multiplex bead assay (MBA) for serological assessment involving improvements in water, sanitation, and hygiene for students attending 42 elementary schools in southern Mali in Western Africa. From students attending grades 1-6,805 dried blood spots (DBS) were collected. Immunoglobulin (Ig) G was eluted from the DBS and was probed for respo...
Open Access DOI:10.23937/IJTD-2017/1710006
Houda Ben Ayed, Makram Koubaa, Chakib Marrakchi, Khaoula Rekik, Fatma Hammami, Fatma Smaoui, Mariem Ben Hmida, Sourour Yaich, Imed Maaloul, Jamel Damak and Mounir Ben Jemaa
Article Type: REVIEW ARTICLE | First Published: September 03, 2018
Tuberculosis (TB) is one of the major public health threats, competing with the human immunodeficiency virus (HIV) as the cause of death due to infectious diseases worldwide. Extrapulmonary tuberculosis (EPTB) contributes to the burden of disease and does not receive specific attention in international control strategies. We aimed to give an update on the current epidemiological data of EPTB, to describe its clinical spectrum, to identify the main risk factors and to propose effective preventive...
Open Access DOI:10.23937/ijtd-2017/1710005
Gebrehiwet Tesfahuneygn and Gebremichael Gebreegziabher
Article Type: Review Article | First Published: August 25, 2018
Vaccines have been hailed as one of the greatest achievements in the public health during the past century. So far, the development of safe and efficacious vaccines has been a major barrier for other infectious agents including fungi, partly due to of our lack of knowledge about the mechanisms that underpin protective immunity....
Open Access DOI:10.23937/ijtd-2017/1710004
Akinneye JO, Fasidi MM, Afolabi OJ and Adesina FP
Article Type: Research Article | First Published: August 04, 2 018
Schistosomiasis (Bilharziasis) is water borne parasitic disease caused by a blood fluke (trematode) of the genus Schistosoma. Adult schistosome worms live in mammalian host and the intermediate host is aquatic snail. Schistosomiasis ranks second to malaria in terms of prevalence and persistence with grave public health and socio-economic importance in endemic communities. This study assessed the prevalence of urinary schistosomiasis among students of five selected secondary schools in Ifedore Lo...
Open Access DOI:10.23937/ijtd-2017/1710003
Lakshmi Vemu, Ashok R, Chaitanya Veena and G Satyanarayana
Article Type: Case Report | First Published: August 04, 2 018
Skin and soft tissue infections (SSTIs) with Nontuberculous Mycobacteria (NTMs) are increasingly encountered in recent times. We describe a case of a chronic non-healing ulcer on the foot of a young immunocompetent lady caused by Mycobacterium simiae. The diagnostic approach and successful management of the case have been reviewed. This is probably the first case report SSTI due to M. simiae from India....
Open Access DOI:10.23937/ijtd-2017/1710002
Evans Paul Kwame Ameade, Cynthia Gbolo Tee, Henrietta Chefudeme Dakurah and Hamdaratu Mateko Opata
Article Type: Research Article | First Published: July 20, 2018
Malaria caused by various species of Plasmodium had brought untold socio-economic burden to poor and developing countries of the world. Most malaria associated deaths occur in children below 5 years. The suggestion that antibodies and toxic nature of fetal hemoglobin provide immunity against malaria in children less than 6 months had been disproven. With Ghana having no treatment guideline on the management of uncomplicated malaria in this age group, this study ascertained how Ghanaian prescribe...
Open Access DOI:10.23937/ijtd-2017/1710001
Christophe Kouakou Nguessan, Serge Kouadio Agbo, Youssouf Traore, Cyrille Gourmanon, Daniel Kouadio Ekra and Simplice Ncho Dagnan
Article Type: Research Article | First Published: May 16, 2018
Rubella is a contagious disease caused by a virus. Rubella is a major cause of miscarriage or serious birth defects in a developing baby if a woman is infected while she is pregnant. Côte d'Ivoire is a country that is not immunizing against rubella in its Expend program on immunization (EPI)....
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