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Journal of
Nutritional Medicine and Diet Care ISSN: 2572-3278

Citation

Gharari Z, Bagheri K, Khodaeiaminjan M, Sharafi A (2019) Potential Therapeutic Effects and Bioavailability of Wogonin, the Flavone of Baikal Skullcap. J Nutri Med Diet Care 5:039. doi.org/10.23937/2572-3278.1510039

Copyright

© 2019 Gharari Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

REVIEW ARTICLE |  OPEN ACCESS DOI: 10.23937/2572-3278.1510039

Potential Therapeutic Effects and Bioavailability of Wogonin, the Flavone of Baikal Skullcap

Zahra Gharari1, Khadijeh Bagheri1, Mortaza Khodaeiaminjan2 and Ali Sharafi3,4*

1Department of Plant production and Genetics, Faculty of Agriculture, University of Zanjan, Zanjan, Iran

2Integrative Plant Biology Department of Plant Genetics Institute, Polish Academy of Science, Poland

3Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Iran

4Zanjan pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran

Abstract

The flavonoids extracted from dried roots of Scutellaria species have been used in traditional Eastern medicine for the treatment of several human ailments, including cancer and inflammation. Modern science proved that wogonin is one of the major bioactive agents responsible for the physiological activity of Baikal skullcap (Scutellaria baicalensis Georgi.), which has been regarded as a potent anticancer agent. In this mini review, anti-inflammatory, antioxidant and anticancer activity of wogonin are discussed. Besides, the bioavailability of wogonin and utilization of nanotechnology to improve the bioavailability of wogonin are also presented.