Review Article Open Access
New Therapeutic Perspectives for the Cognitive Deficit in Alzheimer's Disease: Pharmacological Modulation of Ca2+/cAMP Signaling Interaction
Afonso Caricati Neto and Leandro Bueno Bergantin
Int J Cogn Behav Volume 1, Issue 1
Abstract: Due to the involvement of the imbalance of Ca2+ homeostasis in neuronal cells in the pathogenesis of several neurodegenerative disorders such as Alzheimer's Disease (AD), the use of drugs to prevent or attenuate this imbalance emerged as a new therapeutic perspective for this disease. Then, our recent discovery of the involvement of the interaction between intracellular signaling pathways mediated by Ca2+ and cAMP (Ca2+/cAMP signaling interaction) in the neurotransmission and neuroprotection, and also its pharmacological modulation, opens a large avenue for the drug development for cognitive deficit treatment in AD.