Case Report 

Adenomyosis in an 18-Year-Old Adolescent: A Case Report

Iaponira da Silva Vidal, Lilian Santos Soares, Cassio Aurelio Dutra, Mara Juliane Jovino, Ana Katherine Goncalves and Ricardo Ney Cobucci

Adenomyosis is a rare cause of chronic pelvic pain or severe dysmenorrhea that presents in the adolescent population. Here we describe an 18-year-old nulliparous woman who presented with a history of severe and worsening dysmenorrhea with cramps and increased menstrual flow since the menarche occurred 4-years-ago. A magnetic resonance imaging (MRI) described a poorly defined junctional zone of the endometrium, suggestive of adenomyosis, associated with the discrete heterogeneity of the adjacent myometrium.

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Case Report 

Hot Flushes in a 15-Year-Old Girl Post Treatment of Bilateral Ovarian Dysgerminoma: A Case Report

Iaponira da Silva Vidal, Lilian Santos Soares, Karen Beatriz Gurgel, Ana Katherine Goncalves and Ricardo Ney Cobucci

Ovarian tumors in adolescents are a medical challenge due to their rarity. The aim is to describe a case of adnexal disease in a girl with hot flushes after treatment. A 15-year-old girl presented a history of menstrual delay and progressive increase of abdominal volume. Initially, clinical suspicion was for pregnancy, but after abdominal magnetic resonance imaging, a solid-cystic abdominopelvic mass was revealed. She underwent laparotomy and pathologic evaluation revealed a bilateral ovarian dysgerminoma.

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Case Report 

Splenosis Mimicking Peritoneal Implants in a Female with Ovarian Cystic Masses: A Case Report

Nancy Boniel, Amit Mayer, Alex Rabinovich, Mihai Meirovitz and Alla Khashper

A case of large bilateral cystic ovarian masses is reported. Initial imaging, including ultrasound (US) and computed tomography (CT), showed a large right ovarian cystic tumor, a smaller multicystic left ovarian tumor and multiple solid peritoneal implants suspicious for metastases. Due to a history of remote post-traumatic splenectomy, the presence of bilateral benign ovarian cystic tumors in combination with peritoneal splenosis was considered.

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Case Report 

Case of Outpatient Pregnancy Prolongation at Premature Rupture of Membranes before Reaching the Viability Term

YE Dobrokhotova, AS Olenev, PA Kuzetsov, LS Djokhadze and KI Konstantinova

Premature rupture of membranes is not losing its topicality, as one third of all the premature deliveries starts with the discharge of the amniotic fluid. Despite the fact that the treatment tactics is represented in the normative documents, the world literature describes cases of the outpatient management of patients. The given article describes the case of a successful pregnancy completion as a result of outpatient management, which is considered to be an acceptable option in the case of the pregnant woman and fetus stable state, which allows to avoid nosocomial infections.

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Case Report 

Ovarian Granulosa Cell Tumor: A Clinicopathological Series

Mark R Brincat, David Pisani, Donika Metaraku, Rachel Micallef, Yves Muscat Baron, Eleanor Borg, Annelise Aquilina, James Degaetano and Salvina Zrinzo

Granulosa cell tumours (GCT) are uncommon neoplasms, accounting for 2-5% of all ovarian carcinomas. The pathogenesis of these tumours is characterised by differentiation towards the follicular granulosa cell. However, the exact cell of origin is disputed, with the granulosa cell, thecal cell or fibroblast having been proposed as putative progenitors. A granulosa stem-cell has been described, which has also been suggested as a cell of origin.

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Case Report 

Septicaemia with Fusobacterium necrophorum from Periodontal Disease in Pregnancy Resulting in Immature Birth: Case Report and Review of Literature

D van der Windt, R Kornegoor, R Walhof, BP Overbeek and KM Paarlberg

A 26-year-old woman (gravida four, para two) delivered an immature infant at 23 weeks of gestation after presenting with abnormal vaginal blood loss and sepsis. Blood cultures and placenta cultures showed bacteremia by Fusobacterium necrophorum. Histopathological examination of the placenta was concurrent with that, showing severe chorioamnionitis with funisitis. A dentist and oral surgeon confirmed the diagnosis of generalised periodontal disease.

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Case Report 

Tubo-Ovarian Abscess in Early Pregnancy - Report of a Rare Coexistence

Brandao P , Portela-Carvalho AS, Estevinho C, Soares E and Melo A

Pelvic inflammatory disease is extremely rare during pregnancy. Both differential diagnosis and management of tubo-ovarian abscesses in pregnancy are challenging and associated with poor obstetric outcomes. The authors present a case of a 17-years-old girl with low abdominal pain for five days. A tubo-ovarian abscess was suspected, with an early pregnancy of unknown location. She was admitted to receive intravenous antibiotics and to rule out ectopic pregnancy.

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Case Report 

Laparoscopic Management of Interstitial Ectopic Pregnancy with Endo GIA™ without Rupture

Rawan Al Harmi, Rania Hassan, Basma Darwish and Nawal Dayoub

Interstitial pregnancy is uncommon, accounting for 2-4% of all ectopic pregnancies. It is potentially serious and mortality is most commonly due to rupture and subsequent hemorrhage. Both medical and surgical management options are available, depending on a given individual's case. Currently, the preferred surgical approach is laparoscopy. However, despite the presence of different laparoscopic techniques, there is no consensus on a single best technique. We report a case of a 27-year-old pregnant female who presented with brownish vaginal discharge and mild lower abdominal pain.

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Case Report 

Managing Tetraplegia and its Associated Risks in Pregnancy and Labour- A Case Report

Fatima Rashed, Summia Zaher, and Marion Beard

The management of tetraplegic women in pregnancy and labour is a rare event, with sporadic cases reported worldwide. These women often require increased medical input due to potentially life-threatening complications associated with their spinal cord injury. Of these, autonomic dysreflexia is the most widely feared.

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Case Report 

Biamniotic Parasitic Conjoined Twins with Discordant Genotype

Sofie C Husen, Maarten FCM Knapen, Femke AT de Vries, Robert M Verdijk and Lutgarde CP Govaerts

Conjoined twin pregnancies are uncommon. The prevalence of conjoined twins in the first trimester of pregnancy is estimated as 1:50,000, with an unexplained female predominance (3:1). It is thought that at 13-14 days gestational age an incomplete fission of the germinal disc causes the development of a conjoined twin pregnancy, obligatory being associated with a monochorionic monoamniotic placentation.

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Case Report 

Tension Free Vaginal Tape Erosion into the Urinary Bladder: A Case Report

Priyanka Singh and Han How Chuan

The Tension-free Vaginal Tape (TVT) is the most commonly performed procedure for the management of Stress Urinary Incontinence (SUI). There is insufficient data on the occurrence of complications and their management. The incidence of tape erosion and infection is observed to be higher with synthetic non-absorbable slings.

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Case Report 

Unusual Localization of a Leiomyoma; Vaginal Leiomyoma in a 24 Years Virgin Woman: A Case Report

Najeh Hsayaoui, Wael Mbarki, Hajer Bettaieb, Youssef El Cadhi, Fatma Douik, Hedhili Oueslati, Sana Mezghenni and Chaouki Mbarki

Vaginal leiomyomas are rare benign solid tumors of the vagina with only about 300 reported cases. Here we describe a 24-year-old sexually inactive patient presented with a vaginal bleeding. On ultrasonography, a 5-centimeter vaginal mass was diagnosis in the anterior vaginal wall under urethra.

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Research Article 

Ultrasound and Biochemical First Trimester Markers as Predictive Factors for Intrauterine Growth Restriction

Benitez Martin A, Vargas Perez M and Manzanares Galan S

After analyzing our results, we ascertained that some variables were protective, and others were risk factors for SGA, however a multivariate model established to predict SGA indicates that these were not good predictors of SGA (AUC = 0.65).

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Case Report 

Intravenous Leiomyomatosis of the Uterus: A Case Report

Fatma Douik, Najeh Hsayaoui, Hajer Bettaieb, Wael Mbarki, Hedhili Oueslati and Chaouki Mbarki

Intravenous Leiomyomatosis (IVL) is an unusual clinical condition characterized by histologically benign smooth muscle lesions extending from the uterus into pelvic and systemic veins and, more rarely, into the right cardiac chambers.

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Case Report 

Anterior Vaginal Wall Epitheloid Leiomyoma: A Case Report

Priyanka Singh, Leong May Ying and Han How Chuan

Primary paraurethral tumours of benign nature in females are quite infrequent. Physical examination and imaging modalities like ultrasound and magnetic resonance imaging of the pelvis help in characterising the mass morphologically and structurally. They also help to decipher the relationship of the mass with the urethra and the vagina.

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Case Report 

Laparoscopic Single Mesh Sacrohysteropexy Plus bladder Patch for Pelvic Organ Prolapse

Mai Myoga, Kazuaki Yoshimura, Kazuaki Nishimura, Kaori Hoshino and Toru Hachisuga

Here we introduce a laparoscopic sacrohysteropexy plus bladder patch procedure as a useful operative procedure for POP patients who desire uterine preservation. A 62-year-old woman, gravida 2 para 2 with pelvic organ prolapse quantification (POP-Q) stage III of uterine prolapse and stage II of cystocele, came to our hospital and desired a POP operation with uterine preservation.

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Case Report 

Dextroposition of the Heart Reflected Mosaic Fetal Trisomy 18

Mohamed A Satti, Frederico G Rocha, Erin Beaver and Jeffrey M Dicke

Anatomy scan of a 22 year old prima gravida at 19w4d showed a viable IUP with unilateral choroid plexus cyst and dextroposition of the heart without any other observed structural malformation. Amniocentesis revealed a normal male pattern for chromosomes 13, 18, 21, X and Y by fluorescence in situ hybridization (FISH). However, chromosomal microarray analysis (CMA) for circulating fetal DNA in maternal blood was consistent with mosaic Trisomy 18. The karyotype of cultured dividing cells confirmed 47, XY, +18/46, XY mosaicism.

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Case Report 

Successful Treatment of A Primary Cervical Diffuse Large B-Cell Lymphoma with Rituximab-CHOP Immunochemotherapy

Diaz-De La Noval B, Hernandez A, Zapardiel I, De-Santiago J and Diestro Tejeda

We describe a 46-year-old healthy woman with primary extranodal Non-Hodgkin's diffuse large B-cell lymphoma of the uterine cervix Ann Arbor stage IIEA IPI 1. She presented an acute renal failure and severe ureterohydronephrosis successfully treated with 6 courses of chemotherapy based on Rituximab plus Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (R-CHOP) with no major side effects.

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Letter to Editor 

Cutaneous Horn of the Breast: A Rare Clinical Feature

Cedric Nadeau, David Desseauve and Emilie Laban

A benign cutaneous horn was evocated as its base was thin but the diagnostic of a pre invasive intraepithelial dysplasia or squamous cell carcinoma of the skin had to be eliminated by histological examination. It looked like a solid elongated keratinized tumor connected to the skin by a thin bridge of pink/red regular skin (Figure 1 and Figure 2). No evidence of pre invasive skin lesion was found around. The patient had an excision of the lesion and its base under local anesthesia.

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Research Article 

The Confusion of Mothers with Gestational Diabetes Mellitus due to the Multidimensionality of Healthcare and Therapeutic Care: A Serious Threat to Mother and Fetus's Health

Fatemeh Ghaffari, Zahra Rahnavard, Mahvash Salsali and Soroor Parvizi

Gestational diabetes mellitus (GDM) is a challenge of the 21st century. The management of the diseases confronts numerous issues which lead to undesirable results of care consequences. The aim of this study is to explain factors involved in the confusion of mothers with GDM due to the multidimensionality of healthcare and therapeutic care. The present study was carried out in 2014 with a qualitative method. Purposive sampling was employed to select 17 pregnant women with GDM who had referred to health centers affiliated with Tehran University of Medical Sciences.

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Case Report 

Amniotic Fluid Embolism: Combined Treatment with Surgery and Extracorporeal Membrane Oxygenation Support - A Case Report

Arnon Wiznitzer, Rinat Gabbay-Benziv, Eran Altman, Dan Aravot and Philippe Biderman

A 42-year-old gravida 1, 40-weeks' gestation, presented with rupture of membranes in labor. Her history and prenatal care were unremarkable except for obesity. On physical examination, blood pressure was 156/91 mmHg with no other signs of pre-eclamsia. Due to non-progression at active labor, cesarean section was performed with extended "top-up" epidural and delivery of a healthy boy. Immediately after removal of the placenta, the patient reported chest pain, and became unresponsive. ECG (electrocardiography) demonstrated asystole.

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Case Report 

An Idiopathic Case of Recurrent Spontaneous Ovarian Hyper Stimulation Syndrome

Alessandra Ainsworth, Zaraq Khan and Jani Jensen

We report a case of recurrent spontaneous ovarian hyperstimulation syndrome (OHSS). The patient presented at 8 weeks gestation. Due to severity of symptoms, the patient required both inpatient and outpatient management. Her symptoms resolved at 11 weeks gestation and the pregnancy was carried to term. Recurrent spontaneous OHSS is a rare and potentially morbid event. While most cases will eventually resolve, patients require careful diagnosis, surveillance, and supportive care.

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Case Report 

Urinary Incontinence as a Presenting Symptom of Bladder Cancer

Elena Vilar Gonzalez, Marta Perez de la Fuente, Enrique Gonzalez Diaz

Urinary incontinence is a very common complaint among women. We should think of potentially serious aetiologies when there is no response to empiric treatments, especially in postmenopausal women. We report a case of a 69 year old woman, referred to our pelvic floor unit with urinary incontinence and nocturia. After failing with anticholinergic treatment, a transvaginal ultrasound scanning shows an irregular solid lesion of 6 mm, which was diagnosed by further urological investigation as a transitional cell carcinoma.

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Case Report 

Postpartum Low Back Pain: It is not always What You Think

Melissa Corso, Diane Grondin and Carol Ann Weis

Postpartum back pain is common, with up to 75% of women experiencing back pain immediately following birth. This pain can be moderately to severely debilitating to the new mom, affecting activities of daily living such as caring for her new born, sleep patterns, and otherhousehold activities. However, all low back pain is not created equal and we document a case study with an unusual cause of postpartum back pain.

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ClinMed International Library


Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Contact our editorial office

PubMed Indexed Articles

Can Genetic Testing Provide Information to Develop Customized Nutrigenomic Solutions for Reward Deficiency Syndrome?

Pubmed ID: 26225358
PMC ID: PMC4516390

Acute Ovarian Insufficiency and Uterine Infarction Following Uterine Artery Embolization for Postpartum Hemorrhage

Pubmed ID: 26523290
PMC ID: PMC4623578

Challenges of Fertility Sparing Ovarian Surgery Imposed by Krukenberg Tumors in Pregnancy

Pubmed ID: 26366440
PMC ID: PMC4563814

Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman

Pubmed ID: 27398405
PMC ID: PMC4936830

Hypothesizing that a Pro-Dopaminergic Regulator (KB220z™ Liquid Variant) can Induce "Dopamine Homeostasis" and Provide Adjunctive Detoxification Benefits in Opiate/Opioid Dependence

Pubmed ID: 29034323
PMC ID: PMC5638455

Titanates and Titanate-Metal Compounds in Biological Contexts

Pubmed ID: 26430701
PMC ID: PMC4587770

MyHEART: A Non Randomized Feasibility Study of a Young Adult Hypertension Intervention

Pubmed ID: 28191544
PMC ID: PMC5300088

Exenatide Effects on Cardiometabolic Risk and Weight in Adolescents with Morbid Obesity and Type 2 Diabetes Mellitus: Two Case Reports

Pubmed ID: 27182560
PMC ID: PMC4864000

A New Animal Model to Study Endogenous Cardiotonic Steroids and the Progression of Cardiovascular Events in Salt-Sensitive Hypertension

Pubmed ID: 26457335
PMC ID: PMC4599712

Common Genetic Variation in Circadian Rhythm Genes and Risk of Epithelial Ovarian Cancer (EOC)

Pubmed ID: 26807442
PMC ID: PMC4722961

Active Hexose Correlated Compound Activates Immune Function to Decrease Chlamydia trachomatis Shedding in a Murine Stress Model

Pubmed ID: 27790645
PMC ID: PMC5079436

The Extraction, Anticancer Effect, Bioavailability, and Nanotechnology of Baicalin

Pubmed ID: 27790646
PMC ID: PMC5079443

Kyphosis and Sleep Characteristics in Older Persons: The Rancho Bernardo Study

Pubmed ID: 28480455
PMC ID: PMC5419044

Suppression of Experimental Arthritis through AMP-Activated Protein Kinase Activation and Autophagy Modulation

Pubmed ID: 26120598
PMC ID: PMC4479345

Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjogren's Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study

Pubmed ID: 27110599
PMC ID: PMC4841619

Elder Mistreatment and its Subtypes across Different Sociodemographic and Socioeconomic Groups among U.S. Chinese Community-Dwelling Older Adults

Pubmed ID: 26973979
PMC ID: PMC4786076

Balance and its Clinical Assessment in Older Adults - A Review

Pubmed ID: 26942231
PMC ID: PMC4773046

Caregiver Abuse of Chicago Chinese Older Adults in a Community-Dwelling Population

Pubmed ID: 27606358
PMC ID: PMC5008847

The Relationship of Older Adults' Physical Pain to Depression and Post-Traumatic Stress Disorder (PTSD): A Review

Pubmed ID: 27642644
PMC ID: PMC5023019

Sphingosine 1-Phosphate Receptor 2 Regulates the Migration, Proliferation, and Differentiation of Mesenchymal Stem Cells

Pubmed ID: 27275017
PMC ID: PMC4888913

Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis

Pubmed ID: 27453956
PMC ID: PMC4957014

Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing

Pubmed ID: 27570841
PMC ID: PMC4996274

Long-Term Function, Pain and Medication Use Outcomes of Radiofrequency Ablation for Lumbar Facet Syndrome

Pubmed ID: 26005713
PMC ID: PMC4440581

Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized

Pubmed ID: 25639474
PMC ID: PMC4308811

Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?

Pubmed ID: 26550607
PMC ID: PMC4634668

Differences in ME and CFS Symptomology in Patients with Normal and Abnormal Exercise Test Results

Pubmed ID: 28713856
PMC ID: PMC5510614

Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive Breast Cancer Associates with Postmenopausal Body Size and Recreational Physical Activity

Pubmed ID: 26005715
PMC ID: PMC4440485

A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation

Pubmed ID: 26688830
PMC ID: PMC4682050

Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced Breast Cancer-The Emerging Role of CDK4/6 Inhibitors

Pubmed ID: 26726315
PMC ID: PMC4697745

Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer

Pubmed ID: 26878064
PMC ID: PMC4751054

Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar.

Pubmed ID: 27158665
PMC ID: PMC4858188

Effects of chest physical therapy in patients with non-tuberculous mycobacteria

Pubmed ID: 28804763
PMC ID: PMC5552049

A Community-Based Exercise and Support Group Program Improves Quality of Life in African-American Breast Cancer Survivors: A Quantitative and Qualitative Analysis

Pubmed ID: 26640827
PMC ID: PMC4667740

Four Weeks of Balance Training Does Not Affect Ankle Joint Stiffness in Subjects With Unilateral Chronic Ankle Instability

Pubmed ID: 27642647
PMC ID: PMC5025258

Social Ecology and Diabetes Self-Management among Pacific Islanders in Arkansas

Pubmed ID: 28736764
PMC ID: PMC4667740

Examining Characteristics of Hospitalizations in Heart Failure Patients: Results from The 2009 All-payer Data

Pubmed ID: 28736765
PMC ID: PMC5517048