Open Access DOI:10.23937/2474-3631/1510043
Knowledge and Attitudes of Patent Medicine Vendors towards Tobacco Harm Reduction in Ebonyi State, Nigeria: A Mixed Methods Study
Daniel C Oshi, Kingsley N. Ukwaja, Maria Isabel Espinoza Hidrobo, Chimwemwe Ngoma, Katarzyna Kowalczyk, Attaulah Ahmadi and Sarah N. Oshi
Article Type: Original Research | First Published: 2024/11/14
The negative health consequences of cigarette smoking have been well documented. Cigarette smoking prevalence is high in Nigeria. A very high proportion of smokers in Nigeria are aware of the dangerous effects of cigarette smoking and most of them want to quit, but their quitting attempts often prove unsuccessful. Evidence shows that tobacco harm reduction (THR) products such as electronic cigarettes are effective in helping smokers to quit. Patent medicine vendors (PMVs) have been successfully ...
Open Access DOI:10.23937/2474-3631/1510044
Psychiatric Symptoms Following Sudden Withdrawal from the Drug Pregabalin
Elizabeth Price
Article Type: Letter to the Editor | First Published: 2024/11/14
Doctors should be aware that psychiatric symptoms may occur following sudden withdrawal from the drug pregabalin. Medical and pharmacy staff do not always realise that pregabalin should not be stopped suddenly unless there are compelling reasons, such as severe allergy. Doses should be carefully reduced by tapering, while paying close attention to the possibility of withdrawal symptoms....
Open Access DOI:10.23937/2474-3631/1510041
Pembrolizumab for Locally Advanced or Recurrent/Metastatic Cutaneous Squamous Cell Carcinoma: Long-Term Results of the Phase 2 Keynote-629 Study
Munoz-Couselo E, Hughes BGM, Mortier L, Grob JJ, Gutzmer R, Roshdy O, González Mendoza R, Schachter J, Arance A, Grange F, Meyer N, Joshi A, Billan S, Ojavee SE, Yuan J, Gumuscu B and Bratland Å
Article Type: Poster | First Published: 2024/07/15
Median time from first dose to the data cutoff date of September 13, 2023, was 52.4 months (range, 47.6-56.9) for the LA cohort, 64.7 months (range, 62.1-69.5) for the R/M cohort, and 63.1 months (range, 47.6-69.5) in the total population (Figure 2, Figure 3, Figure 4, Figure 5, Table 1, Table 2 and Table 3)....
Open Access DOI:10.23937/2474-3631/1510040
Understanding Addiction: Insights from Research and Medicine
Kieran Poland, MbChBMRes and Patrick Davies, BMedSci BMB MRCPCH
Article Type: Research Article | First Published: 2024/06/06
Addiction, a multifaceted neurobiological disorder characterized by compulsive substance use despite negative consequences, poses significant challenges to public health worldwide. This paper presents a comprehensive examination of addiction research and medicine, delving into the intricate neurobiological mechanisms, current treatment modalities, and future prospects for intervention. By synthesizing existing knowledge and exploring emerging avenues of inquiry, this review aims to contribute to...
Open Access DOI:10.23937/2474-3631/1510039
Inhibitory Potential of Struchium sparganophora Phytochemicals on Cyclooxygenases and Their Health Implications on Inflammations and Pains
Ololade Zacchaeus S, Oyebanji Olawumi T, Onifade Olayinka F, Olaniran Anikeola C, Idowu Oluwatope O, Quadri-Oloye Mariam T and Tommy Bessie E
Article Type: Research Article | First Published: 2024/06/06
The inhibition of cyclooxygenases provides analgesic effect to relief inflammation and pain. The in silico study herein aimed to predict and elucidate the inhibitory potential of S. Sparganophora phytochemicals on the enzymes. An integrated molecular modeling approach which includes molecular docking, MMGBA, and pharmacokinetic profiling was employed to identify potential inhibitors of COX-1 and COX-2 from the characterized phytochemicals of S. Sparganophora....
Open Access DOI:10.23937/2474-3631/1510038
A Retrospective Longitudinal Cohort Study: The Effect of Long-Term Use of Methadone and Associated Factors on QTc in a Maintenance Program
Julia MM Deuss, MD, Mandy MM Jansen, BSc, Monique CT Bongaerts, MD, Maurice Theunissen, PhD and Marieke HJ van den Beuken-van Everdingen, MD, PhD
Article Type: Research Article | First Published: 2024/05/05
Since the 1960s Methadone Maintenance Treatment (MMT) has led to a great improvement in health status and a decline in mortality among opioid-using patients. However, more awareness has been raised by professionals worldwide to the adverse effects and safety of MMT. This retrospective longitudinal cohort study aimed to investigate the effect of long-term use of methadone on the QTc interval in a population of MMT patients....
Open Access DOI:10.23937/2474-3631/1510036
The Detrimental Effects of Cannabis on Brain. A Concise Review
Omar ME Abdel-Salam
Article Type: Original Article | First Published: July 30, 2022
Marijuana and hashish, from the plant Cannabis sativa L, are the illicit drugs most frequently used worldwide. Cannabis is well known for its recreational effects being popular among adolescents and young adults and is often perceived as harmless. Cannabis, however, impairs working and shortterm memory and is associated with decline in academic functioning, impaired driving skills, cognitive impairment, and progression to other illicit substance use....
Open Access DOI:10.23937/2474-3631/1510035
Association of Substance and Psychiatric Disorders with Health Care Utilization and Cost
David Cawthorpe, BSc, MSc, PhD
Article Type: Original Research | First Published: March 20, 2022
Few studies have directly examined the health care costs of those who suffer from mental disorder problems. The quality of administrative data has improved to the point where such study is currently possible. We report prevalence and cost results for 16 years of physician billing data comparing the health costs of groups with and without substance and/or other psychiatric disorders. A 16-year dataset containing 95846511 physician-assigned International Classification of Disease (ICD) diagnoses a...
