Upregulation of Single Nucleotide Polymorphism of PD-1 Gene (rs10204525) in Chronic Hepatitis B Patients
Peyman Ghorbani, Hamid Reza Mollaei, Seyed Alimohammad Arabzadeh and Mohammad Javad Zahedi
Article Type: Research Article | First Published: May 29, 2019
Programmed death-1 (PD-1) is major inhibitory molecule that reduces T cell activation. PD-1 and their polymorphisms have separately been shown to be associated with hepatitis B virus (HBV) infection. Therefore, we aimed to investigate the association of PD1 polymorphisms with potential of chronic hepatitis B infection in Iranian population to do a Case-Control study....
Antimicrobial Properties of the Probiotic Strain Bacillus Subtilis 534
Olga Efremenkova, Nina Gabrielyan, Irina Malanicheva, Mariya Demiankova, Tatiana Efimenko, Eugene Rogozhin, Sofiya Sharapchenko, Tatyana Krupenio, Dmitrij Davydov and Maksim Kornilov
Article Type: Research Article | First Published: May 11, 2019
The object of our research is the transient probiotic strain Bacillus subtilis 534 that is a basis of the drug Sporobacterin. The strain 534 was cultivated in submerged conditions and the obtained culture liquid (CL) was investigated for antimicrobial activity by diffusion into the agar medium method. As test objects, collection strains of bacteria and fungi were used as well as clinical isolates with different resistance to antibiotics. For preliminary chemical characterization, CL was passed t...