Physicochemical and Biopharmaceutical Characterization of N-Iodomethyl-N,N-Dimethyl-N-(6,6-1 Diphenylhex-5-En-1-Yl) Ammonium Iodide and A Promising Antileishmania Delivery System
Maritza Fernandez, Luz Amalia Rios-Vasquez, Rogelio Ocampo-Cardona, Oscar Florez, David L Cedeno, Teresa M Garrigues, Antonio J Almeida, Ivan D Velez and Sara M Robledo
Article Type: Research Article | First Published: October 13, 2018
Cutaneous leishmaniasis (CL) is an infectious disease endemic in tropical and subtropical countries. The current drugs have severe drawbacks that restrict their use and enhance the need for better drugs. Recently, the N-iodomethyl-N,N-dimethyl-N-(6,6-diphenylhex-5-en-1-yl) ammonium iodide (C6I) was identified as a promising compound for the topical treatment of CL. The need for oral drugs with potential use to treat cutaneous, mucosal and visceral leishmaniasis, in the present work were determin...
Prevalence of Vaginal Infections in Women under Screening to HPV Infection and Cervical Lesions in Brazilian Basic Health Service
Emanuella Francisco Fajardo, Gabriela Roberta Braz, Mara Rosa, Tatiane Marques, Bruno Belmonte Martinelli Gomes, Thiago Mantello Bianco, Ana Karina Marques Salge, Dayana Pousa Siqueira Abrahao, Eduardo Elias Vieira de Carvalho, George Kemil Abdalla and Douglas Reis Abdalla
Article Type: Research Article | First Published: October 06, 2018
Vaginal infections and inflammations are responsible for the most demand at gynaecology, because the main complains are leucorrhea and vulvovaginitis, there is a specifically interest in cervix cancer prevention. The aim of this study is to understand the prevalence of vaginal infections cases and cervical lesions, found in women attended at health basic units from Igarapava, Sao Paulo state, Brazil....
Streptococcus salivarius Meningitis in Immunocompetent: A Case Report
Abdelrahman M Elsawy, Hani S Faidah and Elrashdy M Redwan
Article Type: Case Report | First Published: August 08, 2018
Streptococcus salivarius (S. salivarius) is a rare cause of purulent meningitis. We report a case of meningitis due to S. salivarius in 15-years-old Sudanese boy. Diagnosis was established based on Cerebrospinal fluid (CSF) findings. The patient responded well to systemic antibiotics and recovered completely without any neurological complications after proper supportive measures. In this patient the meningitis caused by S. salivarius was thought to be spontaneous. The importance of bacteriologic...
Potential of Carcinogenesis Induced by John-Cunningham Virus and Crude-Oil Extracts
Shih-Chao Lin, Christopher Z Lien and Chi-Chen Lin
Article Type: Short Communication | First Published: July 13, 2018
John-Cunningham virus (JCV) has been recognized as a major contributor to progressive multifocal leukoencephalopathy (PML) in humans, especially in immunodeficient patients. While the prevalence rate of PML in human populations could be up to 80%, the occurrence of tumorigenesis is around 0.07%. Thus, we investigated whether crude-oil extracts could synergistically increase the carcinogenesis along with T antigen from JC virus in vitro. Here we analysed the cell cycle distribution and cytotoxici...
Potential of Supercritical Solvent Impregnation for Development of Materials with Antibacterial Properties
Article Type: Review Article | First Published: November 20, 2017
Supercritical solvent impregnation is a modern technique which exploits the unique transport properties and qualities of supercritical fluids such as low viscosity, high diffusion coefficients, densities as in a liquid state and zero surface tension, for the fabrication of novel materials. The mentioned properties allow deep penetration of supercritical fluid with a dissolved bioactive substance into a solid matrix enabling even distribution of the active substance through the whole volume of th...