International Journal of

Stem Cell Research & TherapyISSN: 2469-570X

Early Online

 Open Access DOI:10.23937/2469-570X/1410072

Endogenous Soluble TRAIL Contributes to the Survival and Growth of Human Mesenchymal Stem Cells

Joaquín Marco-Brualla, Ana Gallego-Lleyda, Jara Sanz, Paula Desportes, Pablo Fernández, Luis Martínez-Lostao, Pedro Lapuente and Alberto Anel

Article Type: Original Article | First Published: March 13, 2021

TNF-related apoptosis-inducing ligand (TRAIL) is known to induce caspase-dependent apoptosis in tumor cells, while sparing normal cells. However, TRAIL is also able to induce proliferation in cells that are resistant to cell death induction, since it can also activate NF-κB-dependent signaling pathways. Human mesenchymal stem cells (hMSC) transfected with TRAIL have been used to treat cancer, with promising results in pre-clinical models, especially in gliomas. Regarding endogenous TRAIL expres...

Volume 8
Issue 1