Journal of

Genetics and Genome ResearchISSN: 2378-3648

Early Online

 Open Access DOI:10.23937/2378-3648/1410055

MTHFR Polymorphism in Congo Type 2 Diabetics: Prevalence of c.677CT and c.1298AC Mutations and Degenerative Complications

Ikia Monde VR, Boumba ALM, Alarcan H, Poaty H, Vourch P, Durebex C, Ondongo WF, Bouenizabila E, Mokondjimobe E, Andres C and Monabeka HG

Article Type: Research Article | First Published: 2024/02/03

Type 2 diabetes (T2DM) is a multifactorial disease with serious complications, particularly degenerative. Currently, several genes have been identified in its pathogenesis, including the 5,10-methylene tetrahydrofolate reductase (MTHFR) gene with an association of the c.677C>T and c.1298A>C variants. The aim of this study was first to investigate the frequency of these variants in Congolese subjects with T2DM and to compare them with healthy controls. Secondly, to establish a correlation between...

Volume 10
Issue 1