Cardiovascular disease is the leading cause of deaths worldwide. Myocardial ischemia, a common etiological factor in cardiovascular disease, lowers cellular high-energy phosphate levels, i.e. adenosine triphosphate (ATP), with an accompanying impairment in myocardial function. Furthermore, scientists have argued for the importance of ATP levels in supporting both systolic and diastolic function in heart failure. The magnitude of ischemic heart disease and congestive heart failure is generally we...

The authors hypothesize that thrombosis causes both the complications of atherosclerosis as well as the underlying lesion, the atherosclerotic plaque. Atherosclerotic plaques develop from the organization of mural thrombi. In this process, circulating progenitor cells trapped within the thrombus differentiate into myofibroblasts which synthesize collagen, and endothelial cells which form granulation tissue. Eventually, all or most of the thrombus is replaced by collagen. Thus, conditions and dru...

Cardiovascular disease and myocardial infarction comprise the leading causes of more than half of the total death often among elderly people. Psychological stresses, imbalanced diet, sedentary lifestyle, obesity, tobacco, alcohol, and metabolic diseases such as hypothyroidism and diabetes mellitus are the main risk factors for the disease. In order to better understand the underlying risk factor for the disease we performed complete analyses of biochemical factors in sera of obese, non-diabetic ...

In this report, we describe a patient who presented with transient acute abdomen before the onset of an acute myocardial ischemic event. Chest pain, dyspnea, and hypotension requiring vasopressors developed 2 days after the patient presented with paralytic ileus. Transient left-bundle-branch block and mildly elevated troponin and brain-natriuretic peptide levels occurred. Echocardiography and left ventricular angiography revealed extensive periapical akinesia and a left ventricular ejection frac...