Open Access DOI:10.23937/2378-3419/1410192
Blood Plasma Metabolomic and Lipidomic Signatures of Prostate Cancer Using NMR Spectroscopy
Pradeep Kumar, Virendra Kumar, Rajeev Kumar, Sanjay Sharma, Sanjay Thulkar and M A Khan
Article Type: Research Article | First Published: 2024/11/25
Prostate cancer (PCa) with metastasis remains an incurable disease requiring early diagnosis and effective treatments. Bone metastasis is the predominant cause of mortality from PCa. Aggressive PCa metastasizes or spreads to bones, such as the hip, spine, and pelvis. Bone metastatic PCa is considered an advanced stage. This study was designed to determine the association of these metabolites/lipids with the progression of metastases cascade in PCa. Thus, the present study is based on 1H-NMR to i...
Open Access DOI:10.23937/2378-3419/1410191
Cancer Incidence in Married Couples
Sarode Pundaleeka, MD and Sridhar Ramaswamy, PhD
Article Type: Original Article | First Published: 2024/11/21
Cancer among couples has been studied over several decades. In this article, the authors analyze the occurrence of cancer in couples having similar types of cancers in terms of histology, systems and organs based on the data collected....
Open Access DOI:10.23937/2378-3419/1410190
Smoking Effects on Serum Hepcidin Levels in Breast Cancer Patients: A Cross-Sectional Study
Zein Al-Abideen Douba and Rama Ibrahim
Article Type: Original Article | First Published: 2024/11/11
Breast cancer remains a leading cause of cancer-related morbidity and mortality among women worldwide. Hepcidin, a central regulator of iron metabolism, has emerged as a potential biomarker in cancer biology and a predictive agent of recurrence. As smoking represents a risk factor in developing many types of cancer, this article discusses the possibility of the effect of smoking on hepcidin levels in women diagnosed with breast cancer....
Open Access DOI:10.23937/2378-3419/1410189
NMR Spectroscopy-Based Metabolomics Profiling: A Clinically Helpful Approach for Prostate Cancer Early Detection
Pradeep Kumar and Sujeet Kumar Mewar
Article Type: Review Article | First Published: 2024/08/03
PCa diagnosis is difficult since there is/are no acceptable, sensitive, and specific tumor biomarkers. The most common cancer in the world to be diagnosed in males over 50 is prostate cancer (PCa). In its early stages, there are no symptoms, and the cancer grows slowly. Measuring a predetermined list of certain metabolites is the goal of metabolomics. Understanding metabolites and their metabolic pathways is essential for finding new biomarkers, and the most significant pattern may have a big im...
Open Access DOI:10.23937/2378-3419/1410188
Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers among Cancer Patients in Jos, Nigeria
Eugene Bwade Samuel, Amos Dangana, Taofeeq Oduola, Yinka J Oyeniyi, Liviticus Mansura Mangpin, Vileng Felix Gagari, Mercy Ekene Mobi, Ezeama Juliet Chika, Adesuyi A. Omoare, Muhammad Sani Usman and Idris Nasir Abdullahi
Article Type: Research Article | First Published: 2024/07/31
Glucose-6-phosphate dehydrogenase (G6PD) is a sensitive cytosolic antioxidant enzyme that could be associated with carcinogenesis. Hence, its plasma levels are a good indicator to monitor cancer-induced cellular stress. This study aimed to determine the correlation between Glucose-6-phosphate dehydrogenase and oxidative stress markers among cancer patients in Jos, Nigeria....
Open Access DOI:10.23937/2378-3419/1410187
Plasma Cell Neoplasms with Atypical Features in a University Hospital
Everard Kylie R, MD, Zern Chantel, MD and Ikpatt Offiong Francis, MD
Article Type: Review/Case Series | First Published: 2024/07/08
Plasma cell neoplasms are derived from terminally differentiated B-cells. The distinction between anaplastic plasma cell myeloma and plasmablastic lymphoma, a B cell lymphoma, can be challenging. We present 3 cases of neoplasms with plasmacytic features that highlight the heterogeneity of plasma cell neoplasms and challenges in their diagnosis. Molecular profiling of these cases may provide value in their differential diagnosis....
Open Access DOI:10.23937/2378-3419/1410186
Risk Factors for Early Recurrence after Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma
Yoriko Nomura, Tomoki Ryu, Kazuki Takeishi, Gen Yamamoto, Yoshiyuki Wada and Yuko Takami
Article Type: Original Article | First Published: 2024/02/08
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and challenging cancers, causing substantial mortality worldwide. Despite advancements in treatment modalities, the prognosis for patients with PDAC remains dismal, emphasizing the critical need for identifying factors influencing early recurrence and survival post-surgery. This study aimed to clarify the risk factors for early recurrence (within 1 year) in patients who underwent upfront surgery for resectable PDAC....
Open Access DOI:10.23937/2378-3419/1410185
Genomic Profiling of Breast Cancer: A Single Institution's Experience and Impact on Patient Outcomes
Ezzelkdin M. Ibrahim, Bushra A. Al-Quzi, Duaa A. Jabal, Ali M. Bayer, Ahmed Y. Shaheen, Zeinab A. Morsi, Majidah M. Ahmed, Mohammed H. Kulak and Ahmed A. Refae
Article Type: Research Article | First Published: 2024/02/02
Genomic profiling (GP) of breast cancer (BC) tumors is a promising approach to identifying genetic mutations that aid patient management. Herewith, we present a single institutional experience of performing GP to assess its impact on patient outcomes. Tumor tissues of 56 patients were tested using the FoundationOne® next-generation sequencing platform. Patients median age was 54 years; 51 patients had metastatic BC, while 5 had an early-stage disease. The most frequently identified genes were T...
