Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy
Kadriye Sahinturk, MD, Candan Demiroz Abakay, MD, Serdar Sahinturk, MD, PhD, Sebnem Ozemri Sag, Fatma Atalay, Fatma E Can, Meral Kurt, MD, and Sibel Kahraman Cetintas, MD
Article Type: Original Article | First Published: November 11, 2019
One hundred twenty four endometrium cancer patients who were referred for postoperative external radiotherapy and/or brachytherapy during the period between January 2002 and December 2012 at Uludag University Radiation Oncology Department. Out of three all patients received radiotherapy. Since 11 had mixed type pathology, 9 had unspecified paraffine blocks and 2 had unsuccessful MSI analysis, study was performed with 99 patients and all re-staged according to FIGO 2009 staging system. Tumor tiss...
Spontaneous Regression of Hepatic Diffuse Large B-cell Lymphoma in HIV and HCV Positive Patient: A Novel Case Study
Albert Alhatem, Saiaditya Badeti, Chen Liu, Dongfang Liu and Donghong Cai
Article Type: Case Report | First Published: October 23, 2019
Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/c...
Cancer Patterns in Odisha - An Important Mining State in India
Sharmila Chatterjee, MBBS, MPH, CPH, Paul H Levine, MD, Surendra Nath Senapati, MD, Dipti Rani Samanta, MD and Pinaki Panigrahi, MD, PhD
Article Type: Original Research | First Published: October 14, 2019
Odisha, a populous state and a major mining belt in India has high levels of environmental carcinogens. There is no population-based cancer registry in Odisha, thus giving no opportunity to develop systematic studies on important regional carcinogens. This paper highlights current patterns of cancer as seen at Acharya Harihar Regional Cancer Centre (AHRCC), and provides the first opportunity to determine the most important research questions that could drive cancer control programs in Odisha. Tw...
Importance of Time to Chemotherapy Initiation in Small Cell Lung Cancer
Gregory J Kubicek, Rachel Koehler, Matthew J Rossi, Christian Squillante, Alexander Hageboutros, Melvin Pratter, Stephen Akers and Polina Khrizman
Article Type: Original Article | First Published: April 20, 2019
Small cell lung cancer (SCLC) is an aggressive malignancy with a short median survival time. Because of the rapid growth rate there may be an advantage to emergently beginning chemotherapy as soon as SCLC diagnosis is made. All SCLC patients evaluated at Cooper University Hospital from January 2011 to September 2014 were reviewed. Multiple clinical factors were analyzed including timing between diagnosis and start of chemotherapy....
The Use of Carboranes in Cancer Drug Development
Emilia O Zargham, Christian A Mason and Mark W Lee Jr
Article Type: Review Article | First Published: April 18, 2019
Over the past decade, there has been a rising interest in the use of carboranes as a potential pharmacophoric moiety in the development of new drugs for the treatment of various types of cancer. The unique physical and chemical properties of carboranes make their use attractive in drug development. In several instances, the inclusion of carboranes into a drug structure has increased the agent's binding affinity, potency, or bioavailability. The purpose of this review is to highlight applications...
Does a New Information Structure about Cosmetic Outcome of Breast-Conserving Treatment Result in a Better Informed Patient? Outcome of a Comparative Case Study
ATPM Brands-Appeldoorn, MSc, AJG Maaskant-Braat, MD, PhD, VCG Tjan-Heijnen, MD, PhD and RMH Roumen, MD, PhD
Article Type: Original Article | First Published: April 17, 2019
A comparative case study compared data of two cross-sectional studies. The historical group (HG) was treated in 2013, the implementation group (IG) in 2016. The HG received a questionnaire, which resulted in implementation of the following items in our practice, expansion of the BCT brochure and photo book, incorporation of the Harvard and Numeric Rating scale. The IG received the same questionnaire, with the addition of nine more questions concerning specific implementation aspects....
Well Differentiated Neuroendocrine Uncommon Primary Breast Carcinoma: A Case Report
Angela Strazzanti, MD, Claudio Trovato, Angelo Caponnetto, Santi Gangi, Loredana R Villari, Pietro Gangemi and Francesco Basile
Article Type: Case Report | First Published: April 11, 2019
Neuroendocrine breast carcinomas (NEBC) are rarely malignant with a frequency of less than 0.1-0.3% of all breast tumors. The actual incidence of NEBC in BC (Breast Cancer) populations being still largely unknown due to the lack of a clear cut diagnostic criteria. In 2003, the World Health Organization (WHO) Classification of Tumors of the Breast and Female Genital Organs definitely established that the immunohistochemical expression of NE markers is the unique requirement for NEBC diagnosis....