Solitary Brain Metastasis in Low-Risk Prostate Cancer - A Case Report
Sonha Nguyen, Sameer Shah, Neil Dudheker and Vishal Ranpura
Article Type: Case Report | First Published: June 04, 2020
Adenocarcinoma of prostate is the most common cancer affecting men in United States. The most common sites of prostate cancer metastasis are to bone and pelvic lymph nodes. Brain metastases are rare and reported in less than 1% of prostate cancer patients. Among the patients with brain metastasis, most of them had concurrent systemic disease involvement, such as: bone, lymph node, liver and/ or lung metastasis. We report a case of patient with low risk prostate cancer, stage IV B, with well cont...
Primary and Secondary Prevention of Cervical Cancer at Two District Health Centres in the West Region of Cameroon
Tagne Simo Richard, Christian Kamnang Tchakounte, Leonie Marthe Ghomsi Sidje, Jacqueline Ferrand, Armel Herve Nwabo Kamdje, Paul F Seke Etet and Phelix Bruno Telefo
Article Type: Research Article | First Published: April 25, 2020
Cervical cancer is a public health concern for women in Sub-Saharan Africa, where 34 over 100,000 are diagnosed with cervical cancer and 23 over 100,000 die yearly. We evaluated the knowledge and practices of the female population towards the prevention of cervical cancer in the city of Bafoussam, West Cameroon, considering that poor awareness about the disease and its prevention drives its progression in Africa....
A Novel Combined Methodology for Isolation and Detection of Circulating Tumor Cells based on Flow Cytometry and Cellular Filtration Technologies
Nikolaos G Grigoriadis, Konstantinos A Kyritsis, Melpomeni G Akrivou, Lefki-Pavlina N Giassafaki and Ioannis S Vizirianakis
Article Type: Original Article | First Published: February 08, 2020
Cancer cell presents a dynamic nature that evolves over time in its microenvironment through a complicating molecular and cellular interaction network. Despite the progress already achieved in the imaging technologies and the molecular tools used for tumor cell diagnosis and treatment approaches, metastasis still remains a major hindering factor that limits clinical outcomes. Circulating tumor cells (CTCs) present the potential in providing critical information to understand the metastasis proce...
Palmoplantar Erythrodysesthesia Associated with Capecitabine, Epidemiological Mapping and Risk Factors in Morocco
Tarik Hanafi, Hicham Titou, Hasna Kerrouch, Rachid Frikh, Naoufal Hjira and Mohammed Boui
Article Type: Brief Reports | First Published: January 27, 2020
A prospective cohort of a descriptive and analytical study, including sixty-one cases of Palmoplantar erythrodysesthesia in patients treated with capecitabine. The objective of this study is to determine an epidemiological mapping of Palmoplantar erythrodysesthesia in cancer patients on capecitabine treatment and to identify possible risk factors. The incidence of PPE was 64%. The median age of the patients who developed PPE was 54 years. 70% of the cohort was female, breast neoplasia represente...
Hyperpigmentation Associated with Anti-Tumor Chemotherapy: A Series of 54 Cases, Demo-Topographic Aspects and Interest of the Dermatological Intervention
Tarik Hanafi, Hicham Titou, Hasna Kerrouch, Rachid Frikh, Naoufal Hjira and Mohammed Boui
Article Type: Case Series | First Published: January 27, 2020
Three-year prospective study, from April 2016 to May 2019, including patients followed in oncology for malignant neoplasia, who developed hyperpigmentation following the start of antitumor chemotherapy for digestive, mammary and hematologic neoplasms, including the following molecules: 5 Fluorouracil, Tegafur, Cyclophosphamides, and Doxorubicin, in an isolated or combined mode. The study enrolled 54 patients, with an average age of 48 years and extremes ranging from 22 years to 67 years, with a ...
Candidate Genetic Polymorphisms and Haplotypes Associated with Endometrial Cancer Risk (United States)
Jane A McElroy, Robin L Kruse, J David Robertson, Helen Yampara-Iquise, Elizabeth C Bryda and Jeremy F Taylor
Article Type: Original Article | First Published: December 30, 2019
Exploration of single nucleotide polymorphisms (SNPs) that alter the expression or function of a gene may enable the development of diagnostics for endometrial cancer susceptibility. We evaluated eleven candidate SNPs that have previously been reported in the literature or that are associated with cadmium sequestering (i.e., metallothionein) for their effects on endometrial cancer risk. We also predicted haplotypes for SNPs within genes on chromosomes 6, 14 and X and tested haplotype effects for...
Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy
Kadriye Sahinturk, MD, Candan Demiroz Abakay, MD, Serdar Sahinturk, MD, PhD, Sebnem Ozemri Sag, Fatma Atalay, Fatma E Can, Meral Kurt, MD, and Sibel Kahraman Cetintas, MD
Article Type: Original Article | First Published: November 11, 2019
One hundred twenty four endometrium cancer patients who were referred for postoperative external radiotherapy and/or brachytherapy during the period between January 2002 and December 2012 at Uludag University Radiation Oncology Department. Out of three all patients received radiotherapy. Since 11 had mixed type pathology, 9 had unspecified paraffine blocks and 2 had unsuccessful MSI analysis, study was performed with 99 patients and all re-staged according to FIGO 2009 staging system. Tumor tiss...
Spontaneous Regression of Hepatic Diffuse Large B-cell Lymphoma in HIV and HCV Positive Patient: A Novel Case Study
Albert Alhatem, Saiaditya Badeti, Chen Liu, Dongfang Liu and Donghong Cai
Article Type: Case Report | First Published: October 23, 2019
Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/c...
Cancer Patterns in Odisha - An Important Mining State in India
Sharmila Chatterjee, MBBS, MPH, CPH, Paul H Levine, MD, Surendra Nath Senapati, MD, Dipti Rani Samanta, MD and Pinaki Panigrahi, MD, PhD
Article Type: Original Research | First Published: October 14, 2019
Odisha, a populous state and a major mining belt in India has high levels of environmental carcinogens. There is no population-based cancer registry in Odisha, thus giving no opportunity to develop systematic studies on important regional carcinogens. This paper highlights current patterns of cancer as seen at Acharya Harihar Regional Cancer Centre (AHRCC), and provides the first opportunity to determine the most important research questions that could drive cancer control programs in Odisha. Tw...
Importance of Time to Chemotherapy Initiation in Small Cell Lung Cancer
Gregory J Kubicek, Rachel Koehler, Matthew J Rossi, Christian Squillante, Alexander Hageboutros, Melvin Pratter, Stephen Akers and Polina Khrizman
Article Type: Original Article | First Published: April 20, 2019
Small cell lung cancer (SCLC) is an aggressive malignancy with a short median survival time. Because of the rapid growth rate there may be an advantage to emergently beginning chemotherapy as soon as SCLC diagnosis is made. All SCLC patients evaluated at Cooper University Hospital from January 2011 to September 2014 were reviewed. Multiple clinical factors were analyzed including timing between diagnosis and start of chemotherapy....
The Use of Carboranes in Cancer Drug Development
Emilia O Zargham, Christian A Mason and Mark W Lee Jr
Article Type: Review Article | First Published: April 18, 2019
Over the past decade, there has been a rising interest in the use of carboranes as a potential pharmacophoric moiety in the development of new drugs for the treatment of various types of cancer. The unique physical and chemical properties of carboranes make their use attractive in drug development. In several instances, the inclusion of carboranes into a drug structure has increased the agent's binding affinity, potency, or bioavailability. The purpose of this review is to highlight applications...
Does a New Information Structure about Cosmetic Outcome of Breast-Conserving Treatment Result in a Better Informed Patient? Outcome of a Comparative Case Study
ATPM Brands-Appeldoorn, MSc, AJG Maaskant-Braat, MD, PhD, VCG Tjan-Heijnen, MD, PhD and RMH Roumen, MD, PhD
Article Type: Original Article | First Published: April 17, 2019
A comparative case study compared data of two cross-sectional studies. The historical group (HG) was treated in 2013, the implementation group (IG) in 2016. The HG received a questionnaire, which resulted in implementation of the following items in our practice, expansion of the BCT brochure and photo book, incorporation of the Harvard and Numeric Rating scale. The IG received the same questionnaire, with the addition of nine more questions concerning specific implementation aspects....
Well Differentiated Neuroendocrine Uncommon Primary Breast Carcinoma: A Case Report
Angela Strazzanti, MD, Claudio Trovato, Angelo Caponnetto, Santi Gangi, Loredana R Villari, Pietro Gangemi and Francesco Basile
Article Type: Case Report | First Published: April 11, 2019
Neuroendocrine breast carcinomas (NEBC) are rarely malignant with a frequency of less than 0.1-0.3% of all breast tumors. The actual incidence of NEBC in BC (Breast Cancer) populations being still largely unknown due to the lack of a clear cut diagnostic criteria. In 2003, the World Health Organization (WHO) Classification of Tumors of the Breast and Female Genital Organs definitely established that the immunohistochemical expression of NE markers is the unique requirement for NEBC diagnosis....