International Journal of

Cancer and Clinical ResearchISSN: 2378-3419

Early Online

 Open Access DOI:10.23937/2378-3419/1410125

The Role of Human Papillomavirus in Cervical Cancer

Beata Smolarz, Dariusz Samulak, Marianna Makowska, Hanna Romanowicz, Zbigniew Kojs, Luiza Wojcik and Magdalena M Michalska

Article Type: Review Article | First Published: September 28, 2019

Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor - cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This article contains the latest reports on the structure, function and role of HPV in the development of ce...

 Open Access DOI:10.23937/2378-3419/1410124

TCM Combined Chemoradiotherapy in the Treatment of LimitedStage Small Cell Lung Cancer: Current Status and Perspectives

Shulin He, Rui Liu, Qiujun Guo, Huamin Wei, Yanjiu Bao, Xinyao Xu, Shuntai Chen, Honggang Zheng and Baojin Hu

Article Type: Review Article | First Published: September 21, 2019

About 13% of lung cancer cases are of the small cell subtype, but this variant is highly aggressive, and approximately 40% of patients with small cell lung cancer will have limited-stage disease, which is potentially curable with the combination of chemotherapy and radiation therapy. The standard therapy for limited-stage small cell lung cancer is concurrent chemoradiotherapy, and the 5-year survival rate observed in clinical trials is approximately 25%. For patients who obtain a near complete o...

 Open Access DOI:10.23937/2378-3419/1410123

The Resected Tumour Volume of the Specimen as a Marker of the Quality of the Transurethral Resection in T1 Urinary Bladder Cancer

Staffan Jahnson and Hans Olsson

Article Type: Original Article | First Published: September 18, 2019

This prospectively performed population-based study included all patients in the Southeast Healthcare Region in Sweden with T1 UBC registered in the period 1992-2001, inclusive. RV, RTV and important clinic-pathological variables were studied. All patients had T1 tumours including detrusor muscle at the histopathological examination. Median values for RV and RTV were cut-off points for dichotomisation and 3 cm was the cut-off point for tumour size measured at TUR. Recurrence and progression were...

 Open Access DOI:10.23937/2378-3419/1410122

Expression of P53 and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)

Amlani Lahin, Bellile Emily, Spector Matthew, Smith Joshua, Brenner Chad, Rozek Laura, Nguyen Ariane, Zarins Katie, Thomas Daffyd, McHugh Jonathan, Taylor Jeremy and Wolf T Gregory

Article Type: Original Article | First Published: August 09, 2019

Mutation of TP53 is the most common genetic abnormality in head and neck squamous cell carcinoma (HNSCC) and results in an accumulation and expression of p53 protein in tumor cells. Disruptive TP53 mutations are consistently associated with poor prognosis but correlations of p53 expression with mutation or prognosis have been variable and the usefulness of p53 as a target for immunotherapy is unknown. Favorable prognosis is associated with the accumulation of T lymphocytes (TILs) in the tumor mi...

 Open Access DOI:10.23937/2378-3419/1410121

Early Aggressive Management of Postoperative Pancreatic Fistulas following Pancreaticoduodenectomy (PD): A Five-Year Single Institution Experience

Rohan Thakkar, FRCS, David Bourne, Msc, Stacey Vass, Bsc, Aditya Kanwar, FRCS, Theodore Tsirilis, FRCS, John S Hammond, PhD, Colin Wilson, PhD, Gourab Sen, MD, Steven White, MD, Jeremy French, MD, Richard Charnley, DM and Derek Manas, FRCS

Article Type: Original Article | First Published: August 07, 2019

We retrospectively analysed the data that underwent PD between 2013-2017. We reviewed for all patients who experienced Grade B POPF. Data included details of total parenteral nutrition received, dose of octreotide infusion administered, serial drain amylase levels, effluent volume and anthropometry. Outcome measures were weight changes associated with treatment, the number of lines used per patient, the length of treatment, treatment associated complications and 90-day mortality rates....

 Open Access DOI:10.23937/2378-3419/1410120

Performance of Three Prognostic Models in Critically Ill Patients with Cancer: A Prospective Study

Frank D Martos-Benitez, PhD, MD, Hilev Larrondo-Muguercia, MD, David Leon-Perez, MD, Juan C Rivero-Lopez, MD, Versis Orama-Requejo, MD and Jorge L Martinez-Alfonso, MD

Article Type: Original Article | First Published: July 17, 2019

Predicting mortality is one of the greatest challenges for critical care physicians. Severity scoring systems integrate clinical data to estimate the probability of death, which can be used to facilitate resource utilization or continuing quality improvement and to stratify patients for clinical research. Prospective validation in different populations of critically ill patients improves the applicability of the model to these settings. Furthermore, the performance of a prognostic score must be ...

 Open Access DOI:10.23937/2378-3419/1410119

Utility of Magnetic Resonance Imaging (Imaging) in Target Volume Definition for Radiosurgery of Acoustic Neuromas

Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Hakan Gamsiz, Bora Uysal, Bahar Dirican and Murat Beyzadeoglu

Article Type: Original Article | First Published: June 20, 2019

Acoustic neuromas, also known as vestibular schwannomas are benign and slow-growing tumors arising from neural crest-derived Schwann cells. Treatment of acoustic neuromas targets to achieve local control while preserving hearing without comprimising cranial nerve functionality. In this context, radiosurgery in the form of Stereotactic Radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) offer viable therapeutic options for effective management. Multimodality imaging has gained utm...

 Open Access DOI:10.23937/2378-3419/1410118

Frailty as a Prognosis Factor in Cancer for the Elderly

Miguel Angel Acosta-Benito, Rosa Ana Garcia-Pliego, Jaime Barrio-Cortes and Veronica Rodriguez-FernAndez

Article Type: Research Article | First Published: June 20, 2019

Frailty is a geriatric syndrome related to adverse health outcomes in the elderly, due to a decrease systems' functional reserve. Cancer is a common pathology in the elderly, and we need tools for identifying the response to treatment and prognosis of elderly cancer patients. This short revision aims to assess the significance of the detection of frailty in the elderly patient with a tumor as a possible prognostic factor in terms of mortality, and the impact of the 2013 Frailty Consensus in the ...

 Open Access DOI:10.23937/2378-3419/1410117

Current Recommendations of Radioactive Seed ~ (125)I Implantation in Lung Brachytherapy: Moving Forward in Medical Care

Wang Yuchan, Yuan Gengbiao, Lee Changyi, Ran Lifeng and Yang Wei

Article Type: Review Article | First Published: June 20, 2019

Isotopes of radioactive iodine have a persistent lethal effect on the uncontrolled proliferation of tumor cells with a definite curative effect on tumors. It has been proved, up to 87.2% of 3-year's survival rate that could be achieved by radioactive seeds. Iodine-125 radioactive seeds have a long half life and low energy with excellent stable outcomes. Various effective isotopes with advanced techniques are used to place radioactive sources directly into a tumor, tumor bed in treating lung canc...

 Open Access DOI:10.23937/2378-3419/1410116

Breast Cancer Survivors: Is Routine 'Mammographic Only' follow up Imaging Enough or is it Time for Personalised follow up?

Gaurav Jyoti Bansal, Thomas Telford and Kevin Pinto

Article Type: Original Article | First Published: June 20, 2019

Breast cancer is the most common cancer in women, accounting for approximately 15% of all cancers. Over 85% of these people survive beyond 5 years after diagnosis, due to continual progressions in early detection and treatment quality. Despite advances in detection and treatment, 20-30% of patients develop local relapse or distant metastasis. Molecular subtyping of breast cancers based on receptor expression has been introduced in clinical practice and has developed into an important tool in pre...

 Open Access DOI:10.23937/2378-3419/1410115

Breast Fibromatosis: Case Report, Case Series, and Mini Review

Alicia Huff Vinyard, DO, Rachel Berger, MS-IV, TolgaOzmen, MD and Eli Avisar, MD

Article Type: Case Report | First Published: June 15, 2019

Fibromatosis of the breast is a rare, benign tumor, lacking metastatic potential, but can be aggressive and create issues with loco-regional control if not adequately treated. In the literature, fibromatosis of the breast is often discussed only in case reports and small case series. The consensus on treatment remains wide local excision, however, other therapies have been described. In discussion of an interesting case presentation of what we have defined as secondary breast fibromatosis, we re...

 Open Access DOI:10.23937/2378-3419/1410114

A Single Institution Study Experience of Secondary Breast Angiosarcoma after Breast Conserving Treatment: Multidisciplinary Management

Angela Strazzanti, MD, Claudio Trovato, MD, Santi Gangi, MD, Dario Marletta, MD, Roberto Milazzotto, MD and Corrado Spatola, MD

Article Type: Multidisciplinary | First Published: May 08, 2019

The aim of this study, focusing on a small number of cases, is to deal with the angiosarcoma of the breast, representing less than 1% of all soft tissue breast tumors, and finally share our experience. As a consequence of breast-conserving therapy (BCT) that is the standard treatment nowadays, a new type of angiosarcoma has been highlighted: Radiation-Induced Angiosarcoma (RIAS). Here is reported a retrospective analysis of RIAS patients' characteristic features, together with an account of the ...

Volume 6
Issue 3