Punicic Acid Inhibits Proliferation and Induces Apoptosis in Human MCF-7 Breast Cancer Cells
Oluwafemi Gbayisomore, Hannah Klausner and Shelley A Phelan, PhD
Article Type: Research Article | First Published: March 08, 2023
One of the main components of Pomegranate Seed Oil is punicic acid, an omega-5 fatty acid that is capable of inhibiting breast and prostate cancer cell proliferation, although the mechanisms of action are not yet known. In order to further understand its potential anti-cancer properties, we investigated the effect of punicic acid on proliferation and cytotoxicity of human MCF-7 breast cancer cells. Cells were treated with punicic acid for up to 72 hours, and cell proliferation, cytotoxicity, and...
Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer
Dávid Fodor, Eva Pozsgai, Andrew V. Schally, Zoltán László, Éva Gömöri, Éva Szabó, László Rumi, Dorottya Lőcsei, Árpád Boronkai and Szabolcs Bellyei
Article Type: Review Article | First Published: December 31, 2022
Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses and certain clinical and molecular markers have been studied as potential prognosticators of patient survival. The main objective of our study was to investigate the relationship between the expression intensities of certain proteins: Growth Hormone- Releasing Hormone Receptor (GHRH-R), Hsp90, Hsp16.2, p-Akt and SOUL in specimens of locally advanced rectal cancer patients and time to metastasis as well as 10-year Ove...
Colorectal Cancer Screening: Ratios from Hemogram to the Rescue
Purva Trivedi, Mahesh Patel, Sanjay Dhotre and Hansa Goswami
Article Type: Original Article | First Published: October 20, 2022
Colorectal Cancers (CRC) are one of the top ten cancers to increase the burden on the health care system in India. Often patients experience symptoms after carcinoma has significantly progressed. Timely and accurate screening in the target population remains a challenge for clinicians....
The Role of Adjuvant Metronomic Chemotherapy in Increasing Overall Response Rate in Patients with Breast Cancer
Bhushan Jain and Akhila Pakalapati
Article Type: Review Article | First Published: September 18, 2022
Treatment paradigms against cancer have continuously evolved over the years. Having said that, with its prevalence of more than 2 million cases each year, breast cancer represents an urgent global priority . Breast carcinomas accounted for 11.6 % of cancer cases and were the cause of mortality in as many as 6.6 % of women in the world in 2018 . Toxicity and chemoresistance are significant hurdles in conventional chemotherapy and to avoid these issues, a new approach to drug administration,...
Malignant Neural Sheath Tumors of the Head and Neck
Carlos Santiago Ruggeri, Gabriel Rondón Gonzalez, Ana Clara Ragoni and Inés Fagalde
Article Type: Research Article | First Published: August 19, 2022
Malignant neural sheath tumors located in the head and neck region are very rare. Surgical treatment if possible is the best option, trying to obtain wide resection margins free of tumor. To determine the incidence of malignant tumors of neural histology, in relation to nerve tumors originating in the head and neck and description of two clinical cases....
Carcinosarcoma EX Pleomorphic Adenoma of Parotid: An Unusual Entity, A Report of Two Cases with Brief Review of Literature
Aparna Devi, MD, DM, Usha Amirtha, MD, Geeta V Patil Okaly, MD and Raghavendra HV, MD
Article Type: Case Report | First Published: June 30, 2022
A 58-year-old male, underwent total parotidectomy for longstanding preauricular swelling. Histomorphology revealed a biphasic neoplasm composed of carcinoma with plasmacytoid morphology and osteosarcoma in the background of pleomorphic adenoma. Carcinoma component was confirmed to be myoepithelial carcinoma by immunohistochemistry. The patient presented with local recurrence two months later....
Chemoprevention of 1,2 Dimethyl Hydrazine-Induced Colon Tumor in Albino Rat by Meloxicam and its Correlation with Immunoassay of Serum CEA
Saeed Mahmoud Saeed Mohamed, Afaf Mosaad Amin, Suzanne William Skander, Taha Ismail Mahmoud Hewala, Eithar Omer Mohamed Saleh, Aisha Mohammed Osman Salih, Sabah Ali Mugahed Al-Qadasi, Marwan Mustafa Badawi and Mahmoud Assem Hamed
Article Type: Research Article | First Published: April 28, 2022
Colorectal Cancer (CRC) is among the most common types of cancer in the world. Globally a steadily increasing proportion of elderly people in the world result in approximately 16 million new cases of cancer by the year 2021. Regarding treatment; Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect, capacity for cell cycle arrest, and pro-apoptotic effects, also acted as free radical scavenger, in p...
Proposed Immunology of the Spontaneous Remission of Acute Myleiod Leukemia Treated with G-CSF
Article Type: Hypotheses | First Published: April 29, 2022
It is suggested that the spontaneous remission of acute myeloid leukemia, particularly hypoplastic acute myeloid leukemia seen after G-CSF treatment is possibly due to G-CSF augmenting an acute inflammatory response. The acute inflammatory response is one occurring during a low count of activated platelets. Furthermore, it appears if a low platelet count (absence of hyper-coagulation or thrombocytosis) is present then G-CSF administration are more likely to induce a remission of acute myeloid le...
Treatment of Cancer Patients in the Era of the Covid-19 Pandemic
Budi Tulaka, Harlinda Haroen, Linda Wilhelma Ancella Rotty, Pearla Fidei Cindy Lasut and Cecilia Hendratta
Article Type: Research Article | First Published: April 18, 2022
Coronavirus Disease 2019 (COVID-19) is an outbreak of respiratory disease caused by novel coronavirus and has reached pandemic state. Cancer patients have increase susceptibility to infection caused by the malignancy itself and anticancer systemic therapy. Based on individual patient assessment, the oncologist's decision regarding the need for immediate oncological intervention classifies patients into 'urgent' and 'non-urgent' conditions. Consideration of risk and benefit for active interventio...