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Original Article  |   Volume 4, Issue 2

Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue HER2-Positive Breast Cancer Patients

Seiichi Mokuyasu and Yasuhiro Suzuki

Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently evaluated histopathologically. Immunohistochemistry and fluorescence in situ hybridization require invasive enucleation of the tumor tissue and may be affected by heterogeneity.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410089

Original Research  |   Volume 4, Issue 2

Ipilimumab Activity in Advanced Uveal Melanoma: A Pooled Analysis

Muhammad A Khattak and Elin Gray

Uveal Melanoma is a rare tumour that displays different clinical behavior and molecular features compared with cutaneous melanoma. It is generally resistant to systemic therapy and there is no current standard effective therapy to treat patients with advanced disease.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410088

short review article  |   Volume 4, Issue 2

Immune Paralysis and the Spontaneous Remission of Cancer

BH Behzad Niakan

Once a malignant growth grows past a certain size immune tolerance rather than immune sensitization occurs possibly due to the slow tumor growth. As the malignant grows larger some branches of the immune system (adoptive immunity) become protective of it, while other branches of the immune system oppose its growth.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410087

Research Article  |   Volume 4, Issue 2

The Omission of Axillary Lymph Node Dissection in Sentinel Node-Positive Breast Cancer Patients Requires Careful Consideration

Hiroko Nogi, Takashi Kazama, Rei Mimoto, Yoshimi Imawari, Makiko Kamio, Hisashi Shioya, Yasuo Toriumi, Ken Uchida, Masafumi Suzuki and Hiroshi Takeyama

Sentinel Node Biopsy (SNB) is used to accurately assess axillary lymph node status in patients with node-negative breast cancer. The purpose of this study was to assess the association between non-sentinel node (SN) metastasis and clinicopathological findings in patients with one or two SN-positive breast cancer.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410086

Research Article  |   Volume 4, Issue 2

Assessing Response to Chemoradiotherapy on 18F-FDG PET Images in Non-Small Cell Lung Cancer using New Approaches of Histogram and Gray Level Co-Occurrence Matrix

Changdong Ma, Judong Luo, Yong Hou and Changsheng Ma

Twelve patients with newly diagnosed NSCLC and treated with combined Chemoradiotherapy (CRT) were involved in this study. We analyzed the percentage variation of gray value in every gray level or on the whole using histogram analysis algorithm which represents global intensity distribution.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410085

Research Article  |   Volume 4, Issue 2

The Utilization of Partial Orchiectomy in Treating Small Testicular Tumors in the United States

Shaheen Alanee, Joseph Clemons, Bradley Holland, Max Nutt and Danuta Dynda

There is increasing evidence supporting the feasibility of Partial Orchiectomy (PO) as a treatment for small testicular tumors. However, the prevalence of this practice is still unknown. We used the Surveillance, Epidemiology, and End results (SEER) registry to characterize national practice patterns for surgical management of patients with testicular tumors ≤ 2 cm in size, and we examined factors that determined performing PO in such patients.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410084

Research Article  |   Volume 4, Issue 2

Physiological Effort in Submaximal Fitness Tests Predicts Weight Loss in Overweight and Obese Men with Prostate Cancer in a Weight Loss Trial

Andrew D Frugé, John A Dasher, David Bryan, Soroush Rais-Bahrami, Wendy Demark-Wahnefried and Gary R Hunter

Obesity and weight gain after the diagnosis of prostate cancer are associated with an increased risk of prostate cancer recurrence and mortality; individualized plans to help prostate cancer survivors maintain or lose weight may be beneficial for recurrence risk reduction.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410083

Research Article  |   Volume 4, Issue 2

Radiolabeled APIs for the Conduct of Human ADME Studies of Oncology Compounds

Yuexian Li, Mihaela Plesescu and Shimoga R Prakash

Human ADME (Absorption, Distribution, Metabolism, and Excretion) studies of new chemical entities are an important part of the drug development process. These studies are normally performed by using a radioactive tracer (C-14 or H-3) blended with a therapeutic dose of non-radioactive drug in about four to six subjects. The radiolabeled API (Active Pharmaceutical Ingredient) is utilized to evaluate the recovery and track the metabolic fate and physiological disposition of the drug.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410082

Review Article  |   Volume 4, Issue 2

Bioactive Peptides from Legumes as Anticancer Therapeutic Agents

Gonzalez-Montoya Marcela, Cano-Sampedro Eden and Mora-Escobedo Rosalva

Food proteins are a source of nutraceutical and bioactive peptides that promote health and prevent diseases. Legume seed proteins have been widely studied to produce peptides (protein fragments) with a diversity of biological activities.

  PDF   |    Full Text | DOI: 10.23937/2378-3419/1410081