International Journal of

Neurology and NeurotherapyISSN: 2378-3001

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 Open Access DOI:10.23937/2378-3001/1410125

Validation of a Suitable Housekeeping Gene in Human Neuroblastoma SHSY-5Y Cell-Line Treated with Steroid Hormones Progesterone and Testosterone

Paula Maria Neufeld, Jonas Frai, Veronika Matschke, Carsten Theiss and Sarah Stahlke

Article Type: Original Article | First Published: 2023/12/30

In this study, we evaluated the stability of three common housekeeping genes, GAPDH, beta-Actin, and 18S-rRNA, in human neuroblastoma SHSY-5Y cells exposed to varying levels of steroid hormones like progesterone (P4) and testosterone. Housekeeping genes serve as reliable internal controls, assumed to maintain consistent expression across diverse tissues and experimental conditions. Since steroid hormones act as ligand-activated transcription factors, directly impacting gene transcription, the id...

 Open Access DOI:10.23937/2378-3001/1410124

Feasibility, Cooling Efficacy and Precisionofa Novel System for Temperature Management in Cardiac Arrest, Neurogenic Fever and Covid-19

Johanna Kämpe, Akil Awad, Mohammad Fazel Bakhsheshi, PhD, Svensson L MD, PhD and Per Nordberg, MD, PhD

Article Type: Research Article | First Published: 2023/09/29

In critically ill patients, induced hypothermia or active temperature control to avoid fever are used for neuroprotection. The aim of this study was to determine the feasibility and performance of a novel temperature management system inpatients after cardiac arrest, with neurological fever or due to COVID-19 infection....

Volume 10
Issue 2