Dental Stem Cells Characterization and Bone Regenerative Potential in Oral Medicine
Ricardo Rodrigues, Barbara Viana, Ivo Vieira, Joao Tavares, Renato Lobo, Ana Portela and Mario Vasconcelos
Article Type: Review Article | First Published: June 02, 2015
The oral cavity has proven to be an important reservoir of stem cells with the advantage of being a non-invasive source. These cells potential for maxillo-facial bone regeneration has been well documented throughout the last five years. This article aims at reviewing and discussing the different types of dental stem cells available in the oral cavity, their lineage characterization and potential applications in oral medicine; cell collection, isolation and preservation; bone regenerative potenti...
The Decision for Regenerative Endodontic Therapy
Anastasia Agrafioti, Maria Deimezi and Evangelos G. Kontakiotis
Article Type: Review Article | First Published: April 19, 2015
Regenerative endodontics is described as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex, and is considered as an optimal approach for treating the immature permanent tooth with a necrotic pulp....
Enhancement of Human Adipose-Derived Stem Cell Expansion and Stability for Clinical use
Swenn Maxence Krähenbuhl, Anthony Grognuz, Murielle Michetti, Wassim Raffoul and Lee Ann Applegate
Article Type: Research Article | First Published: April 06, 2015
Co-culture techniques associating both dermal firoblasts and epidermal keratinocytes have shown to have better clinical outcome than keratinocyte culture alone for the treatment of severe burns. Since fat grafting has been shown to improve scar remodelling, new techniques such as cell-therapy-assisted surgical reconstruction with isolated and expanded autologous adipose-derived stem cells (ASCs) would be of benefit to increase graft acceptation....
Comparative Characterization of Canine and Human Mesenchymal Stem Cells Derived from Bone Marrow
Bertolo A, Schlaefli P, Malonzo-Marty C, Baur M, Potzel T, Steffen F and Stoyanov J
Article Type: Research Article | First Published: January 19, 2015
Bone marrow is a major source of Mesenchymal Stem Cells (MSC), which are used in tissue engineering and other autologous stem cell therapies. Studies designed to use large canine models and translate the results to human practice must take into account the ex vivo and in vitro differences in the bone marrow samples. A set of morphological and physiological markers was used to compare MSC derived from canine and human bone marrow. Despite anticlotting treatment, frequent bone marrow clotting was ...