PubMed, Embase, and Scopus (2000-2025) were searched for observational studies reporting quantitative biomarker data. Meta-analyses were performed using random-effects models; results were expressed as pooled geometric means or standardized mean differences. Heterogeneity was assessed using I2. Gene Ontology enrichment was performed with Enrichr using the GO Biological Process 2025 library and drug reversal candidates were queried in LINCS L1000 chemical perturbations consensus signatures....