Intercalary Endoprosthetic Reconstruction for Long Bone Defects of the Lower Extremity
Jennifer A Bell, MD, Brandon S Gettleman BS, Alexander B Christ, MD, Caroline E Vonck, MD and Lawrence R Menendez, MD
Article Type: Retrospective Review | First Published: 2023/08/12
Modular intercalary endoprostheses is a potential reconstructive option infrequently studied for diaphyseal defects of long bone. The purpose of this study was to examine the 1) Method of failure rate of revision after reconstruction with modular intercalary endoprostheses based on the anatomic site and 2) Describe the functional status of the patient and use of assistive devices with ambulation....
Epidemiological Study of Penile Cancer in Northeast Brazil
Thais Cristina Loyola da Silva, Érika Gabrielle Pinheiro Ximenes, Ythalo Hugo da Silva Santos, Rodrigo Jerônimo Araújo, Eurides Araújo Bezerra de Macedo, Irami Araújo-Filho, Kleyton Santos de Medeiros and Tirzah Braz Petta
Article Type: Research Article | First Published: 2023/07/10
All patients were diagnosed with squamous cell carcinoma, mainly aged over 50 years, from the state's interior, brown, illiterate, or with incomplete primary education. At diagnosis, 68% of patients were classified as having tumors ≥ T2, and 30% had lymph node involvement. Distant metastases were detected in 2.1% of patients at diagnosis. Most patients received the diagnosis in the initial phase of the disease, but 20.2% were diagnosed in stage IV....
Alterations of Serum Lipids Profiles in Patients with Head and Neck Cancers
Jenan Adnan Sulieman, Youssef Youssef and Mostafa Ibrahim
Article Type: Research Article | First Published: 2023/06/30
The present case-control study comprises of newly diagnosed and histologically confirmed, 50 head and neck cancer cases between 2021-2022 in the Department of Otorhinolaryngology and Head and Neck Surgery, Tishreen University Hospital, Lattakia, with 25 healthy controls. Fasting blood samples were collected and the lipid profile studied and compared between groups in terms of mean and standard deviation....
Punicic Acid Inhibits Proliferation and Induces Apoptosis in Human MCF-7 Breast Cancer Cells
Oluwafemi Gbayisomore, Hannah Klausner and Shelley A Phelan, PhD
Article Type: Research Article | First Published: March 08, 2023
One of the main components of Pomegranate Seed Oil is punicic acid, an omega-5 fatty acid that is capable of inhibiting breast and prostate cancer cell proliferation, although the mechanisms of action are not yet known. In order to further understand its potential anti-cancer properties, we investigated the effect of punicic acid on proliferation and cytotoxicity of human MCF-7 breast cancer cells. Cells were treated with punicic acid for up to 72 hours, and cell proliferation, cytotoxicity, and...