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Case Report  |   Volume 3, Issue 3

Rapid Fatal Progression of Cervical Cancer during Pregnancy Treated by Neoadjuvant Chemotherapy

Iptissem Naoura, Lise Selleret, Frederic Selle and Emile Darai
Abstract

Cervical cancer is the most commonly diagnosed gynaecological malignancy in pregnant women. The prognosis of this cancer does not seem to be influenced by the pregnancy. However, the cancer management comes into competition with maternal and foetal outcomes, especially during the 2nd trimester of pregnancy. Challenging issues lie in the cervical screening during pregnancy, the evaluation of lymph node status and the indication of neoadjuvant chemotherapy to avoid foetal prematurity without comprising maternal prognosis.

PDF   |    Full Text | DOI: 10.23937/2378-3419/3/3/1060

Case Report  |   Volume 3, Issue 3

Appendiceal Metastasis in a Patient with Advanced Breast Cancer on Hormonal Therapy

Edmond Kwan, Nezor Houli, Meron Pitcher and Shirley Wong
Abstract

A 70-year-old woman presented with abdominal pain nine months after the diagnosis of de-novo, hormonal-receptor positive advanced breast cancer. Imaging revealed appendiceal stranding likely representative of acute appendicitis. Surgery was performed, and pathological examination of the inflamed appendix revealed metastatic carcinoma consistent with breast primary. The case highlights the diagnostic challenges of abdominal pain in a patient with advanced cancer.

PDF   |    Full Text | DOI: 10.23937/2378-3419/3/3/1059

Mini Review  |   Volume 3, Issue 3

ADAM17: A Gatekeeper in Immune-Oncology?

Peter R Lowe and Nathalie Corvaia
Abstract

Recent therapeutics searching to reactivate and target the immune system to destroy tumors have demonstrated remarkable success in the treatment of patients with previously intractable disease such as metastatic melanoma. Current research is enlarging the spectrum of targets and strategies for enhancing the immune response against tumors, in order to further improve treatment efficacy. In that respect, ADAM17, has frequently been described for it's over expression or over activation in the tumor microenvironment. ADAM17 is responsible for the shedding of a large number of receptors and ligands involved in immune tumor targeting and the deregulation of this activity should be considered when developing therapeutic strategies.

PDF   |    Full Text | DOI: 10.23937/2378-3419/3/3/1058

Review Article  |   Volume 3, Issue 3

Immune and Genetic Susceptibility in the Development of Cervical Cancer

Barbara Mora, Felipe M Benavente, Carmen G Ili and Priscilla Brebi
Abstract

Cervical cancer is the second most frequent cancer in women worldwide. Although 99.7% of cases are attributed to a previous infection by Human papillomavirus, a small percentage of the infected women progress to cervical cancer, suggesting the existence of different risk factors involved in the development and progression of this pathology. Genetic variability related to the host immune system could play an important role in the defense response to Human papillomavirus and therefore to the probability of developing cervical cancer. Worldwide, several international studies have reported that some genetic variations in immune system, such as polymorphisms in genes HLA, CTLA-4, MTHFR, Tp53 and receptors of natural killer cells are associated with susceptibility to cervical cancer, although these variations can also play a protective role depending on the study population. The role of the genetic factors of the host cell is an important factor in the progression of the cervical cancer.

PDF   |    Full Text | DOI: 10.23937/2378-3419/3/3/1057

Short Chart Review  |   Volume 3, Issue 3

Breast Cancer Screening and Chemoprevention

J Drew Payne, Menfil Orellana-Barrios, Teri Payne, Anita Sultan and Catherine Jones
Abstract

Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer related death among women in the United States. Breast cancer chemoprevention is a proven way to reduce breast cancer incidence. This article will present a short literature review and an assessment and description of breast cancer screening and chemoprevention in an outpatient internal medicine clinic. Records were reviewed to provide description of the screening in an outpatient internal medicine clinic.

PDF   |    Full Text | DOI: 10.23937/2378-3419/3/3/1056

Review Article  |   Volume 3, Issue 3

Second Line and Maintenance Therapy for Advanced Non-Small Cell Lung Cancer without Driver Mutation: An Evolving Paradigm

Stephanie Brule and Paul Wheatley-Price
Abstract

Lung cancer is the most commonly diagnosed cancer amongst men and women combined, and is responsible for the greatest number of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents about 85% of all lung cancers, and is the umbrella term that includes the most common histological subtypes: adenocarcinoma, squamous cell carcinoma and large cell carcinoma. Due to the fact that it is frequently diagnosed at an advanced stage or recurs after potentially curative treatment, the five-year survival rate for all patients diagnosed with NSCLC is only 17%.

PDF   |    Full Text | DOI: 10.23937/2378-3419/3/3/1055


Volume 3
Issue 3