Long-Term Efficacy of Infliximab for Treatment of Severe Behcet's Uveitis
Emanuela Interlandi, Pietro Leccese, Ignazio Olivieri and Loredana Latanza
Article Type: Research Article | First Published: February 26, 2015
Medical records of 32 patients (56 eyes) were retrospectively analysed. Primary outcomes included ocular inflammatory activity, frequency of uveitis attacks and steroid-sparing effect. Results: Mean follow-up was 33,2 months while mean age of patients at disease onset was 33,3 years. Ocular inflammation was bilateral in 75% of cases and consisted in panuveitis in 46,4% of affected eyes....
Effect of Interferon Alfa-2a on Peripheral Blood CD4+CD25+ T Regulatory Cells in Patients with Behcet Uveitis: Preliminary Study
Aylin Koc, Sumru Onal, Aysin Tulunay, Haluk Kazokoglu, Emel Eksioglu Demiralp, Haner Direskeneli and Sule Yavuz
Article Type: Research Article | First Published: February 13, 2015
Purpose: To evaluate the phonotypical and functional effect of interferon alfa-2a therapy on peripheral blood CD4+CD25+ T regulatory (Treg) cells in patients with Behcet uveitis. Methods: Blood was taken from 5 patients with refractory Behcetpanuveitis and 5 age-matched healthy controls. Flow cytometric analysis of CD4+CD25+Treg cells was performed. CD4+CD25+Treg cells were separated by magnetic-assisted cell sorting and co-cultured. Cytokine levels in the supernatants were determined by ELISA.....
Generation of Retinal Progenitor Cell Sheets which Differentiate into Rhodopsin Positive Photoreceptors from Mouse iPS Cell Derived Retinal Progenitor Cell Clones
Noboru Suzuki, Jun Shimizu, Chieko Hirotsu, Erika Takada, Nagisa Arimitsu, Yuji Ueda, Naruyoshi Fujiwara, Tomoko Suzuki and Kenji Takai
Article Type: Research Article | First Published: February 05, 2015
We previously reported successful establishment of retinal progenitor cell clones. Here, we cultured them on temperature reversible gelation polymer, with supplementation of several chemokines. The retinal progenitor cell clones formed a cell sheet with extension of their axon like processes. RT-PCR of the cell sheets after two week culture, they were positive for retinal ganglion cell markers, bipolar cell markers, and photoreceptor cell markers. Immunohistochemistry suggested that the cell she...
Macular Multifocal Granular Hyperfluorescence on Fluorescein Angiography
Article Type: Research Article | First Published: January 30, 2015
Purpose: To investigate the causes of multifocal granular hyperfluorescence at the macula on Fluorescein Angiography (FA) in Japanese patients. Methods: I retrospectively studied 1,457 consecutive Japanese patients (1,457 eyes) who underwent digital simultaneous FA and indocyanine green angiography (ICGA). Results: One hundred forty-seven of the 1,457 eyes had multifocal granular hyperfluorescence on FA images. Of the 147 eyes, 94 (64%) eyes had polypoidal choroidal vasculopathy (PCV); 25 (17%) ...
Optic Disk Size Assessment Techniques: Photo Essay
Sourabh Arora, Helen Chung and Karim Damji
Article Type: Case Report | First Published: January 25, 2015
Measuring optic disc size is an essential part of the optic nerve head for evaluation for glaucoma. Large discs that appearing to have large cups may in fact be physiologic because of normal neuroretinal rim area. Small discs may appear to have a normal cup to disc ratio, but have decreased neuroretinal rim area in association with glaucoma. We illustrate relevance of these points with respect to glaucoma diagnosis in two case examples. We then present clinically relevant techniques to assess di...
Macular Hole Formation Following Choroidal Neovascularization Treatment in A High Myopic Eye with Epiretinal Membrane
Yusaku Yoshida, Manabu Yamamoto, Takeya Kohno and Kunihiko Shiraki
Article Type: Case Report | First Published: January 21, 2015
Purpose: To report on the development of macular hole after treatment of choroidal neovascularization (CNV) in a patient with high myopia and epiretinal membrane (ERM). Methods: Retrospective single case report.Patients: A 60-year-old man presented with reduced vision in his right eye. On the initial examination, the right eye was high myopic with decimal best-corrected visual acuity (BCVA) of 0.3. Results: A subretinal grayish-white lesion was seen at the macula with hemorrhage, and optical coh...
Biweekly Bevacizumab for Refractory Neovascular Age-related Macular Degeneration
Ryan B. Rush and Sloan W. Rush
Article Type: Research Article | First Published: January 13, 2015
Purpose: To evaluate the effectiveness of biweekly (twice-permonth) bevacizumab for treatment-resistant neovascular agerelated macular degeneration (nAMD). Methods: The charts of nAMD subjects treated with biweekly bevacizumab injections because of persistent retinal edema on optical coherence tomography (OCT) despite consecutive monthly anti-vascular endothelial factor (VEGF) therapy were retrospectively reviewed. Results: There were 17 subjects included in the analysis. An average of 10.8 (+/-...