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Clinical Images  |   Volume 3, Issue 1

Endometrioid Adenofibroma: A Case of This Uncommon Benign Tumor of the Ovary Not Associated to Borderline or Endometrioid Carcinoma

Santiago Ortiz and Francisco Tortosa

Endometrioid adenofibroma is a benign epithelial and stromal tumor with an endometrioid epithelial component. Less than 20% of the surface epithelial tumors of the ovary have endometrioid differentiation. The majority of endometrioid ovarian neoplasms are carcinomas and the benign form is rarely find.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510057

Review Article  |   Volume 3, Issue 1

The "Second Opinion Medical Network"

Palmieri B, Laurino C and Vadala Maria

The "Second Opinion Medical Network" is a consultation referral web and Medical Office System involving a wide panel of specialists to which patients affected by different diseases not adequately satisfied in terms of diagnosis and treatment can submit records and data for a clinical update.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510056

Research Article  |   Volume 3, Issue 1

Aliskiren and Losartan Study in Non Diabetic CKD- A 3 Year Second Phase Follow up Study on Proteinuria

Keng-Thye Woo, Choong-Meng Chan, Stephanie Fook-Chong, Cynthia Lim, Jason Choo, Hui-Lin Choong, Suhail Mohamad, Han-Kim Tan, Kok-Seng Wong and Marjorie Foo

This is a 6 year retrospective analysis of the therapeutic efficacy and safety of Combined Aliskiren (150 mg a day) and Losartan (100 mg a day) in non Diabetic Chronic Kidney Disease (CKD) patients. The objective of this Second (2nd) Phase study was to ascertain the proportion of patients who would remain in remission for the next 3 years and for those who had a relapse of proteinuria after stopping treatment in order to decide when would be an optimum time to stop therapy as well as to ascertain the effects of stopping therapy.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510055

Review Article  |   Volume 3, Issue 1

Exosomes in the Pathogenic Protozoan Trypanosoma Cruzi

Wanderley de Souza and Emile Barrias

Significant advances have recently occurred in the identification and characterization of different types of microvesicles released by eukaryotic cells into the extracellular space. Exosomes are one such type of these vesicles they originate from multivesicular bodies and have received much attention.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510054

Case Report  |   Volume 3, Issue 1

Cystic Lymphangioma: an Uncommon Cause of Pediatric Abdominal Pain

Ivan Fernandez-Vega

Lymphangiomas are benign congenital malformations characterized by an abnormal dilatation and proliferation of lymphatic spaces, which are found predominantly in children. Symptomatic mesenteric cyst accounts for only 1 in 20,000 in acute pediatric admission. We describe hereby a case of a previously healthy 6-year-old girl who presented acute three-day pain localized over the right upper abdominal quadrant due to intestinal obstruction.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510053

Original Research  |   Volume 3, Issue 1

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Ayse Ciftci, Handan Aker and Hatice Ozer

The origin of ovarian epithelial tumors is still indistinct. Müllerian and coelomic hypothesis are controversial. Recently, there is also a small number of reports that tubo-peritoneal junction may play an important role in the development of tubo-ovarian tumors. Therefore, we aimed to investigate the relationship between tumors originating from Mullerian epithelium and peritoneal mesothelium, in other words primary and secondary Müllerian systems.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510052

Original Article  |   Volume 3, Issue 1

Aortopathy in Bicuspid Aortic Valve and Marfan Syndrome is Characterized by a Lack of Activation Potential of the Epicardium in the Ascending Aorta

Nimrat Grewal, Marie-Jose Goumans, Marco C DeRuiter, Robert JM Klautz, Robert E Poelmann, Barbara JM Mulder, Ad JJC Bogers, Adriana C Gittenberger-de Groot

Patients with a bicuspid aortic valve (BAV) and Marfan syndrome (MFS) have increased susceptibility for development of aortopathy. In the heart, epicardial cells expressing Wilms tumor suppressor protein (Wt1) are known to become activated after myocardial infarction. We hypothesize that epicardium covering the aorta might show a similar response in BAV and MFS in pathologic conditions.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510051

Case Report  |   Volume 3, Issue 1

Chronic Traumatic Encephalopathy-like Neuropathological Findings without a History of Trauma

Andrew F Gao, David Ramsay, Richelle Twose, Ekaterina Rogaeva, Charles Tator and Lili-Naz Hazrati

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by neurocognitive decline and abnormal neuronal and glial deposition of hyperphosphorylated-tau in a pattern distinct from other tauopathies. These changes are hypothesized to occur following repeated mild traumatic brain injury. We report a case of CTE-like neuropathological changes, and features of motor neuron disease in a patient without history of either head trauma or participation in activities associated with increased risk of concussive or sub-concussive blows.

PDF   |    Full Text | DOI: 10.23937/2469-5807/1510050

Volume 3
Issue 1