International Journal of

Pathology and Clinical ResearchISSN: 2469-5807

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Clinical Images Open Access

Endometrioid Adenofibroma: A Case of This Uncommon Benign Tumor of the Ovary Not Associated to Borderline or Endometrioid Carcinoma

Santiago Ortiz and Francisco Tortosa
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: Endometrioid adenofibroma is a benign epithelial and stromal tumor with an endometrioid epithelial component. Less than 20% of the surface epithelial tumors of the ovary have endometrioid differentiation. The majority of endometrioid ovarian neoplasms are carcinomas and the benign form is rarely find.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510057

Review Article Open Access

The "Second Opinion Medical Network"

Palmieri B, Laurino C and Vadala Maria
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: The "Second Opinion Medical Network" is a consultation referral web and Medical Office System involving a wide panel of specialists to which patients affected by different diseases not adequately satisfied in terms of diagnosis and treatment can submit records and data for a clinical update.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510056

Research Article Open Access

Aliskiren and Losartan Study in Non Diabetic CKD- A 3 Year Second Phase Follow up Study on Proteinuria

Keng-Thye Woo, Choong-Meng Chan, Stephanie Fook-Chong, Cynthia Lim, Jason Choo, Hui-Lin Choong, Suhail Mohamad, Han-Kim Tan, Kok-Seng Wong and Marjorie Foo
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: This is a 6 year retrospective analysis of the therapeutic efficacy and safety of Combined Aliskiren (150 mg a day) and Losartan (100 mg a day) in non Diabetic Chronic Kidney Disease (CKD) patients. The objective of this Second (2nd) Phase study was to ascertain the proportion of patients who would remain in remission for the next 3 years and for those who had a relapse of proteinuria after stopping treatment in order to decide when would be an optimum time to stop therapy as well as to ascertain the effects of stopping therapy.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510055

Review Article Open Access

Exosomes in the Pathogenic Protozoan Trypanosoma Cruzi

Wanderley de Souza and Emile Barrias
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: Significant advances have recently occurred in the identification and characterization of different types of microvesicles released by eukaryotic cells into the extracellular space. Exosomes are one such type of these vesicles they originate from multivesicular bodies and have received much attention.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510054

Case Report Open Access

Cystic Lymphangioma: an Uncommon Cause of Pediatric Abdominal Pain

Ivan Fernandez-Vega
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: Lymphangiomas are benign congenital malformations characterized by an abnormal dilatation and proliferation of lymphatic spaces, which are found predominantly in children. Symptomatic mesenteric cyst accounts for only 1 in 20,000 in acute pediatric admission. We describe hereby a case of a previously healthy 6-year-old girl who presented acute three-day pain localized over the right upper abdominal quadrant due to intestinal obstruction.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510053

Original Research Open Access

Investigation of the Relationship between Malignant Tumors Originated from Peritoneal and Müllerian Epithelium with the Primary and Secondary Müllerian Systems-Immunohistochemical Analysis with Six Markers

Ayse Ciftci, Handan Aker and Hatice Ozer
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: The origin of ovarian epithelial tumors is still indistinct. Müllerian and coelomic hypothesis are controversial. Recently, there is also a small number of reports that tubo-peritoneal junction may play an important role in the development of tubo-ovarian tumors. Therefore, we aimed to investigate the relationship between tumors originating from Mullerian epithelium and peritoneal mesothelium, in other words primary and secondary Müllerian systems.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510052

Original Article Open Access

Aortopathy in Bicuspid Aortic Valve and Marfan Syndrome is Characterized by a Lack of Activation Potential of the Epicardium in the Ascending Aorta

Nimrat Grewal, Marie-Jose Goumans, Marco C DeRuiter, Robert JM Klautz, Robert E Poelmann, Barbara JM Mulder, Ad JJC Bogers, Adriana C Gittenberger-de Groot
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: Patients with a bicuspid aortic valve (BAV) and Marfan syndrome (MFS) have increased susceptibility for development of aortopathy. In the heart, epicardial cells expressing Wilms tumor suppressor protein (Wt1) are known to become activated after myocardial infarction. We hypothesize that epicardium covering the aorta might show a similar response in BAV and MFS in pathologic conditions.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510051

Case Report Open Access

Chronic Traumatic Encephalopathy-like Neuropathological Findings without a History of Trauma

Andrew F Gao, David Ramsay, Richelle Twose, Ekaterina Rogaeva, Charles Tator and Lili-Naz Hazrati
Int J Pathol Clin Res Volume 3, Issue 1

Abstract: Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease characterized by neurocognitive decline and abnormal neuronal and glial deposition of hyperphosphorylated-tau in a pattern distinct from other tauopathies. These changes are hypothesized to occur following repeated mild traumatic brain injury. We report a case of CTE-like neuropathological changes, and features of motor neuron disease in a patient without history of either head trauma or participation in activities associated with increased risk of concussive or sub-concussive blows.

PDF   | Full Text  DOI: 10.23937/2469-5807/1510050

Volume 3
Issue 1