International Journal of Depression and Anxiety is an open access, peer-reviewed, the multidisciplinary journal focusing on effective treatments for those patients experiencing panic attacks, anxiety attacks, phobia, and social phobia. The journal gathers various key symptoms of depression and anxiety and tries adapting new conventional methods in the rehabilitation of the disease.

Journal focus on the clinical and management aspects of anxiety and depression, the two of the most common mental health concerns in our society. The Journal publishes all types of articles such as research, reviews, cases, communications, etc., in the field of depressive, mood and anxiety disorders and their management. The journal is invited for contributions including but not limited to the topics of anxiety disorders, arithmomania, atypical depression, bipolar disorder, catatonic depression, depressive disorder, dysthymia, feeling, gerontophobia, hepatitis C, interferon therapy, interpersonal rejection, melancholia, mental and behavioral disorders, mood, nutritional deficiencies, panic disorder, postpartum depression, psychomotor retardation, sadness, upset, etc. All published articles are accepted after peer review process by highly qualified, expert reviewers to meet the objectives of the standard scientific publication.

Journal Information

Title: International Journal of Depression and Anxiety

ISSN: 2643-4059

Editor-in-chief: Photios Anninos

NLM title abbreviation: Int J Depress Anxiety

ISO abbreviation: Int J Depress Anxiety

Other titles: IJDA

Category: Neurology

DOI: 10.23937/2643-4059

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Publication type(s): Periodicals

Publisher: ClinMed International Library

Country of publication: USA

Language: English

Contact email:

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI


 Open Access DOI:10.23937/2643-4059/1710040

Implementing the Patient Health Questionnaire-9 (PHQ-9) to Identify and Refer Adults with Depression

Shelia M. Brooks

Article Type: Project Report | First Published: 2023/07/21

Depression, if left untreated, may lead to an unhealthy physiological and psychological state. At the project site, there was no current assessment for depressive symptoms or subsequent referral of patients for depression, so an evidence-based solution was sought. The purpose of this quality improvement project was to determine if the translation of Patel, et al.’s research utilizing the Patient Health Questionaire-9 (PHQ-9) depression severity tool would impact the number of referrals to a me...

 Open Access DOI:10.23937/2643-4059/1710033

Use of Objective Rating Scales for Generalized Anxiety by Psychiatry Specialists in Pediatric Populations

Brittany Finocchio, PharmD, BCPP and Wanda Hilliard, DNP, MBA, APRN, PMHNP-BC

Article Type: Research Article | First Published: January 15, 2023

In 2021, leading pediatric healthcare organizations declared a national state of emergency in children’s mental health in America. Anxiety disorders are among the most common mental health conditions affecting pediatric populations. The Diagnostic and Statistical Manual of Mental Disorders, 5th edition, recommends objective measurement of pediatric anxiety for evaluation of symptomatology and treatment response. The objective of this review was to summarize recommendations and resources for me...

 Open Access DOI:10.23937/2643-4059/1710036

Can Deep Brain Stimulation Be a Promising Treatment for Treatment-Resistant Depression?

Nazanin Amirani, MSc* and Ijeuma Nwachuku, PhD

Article Type: Review Article | First Published: February 18, 2023

In recent decades, despite remarkable advances in antidepressant medication, psychotherapy, and electrical stimulation, between 20%-30% of patients suffering from major depressive disorder remain untreated or are at a high risk of relapse. Deep brain stimulation (DBS) is a recently invented modality that has been under investigation since 2005, however, the US Food and Drug Administration (FDA) has not yet approved it as a final line in treating severe depression....

 Open Access DOI:10.23937/2643-4059/1710035

Use of Warmth for the Treatment of Blues

Adhishri Yadav

Article Type: Review Article | First Published: February 16, 2023

Current rise in depression leading to high disease burden and economic strain demands more research and proposals towards effective and practical treatment protocols for Major Depressive Disorders. Heat therapies have gained its reputation as an effective alternative treatment from various psychiatric, medical, and cultural studies which is significantly relevant in view of consideration of the gap between provision and adherence for treatment and ineffectiveness of current treatment choices....

 Open Access DOI:10.23937/2643-4059/1710032

Effective Treatment Interventions for Patients with a Diagnosed Anxiety Disorder

Courtenay Stewart Reiner, Ed.D

Article Type: Research Article | First Published: December 16, 2022

The aim of this study is to review evidence of treatment interventions for patients diagnosed with anxiety disorders. The author searched PubMed, StillOne Search, and EBSCohost for treatment interventions, specifically exercise and pharmaceuticals. Eligible articles were all relevant peer- reviewed articles that evaluated treatment effectiveness of either exercise or pharmaceutical interventions for anxiety disorders....

 Open Access DOI:10.23937/2643-4059/1710029

A Patient Perspective on the Self-Management of Chronic Anxiety and Depression: A Mixed-Methods Study

Maringa HH Zoun, Bauke Koekkoek, Roos A van Grieken, Henny Sinnema, Filip Smit and Jan Spijker

Article Type: Research Article | First Published: November 07, 2022

Self-management is considered relevant and effective for people living with chronic diseases, with studies showing that individuals with persistent anxiety and depressive disorders apply a wide range of cognitive and behavioural strategies to cope with their symptoms. But what is the patient perspective of such interventions?...

 Open Access DOI:10.23937/2643-4059/1710028

Anxiety Symptomatology and Patterns of Coping amongst Medical Doctors and Nurses in Nigeria during the COVID-19 Pandemic: An Online Cross-Sectional Survey

Seb-Akahomen Omonefe J, Okogbenin Esther O, Obagaye Olukunle M, Erohubie Paul O and Aweh Benjamin E

Article Type: Research Article | First Published: December 31, 2021

The unprecedented global crisis triggered by the COVID-19 pandemic led to a cascade of overwhelming pressure on the healthcare system. Frontline healthcare professionals (HCPs), especially doctors and nurses were confronted with an increased risk of mental disorders, most commonly identified are anxiety disorders. This study aimed to determine the prevalence of anxiety symptomatology amongst doctors and nurses in Nigeria and the effects of the coping pattern of participants on the symptoms of an...

 Open Access DOI:10.23937/2643-4059/1710027

The Rise of Anxiety Disorders: Islamic Understanding of Anxiety and Muslim Scholar’s Suggestions to Cope with Distress and Achieve Happiness

Deniz Ecem Şen

Article Type: Review Article | First Published: October 04, 2021

This paper has examined the concept of anxiety, its rise in recent decades, and the relationship between anxiety and religion. To illustrate a unique approach to this emerging problem, we have investigated the Islamic understanding of anxiety and various Muslim scholar’s approach to the term. Since over-thinking and anxiety are universal problems that concern nearly all human beings, this particular subject has been examined by Muslim scholars ranging from Al-Ghazali to Belhî. They tried to s...

 Open Access DOI:10.23937/2643-4059/1710026

Associations between Physical Activity and Depressive Symptoms through Obesity and School Bullying among Adolescents

Evan K Kim and Timothy Munro

Article Type: Research Article | First Published: June 30, 2021

Physical activity has been shown to be associated with improved physical and mental health conditions and can reduce the risk of depressive symptoms among adolescents. While the underlying mechanisms thought to mediate the relation between physical activity and depressive symptoms have not been well-established, the current study investigated the association of physical activity with depressive symptoms and whether this relationship would be explained by obesity and experiencing school bullying....

 Open Access DOI:10.23937/2643-4059/1710025

Repetitive Triggered Somatosensory Discrimination as a Potential Treatment for Treatment Resistant Depression and Anxiety: A Pilot Study

Abraham Shoshani

Article Type: Research Article | First Published: June 23, 2021

Depression and anxiety are the most common mental disorders in Israel. Current pharmacological treatments are frequently insufficient in reducing symptoms, particularly for treatment resistant depression and anxiety. Considerable evidence has accumulated in clinical settings and research studies both with animals and humans that has implicated the involvement of the primary and secondary somatosensory and insular cortices with the regulation of emotions. Awareness deficits and irregularities of ...

 Open Access DOI:10.23937/2643-4059/1710024

The Association between Gratitude and Depression: A Meta- Analysis

Jo A Iodice, John M Malouff and Nicola S Schutte

Article Type: Review Article | First Published: June 23, 2021

Many studies have explored the association between gratitude and depression, but no meta-analysis has been reported. The purpose of this meta-analysis was to fill that gap. The meta-analysis synthesized the association in 70 reported effect sizes from 62 published and unpublished articles, involving a total of 26,427 child, adolescent, and adult participants. The studies were completed by different research teams, using different samples, different measures, and various correlational research de...

 Open Access DOI:10.23937/2643-4059/1710023

Frequency of Mental Behavioral Disorders in the Emergency Staff during the Care of Patients in the Covid-19 Pandemic

Hernández Gómez Jesús Alejandro, Palomec Antonio Lizbeth, Ruiz Mondragón Alberto and Sánchez Martínez Fátima Alondra

Article Type: Research Article | First Published: February 15, 2021

As the health personnel fight it spread of COVID-19, has acquired information of alterations psychological featured in professionals and technicians of the health that is in contact with patients infected by this virus. Of according to center carried out, the more alterations frequent in a 85% are: Anxiety, depression and Post-traumatic stress. Anxiety is define like of the answers of our mind and body before situations of danger or threat, the it depresses us talk about a group of diseases ment...

 Open Access DOI:10.23937/2643-4059/1710022

A Scoping Review of the Association between Smartphone Use and Mental Health among College Students

Jeff Cain, EdD, MS, Jordan L Kelley, PharmD, BCPS and Daniel Malcom, PharmD

Article Type: Case Series | First Published: October 07, 2020

A scoping review of the literature reporting on smartphone use and parameters of mental health from January 2008 to February 2018 was performed for the purpose of summarizing and describing current research findings regarding the association of smartphone use with anxiety, depression, stress, and sleep of college students. The study followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015) guidelines. Thirty-one articles met protocol crite...

 Open Access DOI:10.23937/2643-4059/1710019

Depression in Dialysis: A Poor Prognostic Factor and the Mechanism behind It

Umme Salma Talukder, Hossain Tameem Bin Anayet, Samjhana Mandal, Fahmida Ahmed3,Muhammad Ayaaz Ibrahim and Samira Humaira Habib

Article Type: Research Article | First Published: February 26, 2020

Major Depressive Disorder (MDD) is one of the most common psychiatric illnesses. The effect of depression on one’s physical health is well-known, which can include anything from weight gain or loss to chronic illnesses such as heart disease, kidney or gastrointestinal problems. Provided the increasing prevalence of patients suffering from End Stage Renal Disease (ESRD) and receiving dialysis treatment, it is important to investigate how MDD affects the outcome of their treatment. The incidence...

 Open Access DOI:10.23937/2643-4059/1710021

Analytical Report of Psychological Status of 130 Frontline Medical Staff Dealing With COVID-19

Wang Lijuan, Lu Longxi, Zheng Jisheng, Liu Xiaozheng, Zhu Ruichen and Guo Zhongwei

Article Type: Research Article | First Published: June 10, 2020

China, especial Wuhan city, has been severely affected by COVID-19. This study aimed to understand the psychological status and related factors of frontline medical staff in the COVID-19 epidemic. Participants were 130 first-line medical staff working in Tianyou Hospital, Wuhan. Participants completed the Generalized Anxiety Disorder-7 scale and the Patient Health Questionnaire-9....

 Open Access DOI:10.23937/2643-4059/1710020

Depression in Elderly Life: Psychological and Psychosocial Approaches

Shilpi Tripathi

Article Type: Review Article | First Published: April 04, 2020

Life depression at a later age due to its devastating effects is an important area of public health research. The elderly life depression linked with morbidity, deteriorating physical health, likelihood of suicide attempts and social cognitive functioning. All of which, in turn, are linked to increased life loss. Depression tends to be less common in older adults than in earlier lifespan. All aspects of the older adult’s lifetime condition are risk, protective factors, health, etiology, and ou...

 Open Access DOI:10.23937/2643-4059/1710018

The Relationship of Self-Reported Psychosocial Protective Factors to Characteristics of Adolescent Psychiatric Patients

Shady S Shebak, MD, Tenzing Yangchen, MD, Katherine Shaver, MS and J Eric Vance, MD

Article Type: Research Article | First Published: February 08, 2020

Studies of the phenomenon of psychosocial resilience in the lives of a subset of high-risk individuals have suggested that certain psychosocial protective (resiliency) factors moderate the impact of biopsychosocial risk factors as they contribute to the development of mental illness. Resilience can be defined by factors which are present in high-risk individuals who have escaped illness, but not necessarily present in low-risk individuals who have never been ill. Some studies have provided evide...

 Open Access DOI:10.23937/2643-4059/1710017

Efficacy and Tolerability of Quetiapine Extended Release (XR) as Monotherapy in the Treatment of Major Depressive Disorder

Ozden Arisoy, MD, Michelle Murphy, MD, Edwin Meresh, MD and Angelos Halaris, MD, PhD

Article Type: Research Article | First Published: November 25, 2019

The aim of this study was to confirm the efficacy and tolerability of Quetiapine XR as monotherapy in the treatment of Major Depressive Disorder (MDD) and determine the optimal dosing regimen to maximize efficacy and reduce non-compliance due to side effects. This was a 12-week study with MDD subjects. The primary outcome measure was the Hamilton Rating Scale for Depression (HAMD) total score comparing baseline to end of treatment at week 12. Other assessments included the Hamilton Rating Scale ...

 Open Access DOI:10.23937/2643-4059/1710016

Review of the Effect of Religion on Anxiety

William C Stewart, MD, Megan J Wetselaar, BA, Lindsay A Nelson, BS and Jeanette A Stewart, RN

Article Type: Review Article | First Published: November 04, 2019

Very little information is available about the influence of religion upon anxiety. The objective of this article is to review the medical literature regarding the influence of personal religious belief and religious-based activities on anxiety. Studies were reviewed evaluating anxiety and the effect of religion in peer reviewed medical literature by using search terms in PubMed and Cochrane data bases. There were 32 studies included. This review showed, in almost every study, that religion in ge...

 Open Access DOI: 10.23937/2643-4059/1710015

Psychogenic Voice Disorders Literature Review, Personal Experiences with Opera Singers and Case Report of Psychogenic Dysphonia in Opera Singer

Pedro Claros, Agata Karlikowska, Astrid Claros-Pujol, Andres Claros and Carmen Pujol

Article Type: Review Article | First Published: September 15, 2019

The point of this article is to make a diagnosis of psychological voice disorders easier by reviewing germane to the subject literature. Current view on terminology, classification, clinical manifestation and underlying psychological background of this rare condition is given. Secondly our aim is to asses prevalence ratio of psychological voice disorders in a group of 1520 professional opera singers-people with the most challenging voice effort among professional voice users. Our findings contra...

 Open Access DOI:10.23937/2643-4059/1710014

The Effect of Music Therapy on Cognitive Functions and Adaptation in Alzheimer's Patients

Busra Kayaaslan and Neslihan Lok

Article Type: Review Article | First Published: August 23, 2019

With the increasing life expectancy in the world, chronic diseases are seen in elderly individuals. There is currently no treatment that can prevent, stop or cure Alzheimer’s disease, one of these chronic diseases, or slow down neurodegeneration in AD. The treatments used are symptomatic treatments to slow down the course of the disease. Since the 1960s, psychosocial interventions have been used in addition to medications in the treatment of AD and its use has increased after the 2000s. One of...

 Open Access DOI:10.23937/2643-4059/1710013

Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression

Frank Adu-Nti, George Ghartey-Kwansah and Benjamin Aboagye

Article Type: Review Article | First Published: July 19, 2019

Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly worsening the burden of this illness. The second most frequent mental illness in Europe is mood disorders and they are dominated by MDD, affecting 7% of the population. The recent discovery that the N-methyl-D-aspartate receptor (NMDAR) antagonist; ketamine; a revolutionary novel a...

 Open Access DOI:10.23937/IJDA-2017/1710012

Biopsychosocial Stressors in Pre-liver Transplant Patients: A Case Series

Mahdod Eftekar, MD, FRACGP, FRANZCP

Article Type: Case Series | First Published: April 13, 2019

Liver transplant candidates undergo multiple stressors due to the complexity of the medical, social and psychological circumstances about the transplantation. These stressors may predispose candidates to psychiatric disorders or acopic responses. Authors looked at the medical documents of 43 transplant candidates referred from Jan 2015 to May 2018 retrospectively. The biopsychosocial stressors extracted from the psychiatrist and social worker's notes....

 Open Access DOI:10.23937/IJDA-2017/1710011

Meaning and Agency in Biological Autonomy: The Motor Image in Self Integration

Denis Larrivee

Article Type: Review Article | First Published: March 29, 2019

Understanding the physical basis for mediating personal integration constitutes an important domain of investigation for physical and mental health. Among its singular determinants are behavioral influences that plastically shape integration through motor plans and executed movements, and which also fundamentally contribute to cognition. A key requirement of the motor plan is that of framing motions in the context of an agent, where the body is appropriated as an origin of action emergence. Embo...

 Open Access DOI:10.23937/IJDA-2017/1710010

A Way of Bridging the Gap between Psychological Treatments and Antidepressant Medication

Alejandro Arnaldo Barroso Martinez, PhD

Article Type: LETTER TO EDITOR | First Published: March 22, 2019

Depression is characterized by persistent sadness, accompanied by an inability to carryout daily activities, feelings of worth lessness, guilt, or hopelessness, and thoughts of self-harm. Globally, more than 300 million people of all ages suffer from depression. Especially when long-lasting or severe intensity, depression may be come a serious health condition. At its worst, depression can lead to suicide. Depression is treatable with psychotherapy, also known as talk therapy, antidepressant med...

 Open Access DOI:10.23937/ijda-2017/1710009

Sleep Quality in Osteoporotic Elderly: Relationship to Pain Sensitıvity and Depression

Kasapoglu Aksoy M, Aykurt Karlibel I, Dulger S and Altan L

Article Type: Research Article | First Published: December 12, 2018

The objective of the current study was to assess the impact of sleep quality on pain sensitivity and depressive symptoms in the elderly. In this cross-sectional analytical design study a total of 78 patients (65-85 years) with good general health status and 44 young (30-50 years) healthy volunteers were included. All subjects assessed by Pittsburg sleep quality index (PSQI), pain pressure threshold (PPT) and geriatric depression scale (GDS)....

 Open Access DOI:10.23937/ijda-2017/1710008

State and Trait Anxiety Evaluation in Dental Patients

Hamid Razavian, Sara Mohammadi Sepah V, Hadi Zare and Ali Mohammadi Sepahvandi

Article Type: Research Article | First Published: December 07, 2018

The purpose of this study was to evaluate the possible relation between dental patient's state anxiety, demographic factors and past experience of treatments with their trait anxiety in patients undergoing root canal treatments (RCT). 60 patients participated in this study. A single molar was treated in every patient. At their first visit, patients were asked to fill out a questionnaire about their demographic and educational status as well as a Persian version of STAI-T (Spielberger Trait Anxie...

 Open Access DOI:10.23937/ijda-2017/1710007

Pseudodepression as an Anticipatory Symptom of Frontal Lobe Brain Tumors

Domenico Chirchiglia

Article Type: Short Commentary | First Published: November 16, 2018

Frontal brain tumors often cause psychiatric disorders related to the functions of the prefrontal cortex. The prefrontal cortex expresses cognitive functions, which are superior functions concerning personality, conception, planning, ability to manage social relations. The dorsolateral part of the prefrontal cortex, if damaged, causes a depressive symptomatology, consisting of apathy, mood reduction and other symptoms. Kleist defined depression secondary to brain tumors, pseudodepression syndrom...

 Open Access DOI:10.23937/ijda-2017/1710006

The Health Effects of the Abuse of Ketamine

William J Maloney

Article Type: Short Commentary | First Published: October 26, 2018

Ketamine is a dissociative anesthetic which is used in powdered or liquid form. A number of individuals have abused this drug or have been instrumental in others using this drug as a "date-rape" drug. Abuse of ketamine can result in a number of systemic manifestations including gastrointestinal issues, depression, and respiratory problems and amnesia. Serious debilitating urinary tract symptoms are also seen frequently in those individuals who abuse ketamine. Ketamine, Anesthetic, Phencyclidine,...

 Open Access DOI:10.23937/ijda-2017/1710005

Effects of Non-Focused Elf-Emf Treatment on Hrv: Preliminary Study

Alessandro Greco and Anna Destefani

Article Type: Original Article | First Published: October 19, 2018

Interest in the interaction between electromagnetic fields and biological systems is constantly growing. Among these, excellent results have been achieved in psychiatrics using transcranial magnetic stimulation. However, very little is known of the effects of electromagnetic fields at low frequencies and intensities (ELF-EMF) on the psychological state of subjects given non focused total body treatment. This was one of the reasons for the decision to observe the effects of ELF-EMF treatment on t...

 Open Access DOI:10.23937/IJDA-2017/1710004

Late - Life Depression in North Greece: Prevalence and under Detection

Konstantinos Argyropoulos, Aikaterini Saropoulou and Eleni Jelastopulu

Article Type: Research Article | First Published: October 12, 2018

Depression is the most frequent cause of emotional suffering on late life. The purpose of the present study was to estimate the prevalence of depression and to assess possible under-diagnosis of depressive symptoms in the elderly. A cross-sectional study was conducted among the members of the open day care centers for older people in the municipality of Pella, North Greece. A questionnaire was developed to collect basic demographic data, including three questions from the "European Health Interv...

 Open Access DOI:10.23937/IJDA-2017/1710003

Factors Associating Perceived Stress and Psychological Well-being among Iranian Female Adolescents

Haleh Heizomi, Hamid Allahverdipour, Shahrzad Bazargan Hejazi, Mohammad Asghari Jafarabadi and Anaheed Shirazi

Article Type: Original Research | First Published: October 11, 2018

1) To assess the role of life satisfaction, happiness, hopefulness, and self-efficacy, on perceived stress and PWB among a sample of female high school 9th graders in Tabriz, Iran; 2) To assess direct and indirect relationships of life satisfaction, happiness, hopefulness, and self-efficacy with PWB in the sample, considering the mediator role of perceived stress under a conceptual model. This was a cross-sectional study of 289 randomly-selected female 9th-grader high school students in Tabriz, ...

 Open Access DOI:10.23937/ijda-2017/1710002

Interventions for Mothers with Postpartum Depression: A Systematic Review

Linsu Thomas, Sailaxmi Gandhi and Jithin Thomas Parel

Article Type: Systematic Review | First Published: August 24, 2018

Women may go through a wide range of emotional experiences during pregnancy and the year following birth. In some cases it can result in depressive symptoms which need treatment and supportive interventions. Interventions like individual psychotherapy and counseling with an exploratory, participative approaches were most commonly practiced in low- and middle-income (LAMI) countries. The aim of this study is to investigate systematically the evidence surrounding the impact of such interventions o...

 Open Access DOI:10.23937/ijda-2017/1710001

Trauma Precursors of Obsessive Compulsive Disorder - A Case Series

Vyjayanthi Subramanian and Prashanth Mayur

Article Type: Case Series | First Published: August 23, 2018

Traumatic events are a precursor for not only post traumatic stress disorder but also obsessive compulsive disorder, which tend to have a generally better outcome and response to interventions. Such cases have not been described from an Indian sub-continental background....


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