International Journal of

Stem Cell Research & TherapyISSN: 2469-570X


 Open Access DOI:10.23937/2469-570X/1410044

The C. Elegans Gscs: A Powerful Model for In Vivo Study of Adult Stem Cell Regulation

Patrick Narbonne, Abigail R Gerhold, Jean-Claude Labbe and Paul S Maddox

Article Type: Review Article | First Published: December 10, 2016

Adult stem cells hold tremendous potential for regenerative medicine. Harnessing their therapeutic benefits requires that we gain fundamental understanding of the mechanisms by which stem cells function and divide in vivo. This is hampered by the fact that stem cells often reside in compartments that remain difficult to access using imaging approaches....

 Open Access DOI:10.23937/2469-570X/1410043

Central Odontogenic Fibroma of the Mandible-Revisiting Pathogenesis of Benign Tumor of the Jaw

Qilin Xu, Qunzhou Zhang, Steven Wang, Brian P Ford, Prem Pate, Lee R Carrasco, Anh D Le and Faizan Alawi

Article Type: Case Report | First Published: December 07, 2016

Central odontogenic fibroma (COF) is an uncommon benign tumor of the jaw, which clinically presents as a slow-growing neoplasm with cortical bony expansion. It has been postulated that COF might be derived from the inactive-like small nests or islands of odontogenic epithelium. However, the pathophysiology of this rare benign tumor remains largely unknown. Herein, we reported a case of simple type of COF in the mandible in a 24-year-old man who presented with progressive mandibular swelling and ...

 Open Access DOI:10.23937/2469-570X/1410042

Advancing Research in Regeneration and Repair of the Motor Circuitry: Non-Human Primate Models and Imaging Scales as the Missing Links for Successfully Translating Injectable Therapeutics to the Clinic

Magdalini Tsintou, Kyriakos Dalamagkas and Nikos Makris

Article Type: Review Article | First Published: October 28, 2016

Regeneration and repair is the ultimate goal of therapeutics in trauma of the central nervous system (CNS). Stroke and spinal cord injury (SCI) are two highly prevalent CNS disorders that remain incurable, despite numerous research studies and the clinical need for effective treatments. Neural engineering is a diverse biomedical field that addresses these diseases using new approaches. Research in the field involves principally rodent models and biologically active, biodegradable hydrogels....

 Open Access DOI:10.23937/2469-570X/1410041

Progress towards Clinical Use of iPS Cell Derived Therapies

Malin Kele and Anna Falk

Article Type: Mini-Review | First Published: August 17, 2016

A decade has passed since Shinya Yamanaka published his landmarking publication on how to produce pluripotent stem-cell-like cells and the term induced pluripotent stem cells, iPS cells, was coined. This past decade has been a decade devoted to pluripotent cells, scrutinizing molecular mechanisms in cell identity, and optimizing derivation methods, culture conditions and characterization methods to xenofree and chemically defined clinical-grade pluripotent stem cells....

 Open Access DOI:10.23937/2469-570X/1410040

Generation of Antigen-Presenting Cells from Human Vascular Adventitia-Resident Progenitors

Mohamad Almoussa, Volha Stoll, Diana Klein and Suleyman Ergun

Article Type: Original Article | First Published: August 13, 2016

Macrophages and dendritic cells play a central role in the immune system. Here, we identify CD44(+) vascular wall-resident multipotent stem cells (VW-MPSCs) as progenitors for macrophages and dendritic cell-like cells. Using human internal thoracic artery (hITA) tissue specimens we performed ex vivo sprouting assays followed by immunohistochemistry....

 Open Access DOI:10.23937/2469-570X/1410039

Adult Brain Neurogenesis, Neural Stem Cells and Neurogenic Niches

Lina Maria Delgado-Garcia and Rogerio Martins Amorim

Article Type: Mini Review | First Published: July 28, 2016

During the late 60's, the experiments with brain lesions in rats, suggested the possibility of neurogenesis in the adult brain. Three decades later, the conceptual link between adult neurogenesis and stem cells was proposed. We now know that the adult mammalian brain may have the ability to regenerate through adult neural stem cells (NSCs). Here are briefly reviewed classical and current theories in adult neurogenesis, NSCs and neurogenic niches....

 Open Access DOI:10.23937/2469-570X/1410038

Stem Cells in Adult Homeostasis, Regeneration and Tissue Development of the Digestive Tract Epithelium

Valeria Fernandez Vallone and Marie-Isabelle Garcia

Article Type: Mini-Review | First Published: July 01, 2016

The gastrointestinal epithelium is one of the tissues with highest self-renewing rates under steady-state conditions, and it thereby constitutes an excellent model to better understand how tissues maintain homeostasis. In the past decade, intense research in this field has allowed identifying stem cells responsible for this task and has contributed to uncover the main molecular mechanisms associated with self-renewal and differentiation properties of these cells....

 Open Access DOI:10.23937/2469-570X/1410037

Enteroendocrine Cells, A Potential Way to Control Intestinal Stem Cell Proliferation

Rihab Loudhaief and Armel Gallet

Article Type: Perspective | First Published: July 01, 2016

Organisms are subjected during their lifespan to many environmental stresses such as starvation, temperature variations, chemicals, pathogens, injuries... In order to overcome the incoming stress and to yield an adapted answer, organisms have developed throughout evolution robust and conserved mechanisms such as immune response and tissue regeneration helping at maintaining their physiological equilibrium, i.e. their homeostasis. However, the maintenance of the homeostasis can be compromised in ...

 Open Access DOI:10.23937/2469-570X/1410036

Kartogenin Induced Chondrogenesis of Stem Cells and Cartilage Repair

Fazal-Ur-Rehman Bhatti, Karen A Hasty and Hongsik Cho

Article Type: Short Review | First Published: July 01, 2016

Osteoarthritis (OA) is predicted to be the fourth leading cause of disability in the world by the year 2020. OA results in damage to cartilage tissue and underlying subchondral bone. Current therapeutic options for osteoarthritis (OA) are limited due to the unique nature of cartilage tissue. Alternatively, mesenchymal stem cells (MSCs) have been utilized for cartilage repair, but the formation of an intact neocartilage similar to hyaline cartilage is still a challenge. Kartogenin (KGN), a small ...

Volume 3
Issue 2