International Journal of Blood Research and Disorders is a peer-reviewed publication in the field of blood research. It focuses on all aspects of hematology including blood cells, hematologic diseases, blood hemostatic mechanisms, hemato-oncology, immunology, and transfusion medicine. It also focuses on all aspects of the prevention and therapy of blood disorders.
International Journal of Blood Research and Disorders aims to publish original articles, research, reviews, case reports, short communications, commentaries etc., layering the spectrum of clinical and laboratory hematological practice and research. The classification terms include but not limited to Anemia, Platelet disorders, Eosinophilic disorders, Leukemia, Myeloma, Coagulation disorders, blood Transfusion, sepsis.
International Journal of Blood Research and Disorders ensures the faster publication of high-quality articles with the support of its eminent Editorial board members. Two independent review comments followed by editor's decision will be considered to publish the article. IJBRD is a permanent archive of information on Blood research, disorders and therapeutics which under open access category provides its global readers with free access to its content, thus serving the scientific community.
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Open Access DOI:10.23937/2469-5696/1410072
Siew Lian CHONG, Asral Wirda AHMAD ASNAWI, Kian Boon LAW, Roszymah HAMZAH and Sen MuiTAN
Article Type: Brief Report | First Published: December 23, 2021
The Sysmex XN-3000 is a new automated haematology analyser designed to improve the accuracy of cell counts and the specificity of the flagging events of unusual parameters. By comparing the previous full blood count (FBC) reference intervals in Malaysia for Sysmex XE- 5000, we determined a reference interval for all parameters measured by the Sysmex XN-3000 for the Malaysian population. Through the voluntary recruitment of 397 adults ages 18-45 years, both genders, and the three main ethnic grou...
Open Access DOI:10.23937/2469-5696/1410071
Vladimir Y Khryshchanovich, MD and Natalia Y Skobeleva, BS
Article Type: Letter to Editorial | First Published: December 18, 2021
Late pregnancy and the early postpartum period are characterized by the so-called physiological hypercoagulation: The concentration of blood clotting factors I, II, VIII, IX, X increases twice, the functional activity of platelets increases, and the fibrinolytic activity of serum decreases. On the one hand, the prothrombotic status reduces the risk of massive blood loss in childbirth, and on the other - creates prerequisites for the development of venous thromboembolism. In the context of assess...
Open Access DOI:10.23937/2469-5696/1410070
Evelyn Mgbeoma Eze, Serekara Gideon Christian, Ransom Baribefii Jacob, Barinaaziga Sunday Mbeera, Beatrice Wobiarueri Moore-Igwe and Angela Tornubari Mbari
Article Type: Original Article | First Published: December 04, 2021
Although the therapeutic application of whole blood and blood components can be life-saving, inadequate screening of these products could pose life-threatening problems to the recipient. The aim of this study was to determine the echelons of some haemoparasites (malaria parasite, microfilaria and babesia species) among blood donors in Port Harcourt, Rivers State, Nigeria as well as quantifying their densities. A total of one hundred (100) prospective blood donors from the participating blood ban...
Open Access DOI:10.23937/2469-5696/1410069
DMHMK Dassanayake, VCP Gunawardena and SB Athauda
Article Type: Original Article | First Published: September 29, 2021
HamoglobinE (HbE) is the second commonest structural haemoglobin variant and results from mutation in the β globin gene causing substitution of glutamic acid for lysine at position 26 of the β globin chain. When coinherited with β Thalassemia it becomes a major health burden. To assess the effectiveness of red cell parameters as a screening tool to identify haemoglobin E traits and to develop a score using red cell parameters which help to identify Haemoglobin E traits in population screening...
Open Access DOI:10.23937/2469-5696/1410068
Ling-ming Kong, Xiao-li Zhu and Li-yi Zhang
Article Type: Original Article | First Published: September 22, 2021
This study aimed to investigate the diagnostic value of peripheral microRNA (miRNA) expression in schizophrenia (SZ). By using an Affymetrix array to identify differentially expressed miRNAs in SZ patients; quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to verify identified microRNA and test major depressive disorder (MDD), generalized anxiety disorder (GAD) and mental retardation (MD) related microRNAs for comparison. The expression levels of miR-1972...
Open Access DOI:10.23937/2469-5696/1410067
Article Type: Mini-Review Article | First Published: August 30, 2021
SMYD2 is one of the five members (SMYD1-5) of the Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) protein family and is it known to methylate histone and non-histone substrates. By methylating a wide range of targets, SMYD2 acts as an oncogene in most cancer types. In this review I will comment on the last publications related to the role of SMYD2 in leukemia and I will refer to more extensive reviews if the reader aims to have a b...
Open Access DOI:10.23937/2469-5696/1410066
Richmond R Gomes
Article Type: Review Article | First Published: August 28, 2021
Thalassemia refers to a group of inherited diseases characterized by decreased or absent synthesis of normal globin chains. The direct consequence is an imbalance of the alpha and beta globin chain synthesis that results in anemia from ineffective erythropoiesis and hemolysis. The term thalassemia major refers to the severe form that is often associated with life-long transfusion dependent anemia. Hypogonadism is the most frequently reported endocrine complication, affecting 70-80% of thalassemi...
Open Access DOI:10.23937/2469-5696/1410065
Ersin Toret, Burcu Dural, Yeter Duzenli Kar, Zeynep Canan Ozdemir, Ilknur Ak Sivrikoz and Ozcan Bor
Article Type: Original Article | First Published: April 30, 2021
Acute leukemias are the most common malignancies seen in children and they account for one third of childhood cancers. Children who survived ALL, experience reduced bone mineral density (BMD) due to the disease, long-lasting glucocorticoid usage, chemotherapy toxicities, nutritional deficiencies and physical immobility. The decreased BMD have determined at all stages of disease. This retrospective cross-sectional study purposes to analyse the results of BMD in children who have completed their A...
Open Access DOI:10.23937/2469-5696/1410064
Mohd Mustahsin, Zeba Siddiqi, Ajay Mishra and Garima Singh
Article Type: Case Report | First Published: April 28, 2021
Aplastic Anemia is a rare hematological disorder caused by bone marrow failure leading to pancytopenia. These patients are frequently treated with immunosuppressive therapy which may protect them in developing hyper-inflammatory response which is commonly seen in moderate and severe COVID-19 patients. On the other hand these patients are at high risk for infection and infection related complications. Here we are reporting an adult aplastic anemia patient who developed uncomplicated course of COV...
Open Access DOI:10.23937/2469-5696/1410063
Francisco Tria IV, Philipp W Raess, Daphne Ang, Jose Jasper Andal, Richard Press, Ngoc Tran, Jennifer Dunlap, Joanna Wiszniewska, Tauangtham Anekpuritanang and Guang Fan
Article Type: Research Article | First Published: March 24, 2021
Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by peripheral blood cytopenias, with associated morphologic dysplasias, and recurrent cytogenetic abnormalities. However, approximately 40-50% of MDS have no detectable cytogenetic abnormalities or cytogenetically-normal (CN-MDS). MDS cases with concurrent cytogenetics/FISH and molecular testing were identified from a two-year cohort with a median time to follow-up of 506 days. A total of 153 MDS were gathered, and we identified...
Open Access DOI:10.23937/2469-5696/1410062
Diana Guavita-Navarro, MD, Jairo Cajamarca-Baron, MD, Jhon Buitrago-Bohorquez, MD, Laura Gallego-Cardona, MD, Diana Guevara, MD, Hector Cubides, MD, Ana Maria Arredondo, MD and Alejandro Escobar, MD
Article Type: Case Report | First Published: February 19, 2021
Thrombotic microangiopathy is a group of syndromes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute organ dysfunction secondary to ischemia. It includes a group of diseases such as thrombotic thrombocytopenic purpura. They can be primary or secondary to multiple pathologies, including autoimmune diseases such as systemic lupus erythematosus. These associations are important from the clinical point of view, as they have more severe presentations, high relapse rates,...
Open Access DOI:10.23937/2469-5696/1410061
Robert G Hill, BA and James A Sipp, MD
Article Type: Case Series | First Published: February 19, 2021
This study was performed to review our experience with pediatric patients adaptive immunity to Streptococcus pneumoniae and Haemophilus influenza in the clinical presentation of chronic rhinosinusitis. Currently, there is no specific routine role in healthcare to check the immune status in patients after receiving the vaccinations. Patients were identified from the EMR using the ICD-10 code for chronic sinusitis and were considered eligible if they had titers drawn to evaluate their immunity. Pa...
Open Access DOI:10.23937/2469-5696/1410060
Alphonsus Ogbonna Ogbuabor, PhD, Peter Uwadiegwu Achukwu, PhD, Silas Anayo Ufelle, PhD and Daniel Chukwuemeka Ogbuabor, PhD
Article Type: Review Article | First Published: November 16, 2020
Concerted efforts have been made by scientists over the last decades in elucidating the molecular mechanisms leading to myeloproliferative neoplasms. The identification of oncogenic mutations in signal transduction pathways revealed the role of specific pathways in inducing excessive proliferation of myeloid lineages. The subsequent development of mouse models carrying mutations found in patients proved that the aberrant activation of these specific pathways plays a crucial role in the pathology...
Open Access DOI:10.23937/2469-5696/1410059
Daniela de Oliveira Werneck Rodrigues, Lysla Cardoso Sudário, Olivia Franco dos Santos, Leonardo de Angelli Benedito Cardoso and Luiz Claudio Ribeiro
Article Type: Original Article | First Published: November 16, 2020
Alloimmunization is an immune response against red blood cell (RBC) antigens due to sensitization during RBC transfusion. RBC alloimmunization is more common in sickle cell disease (SCD) with prevalence between 18 and 47%. Retrospective chart review of a cohort of 120 children treated at Fundação Hemominas born between 1998 and 2007 and diagnosed with SCD through neonatal screening. The statistical analysis was made with the usage of Mann-Whitney’s U test, Student’s T-test and Chi-Square t...
Open Access DOI:10.23937/2469-5696/1410058
Article Type: Case Report | First Published: October 14, 2020
Living with a bleeding disorder is something that very few live within the United States. In fact, hemophilia occurs in only approximately 1 in 5,000 live births. There are about 20,000 people with hemophilia A in the US. Hemophilia B is four times less common than hemophilia A. von Willebrand Disease is much more common than both hemophilia A & B which is believed to effect 1% of the population. Von Willebrand disease is estimated to affect 1 in 100 to 10,000 individuals. The 3 common bleeding ...
Open Access DOI:10.23937/2469-5696/1410057
Collins Uchechukwu Obi, Okikioluwa Stephen Aladeyelu, Ijeoma Nnenna Agbiogwu, Nneka Chidimma Agu, Joseph Akinwale Arusiwon and Mercy Oluchukwu Udeh
Article Type: Survey Article | First Published: September 23, 2020
Hundred subjects were involved for this study. The subjects were divided into 2 groups: 50 sickle cell anaemic subjects (20 males and 30 females) and 50 non-sickle cell subjects or control (23 males and 27 females). Sickle cell anaemic subjects were between the age ranges of 15-41 years while control subjects were between 17-31 years. Subjects were both Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria and volunteer students at the Department Medical Laboratory Science, Ambrose Ali Univ...
Open Access DOI:10.23937/2469-5696/1410056
Bashir Abdrhman Bashir and Mohamed Seed Ahmed
Article Type: Original Research | First Published: September 03, 2020
Malaria is a potentially life-threatening disease caused by infection of erythrocytes with one of five different types of protozoan parasites of genus plasmodia. Falciparum species is an aggressive type associated with multiple alterations in hemostasis. A cross-sectional descriptive study was undertaken to screen the effect of malaria infection on coagulation test results in adults with the falciparum malaria parasite. Forty- eight consecutive adults with falciparum malaria were studied along w...
Open Access DOI:10.23937/2469-5696/1410055
Eledo BO, Tommy EO, Onuoha EC, Dunga KE and Okamgba OC
Article Type: Review Article | First Published: August 14, 2020
Malaria remains a major public health problem in endemic areas and due to neglect, the elderly ones are even more exposed now. The objective was to determine the effects (if any) of asymptomatic malaria on some hematological parameters on infected elderly subjects, identify subjects at risk of severe hematological derangement and render advice appropriately. One hundred healthy subjects (45 males and 55 females) having ≥ 60-years-old and without clinical symptoms, were screened for malaria par...
Open Access DOI:10.23937/2469-5696/1410054
Okeke CO and Iloka VC
Article Type: Original Article | First Published: July 25, 2020
A close association has been shown to exist between ABO blood type and the risk of some diseases with non-O (A, B, or AB) individuals having an increased differential disposition to thrombotic disorders. The present study evaluated the fibrinogen levels and platelet count in subjects of different ABO blood groups with the view of ascertaining if disparity exists in the levels of fibrinogen and platelet count amongst the different ABO blood groups....
Open Access DOI:10.23937/2469-5696/1410053
Sona B Nair, Arundhati S Athalye, Prochi F Madon and Firuza R Parikh
Article Type: Case Report | First Published: July 13, 2020
Alpha globin gene structural variants are caused mainly due to point mutations in the alpha globin gene. They are generally asymptomatic but in rare cases cause problems in association with other structural variants of thalassemia. We report here for the first time in Indian population a rare alpha globin gene structural variant named Hb Le Lamentin. Our main aim of presenting this case is to create awareness that this variant may be commonly present in the Indian population also though the prev...
Open Access DOI:10.23937/2469-5696/1410052
Joseph R Nellis, MD, MBA, Michael J Devinney, MD, PhD, Christopher C Young, MD
Article Type: Case Report | First Published: June 04, 2020
There are over 1 million Jehovah’s Witnesses in the United States and nearly 8.5 million worldwide. Within the medical community, they are most notably known for their refusal of blood transfusions. Prior studies have shown that healthy euvolemic volunteers tolerate hemoglobin of 5 g/dL, although when faced with the stress of surgery their operative mortalities are over 30%. Herein we explore the use of Hemopure, HBOC-201, an investigational blood substitute, for a frail 72-year-old female Jeh...
Open Access DOI:10.23937/2469-5696/1410050
Malwina Rybicka-Ramos, Grzegorz Kasiarz, Katarzyna Pluta, Tomasz Wilczynski, Jerzy Pruszynski and Ewa Ziolko
Article Type: Case Report | First Published: June 03, 2020
Gastrointestinal malignancy was suspected in a 68-year-old woman with long-term anemia, thrombocytopenia, leukopenia, the presence of fecal occult blood and elevated levels of CEA and CA 19- 9. However, malignancy was not confirmed. The patient was later hospitalized in the Department of Hematology where hematologic disease was excluded. Cervical and inguinal lymphadenopathy and atypical bone marrow cells collected by aspiration biopsy gave rise to the suspicion of bone marrow involvement by tum...
Open Access DOI:10.23937/2469-5696/1410051
Xiao Hu, Monika Pilichowska and Cindy Varga
Article Type: Case Report | First Published: June 06, 2020
54-year-old gentleman was diagnosed with acquired immunodeficiency syndrome (AIDS) when presenting with shingles in 2016. He was started on HAART but soon noted a very rapid increase in the size of his cervical, axillary and inguinal lymph nodes, along with profound constitutional symptoms. Immune reconstitution syndrome was suspected and prednisone was tried but did not alleviate symptoms. One month later, a core biopsy of the left axillary lymph node was undertaken and demonstrated predominant...
Open Access DOI:10.23937/2469-5696/1410049
J Ferry, S Youssef, P WU and L Hegerova
Article Type: Case Report | First Published: May 25, 2020
Heparin induced thrombocytopenia with thrombosis (HIT) is a paradoxical prothrombotic complication of anticoagulant therapy. We report a case of atraumatic splenic hemorrhage due to splenic vein thrombosis as main indicator to diagnosis of HIT. The presentation is reminiscent of the rare bilateral adrenal hemorrhage due to adrenal necrosis that occurs in HIT. Alternative anticoagulation is mainstay of therapy for HIT despite hemorrhage, given the underlying acquired hypercoagulability....
Open Access DOI:10.23937/2469-5696/1410048
Evelyn Mendonca-Reis, Camila Cristina Guimaraes Nobre, Artur Paes-Chagas, Leandro Miranda-Alves and Clemilson Berto-Junior
Article Type: Original Article | First Published: March 09, 2020
TSH is a peptide hormone synthetized and secreted by pituitary with fundamental importance for thyroid function. TSH receptors are found in other tissue than thyroid playing diverse roles, including erythrocyte. Based on the fact that deformability is one of the most important features of a mature erythrocyte, we aimed to verify if TSH modulates erythrocytes volume and, if does, which signaling is involved in this modulation. Using hemolysis assay, we create a hemolysis curve of erythrocyte in p...
Open Access DOI:10.23937/2469-5696/1410047
Gulsah Durmus, Nevin Karakus, Serkan Yuksel and Nurten Kara
Article Type: Research Article | First Published: February 12, 2020
Coronary artery disease (CAD) is a multifactorial disorder. It is important to identify gene mutations that may be responsible for the development of CAD. The aim of this study was to determine the frequency of twelve cardiovascular disease (CVD) related gene mutations in coronary artery patients. The CVD StripAssay (Vienna Lab, Austria) was performed to analyze the twelve gene mutations on 52 coronary artery patients and 39 healthy controls. After DNA isolation from blood samples, hybridization...
Open Access DOI:10.23937/2469-5696/1410046
Yasemin Ardicoglu Akisin, Gulnaz Kurt, Hüseyin Onay, Ferda Ozkinay and Nejat Akar
Article Type: Case Report | First Published: December 20, 2019
Iron is one of the elements that participate numerous reaction on the body and the structure of hemoglobin to the purpose of carrying oxygen to the tissues. Thus, iron deficiency causes different problems in the body. Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder that has some signs of iron deficiency anemia (IDA) but refractory to oral iron and partially refractory to intravenous iron. The mutation in TMPRSS6 gene causes matriptase-2 protein deficiency that negatively reg...
Open Access DOI:10.23937/2469-5696/1410045
Oyelese AT, Salawu L, Adejuyigbe EA and Olasanmi O
Article Type: Review Article | First Published: December 12, 2019
Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and this has been documented in Nigerian adult patients but not in the pediatric age group. To determine the prevalence of antiphospholipid antibodies in HIV-infected children and its associatio...
Open Access DOI:10.23937/2469-5696/1410044
Ahmet Sarici, Ayshe Slocum, Hilal Er Ulubaba, Mehmet Hanifi Kandemir, Mehmet Ali Erkurt, Emin Kaya and Irfan Kuku
Article Type: Original Article | First Published: August 09, 2019
The aim of treatment in patients with primary immune thrombocytopenia (ITP) is to obtain a safe platelet count to prevent clinically significant bleeding (major bleeding) rather than normalizing the platelet count. In light of this information, treatment indications for newly diagnosed ITP patients include, I) Thrombocyte counts below 30,000/microL and II) Platelet counts above 30,000/microL in correlation with clinically significant bleeding. Corticosteroids make-up the first-line treatment of ...
Open Access DOI:10.23937/2469-5696/1410043
Article Type: Research Article | First Published: July 17, 2019
Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 201...
Open Access DOI:10.23937/2469-5696/1410042
Christian Cajavilca, Tina Yaqing Cai Lam, Alexandra Vaio Sykes, Shannon Wheeler and Rajan R Gadhia
Article Type: Case Report | First Published: July 04, 2019
81-year-old female presented to an outside emergency room with subacute onset of left facial weakness and right hemiparesis for 12 hours. A non-contrast CT scan of the head and CTA head and neck showed no acute findings. Laboratory results were remarkable for a leukocyte count of 245.75 k/uL. She was diagnosed with acute leukemia and transferred to a comprehensive stroke center where she was treated with leukapheresis and hydroxyurea. The patients focal deficits somewhat improved, but in the fol...
Open Access DOI:10.23937/2469-5696/1410041
Michael Tarasev, Marina Muchnik and Sumita Chakraborty
Article Type: Original Article | First Published: June 27, 2019
While in circulation, red blood cells (RBC) need to elastically undergo large deformations without lysing, an ability that may be compromised by cell membrane damage. Such can be tested in vitro by subjecting an RBC sample to external mechanical stress, e.g. through bead milling or oscillation of an object in a sample. In addition to controlling frequency and duration of oscillations, this approach can be further tailored by bead selection/design....
Open Access DOI:10.23937/2469-5696/1410040
Asafa MA, Ogunlade O, Bolarinwa RA, Bisiriyu LA and Asafa ST
Article Type: Research Article | First Published: June 17, 2019
It had been established that ABO blood group system associated with some diseases or disorders. The objective of this study was to determine the effect of ABO blood group on anthropometric indices among apparently healthy young adults of Yoruba ethnicity. Eighty apparently healthy young adults who were purposely selected participated in the study after screening for the ABO blood groups following the standard protocol. They were divided into four equal groups; 20 in each of blood groups A, B, AB...
Open Access DOI:10.23937/2469-5696/1410039
Haruko Tashiro MD, PhD, Yasutoshi Oshima, Ritsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kensuke Matsumoto, Jun Ooi, Naohisa Matsunaga, Yoshinao Kikuchi and Naoki Shirafuji
Article Type: Case Report | First Published: May 16, 2019
Survival rates for patients with severe aplastic anemia have greatly improved with the development of better supportive care including transfusion strategies and the availability of anti-fungal agents. However, invasive fungal infection remains the main cause of death and increases mortality in severe aplastic anemia patients. Among invasive fungal infections, mucormycosis is one of the fatal diseases in immunocompromised patients. We report the case of a 72-year-old man with severe aplastic ane...
Open Access DOI:10.23937/2469-5696/1410038
Article Type: Short review | First Published: April 04, 2019
Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...
Open Access DOI:10.23937/2469-5696/1410037
Sinem Namdaroglu, MD and Gizem Yıldırım
Article Type: Research Article | First Published: March 06, 2019
Even though a single high dose administration of intravenous ferric carboxymaltose (FC) is supposed to be effective, it is unknown whether the second dose of FC given one week after the initial dose provides additional benefits. The aim of the present study was to investigate whether two doses of intravenous ferric carboxymaltose is more effective than a single dose of intravenous FC for replenishing iron stores and correction of anemia in patients with iron deficiency....
Open Access DOI:10.23937/2469-5696/1410036
Kodai Kuriyama, Hiroki Hosoi, Masaya Shimanuku, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Nobuyoshi Hanaoka and Takashi Sonoki
Article Type: Case Report | First Published: January 25, 2019
In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the ...
Open Access DOI:10.23937/2469-5696/1410035
Angeli Ambayya, Andrew Octavian Sasmita, Subramanian Yegappan and Jameela Sathar
Article Type: Research Article | First Published: January 20, 2019
The full blood count (FBC) analyzers, Sysmex XE-5000 and Unicel DxH 800, are equipped to perform routine and extended parameters tests; thus, this study considered extended red blood cell (eRBC) parameters to distinguish iron-deficient erythropoiesis related disorders. Malaysian female subjects comprising three main ethnic groups (Malay, Chinese and Indian) were included. Three groups of findings were distinguished based on FBC, morphology, and iron status of the subjects: normal, latent iron de...
Open Access DOI:10.23937/2469-5696/1410034
Mingjun He, Xiaoli Zhu, Wei Niu, Lingming Kong, Gaofeng Yao and Li-yi Zhang
Article Type: Research Article | First Published: December 12, 2018
Based on the prior studies, altered lncRNAs in peripheral blood Molecular Cells (PBMC) from depression patients were chosen to perform informatics analysis for lncRNA target gene prediction and functional annotation. Microarray was first used to screen dys regulated lncRNAs in the PBMCs of MDD patients, of which 10 lncRNAs were selected for quantitative real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR) study, as well as bioinformatics analysis....
Open Access DOI:10.23937/2469-5696/1410033
Gennadiy Galstyan, Polina Makarova, Elena Parovichnikova, Larisa Kuzmina, Vera Troitskaya, Eduard Gemdzhian and Valeriy Savchenko
Article Type: Original Article | First Published: October 12, 2018
To investigate the safety of the of bone marrow-derived human multipotent mesenchymal stromal cells (MMSCs) administration in neutropenic patients with septic shock. Mesenchymal stromal cells (MMSCs) may represent a promising cell-based therapy of sepsis. MMSCs, activated by lipopolysaccharide or tumor necrosis factor-α, reprogram macrophages by releasing prostaglandin E2. Prostaglandin E2 acts on the macrophages through the EP2 and EP4 receptors and stimulates the production and release of an ...
Open Access DOI:10.23937/2469-5696/1410032
Camila Marca de Veiga Cabral, Walter Moises Tobias Braga, Adriano de Moraes Arantes, Jose Salvador Rodrigues de Oliveira, Gisele Wally Braga Colleoni and Fabio Rodrigues Kerbauy
Article Type: ORIGINAL ARTICLE | First Published: September 07, 2018
The aim of this study is to characterize Treg (FOXP3) and Th17 (RORC)-related genes in patients who underwent hematopoietic cell transplantation (HCT) and correlate them with graft-versus-host disease (GVHD) onset and patients' outcome. Fifty-one patients undergoing allogeneic HCT from matched related donors (MRD) were studied. Samples were collected before HCT, at acute (aGVHD) or chronic GVHD (cGVHD) onset, and 90 days post-HCT for those who did not have signs of aGVHD. FOXP3 and RORC gene exp...
Open Access DOI:10.23937/2469-5696/1410031
Giuseppe Mele and Domenico Pastore
Article Type: Case Reports & Case Series | First Published: July 12, 2018
Patients with relapsed/refractory Multiple Myeloma (rrMM) and End Stage Renal Disease (ESRD) requiring hemodialysis must receive lenalidomide at a dosage of 5 mg daily on days 1-21 of repeated 28-day cycles, due to substantial elimination via the kidneys. Unfortunately, despite dose reduction, severe adverse events occur with a high frequency. Therefore, lenalidomide is recommended mainly in patients with mild-to-moderate renal impairment....
Open Access DOI:10.23937/2469-5696/1410030
Md Serajul Islam and Pavel Kotoucek
Article Type: Case Report | First Published: June 30, 2018
Proteinaceous lymphadenopathy is a rare non-specific lymph node changes incidence of which increases with age. This condition is usually associated with hypergammaglobulinemia or rheumatological conditions. However, this condition can also be due to unknown aetiology as we are presenting a case where no underlying case was found. It may affect nodal function, and rarely may it calcify. Histopathologist needs to be vigilant of this condition as lymphoma with lymph node sclerosis should be conside...
Open Access DOI:10.23937/2469-5696/1410029
Md Serajul Islam and Pavel Kotoucek
Article Type: Research Article | First Published: June 20, 2018
Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cell clones that produce monoclonal immunoglobulin. Dermatomyositis (DM), and to a lesser extent polymyositis (PM), carry a higher risk of cancer than that of the general population as demonstrated by several studies with the prevalence being 32% and 15% for DM and PM respectively. The mechanism underlying the association between idiopathic inflammatory myopathies (IIM) and malignancies remains unclear....
Open Access DOI:10.23937/2469-5696/1410028
Ahmad Al Ghoche, Jean Pegliasco, Jessica Anne-Marie-Sainte, Julien Cuziat, Lucas Meyer, Fatiha Najioullah, Jean Côme Meniane and Samy Chraïbi
Article Type: Case Report | First Published: October 28, 2017
We describe here the first case of a patient with post-ET myelofibrosis treated with ruxolitinib at French West Indies complicated with zika induced meningoencephalitis. Patient presented with fever, confusion along with conjunctivitis, diffuse joints pain and skin rash. PCR was positive for Zika virus in blood, urine and cerebrospinal fluid. Diagnosis of Zika induced meningoencephalitis was confirmed....
Open Access DOI:10.23937/2469-5696/1410027
Poorva Bindal, Heenam Goel, Alexei Shimanovsky, Joseph M Ryan, Jeffrey S Wasser and Enrique Ballesteros
Article Type: Case Report | First Published: September 29, 2017
The incidence of therapy-related Acute Promyelocytic Leukemia (t-APL) has been steadily rising. Radioactive Iodine (RAI) has emerged as a potential leukemogenic insult. Translocation involving the Retinoic Acid Receptor-alpha (RAR-alpha, RARa) gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15....
Open Access DOI:10.23937/2469-5696/1410026
Georges El Hachem
Article Type: Literature Review | First Published: July 31, 2017
Bone Marrow Necrosis (BMN) is an uncommon syndrome characterized by destruction of hematopoietic tissue with preservation of the bone. It presents as localized or diffuse generalized process. Many underlying diseases can lead to marrow necrosis: most commonly malignancies and rarely sickle cell disease....
Open Access DOI:10.23937/2469-5696/1410025
Article Type: Review Article | First Published: March 20, 2017
In recent years, the Polycomb group (PcG) of proteins has been revealed to be involved in the regulation of hematologic stem cell function and differentiation and have been broadly linked to hematologic malignancies. Polycomb proteins are histone modifiers that contain two multi-protein complexes: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2)....
Open Access DOI:10.23937/2469-5696/1410024
Diaz De-La-Noval B, Hernandez Gutierrez A, Zapardiel I, De-Santiago Garcia J and Diestro Tejeda
Article Type: Case Report | First Published: August 30, 2016
The incidence of Non-Hodgkin's Lymphoma (NHL) has been increasing in recent decades, the prevalence of extranodal-NHL is about 30 to 50% of all NHL patients. Primary Large B-cell extranodal lymphoma of the cervix is a very rare disease, 0.008% of all cervical tumors. The Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal lymphoid neoplasm in around 25% of all NHL....
Open Access DOI:10.23937/2469-5696/1410023
Rami Nassabein, Mariam al khatib, Marie Helen Abbas, Marie youssef, Daniel Amer and Jaafar Wazni
Article Type: Case Report | First Published: August 30, 2016
Polycythemia Vera (PV) is a myeloproliferative disorder of bone marrow stem cells characterized by erythrocytosis. Elevated erythropoietin level strongly indicates secondary erythrocytosis and excludes PV diagnosis. However, patients with PV who co-present with Budd-Chiari syndrome (BCS) have been documented with elevated serum erythropoietin levels provided that JAK2 mutation is positive....
Open Access DOI:10.23937/2469-5696/1410022
Mariela Del Carmen Moreno, Cinthia Palacios and Yessenia Cruz
Article Type: Case Report | First Published: August 01, 2016
Bilineal leukemia is a very rare health condition, especially in pediatric patients; it is associated with poor prognosis, even without uniformity therapeutic criteria. Hereby, we present a 4-year-old boy, who debuted as T-cell lymphoblastic lymphoma, he initially received treatment induction, which was unanswered, further studies showed evidence of being bilinear leukemia (T-AML M5). He continued the AML induction therapy followed by four consolidations, achieving CR....
Open Access DOI:10.23937/2469-5696/1410021
Naglaa M Hassan, Nevin M Al-azhary and Marwa M Hussein
Article Type: Research Article | First Published: May 28, 2016
The aim of the study is to assess the level of soluble CD86 (sCD86) in patients with de novo AML and to compare them with a normal control group to determine any possible role with prognosis and clinical outcome, as the significance of sCD86 in hematologic malignancies is still controversial....
Open Access DOI:10.23937/2469-5696/1410020
Viviane Chaves Pereira, Karoline Honorato Costa and Leonardo Rodrigues de Oliveira
Article Type: Case Report | First Published: May 28, 2016
Although they are rare, severe hematologic adverse effects are described and may be fatal. The current study describes the case of a patient presenting psoriatic arthritis, and under prolonged treatment with adalimumab. His condition worsened due to severe acute thrombocytopenia and severe hemorrhagic manifestations. Adalimumab was considered to be the probable cause of the thrombocytopenia and, therefore, its use was discontinued. The treatment consisted of corticosteroids, human immunoglobulin...
Open Access DOI:10.23937/2469-5696/1410019
DA Ammon, H Andruszkow, L Sieg, M Wilhelmi, CF Weber, N Rahe-Meyer and AA Hanke
Article Type: Research Article | First Published: November 27, 2015
Hypothermia and acidosis are risk factors for coagulopathy during trauma. We investigated influence of fibrinogen and factor XIII on whole blood coagulation under hypothermia and acidosis in an In vitro model. Fibrinogen, but not FXIII improved coagulation significantly. Furthermore, combined administration of fibrinogen and FXIII did not show differences to administration of fibrinogen alone....
Open Access DOI:10.23937/2469-5696/1410018
CIFTCIOGLU Sule and EFE Emine
Article Type: Perspective | First Published: September 23, 2015
Hematopoietic stem-cell transplantation (HSCT) is used primarily for hematologic and lymphoid cancers but also for many other disorders. Autologous HSCT (in which stem cells are derived from the patient) is mainly used to treat chemosensitive malignancies. Allogeneic HSCT (in which the stem cells are derived from a donor) is often the preferred treatment option, particularly in patients with acute leukaemia. Oral complications are a significant cause of morbidity and potential mortality for chil...
Open Access DOI:10.23937/2469-5696/1410017
Koksal Deveci, Serdal Korkmaz, Enver Sancakdar, Duygu Acibucu, Filiz Alkan, Hatice Terzi and Mehmet Sencan
Article Type: Research Article | First Published: September 17, 2015
A monoclonal gammopathy is defined as the electrophoretically and antigenically homogeneous protein product of a single clone of B lymphocytes and/or plasma cells that has proliferated beyond the constraints of normal control mechanisms. Monoclonal gammopathies are detected in serum and/or urine from individuals with a wide variety of neoplastic, potentially neoplastic, neurological and infectious conditions....
Open Access DOI:10.23937/2469-5696/1410016
Oktay Bilgir, Ferda Bilgir, Mehmet Calan and Giray Bozkaya
Article Type: Research Article | First Published: September 05, 2015
Generally, ET is a myeloproliferative disorder characterized by persistent peripheral thrombocytosis and abnormal megakaryocytic proliferation in the bone marrow. ET is a rare cause of thrombocytosis and may be associated with both venous and arterial thrombosis in 10-75% of cases, depending largely on the study and whether vasomotor symptoms are included in thrombotic manifestations....
Open Access DOI:10.23937/2469-5696/1410015
Tom Rider, John Jones, John Brewin, Gillian Horne, Jack Wills, Hannah Barton, Kevin Boyd, Timothy Corbett, Sabina Dizdarevic and Timothy Chevassut
Article Type: Research Article | First Published: July 09, 2015
Early stage Hodgkin's Lymphoma (HL) has excellent outcomes and recent research has focused on minimising treatment-related toxicities. However, the role of 18F-florodeoxyglucose positron emission tomography (FDG PET) imaging in this setting is not fully determined. We retrospectively calculated overall survival (OS) and relapse free survival (RFS) in stage I-II HL when radiotherapy was omitted if post-chemotherapy FDG PET imaging was negative....
Open Access DOI:10.23937/2469-5696/1410014
Apostolos Pourtsidis, Marina Servitzoglou, Margarita Baka, Despina Bouhoutsou, Maria Varvoutsi, Dimitrios Doganis, Katherine Strantzia-Michail and Helen Kosmidis
Article Type: Research Article | First Published: May 10, 2015
Aims and background: Our objective was to analyze the clinical and demographic characteristics of children with B-cell lymphoma treated in a single center over the last two decades. Methods: Data was collected by a retrospective review of the charts of all 76 patients treated to our unit, from 1990 to 2010, with FAB LMB 89, 96 protocols and 2003 modifications....
Open Access DOI:10.23937/2469-5696/1410013
Hacene Brouk and Hanifa Ouelaa
Article Type: Review Article | First Published: April 30, 2015
Fetal and neonatal alloimmune thrombocytopenia (F/NAIT), caused by fetomaternal mismatch for human platelet (PLT) alloantigens (HPAs), is the commonest cause of severe thrombocytopenia in term neonates and is analogous to the fetal/neonatal anaemia caused by haemolytic disease of the newborn (HDN). The most feared complication of this syndrome is the occurrence of intracranial hemorrhage leading to death or neurological sequels....
Open Access DOI:10.23937/2469-5696/1410012
Gebrewahd Gebretsadkan, Kebede Tessema, Henock Ambachew and Misganaw Birhaneselassie
Article Type: Research Article | First Published: April 01, 2015
Hematocrit is a test that measures a percentage of blood that is comprised of red blood cell. This is often referred to as packed cell volume (PCV) or erythrocyte volume fraction. It is considered as an integral part of a person's complete blood count, along with hemoglobin concentration, white blood cell count and platelet counts....
Open Access DOI:10.23937/2469-5696/1410011
Shefali Nath and Joshua R Peck
Article Type: Case Report | First Published: March 26, 2015
We report a case of Zieve's syndrome in a patient with a longstanding history of alcohol abuse admitted for acute alcoholic hepatitis. Zieve's syndrome is defied as the triad of hemolytic anemia, hypertriglyceridemia, and jaundice in patients with known liver disease. It is an uncommon diagnosis, but is an important one to consider in patients with known liver disease admitted with these constellation of signs and symptoms....
Open Access DOI:10.23937/2469-5696/1410010
Adrienne A. Phillips, Jalanni Giddings, Shing M. Lee and Steven M. Horwitz
Article Type: Case Report | First Published: March 21, 2015
Adult T-cell Leukemia/Lymphoma (ATLL) is resistant to chemotherapy and the acute and lymphomatous subtypes of disease have a dismal prognosis. There is no standard therapy for relapsed or refractory disease in Western countries and new agents are being explored. Lenalidomide is an immunomodulatory agent with promising activity in hematologic malignancies, including non-Hodgkin's lymphoma and represents a novel therapeutic option. ...
Open Access DOI:10.23937/2469-5696/1410009
Kee Kiat Yeo, Jonathan G. Murnick, Marijean M. Miller and Anne L. Angiolillo
Article Type: Case Report | First Published: February 23, 2015
Intraocular relapse of Acute Lymphoblastic Leukemia (ALL) is rare. Prompt diagnosis and treatment can minimize vision loss. We report a case of a young girl diagnosed with pre-B ALL who was initially treated successfully with chemotherapy....
Open Access DOI:10.23937/2469-5696/1410008
Fatma H Sajwani and Moza A Khuzam
Article Type: Research Article | First Published: February 20, 2015
Thrombophilia is a group of disorders that increases the patient's risk of thrombosis. Inherited causes of thrombophilia are challenging to diagnose and once diagnosed may subject the patient to prolonged treatment. The extent of the condition is not well established in UAE and data on prevalence and demographics are lacking. This study aimed at setting a baseline data on the prevalence, demographics and clinical presentation of thrombophilia in UAE....
Open Access DOI:10.23937/2469-5696/1410007
Michael Bursey, Kane Curtis, Robert Gibson, Hongyan Xu and Matthew Lyon
Article Type: Research Article | First Published: February 17, 2015
Hemoglobin (Hgb) measurement is an important risk-stratification tool for patients presenting to the Emergency Department with vaso-occlusive crisis (VOC) from sickle cell disease (SCD). Point-of- care (POC) Hgb testing such as the HemoCue device decreases time to identification of significant anemia. However, there are no studies evaluating the accuracy of HemoCue testing in patients with SCD and VOC. The purpose of this study was to evaluate the correlation of Hgb measurements from HemoCue com...
Open Access DOI:10.23937/2469-5696/1410006
Starkova AV, Syropyatov B Ya, Sobin FV and Pulina NA
Article Type: Case Report | First Published: February 08, 2015
The aim of this research is to study the mechanism of action of the newly synthesized substance - Thiazoline Ammonium 4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate (FS-169), which possesses the direct anticoagulant activity. The research was conducted with the use of 'АPG4-02-P' coagulometer. For the purposes of the study the rabbit plasma was used. The results show that FS-169 effectively changes Partial thromboplastin time and prothrombin time indicators. However, FS-169 has no influence on...
Open Access DOI:10.23937/2469-5696/1410005
Manuela Pagano, Chiara Galletto, Maurizio Bianchi and Franca Fagioli
Article Type: Case Report | First Published: January 21, 2015
Background: Caffey disease is a rare syndrome caused by mutation in the alpha-1 collagen type I gene, not described in literature as a predisposing condition to cancer development. Observation: We report a case of a 6-years-old female diagnosed with Caffey disease that developed a localized neuroblastoma. The patient had a poor clinical and radiological response with unusual disease dissemination and progression until death. Conclusion: The case is a rare example of rapid progression of localize...
Open Access DOI:10.23937/2469-5696/1410004
Nabeel Al Moamen, Fawzia Mahdi, Ahmed Thabet, Rugaya Abbas, Ebtihal Salman and Ahmed Al Alawi
Article Type: Letter to Editor | First Published: January 15, 2015
A total of 1187 patients with α-thalassemia phenotype presentation have been recruited for this investigation. Preliminary diagnosis of α-thalassemia was based on low hematological indices (MCV and MCH) of the red blood cells and/or persistently low hemoglobin levels, along with low or normal levels of HbA2 and absence of iron deficiency. Th molecular diagnosis of α-thalassemia was established by using a commercially available α-thalassemia strip assay (α-Globin StripAss...
Open Access DOI:10.23937/2469-5696/1410003
Chakra P Chaulagain and Kenneth B Miller
Article Type: Case Report | First Published: December 22, 2014
Malignancy associated Sweet syndrome (acute febrile neutrophilic dermatosis) accounts for approximately 20% of all cases of Sweet syndrome and is characterized by painful, erythematous inflammatory papules and nodules that can precede, coincide or follow malignancies with predilection for hematologic malignancies. Corticosteroids are the cornerstone of treatment with exquisite response which has made many clinicians to include steroid responsiveness as one of the diagnostic criteria. However, re...
Open Access DOI:10.23937/2469-5696/1410002
Article Type: Editorial | First Published: July 31, 2014
Some medicines may interact with mineral, with the result that changes occur in the concentration of minerals and other blood parameters that are associated with mineral status. Interpretation of the results of morphological and biochemical blood analyses therefore needs to take into account the drugs used by patients....
Open Access DOI:10.23937/2469-5696/1410001
Article Type: Editorial | First Published: July 30, 2014
Oncolytic reovirus continues to pick up momentum as a novel agent in the treatment of cancer. Since the initial discovery of the virus' tendency to preferentially replicate in transformed cell lines from studies in the late 1970s, reovirus has rapidly progressed from preclinical to clinical trials evaluating its efficacy across a spectrum of malignancies, including hematologic....
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