International Journal of Blood Research and Disorders is a peer-reviewed publication in the field of blood research. It focuses on all aspects of hematology including blood cells, hematologic diseases, blood hemostatic mechanisms, hemato-oncology, immunology, and transfusion medicine. It also focuses on all aspects of the prevention and therapy of blood disorders.

International Journal of Blood Research and Disorders aims to publish original articles, research, reviews, case reports, short communications, commentaries etc., layering the spectrum of clinical and laboratory hematological practice and research. The classification terms include but not limited to Anemia, Platelet disorders, Eosinophilic disorders, Leukemia, Myeloma, Coagulation disorders, blood Transfusion, sepsis.

International Journal of Blood Research and Disorders ensures the faster publication of high-quality articles with the support of its eminent Editorial board members. Two independent review comments followed by editor's decision will be considered to publish the article. IJBRD is a permanent archive of information on Blood research, disorders and therapeutics which under open access category provides its global readers with free access to its content, thus serving the scientific community.

Journal Information

Title: International Journal of Blood Research and Disorders

ISSN: 2469-5696

Editor-in-chief: Preet M Chaudhary

NLM title abbreviation: Int J Blood Res Disord

ICV: 88.22

ISO abbreviation: Int J Blood Res Disord

Other titles: IJBRD

Category: Human Physiology

DOI: 10.23937/2469-5696

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Publication type(s): Periodicals

Publisher: ClinMed International Library

Country of publication: USA

Language: English

Contact email:

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI


 Open Access DOI:10.23937/2469-5696/1410095

Complications and Response to Treatment Regimens among Multiple Myeloma Patients Attended at Muhimbili National Hospital

Dorothy P Kasubi, Clara C Chamba, Neema Budodi and Samira Mahfudh

Article Type: Original Article | First Published: 2024/02/16

Multiple myeloma is a potentially fatal hematological malignancy characterized by clonal growth of terminally differentiated B cells. The development of novel medicines (proteasome inhibitors, immunomodulatory medications, antibodies targeting cell surface molecules, and autologous stem cell transplantation) has improved patients' quality of life and overall survival rate with multiple myeloma. Despite the advancement of these new therapies that help resolve disease progression and hence provide...

 Open Access DOI:10.23937/2469-5696/1410094

C-mip Involvement as a Thrombosis Risk Factor in Children with Idiopathic Nephrotic Syndrome in Abidjan, Côte D'Ivoire

N'Draman-Donou AE, Yapo AVDP, Koumi-Mélèdje MD, Adjambri AE, N'Guessan-Blao AR, Ehilé-Kacou AM, Bouah-Kamon E, Diarrassouba G, Adjé ML, Sangaré-Bamba M, Lasme-Guillao E and Sawadogo D

Article Type: Original Article | First Published: 2023/12/04

The risk of thrombosis due to idiopathic nephrotic syndrome (INS) appears to be proportional to massive protein leakage. This massive leak could be linked to the overexpression of the c-mip gene. The objective of the current study was to investigate the involvement of the c-mip gene in the risk of occurrence of thrombosis in children with INS in Abidjan....

 Open Access DOI:10.23937/2469-5696/1410093

Case Report and Literature Review on Patient with Sticky Platelet Syndrome and a Series of It's Complications

Lamadrid-Gámez Karina, Lopez-Zendejas Martin, Esesarte-Rodriguez Marisol, Herrera-Rojas Armando, Contreras-Cárdenas Javier, Meraz-Nieto Ivan Eduardo and Torres-García José Javier

Article Type: Case Report | First Published: 2023/11/11

We present the case of a half-blood Mexican male, 48-years-old, with a family and medical history of multiple thromboembolic events that are directly associated with the diagnosis of sticky platelet syndrome. This condition has presented diverse complications of procoagulant activity due to insufficient management therapy. Sticky platelet syndrome is an autosomal disorder that is associated with thromboembolisms....

 Open Access DOI:10.23937/2469-5696/1410092

Correlation of Manual Peripheral Blood Smear Examination with RBC Indices and Histograms Obtained from an Automated Hematological Analyzer in Anemic Patients at Jimma Medical Center, Southwest Ethiopia, 2022

Woyesa Beyene, Tilahun Yemane, Dereje Abebe, Mahder Girma, Fisum Abebe, Menberu Wubete and Edosa Tadasa

Article Type: Original Article | First Published: 2023/11/11

The manual peripheral blood smear examination is a comprehensive examination of the blood film to detect clinically significant abnormalities in leukocyte, erythrocyte, and platelet morphology. It is a time-consuming technique, but it is a more cost-effective and sensitive technique than an automated hematological analyzer. On the other hand, the automated hematology analyzer is faster, more objective, and reduces labor cost but cannot reveal the variety of abnormal cells. ...

 Open Access DOI:10.23937/2469-5696/1410091

Wernicke's Encephalopathy: A Rare but Avoidable Neurological Complication Associated with Allogeneic Stem Cell Transplant

Sujay Rainchwar, Reema Singh, Pritish Chandra Patra, Rohan Halder, Narendra Agrawal, Dinesh Bhurani and Rayaz Ahmed

Article Type: Original Article | First Published: 2023/06/16

Wernicke's encephalopathy is a metabolic disorder caused by thiamine deficiency, and is characterized by acute mental confusion, ophthalmoplegia and ataxia. Its due to nutritional deficiency arising from prolonged illness affecting nutrition of the patient or requiring parenteral nutrition for prolonged duration, debilitating chronic illnesses like solid organ and lymphoid malignancies. It has been commonly seen chronic alcoholics who have poor oral intake....

 Open Access DOI:10.23937/2469-5696/1410090

Clinical Features and Induction Outcome of Adult Patients with Acute Lymphoblastic Leukemia: Findings from a Large Tertiary Care Referral Center in Palestine

Yara Ameerah, Raghad Daas, Reema Salah, Basel Musmar, Riad Amer and Johnny Amer

Article Type: Original Article | First Published: February 11, 2023

To describe the clinical characteristics and the induction outcome of patients with acute lymphoblastic leukemia (ALL) in adulthood in Palestine. A Retrospective single-center study was conducted at An-Najah National University Hospital (NNUH) between January 2014 and December 2018. The files and electronic records of ALL patients were reviewed. All patients at least 15 years or older who were confirmed to have ALL by flow cytometry and started induction chemotherapy at NNUH were included. Descr...

 Open Access DOI:10.23937/2469-5696/1410089

The Relationship between Serum Ferritin and Platelet Count in Yemeni Blood Donors

Boshra Al-Absi and Mohammed Abdul Wahid Almorish

Article Type: Original Article | First Published: January 26, 2023

Regular blood donation often cause iron deficiency. Changes of platelet count have been associated with iron deficiency anemia. We aimed to study the correlation between serum ferritin and platelet count in blood donors. Full blood count was measured by Sysmex- KX- 21N Haematology Analyser. Serum ferritin was examined using electrochemiluminescence technology of Cobas e 411 Analyzer....

 Open Access DOI:10.23937/2469-5696/1410088

Prevalence and Causes of Deferrals among Repeat Blood Donors in Dar es Salaam Tanzania

Irene A Mteta, Clara Chamba, Neema Budodi and Ahlam Nasser

Article Type: Research Article | First Published: January 25, 2023

A well-functioning blood transfusion service is essential for effective health-care delivery. Despite the fact that blood transfusions can save lives, the role of blood transfusion services is to assure the supply of safe blood from healthy donors. Although having a sufficient supply of blood is critical in blood transfusion, the caveat is that the collection and transfusion protocol must not put both the receiver and the donor in danger....

 Open Access DOI:10.23937/2469-5696/1410087

Geographical Variation of Acute Promyelocytic Leukemia: A Single Center Study from Saudi Arabia

Assem Elghazaly

Article Type: Brief Report | First Published: December 11, 2022

There is no obvious underlying cause for de novo acute promyelocytic leukemia (APL). Recently two case studies showed that the virus torque teno mini (TTMV) has a role in the pathogenesis of APL/APL-like disease. Few studies reported seasonal or geographical clustering of the disease. As no local published research addressed the effect of these two factors on the incidence of the disease, we aimed to study the relationship between geographical and seasonal factors and the incidence of APL in the...

 Open Access DOI:10.23937/2469-5696/1410086

A Prospective, Observational Study to Assess Effect of DTT Treatment on ABO Isoagglutinin Titers in O Blood Group Donors

Shweta Ranjan, MBBS, Prashant Pandey, MD, Divya Setya, DNB and Supriya Kumari, MBBS

Article Type: Original Article | First Published: December 08, 2022

To determine actual concentration of clinically significant IgG antibodies, there is need to inactivate IgM antibodies. Aim of this study was to study effect of dithiothreitol (DTT) on ABO isoagglutinin titers performed by column agglutination technology (CAT) and conventional tube technique (CTT) and to compare results obtained by DTT treatment. This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors were included. All samples were c...

 Open Access DOI:10.23937/2469-5696/1410085

A Prospective Observational Study to Compare Heat Inactivated ABO Isoagglutinin Titres Performed by CTT and CAT with Solid Phase Red Cell Adhesion (SPRCA) in O Blood Group Individuals

Shweta Ranjan, MBBS, Prashant Pandey, MD, Divya Setya, DNB and Supriya Kumari, MBBS

Article Type: Original Article | First Published: December 02, 2022

Measurement of actual concentration of IgG requires methods like heat inactivation (HI) of plasma. This study was aimed at comparing of heat treated ABO titers performed by conventional test tube technique (CTT) and column agglutination technique (CAT) with HA/SPRCA. This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors who gave consent for participation were included. All samples were tested by CTT and CAT before and after HI (pCTT...

 Open Access DOI:10.23937/2469-5696/1410084

Iliopsoas Hematoma as Unusually Early Onset of Hemophilia A in a Young Infant

Coppo D, Rossi L, Raffaldi I, Aguzzi S, Castagno E, Ricca I and Bondone C

Article Type: Case Report | First Published: November 14, 2022

A 2-month-old infant was admitted for irritability and hypomobility of the left lower limb. Ultrasound revealed a deep hematoma of the iliopsoas muscle and coagulation tests showed increased activated partial thromboplastin time (aPTT). The finding of marked reduction of blood coagulation factor VIII (FVIII) led to the diagnosis of severe Hemophilia A. The infants were promptly put on i.v. factor VIII concentrates, resulting in rapid clinical improvement....

 Open Access DOI:10.23937/2469-5696/1410083

Magnetic Therapy of Anemia Caused by Inflammations

Manfred Fähnle

Article Type: Original Article | First Published: October 13, 2022

In my paper I describe the magnetic therapy of anemia caused by inflammations, and I explain the physical processes underlying this therapy. Anemia occurs when there are not enough healthy red blood cells to carry oxygen to the organs of the body. The patients suffering from anemia feel cold, tired and weak. The most common type of anemia is the iron deficiency anemia. Iron produces a substance in the red blood cells then enables them to carry oxygen (hemoglobin)....

 Open Access DOI:10.23937/2469-5696/1410082

Evaluation of Changes in Haemostatic Parameters in Pregnancy and Puerperium in Women attending Antenatal Clinic at Rivers State University Teaching Hospital, Nigeria

Echonwere-Uwikor, B.E, Moore-Igwe, BW, Chukuigwe-Igbere, O.E and Chuku, P.H

Article Type: Original Article | First Published: September 15, 2022

This was a cross-sectional study carried out in Rivers State University Teaching Hospital, Port Harcourt with the aim of determining the Changes in Haemostatic Parameters in Pregnancy and puerperium. A total of 500 age-matched apparently healthy women of reproductive age, which consisted of 200 (40%) pregnant women, 200 (40%) puerperium mothers and 100 (20%) non-pregnant women who served as controls were studied. Their ages ranged from 16 to 41 years (mean 27.4 ± 4.3 years)....

 Open Access DOI:10.23937/2469-5696/1410081

Current Trends in Classic Hairy Cell Leukaemia: Aetiology, Diagnosis and Therapy

Udoka Ogobuchi-Odo, MSc, Silas Anayo Ufelle, PhD and Ifeoma Uzoma Agbo, MSc

Article Type: Review Article | First Published: August 29, 2022

Hairy cell leukaemia (HCL) is a rare B-cell neoplasm characterized by pancytopenia, splenomegaly and presence of hairy leukaemic B-cells in the bone marrow. Its aetiology is not clear but occupational and environmental factors are possible risk factors....

 Open Access DOI:10.23937/2469-5696/1410080

Under Reported Potentials of Low Foetal Haemoglobin Concentration in Sickle Cell Disease

Yusuf Ishaya Dogonzo, Obinna Charles Ekoh and Thankgod Nnanna Enewor

Article Type: Original Article | First Published: August 29, 2022

The liver plays a significant role in the maintenance of health and survival of an individual. Any threat to this important organ is a threat to the existence of life. Hence its protection is vital to survival. Individuals with SCD are at high risk of suffering from liver failure due to events resulting from HbS polymerization....

 Open Access DOI:10.23937/2469-5696/1410079

Correlation between Coagulation Tests Parameter with Padua Prediction Score in Covid-19 Patients at General Hospital of Prof. Dr. R. D. Kandou Manado

Masengi SJR, Lasut P, Hendratta C, Rotty LWA and Haroen H

Article Type: Original Article | First Published: July 29, 2022

Coronavirus disease 2019 (COVID-19) was associated with hypercoagulability state, some changes in parameter of coagulation tests, and also cause venous thromboembolism (VTE), which can be predicted with Padua Prediction Score (PPS). In this study, we are going to seek correlation of PPS and some parameter of coagulation tests between mild and moderate - severe COVID-19 patients in isolation room for COVID-19 patients at General Hospital of Prof. dr. R. D. Kandou Manado....

 Open Access DOI:10.23937/2469-5696/1410078

Hemophagocytic Lymphohistiocytosis in A Post Covid-19 Patient with Mds: A Case Report

Ioannis Vasilopoulos, MD, Marina P Siakantaris, MD, PhD, Kalliope Zerzi, MD, Eliana A Konstantinou, MD, John V Asimakopoulos, MD, PhD, Anestis Karapaschalidis, MD, Fotios Panitsas, MD, MSc, Eleni Plata, MD, Maria K Angelopoulou, MD, Theodoros P Vassilakopoulos, MD, PhD and Panayiotis Tsaftaridis, MD, PhD

Article Type: Case Report | First Published: July 13, 2022

Primary or secondary hemophagocytic lymphohistiocytosis (HLH) is characterized by immune activation and lifethreatening cytopenias. Causative relationship between a number of pathogens, autoimmune diseases and even hematologic malignancies with secondary HLH (sHLH) have been reported....

 Open Access DOI:10.23937/2469-5696/1410077

The Severity of Sickle Cell Anemia in Men - The Action of Molecular and Biochemical Markers

Jonathan de Oliveira Rios, Thais Fernandes Ribeiro, Gabriel Felipe Arantes Bertochi, Clarisse Lopes de Castro Lobo and Claudia Regina Bonini Domingos

Article Type: Original Article | First Published: June 23, 2022

Sickle cell disease is characterized by a very heterogeneous clinical course among patients with the same mutations for sickle cell hemoglobin (HbS). Sickle cell anemia (SCA) is a hereditary hemoglobinopathy caused by the homozygosity of a point mutation in the beta-globin gene, which leads to the substitution of glutamic acid for valine in the sixth position....

 Open Access DOI:10.23937/2469-5696/1410076

Clinical Presentations and Predictors of Severe Sickle Cell Disease among Patients Who Attended Muhimbili National Hospital Dar-Es Salaam, Tanzania: A Retrospective Study

Eunice Andrew Shija, Clement Kabakama, Benson Peter Mugaka, Yu-jiao Xiang1 and Yan Shi

Article Type: Original Article | First Published: May 04, 2022

Inherited hemoglobinopathies led by Sickle Cell Disease (SCD) are key contributors to the anaemia burden in Sub-Saharan Africa (SSA). In Tanzania, an estimated six out of one thousand newborns are born with SCD, making Tanzania the fourth country with the highest burden of SCD patients in the world and the third in Africa after Nigeria and the Democratic Republic of Congo (DRC) (Nigeria 85,000, Democratic Republic of Congo 42,000 and Tanzania 11,000). At present, curative options for sickle cell...

 Open Access DOI:10.23937/2469-5696/1410075

Applicability of the Neutrophil/Lymphocyte Ratio in Behavioral Studies

Romes Bittencourt Nogueira de Sousa, Luiz Henrique Alves, Vithoria Caetano Carmo, Cintia da Silva Manso, Fagner Medeiros Alves, Ana Gabriella Pereira Alves, Denise da Silva Pinheiro, Natália Carvalho de Camargo, Laura Carvalho de Camargo, Hully do Nascimento Segatti and Maria Sebastiana Silva

Article Type: Review Article | First Published: April 21, 2022

The balance of neutrophilic and lymphocytic populations in the body is sensitive to neuroendocrine changes present in acute and chronic emotional stress, influencing a range of behaviors intrinsically related to real or potential environmental stressors. In this sense, the Neutrophil/ Lymphocyte Ratio (NLR) is a simple and low-cost tool, derived from the analysis of the blood count, capable of showing changes in several health parameters, since it is related to the pro-inflammatory status of the...

 Open Access DOI:10.23937/2469-5696/1410074

Melphalan and Cytarabine as a Salvage Therapy in Children with Relapsed or Refractory Acute Leukemia

Malaval Carmen Isolde, MD, Queudeville Manon, MD, Döring Michaela, MD, Hartmann Ulrike, Dr. Pharm, Lang Peter, MD, Handgretinger Rupert, MD and Ebinger Martin, MD

Article Type: Research Article | First Published: March 16, 2022

In refractory or relapsed acute leukemia the achievement of a complete remission by a salvage therapy and the performance of allogeneic hematopoietic stem cell transplantation (HSCT) is in most cases the only treatment by which long term disease-free survival can be accomplished. With current salvage regimens a 5 year overall survival rate of 29% is obtained in children with relapsed acute myeloid leukemia (AML) and a 10 year overall survival rate of 36% in children with relapsed acute lymphobla...

 Open Access DOI:10.23937/2469-5696/1410073

Aplastic Anemia-Related Mortality in Brazil, 2000-2018

Augusto Hasiak Santo

Article Type: Case Report | First Published: January 14, 2022

Aplastic anemia (AA) is a rare and serious disease, potentially life-threatening, that affects hematopoietic stem and progenitor cells and is characterized by pancytopenia and a hypoplastic bone marrow. The development of AA result from the destruction of hematopoietic cells by three main mechanisms, including direct environmental injury, dysregulated immune system, and primary inherited or acquired bone marrow failure syndrome. There are no AA specific markers then the diagnosis is reached by e...

 Open Access DOI:10.23937/2469-5696/1410072

Reference Intervals in Malaysia: A Performance Evaluation and Comparison of Haematological Parameters between Sysmex XE-5000 and XN-3000

Siew Lian CHONG, Asral Wirda AHMAD ASNAWI, Kian Boon LAW, Roszymah HAMZAH and Sen Mui TAN

Article Type: Brief Report | First Published: December 23, 2021

The Sysmex XN-3000 is a new automated haematology analyser designed to improve the accuracy of cell counts and the specificity of the flagging events of unusual parameters. By comparing the previous full blood count (FBC) reference intervals in Malaysia for Sysmex XE- 5000, we determined a reference interval for all parameters measured by the Sysmex XN-3000 for the Malaysian population. Through the voluntary recruitment of 397 adults ages 18-45 years, both genders, and the three main ethnic grou...

 Open Access DOI:10.23937/2469-5696/1410071

Coagulation Abnormalities in Pregnant Women with COVID-19

Vladimir Y Khryshchanovich, MD and Natalia Y Skobeleva, BS

Article Type: Letter to Editorial | First Published: December 18, 2021

Late pregnancy and the early postpartum period are characterized by the so-called physiological hypercoagulation: The concentration of blood clotting factors I, II, VIII, IX, X increases twice, the functional activity of platelets increases, and the fibrinolytic activity of serum decreases. On the one hand, the prothrombotic status reduces the risk of massive blood loss in childbirth, and on the other - creates prerequisites for the development of venous thromboembolism. In the context of assess...

 Open Access DOI:10.23937/2469-5696/1410070

Echelons of Some Haemoparasites among Blood Donors in Port Harcourt, Rivers State, Nigeria

Evelyn Mgbeoma Eze, Serekara Gideon Christian, Ransom Baribefii Jacob, Barinaaziga Sunday Mbeera, Beatrice Wobiarueri Moore-Igwe and Angela Tornubari Mbari

Article Type: Original Article | First Published: December 04, 2021

Although the therapeutic application of whole blood and blood components can be life-saving, inadequate screening of these products could pose life-threatening problems to the recipient. The aim of this study was to determine the echelons of some haemoparasites (malaria parasite, microfilaria and babesia species) among blood donors in Port Harcourt, Rivers State, Nigeria as well as quantifying their densities. A total of one hundred (100) prospective blood donors from the participating blood ban...

 Open Access DOI:10.23937/2469-5696/1410069

Assessment of the Usefulness of Red Cell Indices as a Screening Tool in Haemoglobin E Trait: A Cross Sectional Study

DMHMK Dassanayake, VCP Gunawardena and SB Athauda

Article Type: Original Article | First Published: September 29, 2021

HamoglobinE (HbE) is the second commonest structural haemoglobin variant and results from mutation in the β globin gene causing substitution of glutamic acid for lysine at position 26 of the β globin chain. When coinherited with β Thalassemia it becomes a major health burden. To assess the effectiveness of red cell parameters as a screening tool to identify haemoglobin E traits and to develop a score using red cell parameters which help to identify Haemoglobin E traits in population screening...

 Open Access DOI:10.23937/2469-5696/1410068

Diagnostic Value of miR-26b in Schizophrenia

Ling-ming Kong, Xiao-li Zhu and Li-yi Zhang

Article Type: Original Article | First Published: September 22, 2021

This study aimed to investigate the diagnostic value of peripheral microRNA (miRNA) expression in schizophrenia (SZ). By using an Affymetrix array to identify differentially expressed miRNAs in SZ patients; quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to verify identified microRNA and test major depressive disorder (MDD), generalized anxiety disorder (GAD) and mental retardation (MD) related microRNAs for comparison. The expression levels of miR-1972...

 Open Access DOI:10.23937/2469-5696/1410067

SMYD2 in Leukemia: An Update

Teresa Rubio-Tomás

Article Type: Mini-Review Article | First Published: August 30, 2021

SMYD2 is one of the five members (SMYD1-5) of the Su(Var)3-9, Enhancer-of-zeste and Trithorax (SET) and Myeloid, Nervy, and DEAF-1 (MYND) domain-containing (SMYD) protein family and is it known to methylate histone and non-histone substrates. By methylating a wide range of targets, SMYD2 acts as an oncogene in most cancer types. In this review I will comment on the last publications related to the role of SMYD2 in leukemia and I will refer to more extensive reviews if the reader aims to have a b...

 Open Access DOI:10.23937/2469-5696/1410066

Hypogonadotropic Hypogonadism in a Female Patient with Thalassemia Major

Richmond R Gomes

Article Type: Review Article | First Published: August 28, 2021

Thalassemia refers to a group of inherited diseases characterized by decreased or absent synthesis of normal globin chains. The direct consequence is an imbalance of the alpha and beta globin chain synthesis that results in anemia from ineffective erythropoiesis and hemolysis. The term thalassemia major refers to the severe form that is often associated with life-long transfusion dependent anemia. Hypogonadism is the most frequently reported endocrine complication, affecting 70-80% of thalassemi...

 Open Access DOI:10.23937/2469-5696/1410065

Evaluating Bone Mineral Density in Pediatric Acute Lymphoblastic Leukemia Survivors: A Tertiary Care Hospital Experience

Ersin Toret, Burcu Dural, Yeter Duzenli Kar, Zeynep Canan Ozdemir, Ilknur Ak Sivrikoz and Ozcan Bor

Article Type: Original Article | First Published: April 30, 2021

Acute leukemias are the most common malignancies seen in children and they account for one third of childhood cancers. Children who survived ALL, experience reduced bone mineral density (BMD) due to the disease, long-lasting glucocorticoid usage, chemotherapy toxicities, nutritional deficiencies and physical immobility. The decreased BMD have determined at all stages of disease. This retrospective cross-sectional study purposes to analyse the results of BMD in children who have completed their A...

 Open Access DOI:10.23937/2469-5696/1410064

COVID-19 and Aplastic Anemia: Friend or Foe

Mohd Mustahsin, Zeba Siddiqi, Ajay Mishra and Garima Singh

Article Type: Case Report | First Published: April 28, 2021

Aplastic Anemia is a rare hematological disorder caused by bone marrow failure leading to pancytopenia. These patients are frequently treated with immunosuppressive therapy which may protect them in developing hyper-inflammatory response which is commonly seen in moderate and severe COVID-19 patients. On the other hand these patients are at high risk for infection and infection related complications. Here we are reporting an adult aplastic anemia patient who developed uncomplicated course of COV...

 Open Access DOI:10.23937/2469-5696/1410063

Somatic Mutational Analysis using Next Generation Sequencing in Predicting Disease Behavior of Cytogenetically Normal Myelodysplastic Syndromes

Francisco Tria IV, Philipp W Raess, Daphne Ang, Jose Jasper Andal, Richard Press, Ngoc Tran, Jennifer Dunlap, Joanna Wiszniewska, Tauangtham Anekpuritanang and Guang Fan

Article Type: Research Article | First Published: March 24, 2021

Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by peripheral blood cytopenias, with associated morphologic dysplasias, and recurrent cytogenetic abnormalities. However, approximately 40-50% of MDS have no detectable cytogenetic abnormalities or cytogenetically-normal (CN-MDS). MDS cases with concurrent cytogenetics/FISH and molecular testing were identified from a two-year cohort with a median time to follow-up of 506 days. A total of 153 MDS were gathered, and we identified...

 Open Access DOI:10.23937/2469-5696/1410062

Thrombotic Thrombocytopenic Purpura in a Patient with Systemic Lupus Erythematosus

Diana Guavita-Navarro, MD, Jairo Cajamarca-Baron, MD, Jhon Buitrago-Bohorquez, MD, Laura Gallego-Cardona, MD, Diana Guevara, MD, Hector Cubides, MD, Ana Maria Arredondo, MD and Alejandro Escobar, MD

Article Type: Case Report | First Published: February 19, 2021

Thrombotic microangiopathy is a group of syndromes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute organ dysfunction secondary to ischemia. It includes a group of diseases such as thrombotic thrombocytopenic purpura. They can be primary or secondary to multiple pathologies, including autoimmune diseases such as systemic lupus erythematosus. These associations are important from the clinical point of view, as they have more severe presentations, high relapse rates,...

 Open Access DOI:10.23937/2469-5696/1410061

Specific Antibody Deficiency in Pediatric Patients with Chronic Rhinosinusitis

Robert G Hill, BA and James A Sipp, MD

Article Type: Case Series | First Published: February 19, 2021

This study was performed to review our experience with pediatric patients adaptive immunity to Streptococcus pneumoniae and Haemophilus influenza in the clinical presentation of chronic rhinosinusitis. Currently, there is no specific routine role in healthcare to check the immune status in patients after receiving the vaccinations. Patients were identified from the EMR using the ICD-10 code for chronic sinusitis and were considered eligible if they had titers drawn to evaluate their immunity. Pa...

 Open Access DOI:10.23937/2469-5696/1410060

System Biology: An Emerging Toolkit for Improved Tyrosine Kinase Inhibition Therapy for Myeloproliferative Neoplasms

Alphonsus Ogbonna Ogbuabor, PhD, Peter Uwadiegwu Achukwu, PhD, Silas Anayo Ufelle, PhD and Daniel Chukwuemeka Ogbuabor, PhD

Article Type: Review Article | First Published: November 16, 2020

Concerted efforts have been made by scientists over the last decades in elucidating the molecular mechanisms leading to myeloproliferative neoplasms. The identification of oncogenic mutations in signal transduction pathways revealed the role of specific pathways in inducing excessive proliferation of myeloid lineages. The subsequent development of mouse models carrying mutations found in patients proved that the aberrant activation of these specific pathways plays a crucial role in the pathology...

 Open Access DOI:10.23937/2469-5696/1410059

Erythrocyte Alloimmunization in Children with Sickle Cell Disease

Daniela de Oliveira Werneck Rodrigues, Lysla Cardoso Sudário, Olivia Franco dos Santos, Leonardo de Angelli Benedito Cardoso and Luiz Claudio Ribeiro

Article Type: Original Article | First Published: November 16, 2020

Alloimmunization is an immune response against red blood cell (RBC) antigens due to sensitization during RBC transfusion. RBC alloimmunization is more common in sickle cell disease (SCD) with prevalence between 18 and 47%. Retrospective chart review of a cohort of 120 children treated at Fundação Hemominas born between 1998 and 2007 and diagnosed with SCD through neonatal screening. The statistical analysis was made with the usage of Mann-Whitney’s U test, Student’s T-test and Chi-Square t...

 Open Access DOI:10.23937/2469-5696/1410058

Coping with Bleeding Disorders

Tony Brown

Article Type: Case Report | First Published: October 14, 2020

Living with a bleeding disorder is something that very few live within the United States. In fact, hemophilia occurs in only approximately 1 in 5,000 live births. There are about 20,000 people with hemophilia A in the US. Hemophilia B is four times less common than hemophilia A. von Willebrand Disease is much more common than both hemophilia A & B which is believed to effect 1% of the population. Von Willebrand disease is estimated to affect 1 in 100 to 10,000 individuals. The 3 common bleeding ...

 Open Access DOI:10.23937/2469-5696/1410057

Enzyme Activities of Liver Function (Biomarkers) in Sickle Cell Anaemic Patients Attending Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria

Collins Uchechukwu Obi, Okikioluwa Stephen Aladeyelu, Ijeoma Nnenna Agbiogwu, Nneka Chidimma Agu, Joseph Akinwale Arusiwon and Mercy Oluchukwu Udeh

Article Type: Survey Article | First Published: September 23, 2020

Hundred subjects were involved for this study. The subjects were divided into 2 groups: 50 sickle cell anaemic subjects (20 males and 30 females) and 50 non-sickle cell subjects or control (23 males and 27 females). Sickle cell anaemic subjects were between the age ranges of 15-41 years while control subjects were between 17-31 years. Subjects were both Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria and volunteer students at the Department Medical Laboratory Science, Ambrose Ali Univ...

 Open Access DOI:10.23937/2469-5696/1410056

Laboratory Blood Coagulation in Sudanese with Falciparum Malaria: A Glance of Change Outcomes

Bashir Abdrhman Bashir and Mohamed Seed Ahmed

Article Type: Original Research | First Published: September 03, 2020

Malaria is a potentially life-threatening disease caused by infection of erythrocytes with one of five different types of protozoan parasites of genus plasmodia. Falciparum species is an aggressive type associated with multiple alterations in hemostasis. A cross-sectional descriptive study was undertaken to screen the effect of malaria infection on coagulation test results in adults with the falciparum malaria parasite. Forty- eight consecutive adults with falciparum malaria were studied along w...

 Open Access DOI:10.23937/2469-5696/1410055

The Effects of Assymptomatic Malaria on Some Haematological Parameters among the Elderly in a Sub-Urban Community in Southern Nigeria

Eledo BO, Tommy EO, Onuoha EC, Dunga KE and Okamgba OC

Article Type: Review Article | First Published: August 14, 2020

Malaria remains a major public health problem in endemic areas and due to neglect, the elderly ones are even more exposed now. The objective was to determine the effects (if any) of asymptomatic malaria on some hematological parameters on infected elderly subjects, identify subjects at risk of severe hematological derangement and render advice appropriately. One hundred healthy subjects (45 males and 55 females) having ≥ 60-years-old and without clinical symptoms, were screened for malaria par...

 Open Access DOI:10.23937/2469-5696/1410054

Influence of ABO Blood Group on Fibrinogen Levels and Platelet Count in Apparently Healthy Nigerian Subjects

Okeke CO and Iloka VC

Article Type: Original Article | First Published: July 25, 2020

A close association has been shown to exist between ABO blood type and the risk of some diseases with non-O (A, B, or AB) individuals having an increased differential disposition to thrombotic disorders. The present study evaluated the fibrinogen levels and platelet count in subjects of different ABO blood groups with the view of ascertaining if disparity exists in the levels of fibrinogen and platelet count amongst the different ABO blood groups....

 Open Access DOI:10.23937/2469-5696/1410053

First Report of Hemoglobin Le Lamentin [Alpha 20 (B1) His -> Gln] in the Alpha1 Globin Gene in an Indian Patient and a Brief Update

Sona B Nair, Arundhati S Athalye, Prochi F Madon and Firuza R Parikh

Article Type: Case Report | First Published: July 13, 2020

Alpha globin gene structural variants are caused mainly due to point mutations in the alpha globin gene. They are generally asymptomatic but in rare cases cause problems in association with other structural variants of thalassemia. We report here for the first time in Indian population a rare alpha globin gene structural variant named Hb Le Lamentin. Our main aim of presenting this case is to create awareness that this variant may be commonly present in the Indian population also though the prev...

 Open Access DOI:10.23937/2469-5696/1410052

Hemopure, HBOC-201, for Life Threatening Anemia in a Jehovah’s Witness

Joseph R Nellis, MD, MBA, Michael J Devinney, MD, PhD, Christopher C Young, MD

Article Type: Case Report | First Published: June 04, 2020

There are over 1 million Jehovah’s Witnesses in the United States and nearly 8.5 million worldwide. Within the medical community, they are most notably known for their refusal of blood transfusions. Prior studies have shown that healthy euvolemic volunteers tolerate hemoglobin of 5 g/dL, although when faced with the stress of surgery their operative mortalities are over 30%. Herein we explore the use of Hemopure, HBOC-201, an investigational blood substitute, for a frail 72-year-old female Jeh...

 Open Access DOI:10.23937/2469-5696/1410050

Atypical Clinical Picture of Breast Cancer with Dominant Symptoms of Hematologic and Gastrointestinal Malignancies

Malwina Rybicka-Ramos, Grzegorz Kasiarz, Katarzyna Pluta, Tomasz Wilczynski, Jerzy Pruszynski and Ewa Ziolko

Article Type: Case Report | First Published: June 03, 2020

Gastrointestinal malignancy was suspected in a 68-year-old woman with long-term anemia, thrombocytopenia, leukopenia, the presence of fecal occult blood and elevated levels of CEA and CA 19- 9. However, malignancy was not confirmed. The patient was later hospitalized in the Department of Hematology where hematologic disease was excluded. Cervical and inguinal lymphadenopathy and atypical bone marrow cells collected by aspiration biopsy gave rise to the suspicion of bone marrow involvement by tum...

 Open Access DOI:10.23937/2469-5696/1410051

Multicentric Castleman’s Disease with Disseminated Kaposi’s Sarcoma: A Report of Prolonged Misdiagnosis

Xiao Hu, Monika Pilichowska and Cindy Varga

Article Type: Case Report | First Published: June 06, 2020

54-year-old gentleman was diagnosed with acquired immunodeficiency syndrome (AIDS) when presenting with shingles in 2016. He was started on HAART but soon noted a very rapid increase in the size of his cervical, axillary and inguinal lymph nodes, along with profound constitutional symptoms. Immune reconstitution syndrome was suspected and prednisone was tried but did not alleviate symptoms. One month later, a core biopsy of the left axillary lymph node was undertaken and demonstrated predominant...

 Open Access DOI:10.23937/2469-5696/1410049

Heparin-Induced Thrombocytopenia Presenting as Splenic Hemorrhage Following Cardiac Surgery: A Case Report

J Ferry, S Youssef, P WU and L Hegerova

Article Type: Case Report | First Published: May 25, 2020

Heparin induced thrombocytopenia with thrombosis (HIT) is a paradoxical prothrombotic complication of anticoagulant therapy. We report a case of atraumatic splenic hemorrhage due to splenic vein thrombosis as main indicator to diagnosis of HIT. The presentation is reminiscent of the rare bilateral adrenal hemorrhage due to adrenal necrosis that occurs in HIT. Alternative anticoagulation is mainstay of therapy for HIT despite hemorrhage, given the underlying acquired hypercoagulability....

 Open Access DOI:10.23937/2469-5696/1410048

Effects of TSH on Erythrocyte Osmotic Fragility: Signaling Pathway

Evelyn Mendonca-Reis, Camila Cristina Guimaraes Nobre, Artur Paes-Chagas, Leandro Miranda-Alves and Clemilson Berto-Junior

Article Type: Original Article | First Published: March 09, 2020

TSH is a peptide hormone synthetized and secreted by pituitary with fundamental importance for thyroid function. TSH receptors are found in other tissue than thyroid playing diverse roles, including erythrocyte. Based on the fact that deformability is one of the most important features of a mature erythrocyte, we aimed to verify if TSH modulates erythrocytes volume and, if does, which signaling is involved in this modulation. Using hemolysis assay, we create a hemolysis curve of erythrocyte in p...

 Open Access DOI:10.23937/2469-5696/1410047

Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease

Gulsah Durmus, Nevin Karakus, Serkan Yuksel and Nurten Kara

Article Type: Research Article | First Published: February 12, 2020

Coronary artery disease (CAD) is a multifactorial disorder. It is important to identify gene mutations that may be responsible for the development of CAD. The aim of this study was to determine the frequency of twelve cardiovascular disease (CVD) related gene mutations in coronary artery patients. The CVD StripAssay (Vienna Lab, Austria) was performed to analyze the twelve gene mutations on 52 coronary artery patients and 39 healthy controls. After DNA isolation from blood samples, hybridization...

 Open Access DOI:10.23937/2469-5696/1410046

First Observation of Two TMPRSS6 Gene Mutations (G603R and K636AFSX17) in Turkish Population

Yasemin Ardicoglu Akisin, Gulnaz Kurt, Hüseyin Onay, Ferda Ozkinay and Nejat Akar

Article Type: Case Report | First Published: December 20, 2019

Iron is one of the elements that participate numerous reaction on the body and the structure of hemoglobin to the purpose of carrying oxygen to the tissues. Thus, iron deficiency causes different problems in the body. Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder that has some signs of iron deficiency anemia (IDA) but refractory to oral iron and partially refractory to intravenous iron. The mutation in TMPRSS6 gene causes matriptase-2 protein deficiency that negatively reg...

 Open Access DOI:10.23937/2469-5696/1410045

Prevalence of Antiphospholipid Antibodies in HIV-Infected Children in Ile-Ife, South-Western Nigeria

Oyelese AT, Salawu L, Adejuyigbe EA and Olasanmi O

Article Type: Review Article | First Published: December 12, 2019

Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and this has been documented in Nigerian adult patients but not in the pediatric age group. To determine the prevalence of antiphospholipid antibodies in HIV-infected children and its associatio...

 Open Access DOI:10.23937/2469-5696/1410044

Repeat Ultrasonographic Examinations Reveal Accessory Spleen in a Case with Relapse ITP

Ahmet Sarici, Ayshe Slocum, Hilal Er Ulubaba, Mehmet Hanifi Kandemir, Mehmet Ali Erkurt, Emin Kaya and Irfan Kuku

Article Type: Original Article | First Published: August 09, 2019

The aim of treatment in patients with primary immune thrombocytopenia (ITP) is to obtain a safe platelet count to prevent clinically significant bleeding (major bleeding) rather than normalizing the platelet count. In light of this information, treatment indications for newly diagnosed ITP patients include, I) Thrombocyte counts below 30,000/microL and II) Platelet counts above 30,000/microL in correlation with clinically significant bleeding. Corticosteroids make-up the first-line treatment of ...

 Open Access DOI:10.23937/2469-5696/1410043

Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?

Hakan Kaya

Article Type: Research Article | First Published: July 17, 2019

Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 201...

 Open Access DOI:10.23937/2469-5696/1410042

Geriatric Presentation of Hyperleukocytosis in Setting of B-Cell Acute Lymphoblastic Leukemia, Border-Zone Ischemic Stroke and Endocarditis

Christian Cajavilca, Tina Yaqing Cai Lam, Alexandra Vaio Sykes, Shannon Wheeler and Rajan R Gadhia

Article Type: Case Report | First Published: July 04, 2019

81-year-old female presented to an outside emergency room with subacute onset of left facial weakness and right hemiparesis for 12 hours. A non-contrast CT scan of the head and CTA head and neck showed no acute findings. Laboratory results were remarkable for a leukocyte count of 245.75 k/uL. She was diagnosed with acute leukemia and transferred to a comprehensive stroke center where she was treated with leukapheresis and hydroxyurea. The patients focal deficits somewhat improved, but in the fol...

 Open Access DOI:10.23937/2469-5696/1410041

Impact of the Oscillating Bead Size and Shape on Induced Mechanical Stress on Red Blood Cells and Associated Hemolysis in Bead Milling

Michael Tarasev, Marina Muchnik and Sumita Chakraborty

Article Type: Original Article | First Published: June 27, 2019

While in circulation, red blood cells (RBC) need to elastically undergo large deformations without lysing, an ability that may be compromised by cell membrane damage. Such can be tested in vitro by subjecting an RBC sample to external mechanical stress, e.g. through bead milling or oscillation of an object in a sample. In addition to controlling frequency and duration of oscillations, this approach can be further tailored by bead selection/design....

 Open Access DOI:10.23937/2469-5696/1410040

ABO Blood Group: Its Relationship with Anthropometric Parameters Among Young Adult Nigerians of Yoruba Ethnicity

Asafa MA, Ogunlade O, Bolarinwa RA, Bisiriyu LA and Asafa ST

Article Type: Research Article | First Published: June 17, 2019

It had been established that ABO blood group system associated with some diseases or disorders. The objective of this study was to determine the effect of ABO blood group on anthropometric indices among apparently healthy young adults of Yoruba ethnicity. Eighty apparently healthy young adults who were purposely selected participated in the study after screening for the ABO blood groups following the standard protocol. They were divided into four equal groups; 20 in each of blood groups A, B, AB...

 Open Access DOI:10.23937/2469-5696/1410039

Fatal Systemic Mucormycosis after Rabbit Anti-Thymocyte Globulin Therapy in a Severe Aplastic Anemia Patient

Haruko Tashiro MD, PhD, Yasutoshi Oshima, Ritsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kensuke Matsumoto, Jun Ooi, Naohisa Matsunaga, Yoshinao Kikuchi and Naoki Shirafuji

Article Type: Case Report | First Published: May 16, 2019

Survival rates for patients with severe aplastic anemia have greatly improved with the development of better supportive care including transfusion strategies and the availability of anti-fungal agents. However, invasive fungal infection remains the main cause of death and increases mortality in severe aplastic anemia patients. Among invasive fungal infections, mucormycosis is one of the fatal diseases in immunocompromised patients. We report the case of a 72-year-old man with severe aplastic ane...

 Open Access DOI:10.23937/2469-5696/1410038

MEK1/2 as a Therapeutic Target in Sickle Cell Disease

Rahima Zennadi

Article Type: Short review | First Published: April 04, 2019

Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...

 Open Access DOI:10.23937/2469-5696/1410037

Is an Additional Dose of Intravenous Ferric Carboxymaltose Useful in the Treatment of Iron Deficiency Anemia?

Sinem Namdaroglu, MD and Gizem Yıldırım

Article Type: Research Article | First Published: March 06, 2019

Even though a single high dose administration of intravenous ferric carboxymaltose (FC) is supposed to be effective, it is unknown whether the second dose of FC given one week after the initial dose provides additional benefits. The aim of the present study was to investigate whether two doses of intravenous ferric carboxymaltose is more effective than a single dose of intravenous FC for replenishing iron stores and correction of anemia in patients with iron deficiency....

 Open Access DOI:10.23937/2469-5696/1410036

Diffuse Large B-Cell Lymphoma during Complete Remission of Acute Myeloid Leukemia (M4Eo) Exhibiting Immunoglobulin Heavy Chain Gene Rearrangement and Inv(16)

Kodai Kuriyama, Hiroki Hosoi, Masaya Shimanuku, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Nobuyoshi Hanaoka and Takashi Sonoki

Article Type: Case Report | First Published: January 25, 2019

In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the ...

 Open Access DOI:10.23937/2469-5696/1410035

Utilizing Extended Red Blood Cell Parameters to Distinguish Iron-Deficient Erythropoiesis - Related Disorders in Malaysian Female Population

Angeli Ambayya, Andrew Octavian Sasmita, Subramanian Yegappan and Jameela Sathar

Article Type: Research Article | First Published: January 20, 2019

The full blood count (FBC) analyzers, Sysmex XE-5000 and Unicel DxH 800, are equipped to perform routine and extended parameters tests; thus, this study considered extended red blood cell (eRBC) parameters to distinguish iron-deficient erythropoiesis related disorders. Malaysian female subjects comprising three main ethnic groups (Malay, Chinese and Indian) were included. Three groups of findings were distinguished based on FBC, morphology, and iron status of the subjects: normal, latent iron de...

 Open Access DOI:10.23937/2469-5696/1410034

Bioinformatics Analysis of Altered lncRNAs in Peripheral Blood Molecular Cells from Major Depressive Disorder (MDD) Patients

Mingjun He, Xiaoli Zhu, Wei Niu, Lingming Kong, Gaofeng Yao and Li-yi Zhang

Article Type: Research Article | First Published: December 12, 2018

Based on the prior studies, altered lncRNAs in peripheral blood Molecular Cells (PBMC) from depression patients were chosen to perform informatics analysis for lncRNA target gene prediction and functional annotation. Microarray was first used to screen dys regulated lncRNAs in the PBMCs of MDD patients, of which 10 lncRNAs were selected for quantitative real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR) study, as well as bioinformatics analysis....

 Open Access DOI:10.23937/2469-5696/1410033

The Results of the Single Center Pilot Randomized Russian Clinical Trial of Mesenchymal Stromal Cells in Severe Neutropenic Patients with Septic Shock (RUMCESS)

Gennadiy Galstyan, Polina Makarova, Elena Parovichnikova, Larisa Kuzmina, Vera Troitskaya, Eduard Gemdzhian and Valeriy Savchenko

Article Type: Original Article | First Published: October 12, 2018

To investigate the safety of the of bone marrow-derived human multipotent mesenchymal stromal cells (MMSCs) administration in neutropenic patients with septic shock. Mesenchymal stromal cells (MMSCs) may represent a promising cell-based therapy of sepsis. MMSCs, activated by lipopolysaccharide or tumor necrosis factor-α, reprogram macrophages by releasing prostaglandin E2. Prostaglandin E2 acts on the macrophages through the EP2 and EP4 receptors and stimulates the production and release of an ...

 Open Access DOI:10.23937/2469-5696/1410032

Expression of Foxp3 and Rorc Genes in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation: Impact in the Development of Acute and Chronic Graft-Versus-Host Disease

Camila Marca de Veiga Cabral, Walter Moises Tobias Braga, Adriano de Moraes Arantes, Jose Salvador Rodrigues de Oliveira, Gisele Wally Braga Colleoni and Fabio Rodrigues Kerbauy

Article Type: ORIGINAL ARTICLE | First Published: September 07, 2018

The aim of this study is to characterize Treg (FOXP3) and Th17 (RORC)-related genes in patients who underwent hematopoietic cell transplantation (HCT) and correlate them with graft-versus-host disease (GVHD) onset and patients' outcome. Fifty-one patients undergoing allogeneic HCT from matched related donors (MRD) were studied. Samples were collected before HCT, at acute (aGVHD) or chronic GVHD (cGVHD) onset, and 90 days post-HCT for those who did not have signs of aGVHD. FOXP3 and RORC gene exp...

 Open Access DOI:10.23937/2469-5696/1410031

Lenalidomide Plus Dexamethasone is an Active Rescue Treatment for Myeloma with Severe Renal Impairment Failing to Bortezomib-Based Induction Therapy

Giuseppe Mele and Domenico Pastore

Article Type: Case Reports & Case Series | First Published: July 12, 2018

Patients with relapsed/refractory Multiple Myeloma (rrMM) and End Stage Renal Disease (ESRD) requiring hemodialysis must receive lenalidomide at a dosage of 5 mg daily on days 1-21 of repeated 28-day cycles, due to substantial elimination via the kidneys. Unfortunately, despite dose reduction, severe adverse events occur with a high frequency. Therefore, lenalidomide is recommended mainly in patients with mild-to-moderate renal impairment....

 Open Access DOI:10.23937/2469-5696/1410030

Benign Lymphadenopathy Presented in a Malignant Pathway - A Rare Case of Proteinaceous Lymphadenopathy

Md Serajul Islam and Pavel Kotoucek

Article Type: Case Report | First Published: June 30, 2018

Proteinaceous lymphadenopathy is a rare non-specific lymph node changes incidence of which increases with age. This condition is usually associated with hypergammaglobulinemia or rheumatological conditions. However, this condition can also be due to unknown aetiology as we are presenting a case where no underlying case was found. It may affect nodal function, and rarely may it calcify. Histopathologist needs to be vigilant of this condition as lymphoma with lymph node sclerosis should be conside...

 Open Access DOI:10.23937/2469-5696/1410029

Multiple Myeloma Associated with Dermatomyositis: A Short Report and Mini-Review

Md Serajul Islam and Pavel Kotoucek

Article Type: Research Article | First Published: June 20, 2018

Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cell clones that produce monoclonal immunoglobulin. Dermatomyositis (DM), and to a lesser extent polymyositis (PM), carry a higher risk of cancer than that of the general population as demonstrated by several studies with the prevalence being 32% and 15% for DM and PM respectively. The mechanism underlying the association between idiopathic inflammatory myopathies (IIM) and malignancies remains unclear....

 Open Access DOI:10.23937/2469-5696/1410028

Zika Induced Meningoencephalitis in a Ruxolitinib Treated Patient with Secondary Myelofibrosis

Ahmad Al Ghoche, Jean Pegliasco, Jessica Anne-Marie-Sainte, Julien Cuziat, Lucas Meyer, Fatiha Najioullah, Jean Côme Meniane and Samy Chraïbi

Article Type: Case Report | First Published: October 28, 2017

We describe here the first case of a patient with post-ET myelofibrosis treated with ruxolitinib at French West Indies complicated with zika induced meningoencephalitis. Patient presented with fever, confusion along with conjunctivitis, diffuse joints pain and skin rash. PCR was positive for Zika virus in blood, urine and cerebrospinal fluid. Diagnosis of Zika induced meningoencephalitis was confirmed....

 Open Access DOI:10.23937/2469-5696/1410027

Interstitial Deletion of Chromosome 9q in Therapy-Related Acute Promyelocytic Leukemia with Pathognomonic t(15;17) in a Patient Exposed to Radioactive Iodine

Poorva Bindal, Heenam Goel, Alexei Shimanovsky, Joseph M Ryan, Jeffrey S Wasser and Enrique Ballesteros

Article Type: Case Report | First Published: September 29, 2017

The incidence of therapy-related Acute Promyelocytic Leukemia (t-APL) has been steadily rising. Radioactive Iodine (RAI) has emerged as a potential leukemogenic insult. Translocation involving the Retinoic Acid Receptor-alpha (RAR-alpha, RARa) gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15....

 Open Access DOI:10.23937/2469-5696/1410026

Bone Marrow Necrosis: An Unusual Misdiagnosed Serious Complication

Georges El Hachem

Article Type: Literature Review | First Published: July 31, 2017

Bone Marrow Necrosis (BMN) is an uncommon syndrome characterized by destruction of hematopoietic tissue with preservation of the bone. It presents as localized or diffuse generalized process. Many underlying diseases can lead to marrow necrosis: most commonly malignancies and rarely sickle cell disease....

 Open Access DOI:10.23937/2469-5696/1410025

Polycomb Proteins in Hematopoiesis and Hematologic Malignancie

Jie Li

Article Type: Review Article | First Published: March 20, 2017

In recent years, the Polycomb group (PcG) of proteins has been revealed to be involved in the regulation of hematologic stem cell function and differentiation and have been broadly linked to hematologic malignancies. Polycomb proteins are histone modifiers that contain two multi-protein complexes: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2)....

 Open Access DOI:10.23937/2469-5696/1410024

Successful Treatment of a Primary Cervical Diffuse Large B-cell Lymphoma with Rituximab-CHOP Immunochemotherapy

Diaz De-La-Noval B, Hernandez Gutierrez A, Zapardiel I, De-Santiago Garcia J and Diestro Tejeda

Article Type: Case Report | First Published: August 30, 2016

The incidence of Non-Hodgkin's Lymphoma (NHL) has been increasing in recent decades, the prevalence of extranodal-NHL is about 30 to 50% of all NHL patients. Primary Large B-cell extranodal lymphoma of the cervix is a very rare disease, 0.008% of all cervical tumors. The Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal lymphoid neoplasm in around 25% of all NHL....

 Open Access DOI:10.23937/2469-5696/1410023

Polycythemia Vera with High Erythropoietin Level: Case Report

Rami Nassabein, Mariam al khatib, Marie Helen Abbas, Marie youssef, Daniel Amer and Jaafar Wazni

Article Type: Case Report | First Published: August 30, 2016

Polycythemia Vera (PV) is a myeloproliferative disorder of bone marrow stem cells characterized by erythrocytosis. Elevated erythropoietin level strongly indicates secondary erythrocytosis and excludes PV diagnosis. However, patients with PV who co-present with Budd-Chiari syndrome (BCS) have been documented with elevated serum erythropoietin levels provided that JAK2 mutation is positive....

 Open Access DOI:10.23937/2469-5696/1410022

First Haploidentical Transplant in Peru in Pediatric Patient with Bilineal Leukemia

Mariela Del Carmen Moreno, Cinthia Palacios and Yessenia Cruz

Article Type: Case Report | First Published: August 01, 2016

Bilineal leukemia is a very rare health condition, especially in pediatric patients; it is associated with poor prognosis, even without uniformity therapeutic criteria. Hereby, we present a 4-year-old boy, who debuted as T-cell lymphoblastic lymphoma, he initially received treatment induction, which was unanswered, further studies showed evidence of being bilinear leukemia (T-AML M5). He continued the AML induction therapy followed by four consolidations, achieving CR....

 Open Access DOI:10.23937/2469-5696/1410021

Significance of sCD86 Levels in Acute Myelogenous Leukemia Patients: An Egyptian Study

Naglaa M Hassan, Nevin M Al-azhary and Marwa M Hussein

Article Type: Research Article | First Published: May 28, 2016

The aim of the study is to assess the level of soluble CD86 (sCD86) in patients with de novo AML and to compare them with a normal control group to determine any possible role with prognosis and clinical outcome, as the significance of sCD86 in hematologic malignancies is still controversial....

 Open Access DOI:10.23937/2469-5696/1410020

Chronic Use of Adalimumab as Potential Cause of Severe Thrombocytopenia in Psoriatic Arthritis Patient: The Need for Regular Monitoring of Cytopenias

Viviane Chaves Pereira, Karoline Honorato Costa and Leonardo Rodrigues de Oliveira

Article Type: Case Report | First Published: May 28, 2016

Although they are rare, severe hematologic adverse effects are described and may be fatal. The current study describes the case of a patient presenting psoriatic arthritis, and under prolonged treatment with adalimumab. His condition worsened due to severe acute thrombocytopenia and severe hemorrhagic manifestations. Adalimumab was considered to be the probable cause of the thrombocytopenia and, therefore, its use was discontinued. The treatment consisted of corticosteroids, human immunoglobulin...

 Open Access DOI:10.23937/2469-5696/1410019

In vitro Influence of Fibrinogen and Factor XIII on Viscoelastic Characteristics of Clot Formation under Hypothermia and Acidosis

DA Ammon, H Andruszkow, L Sieg, M Wilhelmi, CF Weber, N Rahe-Meyer and AA Hanke

Article Type: Research Article | First Published: November 27, 2015

Hypothermia and acidosis are risk factors for coagulopathy during trauma. We investigated influence of fibrinogen and factor XIII on whole blood coagulation under hypothermia and acidosis in an In vitro model. Fibrinogen, but not FXIII improved coagulation significantly. Furthermore, combined administration of fibrinogen and FXIII did not show differences to administration of fibrinogen alone....

 Open Access DOI:10.23937/2469-5696/1410018

The Management of Mucositis of Pediatric Hematopoietic Stem-Cell Transplantation


Article Type: Perspective | First Published: September 23, 2015

Hematopoietic stem-cell transplantation (HSCT) is used primarily for hematologic and lymphoid cancers but also for many other disorders. Autologous HSCT (in which stem cells are derived from the patient) is mainly used to treat chemosensitive malignancies. Allogeneic HSCT (in which the stem cells are derived from a donor) is often the preferred treatment option, particularly in patients with acute leukaemia. Oral complications are a significant cause of morbidity and potential mortality for chil...

 Open Access DOI:10.23937/2469-5696/1410017

The Evaluation of Serum Protein and Serum Immunofixation Electrophoresis Results in Patients with Monoclonal and Polyclonal Gammopathy: A Single Center Experience

Koksal Deveci, Serdal Korkmaz, Enver Sancakdar, Duygu Acibucu, Filiz Alkan, Hatice Terzi and Mehmet Sencan

Article Type: Research Article | First Published: September 17, 2015

A monoclonal gammopathy is defined as the electrophoretically and antigenically homogeneous protein product of a single clone of B lymphocytes and/or plasma cells that has proliferated beyond the constraints of normal control mechanisms. Monoclonal gammopathies are detected in serum and/or urine from individuals with a wide variety of neoplastic, potentially neoplastic, neurological and infectious conditions....

 Open Access DOI:10.23937/2469-5696/1410016

The Levels of PAI-1, Urokinase uPA, Thrombomodulin and TFPI in Essential Thrombocythemia

Oktay Bilgir, Ferda Bilgir, Mehmet Calan and Giray Bozkaya

Article Type: Research Article | First Published: September 05, 2015

Generally, ET is a myeloproliferative disorder characterized by persistent peripheral thrombocytosis and abnormal megakaryocytic proliferation in the bone marrow. ET is a rare cause of thrombocytosis and may be associated with both venous and arterial thrombosis in 10-75% of cases, depending largely on the study and whether vasomotor symptoms are included in thrombotic manifestations....

 Open Access DOI:10.23937/2469-5696/1410015

The Role of Positron Emission Tomography Imaging in the Risk-Adapted Treatment of Stage I-II Hodgkin's Lymphoma - A Retrospective Analysis

Tom Rider, John Jones, John Brewin, Gillian Horne, Jack Wills, Hannah Barton, Kevin Boyd, Timothy Corbett, Sabina Dizdarevic and Timothy Chevassut

Article Type: Research Article | First Published: July 09, 2015

Early stage Hodgkin's Lymphoma (HL) has excellent outcomes and recent research has focused on minimising treatment-related toxicities. However, the role of 18F-florodeoxyglucose positron emission tomography (FDG PET) imaging in this setting is not fully determined. We retrospectively calculated overall survival (OS) and relapse free survival (RFS) in stage I-II HL when radiotherapy was omitted if post-chemotherapy FDG PET imaging was negative....

 Open Access DOI:10.23937/2469-5696/1410014

Pediatric B-cell Non-Hodgkin Lymphoma: 21-year Experience with FAB-LMB Protocols in a Single Institute in Greece

Apostolos Pourtsidis, Marina Servitzoglou, Margarita Baka, Despina Bouhoutsou, Maria Varvoutsi, Dimitrios Doganis, Katherine Strantzia-Michail and Helen Kosmidis

Article Type: Research Article | First Published: May 10, 2015

Aims and background: Our objective was to analyze the clinical and demographic characteristics of children with B-cell lymphoma treated in a single center over the last two decades. Methods: Data was collected by a retrospective review of the charts of all 76 patients treated to our unit, from 1990 to 2010, with FAB LMB 89, 96 protocols and 2003 modifications....

 Open Access DOI:10.23937/2469-5696/1410013

Fetal and Neonatal Alloimmune Thrombocytopenia: Advances in Laboratory Diagnosis and Management

Hacene Brouk and Hanifa Ouelaa

Article Type: Review Article | First Published: April 30, 2015

Fetal and neonatal alloimmune thrombocytopenia (F/NAIT), caused by fetomaternal mismatch for human platelet (PLT) alloantigens (HPAs), is the commonest cause of severe thrombocytopenia in term neonates and is analogous to the fetal/neonatal anaemia caused by haemolytic disease of the newborn (HDN). The most feared complication of this syndrome is the occurrence of intracranial hemorrhage leading to death or neurological sequels....

 Open Access DOI:10.23937/2469-5696/1410012

The Comparison between Microhematocrit and Automated Methods for Hematocrit Determination

Gebrewahd Gebretsadkan, Kebede Tessema, Henock Ambachew and Misganaw Birhaneselassie

Article Type: Research Article | First Published: April 01, 2015

Hematocrit is a test that measures a percentage of blood that is comprised of red blood cell. This is often referred to as packed cell volume (PCV) or erythrocyte volume fraction. It is considered as an integral part of a person's complete blood count, along with hemoglobin concentration, white blood cell count and platelet counts....

 Open Access DOI:10.23937/2469-5696/1410011

Hemolytic Anemia in Alcohol-Induced Liver Disease: A Case Report on Zieve's Syndrome

Shefali Nath and Joshua R Peck

Article Type: Case Report | First Published: March 26, 2015

We report a case of Zieve's syndrome in a patient with a longstanding history of alcohol abuse admitted for acute alcoholic hepatitis. Zieve's syndrome is defied as the triad of hemolytic anemia, hypertriglyceridemia, and jaundice in patients with known liver disease. It is an uncommon diagnosis, but is an important one to consider in patients with known liver disease admitted with these constellation of signs and symptoms....

 Open Access DOI:10.23937/2469-5696/1410010

Lenalidomide in patients with Relapsed or Refractory HTLV-1 Related Adult T cell Leukemia/Lymphoma (ATLL)

Adrienne A. Phillips, Jalanni Giddings, Shing M. Lee and Steven M. Horwitz

Article Type: Case Report | First Published: March 21, 2015

Adult T-cell Leukemia/Lymphoma (ATLL) is resistant to chemotherapy and the acute and lymphomatous subtypes of disease have a dismal prognosis. There is no standard therapy for relapsed or refractory disease in Western countries and new agents are being explored. Lenalidomide is an immunomodulatory agent with promising activity in hematologic malignancies, including non-Hodgkin's lymphoma and represents a novel therapeutic option. ...

 Open Access DOI:10.23937/2469-5696/1410009

The Use of Diffusion Weighted Imaging in the Diagnosis of Intraocular Relapse of Acute Lymphoblastic Leukemia: A Case Report

Kee Kiat Yeo, Jonathan G. Murnick, Marijean M. Miller and Anne L. Angiolillo

Article Type: Case Report | First Published: February 23, 2015

Intraocular relapse of Acute Lymphoblastic Leukemia (ALL) is rare. Prompt diagnosis and treatment can minimize vision loss. We report a case of a young girl diagnosed with pre-B ALL who was initially treated successfully with chemotherapy....

 Open Access DOI:10.23937/2469-5696/1410008

Thrombophilia: Demographics and Clinical Presentation in United Arab Emirates

Fatma H Sajwani and Moza A Khuzam

Article Type: Research Article | First Published: February 20, 2015

Thrombophilia is a group of disorders that increases the patient's risk of thrombosis. Inherited causes of thrombophilia are challenging to diagnose and once diagnosed may subject the patient to prolonged treatment. The extent of the condition is not well established in UAE and data on prevalence and demographics are lacking. This study aimed at setting a baseline data on the prevalence, demographics and clinical presentation of thrombophilia in UAE....

 Open Access DOI:10.23937/2469-5696/1410007

HemoCue versus Complete Blood Count for Hemoglobin Measurement in Adults with Vaso-occlusive Crisis due to Sickle Cell Disease

Michael Bursey, Kane Curtis, Robert Gibson, Hongyan Xu and Matthew Lyon

Article Type: Research Article | First Published: February 17, 2015

Hemoglobin (Hgb) measurement is an important risk-stratification tool for patients presenting to the Emergency Department with vaso-occlusive crisis (VOC) from sickle cell disease (SCD). Point-of- care (POC) Hgb testing such as the HemoCue device decreases time to identification of significant anemia. However, there are no studies evaluating the accuracy of HemoCue testing in patients with SCD and VOC. The purpose of this study was to evaluate the correlation of Hgb measurements from HemoCue com...

 Open Access DOI:10.23937/2469-5696/1410006

The Study of the Mechanism of Action of the Newly Synthesized Direct Anticoagulant of Thiazoline Ammonium -4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate

Starkova AV, Syropyatov B Ya, Sobin FV and Pulina NA

Article Type: Case Report | First Published: February 08, 2015

The aim of this research is to study the mechanism of action of the newly synthesized substance - Thiazoline Ammonium 4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate (FS-169), which possesses the direct anticoagulant activity. The research was conducted with the use of 'АPG4-02-P' coagulometer. For the purposes of the study the rabbit plasma was used. The results show that FS-169 effectively changes Partial thromboplastin time and prothrombin time indicators. However, FS-169 has no influence on...

 Open Access DOI:10.23937/2469-5696/1410005

A Case of Localized Neuroblastoma in Caffey Disease, with Early and Uncommon Progression

Manuela Pagano, Chiara Galletto, Maurizio Bianchi and Franca Fagioli

Article Type: Case Report | First Published: January 21, 2015

Background: Caffey disease is a rare syndrome caused by mutation in the alpha-1 collagen type I gene, not described in literature as a predisposing condition to cancer development. Observation: We report a case of a 6-years-old female diagnosed with Caffey disease that developed a localized neuroblastoma. The patient had a poor clinical and radiological response with unusual disease dissemination and progression until death. Conclusion: The case is a rare example of rapid progression of localize...

 Open Access DOI:10.23937/2469-5696/1410004

Diverse Genotype Presentation of the Saudi-Type Poly A Signal Mutation (αTsaudiα) in the Population of Bahrain

Nabeel Al Moamen, Fawzia Mahdi, Ahmed Thabet, Rugaya Abbas, Ebtihal Salman and Ahmed Al Alawi

Article Type: Letter to Editor | First Published: January 15, 2015

A total of 1187 patients with α-thalassemia phenotype presentation have been recruited for this investigation. Preliminary diagnosis of α-thalassemia was based on low hematological indices (MCV and MCH) of the red blood cells and/or persistently low hemoglobin levels, along with low or normal levels of HbA2 and absence of iron deficiency. Th molecular diagnosis of α-thalassemia was established by using a commercially available α-thalassemia strip assay (α-Globin StripAss...

 Open Access DOI:10.23937/2469-5696/1410003

Lenalidomide as a Steroid Sparing Agent in a Myelodysplastic Syndrome Patient with Refractory Sweet Syndrome

Chakra P Chaulagain and Kenneth B Miller

Article Type: Case Report | First Published: December 22, 2014

Malignancy associated Sweet syndrome (acute febrile neutrophilic dermatosis) accounts for approximately 20% of all cases of Sweet syndrome and is characterized by painful, erythematous inflammatory papules and nodules that can precede, coincide or follow malignancies with predilection for hematologic malignancies. Corticosteroids are the cornerstone of treatment with exquisite response which has made many clinicians to include steroid responsiveness as one of the diagnostic criteria. However, re...

 Open Access DOI:10.23937/2469-5696/1410002

Pharmacological Treatment may Impair Mineral Status in Blood

Joanna Suliburska

Article Type: Editorial | First Published: July 31, 2014

Some medicines may interact with mineral, with the result that changes occur in the concentration of minerals and other blood parameters that are associated with mineral status. Interpretation of the results of morphological and biochemical blood analyses therefore needs to take into account the drugs used by patients....

 Open Access DOI:10.23937/2469-5696/1410001

The Progress of Oncolytic Reovirus in Hematologic Malignancies: Can we Combat Blood Cancer with the Cold?

Jun Gong

Article Type: Editorial | First Published: July 30, 2014

Oncolytic reovirus continues to pick up momentum as a novel agent in the treatment of cancer. Since the initial discovery of the virus' tendency to preferentially replicate in transformed cell lines from studies in the late 1970s, reovirus has rapidly progressed from preclinical to clinical trials evaluating its efficacy across a spectrum of malignancies, including hematologic....


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ClinMed Journals Index Copernicus Values

Clinical Medical Image Library: 93.51

International Journal of Critical Care and Emergency Medicine: 92.83

International Journal of Sports and Exercise Medicine: 91.84

International Journal of Womens Health and Wellness: 91.79

Journal of Musculoskeletal Disorders and Treatment: 91.73

Journal of Geriatric Medicine and Gerontology: 91.55

Journal of Infectious Diseases and Epidemiology: 91.55

Clinical Medical Reviews and Case Reports: 91.40

International Archives of Nursing and Health Care: 90.87

International Journal of Ophthalmology and Clinical Research: 90.80

International Archives of Urology and Complications: 90.73

Journal of Clinical Nephrology and Renal Care: 90.33

Journal of Family Medicine and Disease Prevention: 89.99

Journal of Clinical Gastroenterology and Treatment: 89.54

Journal of Dermatology Research and Therapy: 89.34

International Journal of Clinical Cardiology: 89.24

International Journal of Radiology and Imaging Technology: 88.88

Obstetrics and Gynaecology Cases - Reviews: 88.42

International Journal of Blood Research and Disorders: 88.22

International Journal of Diabetes and Clinical Research: 87.97

New Issues


International Journal of Clinical Cardiology

ISSN: 2378-2951 | ICV: 89.24



Obstetrics and Gynaecology Cases - Reviews

ISSN: 2377-9004 | ICV: 88.42



Journal of Hypertension and Management

ISSN: 2474-3690 | ICV: 87.69



International Journal of Diabetes and Clinical Research

ISSN: 2377-3634 | ICV: 87.97



Journal of Infectious Diseases and Epidemiology

ISSN: 2474-3658 | ICV: 91.55