Open Access DOI:10.23937/2643-4563/1710055
RNA m6A Modifications and Cancer
Afrasiyab, Sadaf Ayaz, Peilin Zheng and Shoujun Huang
Article Type: Review Article | First Published: 2023/11/02
Epitranscriptomic modifications of RNA, particularly N6-methyladenosine (m6A), have emerged as pivotal players in cancer biology. RNA m6A modifications dynamically regulate gene expression, influencing various aspects of RNA processing, stability, and translation. In the context of cancer, dysregulation of RNA m6A modification has been implicated in tumorigenesis, metastasis, therapy resistance, and the tumor micro environment. ...
Open Access DOI:10.23937/2643-4563/1710054
Rare Breast Cancer: Primary Melanoma of Breast Parenchyma
Mohamed Moneer Abulfotooh Alsayed, MSc, MRCS, Amal Yousif Saleh Abdullah, Ashraf Ahmed Abdeltawab Ibrahim, Ghaidaa Naser Abdul Razak, Sana Tabish and Rana Al Abdulghani
Article Type: Case Report | First Published: 2023/10/14
Melanoma is a highly aggressive cancer that can be cutaneous (most common) or mucosal, affecting the skin or mucous membranes at any organ in the body. It can also be found in the eye (uveal). Breast melanoma is rare, and it can manifest in one of three forms: 1) Metastatic secondary to primary melanoma at another site, 2) Primary cutaneous melanoma arising at the breast skin, or 3) Primary non-cutaneous melanoma arising in the breast parenchyma itself. ...
Open Access DOI:10.23937/2643-4563/1710053
Liver Metastasis: Current Concepts in Management and Future Perspectives
Aditya Sharma, Ram Niwas Meena, Rahul Khanna and Seema Khanna
Article Type: Review Article | First Published: 2023/08/20
Liver metastasis can be defined as the seeding of a malignant tumour from other organs affected by cancer. About half of the patients with colorectal cancer develop liver metastases during the progressive course of the disease. Surgery is the only curative treatment for patients with metastatic liver disease, and the five-year survival rate after resection of all detectable liver metastases can be as high as 40%. Unfortunately, only 25% of patients with liver metastases are candidates for liver ...
Open Access DOI:10.23937/2643-4563/1710052
Dose Variation Profiles of Small Fields with a 10 MV Photon Beam
Caio Fernando Teixeira Portela and Arnaldo Prata Mourão
Article Type: Original Article | First Published: 2023/05/20
Radiotherapy is a treatment of carcinogenic tumors using ionising radiation and the improvement of radiotherapy techniques has been conducted to protection of healthy tissues. Recent implementations have employed static fields with small dimensions. The interests for this work were small fields, used in modern techniques such as Stereotactic Radiation Therapy (SRS) and Intensity Modulated Radiation Therapy (IMRT). These fields have special characteristics that refer to the non-establishment of t...
Open Access DOI:10.23937/2643-4563/1710051
Two Cases of Primary Leiomyosarcoma of the Vagina: Histomorphologic Presentation with Review of the Literature
Mouamba FG, Buambo RG, Mozoma L, Samba B, Bizib GC, Mavoungou K, Bizib GC, Senga B and Peko JF
Article Type: Case Report | First Published: March 16, 2023
Leiomyosarcoma is a rare lesion and its localization to the vagina extremely rare. We report two cases of primary leiomyasarcoma of the vagina, involving the posterior wall, in a 46-year-old woman and a 56-year-old woman, describing their histomorphological and evolutionary characteristics, with review of the literature....
Open Access DOI:10.23937/2643-4563/1710050
Borderline Ovarian Tumors a Five-year Retrospective Clinicopathologic Study of 69 Cases in Egyptian NCI (2013-17)
Muhammad Adel Ali, Mohamed Abd El Fattah El Zohairy, Nesreen Hassan Hafez and Amr Kamal
Article Type: Retrospective Study | First Published: March 16, 2023
In the current study, we report our experience with borderline ovarian tumors. We collected and analyzed retrospective data on the pathology, management, disease free survival (DFS) of patients with borderline ovarian tumors (BOT) who underwent surgical management at or were referred to department of surgical oncology, National Cancer Institute, Cairo University (NCI) from January 2013 to December 2017....
Open Access DOI:10.23937/2643-4563/1710049
Duodenal Metastasis of a Pulmonary Adenocarcinoma: Report of a Case and Review of the Literature
Maryam Zaouit, Nisrine Bennani Guebessii, Fadwa Oudad, Ayoub Khoaja, Imane Aaribi, Loubna Hejjane, Nadia Benchekroun, Souha Sahraoui and Abdellatif Benider
Article Type: Case Report | First Published: March 06, 2023
Symptomatic gastrointestinal metastases from lung cancer were considered quite rare given their low incidence, especially the duodenal location. In this article, we report a clinical case of a patient followed for a pulmonary adenocarcinoma revealed by a duodenal metastasis. The patient was a 63-year-old female. She was admitted to the oncology department of the Ibn Rochd University Hospital for a low digestive hemorrhage ‘’Melena’’ complicated by acute anemia....
