Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer
Yoshiaki Nagatani, Yoshinori Imamura, Tsutomu Nakamura, Kazuhiko Yamashita, Mamoru Okuno, Hiroyuki Yasui, Jun Hiraoka, Riho Niigata, Keiji Kono, Yasuko Hyogo, Hirotaka Suto, Kei Takenaka, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota and Hironobu Minami
Article Type: Original Article | First Published: September 16, 2019
Although oxaliplatin is one of the main anticancer agents used against colorectal cancer, data on the pharmacokinetics of oxaliplatin in patients on hemodialysis are limited. In this case study, we evaluated the pharmacokinetics and safety of oxaliplatin in a patient on hemodialysis treated for colon cancer. A 68-year-old Japanese woman receiving chronic hemodialysis was treated for metastatic colon cancer with modified FOLFOX6 plus bevacizumab every 2 weeks. Initial oxaliplatin dose was reduc...
Nimotuzumab in Advanced Cervical Cancer: Safety and Efficacy Profile
Raiza Ruiz Lorente, Sayly Alfonso, Yamilka Sanchez, Carmen Elena Viada, Ramon Ortiz, Mayelin Troche, Meylan Cepeda, Ana Rosa Vals, Leticia Cabrera, Annia Gorte, Delmis Maira Batista, Milagros Domenech, Jessica Garcia Viamontes, Conrado Ramos Mico and Mayra Ramos Suzarte
Article Type: Review Article | First Published: July 29, 2019
The EGF receptor is over expressed in tumors of epithelial origin and is associated with a poor prognosis of the disease. An Expanded Clinical Access Program was carried out, in which patients with cervical uterine cancer in advanced stages of the disease without another therapeutic alternative were treated with nimotuzumab, anti-epidermal growth factor receptor humanized monoclonal antibody to evaluate the safety and efficacy of this therapy. Seventy-five patients with confirmed histological di...
Impact of the Number of Dissected Axillary Lymph Nodes on Survival in Breast Cancer Patients
Emad Eldin Nabil, Ahmed M Maklad, Ashraf Elyamany, Emad Gomaa and Moamen M Ali
Article Type: Research Article | First Published: June 05, 2019
For patients with breast cancer, axillary dissection was a standard treatment, especially with patient with positive metastases in the sentinel nodes. For some patients axillary dissection might be over-treatment, including those who have had a mastectomy. Especially with the new trend of many radiation-therapy centers, provide radiation-therapy for any number of positive lymph nodes. The aim of our work is to evaluate the impact of number of dissected axillary Lymph Nodes (LN), on Overall Survi...
Atypical Presentation of Denny-Brown Syndrome: A Case Report and Review of Literature
Romeo V Porlas Jr, MD, Scott Riley K Ong, MD, Gerard Raimon Saranza, MD, FPNA and Jose Paciano B Reyes, MD, FPNA
Article Type: Case Report | First Published: June 01, 2019
Paraneoplastic subacute sensory Denny-Brown neuronopathy
affects the peripheral nervous system and commonly
associated with small cell lung carcinoma and with other tumor
types in 14.4% of cases. Presented is a case of 23, female with progressive numbness
of extremities and ataxia. Investigations showed diffuse
sensory neuronopathy and elevated CSF IgG on CSF
studies. Paraneoplastic autoantibodies revealed negative
results yet imaging showed an anterior mediastinal mass,
which turned B-c...
Prostatic Ductal Adenocarcinoma: An Unusual Subtype of Prostate Cancer
Dinesh Kumar, MBBS, MS and John Lobo, MD
Article Type: Case Report | First Published: May 25, 2019
Ductal adenocarcinoma of the prostate (DAP) is defined as malignant epithelial cells filling large prostatic acini ducts, with preservation of basal cells forming either solid or dense cribriform patterns or a loose cribriform or micropapillary pattern with either marked nuclear atypia (nuclear size six times normal or larger) or Nonfocal comedonecrosis. DAP is a rare variant of prostate cancer, and has poorly-identified clinical characteristics....
Hydropneumopericardium: Unusual Complication of Proton Radiotherapy
Nakamura Yasuhiro, MD
Article Type: Clinical Image | First Published: May 13, 2019
Hydropnemopericardium is a very rare condition, which arises from penetrating trauma or blunt chest injury, development secondary to procedures, fistulization from adjacent structures and pericardial infections. This patient was 60-year-old man with hepatocellular carcinoma (HCC) presented to outpatients clinic with stomach pain, fatigue and anorexia. The patient was afebrile but laboratory profile manifested an excessive inflammatory response and disseminated intravascular coagulation. We detec...