Open Access DOI:10.23937/2643-4563/1710055
RNA m6A Modifications and Cancer
Afrasiyab, Sadaf Ayaz, Peilin Zheng and Shoujun Huang
Article Type: Review Article | First Published: 2023/11/02
Epitranscriptomic modifications of RNA, particularly N6-methyladenosine (m6A), have emerged as pivotal players in cancer biology. RNA m6A modifications dynamically regulate gene expression, influencing various aspects of RNA processing, stability, and translation. In the context of cancer, dysregulation of RNA m6A modification has been implicated in tumorigenesis, metastasis, therapy resistance, and the tumor micro environment. ...
Open Access DOI:10.23937/2643-4563/1710051
Two Cases of Primary Leiomyosarcoma of the Vagina: Histomorphologic Presentation with Review of the Literature
Mouamba FG, Buambo RG, Mozoma L, Samba B, Bizib GC, Mavoungou K, Bizib GC, Senga B and Peko JF
Article Type: Case Report | First Published: March 16, 2023
Leiomyosarcoma is a rare lesion and its localization to the vagina extremely rare. We report two cases of primary leiomyasarcoma of the vagina, involving the posterior wall, in a 46-year-old woman and a 56-year-old woman, describing their histomorphological and evolutionary characteristics, with review of the literature....
Open Access DOI:10.23937/2643-4563/1710050
Borderline Ovarian Tumors a Five-year Retrospective Clinicopathologic Study of 69 Cases in Egyptian NCI (2013-17)
Muhammad Adel Ali, Mohamed Abd El Fattah El Zohairy, Nesreen Hassan Hafez and Amr Kamal
Article Type: Retrospective Study | First Published: March 16, 2023
In the current study, we report our experience with borderline ovarian tumors. We collected and analyzed retrospective data on the pathology, management, disease free survival (DFS) of patients with borderline ovarian tumors (BOT) who underwent surgical management at or were referred to department of surgical oncology, National Cancer Institute, Cairo University (NCI) from January 2013 to December 2017....
Open Access DOI:10.23937/2643-4563/1710049
Duodenal Metastasis of a Pulmonary Adenocarcinoma: Report of a Case and Review of the Literature
Maryam Zaouit, Nisrine Bennani Guebessii, Fadwa Oudad, Ayoub Khoaja, Imane Aaribi, Loubna Hejjane, Nadia Benchekroun, Souha Sahraoui and Abdellatif Benider
Article Type: Case Report | First Published: March 06, 2023
Symptomatic gastrointestinal metastases from lung cancer were considered quite rare given their low incidence, especially the duodenal location. In this article, we report a clinical case of a patient followed for a pulmonary adenocarcinoma revealed by a duodenal metastasis. The patient was a 63-year-old female. She was admitted to the oncology department of the Ibn Rochd University Hospital for a low digestive hemorrhage ‘’Melena’’ complicated by acute anemia....
Open Access DOI:10.23937/2643-4563/1710048
Nodular Melanoma: A Case Report and Review of Literature
Ramon Eduardo Garcia Cahuich, Bianca Susana de la Torre Cuevas, Oscar Rene Vazquez Melo, Alondra Yereldi Naranjo Cruz and María Valeria Jiménez Báez
Article Type: Case Report | First Published: December 18, 2022
A malignant melanoma is an abnormal proliferation of pigmented cells in the body. Half of these tumors have BRAF mutations, with a worse response to treatment. We present the case of a 58-year-old male with a pigmented nodular lesion on the right calf and inguinal lymphadenopathy; a positive biopsy for nodular malignant melanoma (MMN) with the largest diameter of 2 mm, Clark level III and Breslow of 3 mm. Four months after tumor resection of the right pelvic limb and right lymphadenectomy are pe...
Open Access DOI:10.23937/2643-4563/1710047
Impact of the Covid-19 Pandemic on the Lung Cancer Management Process at the Mohamed VI Center for the Treatment of Cancer in Morocco
PANANDTIGRI Souleymane, BENCHAKROUN Nadia, SYLLA Abdou El Karim, CHEKRINE Tarik, BOURHAFOUR Mouna, BOUCHBIKA Zineb, JOUHADI Hassan, TAWFIQ Nezha, NANI Samira and SAHRAOUI Souha
Article Type: Original Article | First Published: November 06, 2022
Lung cancer being one of the main causes of mortality in Morocco, the coronavirus pandemic (COVID-19) has changed the processes of diagnosis and referral of lung cancer cases to oncology services. The objectives of this study were to describe the changes in the process of caring for lung cancer and to identify the activities affected during the COVID-19 pandemic in the Mohamed VI center for the treatment of cancers of the CHU IBN ROCHD of Casablanca in Morocco....
Open Access DOI:10.23937/2643-4563/1710045
Leiomyosarcoma of the Inferior Vena Cava Presenting as a Renal Mass: A Case Report
Hind Saad Al-Otaibi, Mohammed Hassan Ahmed, Ghaidaa Naser AbdulRazak, David Bakiratharajan, Talal Abdulla Alanzi and Tarek Essam Eldin Ahmed
Article Type: Case Report | First Published: August 29, 2022
Leiomyosarcomas (LMS) are rare tumors associated with poor outcomes. Treatment of the condition is challenging due to limited cases in the literature. Here, we present a case of a 46-year-old male who presented with left lower limb deep vein thrombosis, with an ultrasound scan revealing a right renal mass. MRI demonstrated a large, well-circumscribed lesion engulfing the middle and lower right renal poles associated with an invasion of the related part of the inferior vena cava (IVC), right rena...
Open Access DOI:10.23937/2643-4563/1710044
Carcinoma Breast: Correlation of Immunohistohemical Expression of Cyclin D1 and Its Correlation with Clinicopathological Parameters in Indian Patients at Tertiary Care Hospital
Ritu Mehta and Rashmi Yadav
Article Type: Original Article | First Published: August 29, 2022
To study the prevalence of Cyclin D1 expression and its correlation with other clinicopathological parameters like age, tumor size, lymph node status, MBR grade, and expression of other immunohistochemical markers like ER, PR, Her 2 - neu, and Ki67. Thirty cases diagnosed were included in the study. All the cases were subjected to routine histopathology along with IHC for ER PR, Her2-neu, Ki67, and Cyclin D1....
Open Access DOI:10.23937/2643-4563/1710043
Feasibility and Value of Salivary Cortisol Sampling to Reflect Distress in Head and Neck Cancer Patients Undergoing Chemoradiation: A Proof-of-Concept Study
Karishma Chhabria, MPH, PhD, Mark Bonnen, MD, Joshua Asper, PA-C, Giselle D Carnaby, MPH, PhD
Article Type: Systematic Review | First Published: September 12, 2022
Head and neck cancer (HNC) patients undergoing chemo/radiation commonly experience severe and persistent distress associated with treatment related fear and physical side effects such as xerostomia, dysphagia, and dryness of mouth. Cortisol, a stress sensitive hormone, can be easily measured in saliva to reflect biobehavioral responses to such stressors. Unfortunately, it has not been used in this population due to concerns associated with chemoradiation (C/RT) related xerostomia....
Open Access DOI:10.23937/2643-4563/1710042
Breast Cancer in Men: A Systematic Review of the Literature from the Arab World
Pierre El Sett, Georges Jammal, Antoine El Sett, Ronaldo Elkaddoum, Hampig Raphael Kourie
Article Type: Systematic Review | First Published: July 29, 2022
Breast Cancer (BC) is the most frequent cancer worldwide accounting for 11.7% of all cancers but only for 1% of men’s cancers; therefore, men’s breast cancer is rarely discussed, especially in the Arab World. This review, the first of its kind in the region, aims at reporting current trends in the epidemiology of BC in men, based on studies from the Arab region....
Open Access DOI:10.23937/2643-4563/1710039
Surgery of Oncologic Surgical Pathologies during the COVID-19 Pandemic: The Ordeal of the Oncologic Patient
María Mercedes de la Torre-Bustamante, Juan Felipe Casabon-Pastrana, Diego Alejandro Largo- Cordoba, Diego Armando Gomajoa-Guerrero and Michael Gregorio Ortega-Sierra
Article Type: Editorial | First Published: March 24, 2022
The COVID-19 pandemic has been one of the worst global public health crises of the 21st century. Global health was strongly affected by the dynamics of nations in the face of measures to contain the SARS-Cov-2 infection, such as confinement and redistribution of resources, which delayed the diagnosis and treatment of a large number of diseases, negatively modifying the prognosis and quality of life of these patients. The burden of surgical and oncological diseases is currently very high, and its...
Open Access DOI:10.23937/2643-4563/1710038
Prognostic Value of the Ki67 Proliferation Index, CD10 and MUM1 in Follicular Lymphoma
Minh Phuong Vu, Thanh Vui Le and Van Oanh Kieu
Article Type: Original Article | First Published: March 24, 2022
Follicular lymphoma (FL) is an indolent lymphoma and is associated with a long survival time. However, there are patients who had an early progression after standard therapy. Our aim was to analyze the prognostic value of Ki67, CD10 and MUM1 expression in FL. Immunohistochemical staining for Ki67, CD10 and MUM1 was performed on formalin-fixed paraffinembedded biopsy tissues from 27 patients with FL. Patients were grouped according to the levels of the Ki67 proliferation index (PI). Survival time...
Open Access DOI:10.23937/2643-4563/1710037
Impacts of Genetic Polymorphisms on Breast Cancer
Hafez Ahmed and Mohamed Hussein
Article Type: Review Article | First Published: March 16, 2022
Breast cancer (BC), a malignant proliferation of the epithelial cells that line the ducts or lobules of the breast, is the most common malignancy in women, accounting for approximately one-third of all cancers in women worldwide. According to its death rate, it is the second most frequent cancer causing mortality for women worldwide. Polymorphism involves one of two or more variants of a particular DNA sequence. The most common type of polymorphism involves variation at a single base pair. In re...
Open Access DOI:10.23937/2643-4563/1710034
Cell Proliferation, Contact Inhibition, and Apoptosis Profiling in a Benign and Malignant Breast Lesion
Olakayode V Ekundina, Chiamaka C Ejelue, Ondokeyi P Apulu and Ore-oluwa O Ayodele
Article Type: Original Article | First Published: January 29, 2022
Monitoring and diagnosis of benign or premalignant breast lesions as it progresses to a malignant condition is very necessary for its ability to predict or curb the progression of a breast lesion to the malignant condition and Immunohistochemistry has been proven to be a useful tool in achieving this as immunohistochemical markers are corresponding and specific in nature. The primary objective of this case-control study is to study the expression of KI67, E-cadherin, and P53 in normal breast tis...
Open Access DOI:10.23937/2643-4563/1710036
Bladder Neuroendocrine Carcinoma: About Five Cases and Review of the Literature
Maryam Zaouit, Farida Marnissi, Hassan Jouhadi, Nadia Benchekroun, Asma Elkbir, Souha Sahraoui and Abdellatif Benider
Article Type: Case series | First Published: February 07, 2022
This is a retrospective descriptive study of five cases of neuroendocrine carcinoma of the bladder collected at the Mohammed VI Center, between January 2017 and December 2020. The diagnosis was confirmed by immunohistochemical study. The median age is 61 years (extremes: 36-73 years), all patients are male. The average delay of consultation is 7 months (extremes: 2-12 months). Chronic smoking was found in three patients. Hematuria was the cardinal sign in 4 cases. Irritative urinary disorders su...
Open Access DOI:10.23937/2643-4563/1710035
Relationship between Awareness of Healthy Lifestyle and Perception of Breast Cancer among Women of Reproductive Age
Yeliz VARIŞOĞLU, PhD and Pınar IRMAK VURAL, PhD
Article Type: Original Article | First Published: January 31, 2022
The aim of this study was to determine the relationship between awareness of healthy lifestyle and breast cancer perception among women of reproductive age. This descriptive co relational study was conducted on 642 women. Data were collected using the sociodemographic data form, the Healthy Lifestyle Awareness Scale (HLAS), and the Breast Cancer Perception Scale (BCPS). A moderate, significant, and positive correlation was found between the HLAS total score and the scores obtained from the BCPS ...
Open Access DOI:10.23937/2643-4563/1710033
Prognostic Utility of Targeted Circulating Cell-Free DNA versus Formalin-Fixed Paraffin-Embedded DNA Mutation Analysis for Advanced Lung Cancer
Madli Tamm, Mart Kals, Tarmo Annilo, Kersti Oselin, Katrin Keerma, Paula Ann Kivistik, Miriam Nurm, Margot Saare, Jana Jaal and Neeme Tõnisson
Article Type: Original Article | First Published: January 23, 2022
Cancer burden is a globally growing problem. Early diagnosis and targeted treatment decrease patients’ death rate, pain, and treatment expenses. Liquid biopsy can be used for early cancer detection, treatment selection, and progression and treatment response monitoring. We evaluated the performance of circulating cell-free DNA (cfDNA) and formalin-fixed paraffin-embedded (FFPE) tissue DNA analyses using a commonly employed targeted therapeutic pathway in predicting the outcomes of patients wit...
