International Journal of

Oncology ResearchISSN: 2643-4563

Early Online

 Open Access DOI:10.23937/2643-4563/1710041

Vulvar Biopsy as a Key for the Diagnosis of Langerhans Cell Histiocytosis with Multifocal Involvement: Case Report and Review of Literature

Sandra M Buitrago, Carolina Morante C, Laura Hernandez, Martha C Mendez

Article Type: Clinical Case | First Published: June 30, 2022

Langerhans cell histiocytosis is a rare disease and due to its heterogeneous presentation represents a diagnostic and therapeutic challenge. We present the case of a patient with diabetes insipid us and panhypopituitarism, with the appearance of painful vulvar ulcers. The vulvar biopsy confirmed Langerhans cell histiocytosis with spreading to multiple organs, so it was decided to start chemotherapy, achieving the complete elimination of all lesions....

 Open Access DOI:10.23937/2643-4563/1710040

Epidemiological Profile and Therapeutic Results of Brain Metastases after Encephalic Radiotherapy in Toto

M Zaouit, N Benchakroun, Z Bouchbika, H Jouhadi, N Tawfiq, S Sahraoui, and A Benider

Article Type: Abstract | First Published: June 30, 2022

Brain metastases are considered to be the most common malignant brain tumors in adults, and constitute a major challenge in oncology. The objective of our study is to analyze the epidemiological, clinical and paraclinical parameters of patients with brain metastases and treated by encephalic radiotherapy during the year 2020 at the Mohamed VI center of the Ibn Rochd CHU....

 Open Access DOI:10.23937/2643-4563/1710039

Surgery of Oncologic Surgical Pathologies during the COVID-19 Pandemic: The Ordeal of the Oncologic Patient

María Mercedes de la Torre-Bustamante, Juan Felipe Casabon-Pastrana, Diego Alejandro Largo- Cordoba, Diego Armando Gomajoa-Guerrero and Michael Gregorio Ortega-Sierra

Article Type: Editorial | First Published: March 24, 2022

The COVID-19 pandemic has been one of the worst global public health crises of the 21st century. Global health was strongly affected by the dynamics of nations in the face of measures to contain the SARS-Cov-2 infection, such as confinement and redistribution of resources, which delayed the diagnosis and treatment of a large number of diseases, negatively modifying the prognosis and quality of life of these patients. The burden of surgical and oncological diseases is currently very high, and its...

 Open Access DOI:10.23937/2643-4563/1710038

Prognostic Value of the Ki67 Proliferation Index, CD10 and MUM1 in Follicular Lymphoma

Minh Phuong Vu, Thanh Vui Le and Van Oanh Kieu

Article Type: Original Article | First Published: March 24, 2022

Follicular lymphoma (FL) is an indolent lymphoma and is associated with a long survival time. However, there are patients who had an early progression after standard therapy. Our aim was to analyze the prognostic value of Ki67, CD10 and MUM1 expression in FL. Immunohistochemical staining for Ki67, CD10 and MUM1 was performed on formalin-fixed paraffinembedded biopsy tissues from 27 patients with FL. Patients were grouped according to the levels of the Ki67 proliferation index (PI). Survival time...

 Open Access DOI:10.23937/2643-4563/1710037

Impacts of Genetic Polymorphisms on Breast Cancer

Hafez Ahmed and Mohamed Hussein

Article Type: Review Article | First Published: March 16, 2022

Breast cancer (BC), a malignant proliferation of the epithelial cells that line the ducts or lobules of the breast, is the most common malignancy in women, accounting for approximately one-third of all cancers in women worldwide. According to its death rate, it is the second most frequent cancer causing mortality for women worldwide. Polymorphism involves one of two or more variants of a particular DNA sequence. The most common type of polymorphism involves variation at a single base pair. In re...

 Open Access DOI:10.23937/2643-4563/1710034

Cell Proliferation, Contact Inhibition, and Apoptosis Profiling in a Benign and Malignant Breast Lesion

Olakayode V Ekundina, Chiamaka C Ejelue, Ondokeyi P Apulu and Ore-oluwa O Ayodele

Article Type: Original Article | First Published: January 29, 2022

Monitoring and diagnosis of benign or premalignant breast lesions as it progresses to a malignant condition is very necessary for its ability to predict or curb the progression of a breast lesion to the malignant condition and Immunohistochemistry has been proven to be a useful tool in achieving this as immunohistochemical markers are corresponding and specific in nature. The primary objective of this case-control study is to study the expression of KI67, E-cadherin, and P53 in normal breast tis...

 Open Access DOI:10.23937/2643-4563/1710036

Bladder Neuroendocrine Carcinoma: About Five Cases and Review of the Literature

Maryam Zaouit, Farida Marnissi, Hassan Jouhadi, Nadia Benchekroun, Asma Elkbir, Souha Sahraoui and Abdellatif Benider

Article Type: Case series | First Published: February 07, 2022

This is a retrospective descriptive study of five cases of neuroendocrine carcinoma of the bladder collected at the Mohammed VI Center, between January 2017 and December 2020. The diagnosis was confirmed by immunohistochemical study. The median age is 61 years (extremes: 36-73 years), all patients are male. The average delay of consultation is 7 months (extremes: 2-12 months). Chronic smoking was found in three patients. Hematuria was the cardinal sign in 4 cases. Irritative urinary disorders su...

 Open Access DOI:10.23937/2643-4563/1710035

Relationship between Awareness of Healthy Lifestyle and Perception of Breast Cancer among Women of Reproductive Age

Yeliz VARIŞOĞLU, PhD and Pınar IRMAK VURAL, PhD

Article Type: Original Article | First Published: January 31, 2022

The aim of this study was to determine the relationship between awareness of healthy lifestyle and breast cancer perception among women of reproductive age. This descriptive co relational study was conducted on 642 women. Data were collected using the sociodemographic data form, the Healthy Lifestyle Awareness Scale (HLAS), and the Breast Cancer Perception Scale (BCPS). A moderate, significant, and positive correlation was found between the HLAS total score and the scores obtained from the BCPS ...

 Open Access DOI:10.23937/2643-4563/1710033

Prognostic Utility of Targeted Circulating Cell-Free DNA versus Formalin-Fixed Paraffin-Embedded DNA Mutation Analysis for Advanced Lung Cancer

Madli Tamm, Mart Kals, Tarmo Annilo, Kersti Oselin, Katrin Keerma, Paula Ann Kivistik, Miriam Nurm, Margot Saare, Jana Jaal and Neeme Tõnisson

Article Type: Original Article | First Published: January 23, 2022

Cancer burden is a globally growing problem. Early diagnosis and targeted treatment decrease patients’ death rate, pain, and treatment expenses. Liquid biopsy can be used for early cancer detection, treatment selection, and progression and treatment response monitoring. We evaluated the performance of circulating cell-free DNA (cfDNA) and formalin-fixed paraffin-embedded (FFPE) tissue DNA analyses using a commonly employed targeted therapeutic pathway in predicting the outcomes of patients wit...

Volume 5
Issue 1