International Journal of

Oncology ResearchISSN: 2643-4563

Early Online

 Open Access DOI:10.23937/2643-4563/1710017

Pharmacokinetics of Oxaliplatin in a Hemodialysis Patient with Metastatic Colon Cancer

Yoshiaki Nagatani, Yoshinori Imamura, Tsutomu Nakamura, Kazuhiko Yamashita, Mamoru Okuno, Hiroyuki Yasui, Jun Hiraoka, Riho Niigata, Keiji Kono, Yasuko Hyogo, Hirotaka Suto, Kei Takenaka, Yohei Funakoshi, Masanori Toyoda, Naomi Kiyota and Hironobu Minami

Article Type: Original Article | First Published: September 16, 2019

Although oxaliplatin is one of the main anticancer agents used against colorectal cancer, data on the pharmacokinetics of oxaliplatin in patients on hemodialysis are limited. In this case study, we evaluated the pharmacokinetics and safety of oxaliplatin in a patient on hemodialysis treated for colon cancer. A 68-year-old Japanese woman receiving chronic hemodialysis was treated for metastatic colon cancer with modified FOLFOX6 plus bevacizumab every 2 weeks. Initial oxaliplatin dose was reduc...

 Open Access DOI:10.23937/2643-4563/1710016

Nimotuzumab in Advanced Cervical Cancer: Safety and Efficacy Profile

Raiza Ruiz Lorente, Sayly Alfonso, Yamilka Sanchez, Carmen Elena Viada, Ramon Ortiz, Mayelin Troche, Meylan Cepeda, Ana Rosa Vals, Leticia Cabrera, Annia Gorte, Delmis Maira Batista, Milagros Domenech, Jessica Garcia Viamontes, Conrado Ramos Mico and Mayra Ramos Suzarte

Article Type: Review Article | First Published: July 29, 2019

The EGF receptor is over expressed in tumors of epithelial origin and is associated with a poor prognosis of the disease. An Expanded Clinical Access Program was carried out, in which patients with cervical uterine cancer in advanced stages of the disease without another therapeutic alternative were treated with nimotuzumab, anti-epidermal growth factor receptor humanized monoclonal antibody to evaluate the safety and efficacy of this therapy. Seventy-five patients with confirmed histological di...

 Open Access DOI:10.23937/2643-4563/1710015

Impact of the Number of Dissected Axillary Lymph Nodes on Survival in Breast Cancer Patients

Emad Eldin Nabil, Ahmed M Maklad, Ashraf Elyamany, Emad Gomaa and Moamen M Ali

Article Type: Research Article | First Published: June 05, 2019

For patients with breast cancer, axillary dissection was a standard treatment, especially with patient with positive metastases in the sentinel nodes. For some patients axillary dissection might be over-treatment, including those who have had a mastectomy. Especially with the new trend of many radiation-therapy centers, provide radiation-therapy for any number of positive lymph nodes. The aim of our work is to evaluate the impact of number of dissected axillary Lymph Nodes (LN), on Overall Survi...

 Open Access DOI:10.23937/2643-4563/1710014

Atypical Presentation of Denny-Brown Syndrome: A Case Report and Review of Literature

Romeo V Porlas Jr, MD, Scott Riley K Ong, MD, Gerard Raimon Saranza, MD, FPNA and Jose Paciano B Reyes, MD, FPNA

Article Type: Case Report | First Published: June 01, 2019

Paraneoplastic subacute sensory Denny-Brown neuronopathy affects the peripheral nervous system and commonly associated with small cell lung carcinoma and with other tumor types in 14.4% of cases. Presented is a case of 23, female with progressive numbness of extremities and ataxia. Investigations showed diffuse sensory neuronopathy and elevated CSF IgG on CSF studies. Paraneoplastic autoantibodies revealed negative results yet imaging showed an anterior mediastinal mass, which turned B-c...

 Open Access DOI:10.23937/2643-4563/1710013

Prostatic Ductal Adenocarcinoma: An Unusual Subtype of Prostate Cancer

Dinesh Kumar, MBBS, MS and John Lobo, MD

Article Type: Case Report | First Published: May 25, 2019

Ductal adenocarcinoma of the prostate (DAP) is defined as malignant epithelial cells filling large prostatic acini ducts, with preservation of basal cells forming either solid or dense cribriform patterns or a loose cribriform or micropapillary pattern with either marked nuclear atypia (nuclear size six times normal or larger) or Nonfocal comedonecrosis. DAP is a rare variant of prostate cancer, and has poorly-identified clinical characteristics....

 Open Access DOI:10.23937/2643-4563/1710012

Hydropneumopericardium: Unusual Complication of Proton Radiotherapy

Nakamura Yasuhiro, MD

Article Type: Clinical Image | First Published: May 13, 2019

Hydropnemopericardium is a very rare condition, which arises from penetrating trauma or blunt chest injury, development secondary to procedures, fistulization from adjacent structures and pericardial infections. This patient was 60-year-old man with hepatocellular carcinoma (HCC) presented to outpatients clinic with stomach pain, fatigue and anorexia. The patient was afebrile but laboratory profile manifested an excessive inflammatory response and disseminated intravascular coagulation. We detec...

Volume 2
Issue 1