International Journal of Allergy Medications is a peer-reviewed open access journal that presents the latest advances in the Allergy research and it's Medication. It acts as a great platform for clinical researchers and health care practitioners to present their work in the form of original, research, reviews, commentaries, shorts communications, letters, oral presentations and case studies.
International Journal of Allergy Medications covers different aspects of allergy viz. Allergy, Irritant Induced Asthma, Allergic Rhinitis, Allergy Associated Skin Tests and Treatment, Allergy Test Results Scale, Asthma and Anesthesia and its Related Allergy, Asthma, Atopic Dermatitis, Chronic Obstructive Pulmonary Disease (COPD) Allied Inflammation, Clinical Immunology, Drug Allergies, Ethanol Associated Allergy, Food Allergy, Hypersensitivity, Oil and Vitamin Associated Inflammation, Pollen Allergy, Reactive Airways Dysfunction Syndrome, Reactive Attachment Disorder (RADS) Syndrome, Saliva Allergy, etc. All the submitted articles pass through a rapid peer - review process. It allows publication of high quality articles under the supervision of eminent and experienced editorial board members.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2572-3308.1510041
S Aissani, I Ararem, H Haouichat, ME Haffaf and A Zitouni
Article Type: Research Article | First Published: June 06, 2019
Premenstrual asthma (APM) is often confused by the patient and/or doctor with the symptoms of asthma in general. The purpose of our study is to investigate the clinical and spirometric characteristics of APM. Prospective descriptive study from 2011 to 2017, on 95 non-menopausal asthma patients, divided into 2 with and without APM. They benefited on a single menstrual cycle of spirometry during the follicular phase, luteal and premenstrual and cutaneous tests....
Open Access DOI:10.23937/2572-3308.1510040
Omar E Mohamed, Toni Osborne, Jane Heslegrave and Mamidipudi Thirumala Krishna
Article Type: Case Report | First Published: May 25, 2019
A 57-year-old gentleman of an Asian background developed generalised urticaria, breathlessness and loss of consciousness following ingestion of Singoda flour (water caltrop flour). He was successfully resuscitated with adrenaline, chlorpheniramine and hydrocortisone. Acute mast cell tryptase was elevated and the skin prick test to water caltrop seed was positive. ...
Open Access DOI:10.23937/2572-3308.1510039
Article Type: Short Communication | First Published: May 25, 2019
Airway colonization with Aspergillus species, typically A. fumigatus, is frequent among cystic fibrosis (CF) patients. A subgroup of the patients develops allergic bronchopulmonary aspergillosis (ABPA) - an immunological reaction directed against the fungal infection with serious clinical consequences for the patients. Between one and 15% of the CF population is reported to be affected by ABPA....
Open Access DOI:10.23937/2572-3308.1510038
Germain N, Gerth van Wijk R, Aballea S, Abetz-Webb L, Domdey A, Romano M and Toumi M
Article Type: Research Article | First Published: April 03, 2019
Allergic rhinitis is a major chronic respiratory disease that affects between 10% and 30% of adults and up to 40% of children globally. The purpose of this study was to understand the impact of allergic rhinitis and subsequent GRAZAX grass allergy immunotherapy (AIT) treatment on adults' and adolescents' quality of life. Clinicians treating allergic rhinitis in the Netherlands and Germany recruited adults and adolescents who had received at least 3 years of GRAZAX® treatment. Telephone intervie...
Open Access DOI:10.23937/2572-3308.1510037
Luisa Ricciardi, Fabiana Furci and Isola Stefania
Article Type: REVIEW ARTICLE | First Published: March 04, 2019
Histamine is a chemical messenger synthesized from the amino acid histidine by L-histidine decarboxylase. It plays an important role in the system of immunoregulation and in acute and chronic allergic inflammation binding to four subtypes of receptors H1, H2, H3 and H4, described as heptahelical transmembrane molecules that activate specific G-proteins. These receptors placed on the membranes of different cellular jambs (mast cells, endothelial cells, sensory nerve fibres, bronchial smooth muscl...
Open Access DOI:10.23937/2572-3308.1510036
Becerril-Bautista Baltazar, Jimenez-Uscanga Ruben Dario, Vargas-Camano Maria Eugenia, Cesar Daniel Alonso-Bello, Lozano-Patino Fernando, Sanchez-Leon Maria del Carmen, Juarez-Santiago Lucero and Maria Isabel Castrejon-Vazquez
Article Type: Original Article | First Published: October 17, 2018
Allergic rhinitis (AR) is an inflammatory disease mediated by immunoglobulin E (IgE) following exposure of the nasal mucosa to an allergen. Glycophosphopeptical (GFP) is a molecule composed of polysaccharides of fungal origin and proteins of vegetal origin, adsorbed in an inorganic phosphate-sulfate-calcium matrix, stimulates the innate immunity, during infectious processes. The objective of the study was to analyze the clinical response of specific immunotherapy (SIT) and the use of GFP in pati...
Open Access DOI:10.23937/2572-3308.1510035
Farrukh Sheikh, Safiah Sumayli, Hasan Hakami, Agha M Rehan Khaliq, Sulaiman Al Gazlan, Hasan Alrayes, Ghuzayel Al-Dawsari, Riad El Fakih and Rand Arnaout
Article Type: Short Communication | First Published: September 22, 2018
We report the first case of severe intractable thrombocytopenia in a patient with adenosine deaminase deficiency, Severe Combined Immune Deficiency (SCID), necessitating hematopoietic stem cell transplant. This patient developed severe thrombocytopenia from polyethylene glycol adenosine deaminase and needed a hematopoietic stem cell transplant as an adolescent. She did well afterwards, overall. Although rare, thrombocytopenia can result from polyethylene glycol adenosine deaminase. Hematopoietic...
Open Access DOI:10.23937/2572-3308.1510034
Katharine J Foster, Jonathan Rodrigues, Julia Lee, Sara Powell, Roua Azmeh and Alan P Knutsen
Article Type: Research Article | First Published: August 18, 2018
Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome (PFAPA) is characterized by periodic cyclical fever, cervical adenopathy, pharyngitis, and aphthous stomatitis. Administration of oral corticosteroids at the onset of fever is the current initial treatment. Tonsillectomy resolves PFAPA symptoms in 50-100% of patients....
Open Access DOI:10.23937/2572-3308.1510033
Article Type: Case Report | First Published: August 13, 2018
According to the traditional concept of the contemporary Immunology, neither autoimmune diseases nor allergic diseases can be cured completely. Nevertheless, a fortunate coincidence led the author to discover a novel concept that eliminations of the causes of these diseases are possible. In other words, combinations of pathogenic antibodies with responsible cells, namely, cytolytic T lymphocytes in cases of autoimmune diseases and mast cells in cases of allergic diseases, can be decomposed by re...
Open Access DOI:10.23937/2572-3308.1510032
Angel San Miguel-RodrIguez, Alicia Armentia, Sara MartIn-Armentia, Blanca MartIn-Armentia, Mª Carmen Lozano Estevan and Irene Iglesias Peinado
Article Type: Original Article | First Published: August 08, 2018
Allergic drug reactions (ADR) are the third most common reason for consultation in allergy services. Epidemiological data are imprecise. Globally, ADR affect 10-20% of hospitalized patients and up to 7% of outpatients. However, this might be an underestimate due to underreporting, or an overestimate due to unexplained reactions often being classified as "allergic". ...
Open Access DOI:10.23937/2572-3308.1510031
Farrukh Sheikh, Agha M Rehan Khaliq, Qasim A Sheikh, Abdul Hadi Al Qahtani, Samia Al Hashim, Rand Arnaout and Rashid Amin
Article Type: Research Article | First Published: August 06, 2018
Vitamin D has immunomodulatory properties. Most of the evidence points towards a causal association between low vitamin D levels and the development of asthma and allergy but the results are not conclusive. We studied the vitamin D levels of patients with anaphylaxis and compared them to previously published vitamin D levels in the Saudi population....
Open Access DOI:10.23937/2572-3308.1510030
Rezan Akpinar and Saliha Karatay
Article Type: Literature Review | First Published: July 06, 2018
Atopic dermatitis, or allergic eczema, is a chronic inflammatory skin condition which is noncontagious and leads to itchy, dry skin lesions that can damage the intact skin barrier. Although the etiology is not known, it is widely believed that family history and allergies play a role. The incidence of atopic dermatitis is usually higher in early childhood, while other allergic conditions can develop later in life, such as allergic rhinitis and asthma. Atopic dermatitis is typically treated throu...
Open Access DOI:10.23937/2572-3308.1510029
Carlos Alberto Sanchez Salguero, Alvaro Isidro Sanchez Chacon and Patricia Ceballos Chacon
Article Type: Research Article | First Published: June 27, 2018
Egg allergy is the most common cause of food allergy in children under the age of 5, with a prevalence of 0.5-2.5%. In general, its prognosis is good; since in most cases tolerance is achieved within the early life in young children after following a exclusion diet. Alternatively, oral immunotherapy (OIT) or tolerance induction may be contemplated....
Open Access DOI:10.23937/2572-3308.1510028
Carlos Alberto Sanchez Salguero and Alvaro Isidro Sanchez Chacon
Article Type: Review Article | First Published: June 25, 2018
Atopic Dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an immune mechanism. It appears in genetically predisposed children in whom hypersensitivity reactions to varied antigens (food, neumoalergens, bacterial proteins), release inflammatory mediators that lead to the development of eczematous skin lesions. It diagnosis is eminently clinical being the criteria of Hanifin-Rajka of 1980 the most used....
Open Access DOI:10.23937/2572-3308.1510027
Article Type: Short Communication | First Published: June 07, 2018
In pediatric population, it manifests with isolated skin mastocytoma, a red brown papule and nodule that may urticate (Darier's sign) or with multiple and diffuse similar lesions as observed in urticaria pigmentosa. Both condition usually remains localized to the skin and spontaneously regresses with age. In infants less than 3 year, it is also described a rare diffuse cutaneous mastocytosis with erythrodermia and bullous lesions....
Open Access DOI:10.23937/2572-3308.1510026
Evgeni Stanev and Maria Dencheva
Article Type: Case Report | First Published: April 14, 2018
We report the case of a 23-years-old female dental medicine student with contact dermatitis on her hands caused by methacrylates. Forty-eight-hour closed patch testing showed positive reactions to Ethylenglicol dimethacrylate, 1,6-Hexanediol diacrylate, 1,4-Butanediol dimethacrylate, Drometrizole. These are identified as contact allergens. They can be found in the dental materials, but also in the nail polish....
Open Access DOI:10.23937/2572-3308/1510025
Grazyna Rowicka, Malgorzata Strucinska, Agnieszka Riahi and Halina Weker
Article Type: Research Article | First Published: November 29, 2017
Children with Cow's Milk Protein Allergy (CMPA), treated with a milk-free diet, may be at risk of deficiency of nutrients important for appropriate development. The aim of the study was to evaluate the diets and the nutritional status of children with CMPA....
Open Access DOI:10.23937/2572-3308.1510024
Michael Malone and Tara M Kennedy
Article Type: Review Article | First Published: March 27, 2017
A literature search was undertaken. We searched the databases of Pubmed, MEDLINE, EMBASE databases, and Cochrane Library from 1990 to October 2016, using key words: Allergy, Medications, Antihistamines, Decongestants, Montelukast, Side effects, Adverse Events, Adverse, Effects, Zinc, Steroids, Pregnancy, Reviews, RCT, and Case Report....
Open Access DOI:10.23937/2572-3308.1510023
Sheel Patel, Usama Hanhan, Caroline Perkowski and James Orlowski
Article Type: Case Report | First Published: March 21, 2017
Asthma is a chronic inflammatory condition of the airways characterized by airflow obstruction, caused by bronchoconstriction, airway edema, acute inflammation and increased secretions, most commonly treated with albuterol. Albuterol functions by activating beta-2-adrenergic receptors on airway smooth muscles stimulating adenyl cyclase and increasing production of C-AMP causing relaxation of the smooth muscle and bronchodilation....
Open Access DOI:10.23937/2572-3308.1510022
Munyaradzi Mukesi, Ingenecie N Phillipus, Sylvester R Moyo and Owen PL Mtambo
Article Type: Research Article | First Published: February 13, 2017
Skin allergy is a type of allergy that results in skin lesions due to reactions that occur in the immune system when the body is exposed to allergens. There are several types of skin allergies which include atopic dermatitis, contact dermatitis, urticaria, angioedema and hay fever. However, there is little known about skin allergy in Namibia as no studies have ever been done on this condition among adolescents in the country....
Open Access DOI:10.23937/2572-3308.1510021
Mariko Sugiura and Keiji Sugiura
Article Type: Case Report | First Published: November 28, 2016
We report the case of a 63-year-old female homemaker with contact dermatitis on her hands caused by extract of Tanacetum parthenium (feverfew). Forty-eight-hour closed patch testing showed positive reactions to sesquiterpene lactone mix (0.1% pet) and extract of Tanacetum parthenium (0.2%). The extract, sesquiterpene lactones of Tanacetum parthenium, is identified as a contact allergen. A member of the chrysanthemum family, feverfew is common worldwide, and there are many products that include e...
Open Access DOI:10.23937/2572-3308.1510020
Balakrishnan Menon, Charanjeet Kaur, Harsh Vardhan, Arya Gopi and Md Yousoof Dar
Article Type: Research Article | First Published: September 30, 2016
The role of systemic inflammation in COPD has been proved in recent studies. It is associated with increased level of inflammatory cytokines such as IL-6 (Interleukin 6) & inflammatory mediators such as hs-CRP (high sensitivity C Reactive Protein). There is also extensive evidence supporting the action of vitamin D in immunity & inflammation. Low blood levels of 25-hydroxyvitamin D have been associated with a higher risk of respiratory infections in general populations and higher risk of exacerb...
Open Access DOI:10.23937/2572-3308.1510019
Rauna Fanuel Kandowishi, Munyaradzi Mukesi, Sylvester Rodgers Moyo and Kang Erxun
Article Type: Research Article | First Published: August 02, 2016
The aetiology of atopic dermatitis remains poorly understood in Namibia despite considerable research in other developing and developed countries. Although there is growing knowledge about factors that may predispose to the onset of atopic dermatitis (AD), as well as factors which may exacerbate existing disease among school children in Namibia very little is known about the epidemiology of atopic dermatitis (AD), and studies from Southern Africa and Namibia in particular are limited. The resear...
Open Access DOI:10.23937/2572-3308.1510018
Carlos Alberto Sanchez Salguero and Alvaro Isidro Sanchez Chacon
Article Type: Mini Review | First Published: July 01, 2016
Objective: The aim of this study was to evaluate the safety and efficacy of oral rush desensitization in children with cow milk allergy. Material and methods: Prospective study: We included IgE-mediated cow milk allergy children over 3 years in 3 Spanish hospitals. Increasing doses of cow milk for 5 days from 1cc of 1% to 200 cc of pure milk were administered. Clinical follow-up was conducted and we compared specific IgE levels at onset, 6, 12 and 24 months after desensitization. ...
Open Access DOI:10.23937/2572-3308.1510017
Isaac Melamed and Melinda Heffron
Article Type: Mini Review | First Published: July 01, 2016
The association between ADHD and allergy remains controversial. Our previous findings suggest that nerve growth factor may link the nervous and immune systems. The primary objective of this study was to determine if a combination of cetirizine + methylphenidate is effective in children with comorbid ADHD and allergic rhinitis. We also examined the role of nerve growth factor in these comorbidities. Our randomized, double-blind, placebo-controlled, crossover study enrolled 38 children diagnosed w...
Open Access DOI:10.23937/2572-3308.1510016
Carlos Alberto Sanchez Salguero and Alvaro Isidro Sanchez Chacon
Article Type: Mini Review | First Published: April 30, 2016
The hereditary angioedema due to C1 inhibitor deficiency (C1 esterase inhibitor), is classified in two types and is considered a disease, included in the group of rare diseases, which usually occurs during childhood and adolescence with intermittent attacks of angioedema that can endanger the patient's life. The diagnosis should be possible as early as we should avoid establishing ineffective treatments, and always seek the best treatment for inflammation. There have been several expert meetings...
Open Access DOI:10.23937/2572-3308.1510015
Paola L Smaldini and Guillermo H Docena
Article Type: Mini Review | First Published: March 31, 2016
Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and the potential for fatal anaphylaxis during accidental exposure to the allergen. The current treatment remains strict avoidance, although the disease is not cured. Allergen specific immunotherapy for food allergy is currently being actively evaluated, but is still experimental. Nevertheless, it is the only disease-modifying therapy for IgE-mediated food allerg...
Open Access DOI:10.23937/2572-3308.1510014
Nucera Eleonora, Aruanno Arianna, Rizzi Angela, Giampietro Antonella, Cimino Vincenzo, De Marinis Laura and Schiavino Domenico
Article Type: Case Report | First Published: March 31, 2016
We report the case of a 4-year old girl, with idiopathic CPP and negative clinical history for allergic diseases, who experienced multiple episodes of erythematous rashes after 40-60 minutes from the subcutaneous administration of Decapeptyl (triptorelin). Every time her symptoms were treated with antihistamines and corticosteroids and receded in four days....
Open Access DOI:10.23937/2572-3308.1510013
Smolkin YS and Grishchenko EA
Article Type: Short Review | First Published: March 29, 2016
Healthy people are constantly exposed to foreign proteins but in contrast to allergic individuals they do not develop any immune response. Cornerstone of such difference is tolerance. Oral tolerance in allergic people is of highest priority. Oral tolerance is specific suppression of cellular and/or humoral immune responses to an antigen by prior administration of the antigen by the oral route. It may develop naturally or be allergen immunotherapy (AIT) induced....
Open Access DOI:10.23937/2572-3308.1510012
Rosa Gimenez-Garcia and MariaNunez-Cabezon
Article Type: Case Report | First Published: March 29, 2016
The term pemphigus refers to a group of autoimmune intraepidermal blistering diseases of skin and mucous membranes in which there is loss of adhesion between keratinocytes, following disruption of desmosomes, as a consequence of autoantibody binding to various antigens on the cell surface. Drug-induced pemphigus mimics idiopathic pemphigus clinically, histopathologically and immunologically. Exogenous factors as burns, UV radiation and X-rays can be involved in the development of pemphigus....
Open Access DOI:10.23937/2572-3308.1510011
Lin Kun and Li Li
Article Type: Review Article | First Published: January 10, 2016
Allergic disease is a prevalent clinical and public health problem, and is among the most common health issues worldwide. The therapeutic strategies include two major categories: allergen-specific immunotherapy (AIT) and non-specific therapies. AIT is associated with improved tolerance to allergen challenge, with a decrease in immediate-phase and late-phase allergic inflammation....
Open Access DOI:10.23937/2572-3308.1510010
Karl E Peace and Macaulay Okwuokenye
Article Type: Short Review | First Published: November 05, 2015
This brief communication provides information to those developing monitoring plans for serious adverse events (SAE's) following regulatory approval of a new drug. In addition, we (1) illustrate how many patients would need to be treated in order to have high confidence of seeing at least 1 pre-specified SAE, (2) show that absence of proof of a SAE is not proof of absence of that SAE, and (3) identify statistical methodology that could be used for formal statistical monitoring of SAE's....
Open Access DOI:10.23937/2572-3308.1510009
Jun Kido, Natsuko Nishi, Sachiko Misumi and Tomoaki Matsumoto
Article Type: Short Review | First Published: November 02, 2015
Recently, public interest in food allergies has been increasing because of increasing prevalence of these allergies among children. In Japan, hen egg and cow milk allergies account for nearly 50% of all cases of childhood food allergies. Patients with hen egg and cow milk allergies should avoid these foods and products that contain them until they have outgrown their allergies. However, regarding nutrition, quality of diet, and hyposensitization, it is significantly important for these patients ...
Open Access DOI:10.23937/2572-3308.1510008
Article Type: Review Article | First Published: September 11, 2015
Atopy can interfere with a child's life at any age level, with varying severity. Intractable diarrhea due to CM allergy (CMA) and AD are the most frequent in infants, where the clinical manifestations are more severe than in older children. Respiratory allergy and bronchial asthma can be serious illnesses in younger as well as in older children....
Open Access DOI:10.23937/2572-3308.1510007
Juan Luis Estrada-Rodriguez, Angel Rodriguez-Paredes, Margarita Latasa and Jose Luis Perez-Laiz
Article Type: Case Report | First Published: September 04, 2015
We notice a patient consulting for several eczema episodes related to topical ointments containing lidocaine. Study was made, and amyde-type local anesthetics cross-reactivity in this patient, is reported. Usefulness of different diagnostic tests is also discussed....
Open Access DOI:10.23937/2572-3308.1510006
Ozlem Yilmaz Ozbek
Article Type: Short Review | First Published: September 04, 2015
Anaphylaxis is a systemic, life-threatening reaction and immediate treatment is essential. The reaction can be fatal even with epinephrine injection. Epinephrine auto-injectors have been used in the emergency treatment of anaphylaxis since the 1980s. In this review, indications for the prescription, types, administration, and the problems with the use of epinephrine auto-injectors are discussed. The importance of patient and caregiver education is highlighted....
Open Access DOI:10.23937/2572-3308.1510005
Article Type: Editorial | First Published: July 22, 2015
In contrast to positively acting signaling elements/ pathways that are typically targeted by small-molecule inhibitors, attenuating/ inhibiting signaling proteins would have to be pharmacologically activated to accomplish suppression of cellular pro-inflammatory reactions. Indeed, the meroterpenoid pelorol identified in sponge extract was demonstrated to efficiently activate SHIP1 phosphatase function and structural analogs thereof exhibited even greater activity in cell and mouse models of infl...
Open Access DOI:10.23937/2572-3308.1510004
Article Type: Editorial | First Published: May 16, 2015
In this editorial, I describe the difficulties of diagnosing soy sauce allergies, since soy sauce produces histamine during brewing and storing. Some Japanese people develop irritation, itching and cellulitis after consuming foods with soy sauce. These symptoms could be caused by soy sauce allergy, histamine poisoning and/or other factors....
Open Access DOI:10.23937/2572-3308.1510003
Zihan Zheng and Xinyi Huang
Article Type: Review Article | First Published: April 15, 2015
Asthma is a complex chronic inflammatory disease of the airways that is of increasing prevalence. Many different cell types are critically involved in its pathogenesis, including several classes of T helper cells. These cells may serve to generally organize the asthmatic response by virtue of the cytokines and other factors they release, which trigger downstream effects on a wide variety of cells....
Open Access DOI:10.23937/2572-3308.1510002
Article Type: Editorial | First Published: February 23, 2015
The nasal allergic response is a complex process involving the interaction of many mediators. The current therapeutic strategy is mainly based on drugs (antihistamines, nasal corticosteroids, etc.) and allergen immunotherapy. The most effective medication in persistent rhinitis is topical corticosteroid, which decreases all symptoms. Antihistamines reduce nasal itch, sneeze and rhinorrhea....
Open Access DOI:10.23937/2572-3308.1510001
Arzu Didem Yalcin
Article Type: Editorial | First Published: February 16, 2015
Asthma is described as a complex disease arising from the contribution of multiple genetic and environmental factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment. At the end of 2010, 100 genes including IL-1R1,1RN, 3, 4, 5, 8RA, 9, 10, 12, 13, CTLA-4, and ADAM33, among others had been associated with asthma in six or more separate pop...
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