Allergic Rhinitis Medications
Department of Otolaryngology, Sapporo Medical University, Japan
*Corresponding author: Hideaki Shirasaki, Department of Otolaryngology, Sapporo Medical University, School of Medicine, Japan, E-mail: email@example.com
Int J Aller Medcations; Volume 1, Issue 1 Editorial IJAM-1-002e
Received: February 16, 2015: Accepted: February 20, 2015: Published: February 23, 2015
Citation: Shirasaki H (2015) Allergic Rhinitis Medications. Int J Aller Medcations 1:002e
Copyright: © 2015 Shirasaki H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cysteinyl leukotrienes, Allergic rhinitis, PAF, Thromboxane, Glucocorticoids
The nasal allergic response is a complex process involving the interaction of many mediators. The current therapeutic strategy is mainly based on drugs (antihistamines, nasal corticosteroids, etc.) and allergen immunotherapy. The most effective medication in persistent rhinitis is topical corticosteroid, which decreases all symptoms . Antihistamines reduce nasal itch, sneeze and rhinorrhea . Cysteinyl Leukotrienes (CysLTs) play an important role in allergic rhinitis because CysLT1 receptor antagonists relieve the symptoms of allergic rhinitis . CysLT1 receptor antagonists provide a new opportunity for simultaneous management of allergic diseases of the upper and lower respiratory tract. The combination therapy is more effective and acts more rapidly than either drug used alone. Ramatroban, a thromboxane A2 receptor antagonist with clinical efficacy in allergic rhinitis, was shown to also antagonize the prostaglandin D2 receptor CRTH2 [4,5]. In addition to other inflammatory mediators, PAF have a relevant participation in allergic inflammation . Rupatadine is a dual inhibitor of histamine H1 and PAF receptors, which has been shown to be an effective and generally well-tolerated treatment for allergic rhinitis and chronic urticaria. These medications for allergic rhinitis offer numerous options that are effective, and readily available to target specific nasal symptoms.
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