International Archives of Endocrinology Clinical Research is an open access peer reviewed journal that publishes articles in the field of endocrinology metabolism and clinical research. The journal mainly encompass the endocrine glands, its secretions and their coordination with metabolism.
International Archives of Endocrinology Clinical Research is a reliable source of information for the researcher and practitioners in the field of endocrinology such as Adrenal Disorders, Anti-obesity Drugs, Atypical Antipsych, Autoantibodies, Autoimmune Attack, Beta Cell Loss, Calcium Homeostasis Disorders, Comparative Endocrinology, Diabetes Insipidus, Diabetes Mellitus, Endocrine Emergencies, Endocrine Tumors, Endogenous Insulin, Gastric Balloon, Gestational Diabetes, Glucose Homeostasis, Histogenesis, Hormones, Hyperglycemia, Hypoglycemia, Ketoacidosis, Ketosis, Metabolism, Neonatal Diabetes, Neuroendocrinology, Obesity Risks, Organogenesis, Pediatric Endocrinology, Pituitary Gland Disorders, Reproductive Endocrinology, Sex hormone Disorders, Thyroid Disorders, etc. Two independent review comments followed by editor's decision will be considered to publish the article. IAECR is a permanent archive of endocrinology information under open access category provides its global readers with free access to its content, thus serving the scientific community.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2572-407X.1510036
Oluwarotimi B. Olopade, Ifedayo A. Odeniyi, Sekinat A. Adejumobi, Ifeyinwa N. Ijeh, Olufemi A Fasanmadeo and Atul Kalhan
Article Type: Systematic Review | First Published: 2024/01/19
A systematic review was conducted using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 guidelines. Six databases (PubMed, Scopus, Wiley Library, Embase, Cochrane database for systematic reviews and Google Scholar) were searched for relevant articles. The Distiller-SR software was used for journal screening, duplicate removal and data extraction....
Open Access DOI:10.23937/2572-407X.1510035
Richmond R Gomes and Habiba Akhter
Article Type: Case Report | First Published: 2023/12/30
Cushing syndrome (CS) is a rare disease that results from prolonged supraphysiologic tissue action of glucocorticoids. This can be caused by a tumor of the adrenal glands, the lungs or the pituitary gland. When a pituitary tumor produces too much ACTH (adrenocorticotropic hormone), it causes the overproduction of cortisol by the adrenal glands. When the pituitary is the source of the over production, it is called Cushing's disease. Cushing's disease (CD) remains a diagnostic and therapeutic chal...
Open Access DOI:10.23937/2572-407X.1510034
Fentahun Meseret, Silenat Muluken, Tilaye Gebru and Tsegasew Embiale
Article Type: Clinical Endocrinology | First Published: 2023/12/30
Length of hospital stay, complication and mortality are the primary outcomes that should be measured during diabetic ketoacidosis management. However, data associated with the length of stay, complications, and mortality rate due to diabetic ketoacidosis remains limited in Ethiopia. In addition, nonfiction is very scarce about factors associated with treatment outcomes starting from its initial presentation and the overall management process. ...
Open Access DOI:10.23937/2572-407X.1510033
Stephanie T Walls, BSc and Mary Ryan, MB BCH BAO MA TCD MD MRCP
Article Type: Case Report | First Published: March 27, 2023
A 47-year-old female was referred with elevated plasma thyroid stimulating hormone (TSH) levels. The patient reported increased hair loss and infrequent menstrual periods which is likely related to her recent significant weight loss and perimenopausal symptoms respectively. No other stigmata of thyroid disease were noted, and the patient appeared euthyroid clinically. ...
Open Access DOI:10.23937/2572-407X.1510032
Jia Wei Tan, MD, Sachin K Majumdar, MD
Article Type: Brief Report | First Published: December 11, 2022
To compare the Free Style Libre (FSL) 2 14- day Flash Glucose Monitoring (FGM) and Point-Of-Care Capillary (POC) Blood Glucose (BG) testing among critically ill patients who receive insulin infusion. We conducted an open-label, prospective study and enrolled stepdown or critical care unit patients on intravenous insulin. Paired POC and GCM values were obtained to calculate the Mean Absolute Relative Difference (MARD). Accuracy was further evaluated with error grid analysis between matched glucos...
Open Access DOI:10.23937/2572-407X.1510031
Selia Chowdhury, Mehedi Hasan Bappy, Md. Shahraj Chowdhury, Santiago Clocchiatti-Tuozzo, Muhammad Haseeb ul Rasool, Shreeya Desai, Catalina Sekzer and Pawan Kumar Thada
Article Type: Literature Review | First Published: May 31, 2022
Insulin is one of the greatest medical discoveries of the twentieth century and it continues to be the solitary effective treatment for type 1 diabetes mellitus patients and save millions of lives around the world. In 2021, we have rejoiced 100 years of insulin discovery....
Open Access DOI:10.23937/2572-407X.1510030
Ahmet GORGEL, Devrim DOLEK CETİNKAYA, Fusun SALGUR, Mustafa DEMIRPENCE, Husnu YILMAZ and Mitat BAHCECİ
Article Type: Research Article | First Published: April 14, 2022
The aim of our study is to evaluate the patients with adrenal incidentaloma in terms of clinical and endocrinological features and, to determine whether a correlation between the malignancy and preoperative tumor size via analyzing of the histopathological results of the masses. This study was performed on 320 patients (86 males, 234 females) with adrenal incidentaloma who visited our clinic during a period of 3 years. Chi-square test was used to categorize the patients according to their hormon...
Open Access DOI:10.23937/2572-407X.1510029
Arul Prakash Rajadurai
Article Type: Case Report | First Published: February 26, 2022
We present an interesting case of De Quervin’s Thyroiditis following Enteric fever with classical features of pain neck and hyperthyroidism ended up in Hypothyroidism. A 34-years-old women consulted surgeon for neck pain and swelling for 1 week, and expressed her fear of cancer of thyroid. She told that her distant relative had thyroid cancer. Surgeon noted a tender goitre, moving with deglutition, no nodules or nodes in the neck and mild features of hyperthyroidism like palpitation, tremor. H...
Open Access DOI:10.23937/2572-407X.1510028
I. Hallab, H.Titou, R. Frikh, N. Hjira and M. Boui
Article Type: Case Report | First Published: December 31, 2021
Diabetes bullosis is a chronic manifestation, a specific cutaneous marker, of diabetes mellitus essentially insulindependent. It is very rare. Its etiology is still unknown. It is seen more frequently in long-standing diabetic patients commonly with peripheral neuropathy, retinopathy, or nephropathy. The lesions are usually asymptomatic. There are no specific tests for DB. The diagnosis is based on characteristic findings, clinical course, and the exclusion of other bullous disorders. Its evolut...
Open Access DOI:10.23937/2572-407X.1510027
Alhad Mulkalwar, Sujay Jaju and Samir Deolekar
Article Type: Clinical Image | First Published: September 30, 2021
A 55-year-old female patient presented with a swelling in the front and sides of the neck (Figure 1) for last 1 year which was initially increasing slowly in size but for the last 5 months, the patient noticed that the swelling was rapidly increasing in size. She was complaining of dull aching pain over the swelling for last 3 months. She also complained of slight hoarseness of voice for last 2 months. She had slight difficulty in swallowing and breathing. There were no symptoms suggestive of hy...
Open Access DOI:10.23937/2572-407X.1510026
Richmond Ronald Gomes
Article Type: Case Report | First Published: September 22, 2021
Cerebral Venous Sinus Thrombosis (CVST) is a rare cerebrovascular condition accounting for 0.5-1% of all types of strokes in the general population and 12.5% of cases are considered to be idiopathic. Hypercoagulability, local bloodstream stasis, and vessel wall abnormalities may contribute to the development of this condition. The thyrotoxic phase of Graves’ disease is associated with venous thrombosis caused by hypercoagulability, which is in turn induced by increased levels of homocysteine a...
Open Access DOI:10.23937/2572-407X.1510025
James M. Meyer and Mary C. Devona
Article Type: Research Article | First Published: August 20, 2021
Severe hypoglycemia is an emergency condition where very low blood sugar may lead to confusion, seizure, unconsciousness, and if left untreated, death. It has been identified as a cause for recurrent morbidity in people with either Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D); however, the understanding of signs and symptoms of Severe Hypoglycemia (SH), as well as when to use glucagon, tend to vary between patients, caregivers, and adult and pediatric endocrinologists (specialists). The purpos...
Open Access DOI:10.23937/2572-407X.1510024
The Incidence and Predictors of Poor Glycemic Control among Adults with Type 2 Diabetes Mellitus in Ambulatory Clinic of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Cross Sectional Study
Gudisa Bereda and Gemechis Bereda
Article Type: Research Article | First Published: August 11, 2021
Diabetes mellitus refers to a grouping of metabolic diseases involving prolonged hyperglycemia caused by the inadequate secretion of insulin, poor insulin action, or a combination of the two. Poor glycaemic control is a major public health problem among patients with type 2 diabetes mellitus. To expose the incidence and predictors of poor glycemic control among adults with type 2 diabetes mellitus in ambulatory clinic of Mettu Karl Referral Hospital. An institutional based prospective cross-sect...
Open Access DOI:10.23937/2572-407X.1510023
İhsan Boyacı, Türkan Yiğitbaşı and Handan Ankaralı
Article Type: Original Article | First Published: July 19, 2021
The oxidative status may not only be a cause of diabetes, but also a consequence of diabetes. We aimed to evaluate the relationship between hyperglycemia levels and oxidative status in patients with type 2 diabetes using Total Antioxidant Capacity (TAC), Total Oxidative State (TOS) and Oxidative Stress İndex (OSI). In this study, 145 patients diagnosed with prediabetes (n = 28) and type 2 diabetes (n = 117) according to HbA1c and oral glucose tolerance test (OGTT) levels were divided into five ...
Open Access DOI:10.23937/2572-407X.1510022
Nadiya Al Rahbi, Issa Al Salmi, Sadiq Abdul Baqi, Muna Al Bulushi and Suad Hannawi
Article Type: Research Article | First Published: December 03, 2020
End-Stage Kidney Disease (ESKD) has a major effect on global health, both as a direct cause of global morbidity and mortality. Peritoneal Dialysis (PD) utilization increases gradually due to increase of patient’s awareness for different types of RRT. Glucose constitutes the main component of the PD fluid utilized by the patients. In this study, we aim to evaluate the various demography and clinical and laboratory data before and a year after initiation of PD and determine the impact of glucose...
Open Access DOI:10.23937/2572-407X.1510020
Idit Tessler MD, MPH, Oded Cohen MD, Judith Diment MD, Yonatan Lahav MD, Doron Halperin MD, MPH and Taiba Zornitzki MD
Article Type: Case Report | First Published: May 18, 2020
Solitary pulmonary lung nodule is a rare presentation of differentiated thyroid metastatic disease with significantly increased mortality. Current data about diagnosis and treatment are limited, based mostly on case reports. The patient initially underwent a total thyroidectomy and received radioactive treatment for locally advanced papillary thyroid carcinoma. During the follow-up scans, a solitary nodule in the left lung was identified, with positive uptake in fluorodeoxyglucose PET-CT but not...
Open Access DOI:10.23937/2572-407X.1510021
José Carlos de la Flor Merino, MD, Laura Mola Reyes, MD, Francisco Valga Amado, MD, Alexander Marshall and Miguel Rodeles del Pozo, MD
Article Type: Letter to the Editor | First Published: August 03, 2020
SARS-CoV-2 disease (COVID-19) has dramatically increased since March 2020. There is insufficient data to establish the risk of acquiring the hyponatremia in patient with COVID-19 infection. We report here the clinical features and therapeutic course of the severe hyponatremia secondary to pituitary macroadenoma with confirmed COVID-19 pneumonia. This is a 59-year-old man without renal disease, who developed severe hyponatremia, hardly explained by the emetic episode and/or diuretic treatment wit...
Open Access DOI:10.23937/2572-407X.1510019
Darren B Abbas, MD, Eric Goldschmidt, MD, Christina Camick, MD, Weikai Qu, MD, PhD and Jorge Ortiz, MD
Article Type: ORIGINAL ARTICLE | First Published: December 13, 2019
Solid organ transplant recipients, and in particular Kidney Transplant (KTx) patients, are at increased risk for developing thyroid cancers due to immunosuppression and improved long-term survival post-transplant. Using the HCUP NIS database, we compared mortality rate, disposition, LOS, and total hospital charge between KTx and Non-KTx patients following thyroidectomy for thyroid cancer during 2008-2014....
Open Access DOI:10.23937/2572-407X.1510018
Lau CS and Aw TC
Article Type: REVIEW ARTICLE | First Published: December 04, 2019
Prolactin is a hormone secreted by the anterior pituitary lactotrophs and is controlled by the influence of hypothalamic dopamine. PRL stimulates the proliferation and differentiation of mammary cells for lactation. There are many causes for hyperprolactinemia, including analytical, physiological, pharmacological, pathological and idiopathic causes. Macroprolactin is a significant analytical cause of hyperprolactinemia, and the most common cause of pathological hyperprolactinemia is prolactin se...
Open Access DOI:10.23937/2572-407X.1510017
F Fokoue, S El Mselmi and N Ismaili Alaoui
Article Type: REVIEW ARTICLE | First Published: November 16, 2019
We report the case of an infant with McCune-Albright syndrome who was diagnosed with polyostotic fibrous dysplasia using 99m Tc-HMDP bone scintigraphy outside the clinical presentation, although not conventionally presented by the infant. The aim of this work is to show the interest of bone scintigraphy in the diagnosis of McCune Albright syndrome....
Open Access DOI:10.23937/2572-407X.1510016
Hiroshi BANDO, MD, PhD
Article Type: COMMENTARY | First Published: June 03, 2019
One of the recent crucial medical problems in the world has been diabetes mellitus, which is increasing in developed and also developing countries. Furthermore, dementia and Mild Cognitive Impairment (MCI) in the elderly has been also medical and social problems due to the extended life span....
Open Access DOI:10.23937/2572-407X.1510015
Reference Intervals for TSH on the Architect Analyser Based on the National Academy of Clinical Biochemistry (NACB) Guidelines Derived from Healthy Multi-Ethnic Asians Attending a Community Health Fair
TC Aw, J Sickan, Shaoqing X Du, J Li, H Janel and A Beshiri
Article Type: Research Article | First Published: May 30, 2019
Thyroid diseases are prevalent in Malaysia. A community health survey was undertaken to improve community awareness of the risks of common non-communicable diseases such as thyroid disorders and the benefits of screening for prevention and early detection of these conditions. Thyroid stimulating hormone (TSH) is the main biomarker and initial test for thyroid dysfunction. However, no formal reference interval (RI) data for TSH is available in Malaysia and South East Asia. All TSH reference inter...
Open Access DOI:10.23937/2572-407X.1510014
Erdal Sayyigit, Zafer Pekkolay and Alpaslan Kemal Tuzcu
Article Type: Original Article | First Published: October 12, 2018
The incidence of thyroid cancer has increased in recent years. This increase may be due to the change of metabolic parameters in patients. This study was designed to clarify the association of malignancy of thyroid nodules with metabolic parameters. This study designed as a cross-sectional study between January 2018 and May 2018. Samples were collected from the patients by thyroid fine needle biopsy and patients who had thyroid surgery. Group 1 patients were pathologically benign patients; Group...
Open Access DOI:10.23937/2572-407X.1510013
Branavan Umayal, NV Chandrasekharan, WSS Wijesundera and Chandrika N Wijeyaratne
Article Type: Short Communication | First Published: October 08, 2018
Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder, present in 5-13% women of reproductive age. The endocrine manifestations of PCOS include excess androgen production of ovarian and/or adrenal origin and arrested follicular development leading to chronic oligo- or anovulation. Long term health risks of women with PCOS include cardiovascular disease, type 2 diabetes mellitus and endometrial cancer. PCOS is diagnosed by chronic anovulation, polycystic ovaries on ultrasound and bioche...
Open Access DOI:10.23937/2572-407X.1510012
Serap Yildirim, Arzu Sahin, Abdulkadir Yildirim, Mutlu Kuyucu, Engin Sebin, Senol Dane and Eda Dokumacioglu
Article Type: Research Article | First Published: July 28, 2018
Migraine is a chronic disease which affects approximately 12-18% of the society, can be accompanied by neurologic and systemic symptoms, and is characterised by mild or severe recurring headache attacks. The aim of this study is to determine serum apelin-36 level in the patients with migraine with aura and without aura and to compare the obtained data with the data of the healthy control group. The migren study group consisted of 44 women patients, suffering from migraine with (n = 16) and witho...
Open Access DOI:10.23937/2572-407X.1510011
Solen Himmetoglu, Selin Yuksel, Taner Damcı, Hasan Ilkova and Yildiz Dincer
Article Type: Research Article | First Published: November 22, 2017
Beta cell death by apoptosis is an important mechanism in beta cell dysfunction and development of diabetes. Inhibition of apoptosis may be helpful approach in the prevention of diabetes....
Open Access DOI:10.23937/2572-407X.1510010
Takuma Hayashi, Tomoyuki Ichimura, Mari Kasai, Gal Gur, Pnina Yaish, Dorit Zharhary, Yae Kanai, Susumu Tonegawa, Nobuo Yaegashi and Ikuo Konishi
Article Type: Short Communication | First Published: September 28, 2017
Uterine sarcomas comprise a group of rare tumours with differing tumour pathobiology, natural history and response to clinical treatment. Diagnosis is often made following surgical treatment for presumed malignant mesenchymal tumours and benign tumours. Currently pre-operative diagnosis does not reliably distinguish between malignant mesenchymal tumours....
Open Access DOI:10.23937/2572-407X.1510009
Ram B Jain
Article Type: Research Article | First Published: July 01, 2017
Data from National Health and Nutrition Examination Survey for 2007-2012 were used to evaluate associations between urine and blood lead and Thyroid Stimulating Hormone (TSH), Free and Total Triiodothyronine (FT3, TT3), and Free and Total Thyroxine (FT4, TT4)....
Open Access DOI:10.23937/2572-407X.1510008
Harbi Khalayleh, Hilla Knobler, Vitaly Medvedovsky, Edit Feldberg, Judith Diment, Lena Pinkas, Guennadi Kouniavsky and Taiba Zornitzki
Article Type: Case Report | First Published: February 21, 2017
A 42-year-old normotensive woman with neurofibromatosis type 1 (NF1) with typical cutaneous manifestations (multiple neurofibromas, cafe-au-lait spots and axillary freckling), underwent evaluation for abdominal pain and a large left adrenal mass displacing the spleen pancreas and colon, was found upon a CT scan....
Open Access DOI:10.23937/2572-407X.1510007
KS Moalla, N Bouzidi, M Damak, M Abid and C Mhiri
Article Type: Case Report | First Published: February 21, 2017
Primary hyperparathyroidism (PHPT) is defined as an inappropriate and excessive secretion of parathyroid hormone (PTH). It is usually asymptomatic and often diagnosed after a fortuitous discovery of hypercalcemia. We report the case of severe myopathy revealing PHPT secondary to parathyroid carcinoma (PC) with lung metastasis....
Open Access DOI:10.23937/2572-407X.1510006
Maria Pires and Francisco Tortosa
Article Type: Mini Review | First Published: October 27, 2016
Folliculo-stellate cells (FSCs) are a non-endocrine population of sustentacular-like, star-shaped and follicle-forming cells, which contribute about 5-10% of elements from the anterior pituitary lobe. First identified with electron microscopy as non-hormone secreting accessory cells, light microscopy has revealed many of their cytophysiological features, and is known as positive for S-100 protein, a marker for FSCs. They are currently considered as functionally and phenotypically heterogeneous.....
Open Access DOI:10.23937/2572-407X.1510005
Ram B Jain
Article Type: Research article | First Published: December 10, 2015
The effect of race/ethnicity and smoking on diurnal variations in total serum testosterone level (T-TST) was evaluated by analyzing data from NHANES for 2011-2012 for adolescent and adult males. For adolescent males, diurnal variability in T-TST levels was substantially smaller among smokers than nonsmokers for non-Hispanic white (NHW) and Hispanics but the reverse was true for non-Hispanic black (NHB). For adult males, morning levels of T-TST were 21-31% higher than the T-TST levels during even...
Open Access DOI:10.23937/2572-407X.1510004
Ram B Jain
Article Type: Research article | First Published: November 16, 2015
Objective: This study was undertaken to describe the thyroid profile of reference U.S. population including generating reference ranges for thyroid stimulating hormone (TSH), free and total triiodothyronine (FT3, TT3), free and total thyroxine (FT4, TT4), and thyroglobulin. Design and methods: Publically available data from National Health and Nutrition Examination Survey (NHANES) for the cycles 2007-2012 were analyzed for this purpose....
Open Access DOI:10.23937/2572-407X.1510003
Fathimabeebi PK, Noor Bader Al Busaidi and Mohamed Al Lamki
Article Type: Case Report | First Published: October 13, 2015
Background: Moderate to severe hypercalcemia associated with hyperthyroidism is not very common and can raise a diagnostic challenge to the treating physician. Objective: To present a case of thyrotoxicosis manifested with symptoms of hypercalcemia and resolution of symptoms after rendering euthyroid. Method: We report the case of a 61 year old Omani gentleman, who presented with symptoms of hypercalcemia like weight loss (10 kg) with poor appetite, constipation and depression as first manifesta...
Open Access DOI:10.23937/2572-407X.1510002
Alexander E. Berezin
Article Type: Mini Review | First Published: September 17, 2015
Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the regulation of the inflammatory respon...
Open Access DOI:10.23937/2572-407X.1510001
Asma Deeb, Rawan Al Hazaimeh, Salima Attia, Abubaker ElFatih, Omar Afandi and Nico Nagelkerke
Article Type: Original Article | First Published: May 28, 2015
The incidence of obesity in children is increasing. In the United Arab Emirates (UAE), childhood overweight and obesity reached up to 25% of the population. In addition, UAE has become one of the highest countries in the prevalence of type 2 diabetes. Various forms of life style behavior and dietary habits have contributed to obesity and the development of the metabolic syndrome. We aim to study energy intake, dietary habits and life style behavior in obese children with dyslipidemia in the UAE ...
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