International Archives of Clinical Pharmacology (IACP) is an international peer-reviewed journal committed to promoting the best standards of scientific discoveries and scientific knowledge in the field of Clinical Pharmacology. IACP cover major areas of Pharmacogenetics, Drug Delivery & Metabolism, Drug Interactions, Nephrotoxic & Neurotoxic Agents, Immunopharmacology & Immunotoxicology, Pedagogy in Pharmacology, Pharamacokinetics: Validation, Metabolism, Pharmacodynamics, Pharmacoeconomics, Pharmacoepidemiology, Pharmacogenetics, Pharmacokinetics, Pharmacology and its Therapeutics, Pharmacology for Health Sciences, Pharmacology of the Central Nervous System, Pharmacovigilance, Practical Problems in Biometry, Proteomics & Metabolomics, Radio Chemicals and Radiopharmaceuticals, Therapeutic Drug Monitoring, etc.

We consider to publish original research articles, reviews, clinical studies and commentaries, short communications, reports, opinions, editorials etc., on all aspects of pharmacology. IACP ensures the faster publication of high quality articles and is a permanent archive of pharmacology information.

 
Journal Information

Title: International Archives of Clinical Pharmacology

ISSN: 2572-3987

Editor-in-chief: Dayue Darrel Duan

NLM title abbreviation: Int Arch Clin Pharmacol

ISO abbreviation: Int Arch Clin Pharmacol

Other titles: IACP

Category: Drug Delivery & Metabolism

Country of publication: USA

Language: English

DOI: 10.23937/2572-3987

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication type(s): Periodicals

Publisher: ClinMed International Library

Contact email: contact@clinmedjournals.org

 
Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 

 Open Access DOI:10.23937/2572-3987.1510015

New Therapeutic Strategy for the Neurodegenerative Diseases: Pharmacological Modulation of Ca2+/Camp Signaling Interaction

Afonso Caricati-Neto and Leandro Bueno Bergantin

Article Type: Review Article | First Published: May 09, 2018

Due to the involvement of the imbalance of neuronal Ca2+ homeostasis in the pathogenesis of several neurodegenerative diseases, the use of drugs to prevent or attenuate this imbalance emerged as a new therapeutic strategy for treating these diseases....
 

 Open Access DOI:10.23937/2572-3987.1510014

Assessment of Iron Overload and Chelation Therapy in Adult Inpatients with Sickle Cell Disease

Nicole Bohm, Brittany Toussaint, Stefanie Sarratt, Leigh Vaughan and Ashley Duckett

Article Type: Short Communication | First Published: March 24, 2018

There is no consensus for the role of iron chelation therapy in patients with sickle cell disease receiving blood transfusions while hospitalized. The primary objective of this study was to assess the frequency of iron overload in adult inpatients with sickle cell disease and characterize the use of inpatient intravenous iron chelation therapy at the time of red blood cell transfusion....
 

 Open Access DOI:10.23937/2572-3987.1510013

Novel Concepts for Clinical Pharmacology from "Calcium Paradox" due to Neuronal Interaction between Signalling Pathways Mediated by Ca2+ and cAMP: from 1975 to 2017

Leandro Bueno Bergantin and Afonso Caricati-Neto

Article Type: Mini Review | First Published: November 24, 2017

The solution for the so-called "calcium paradox" has been revealed 4 years ago, when we demonstrated the involvement of the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling interaction) in this enigma....
 

 Open Access DOI:10.23937/2572-3987.1510012

Dietary Flavonoids and Colorectal Cancer: Evidence from Epidemiological Studies

Katrin Sak

Article Type: Review Article | First Published: October 11, 2017

Identification of dietary agents related to colorectal carcinogenesis is of high importance to decrease the global burden of this severe disorder. As flavonoids abundantly present in plant-based food items are suggested to exert various anticancer activities in numerous experimental models, evidence from epidemiological studies about association....
 

 Open Access DOI:10.23937/2572-3987.1510011

Prolonged Coagulopathy Following Rattlesnake Envenomation Responsive to Antivenom: A Case Report

Megan Z Roberts, Brian P McKinzie, Stuart M Leon, Stephen A Fann and Nicole M Bohm

Article Type: Case Report | First Published: July 19, 2017

Venom-specific immunoglobulin G fragments are used for the management of patients with North American crotalid envenomation. In this case, ongoing coagulopathy and clinically significant sequelae required a protracted course of antivenom therapy in a patient experiencing severe rattlesnake envenomation....
 

 Open Access DOI:10.23937/2572-3987.1510010

Pharmaceutical Characterization and Detection Using Surface-Enhanced Raman Scattering

Tawfik A Saleh

Article Type: Review Article | First Published: April 07, 2017

Surface-enhanced Raman scattering (SERS) is a surface sensitive method that results in the enhancement of Raman scattering by molecules adsorbed on rough metal surfaces. The enhancement factor can be as much as 107 -1015, which allows the technique to be sensitive enough to detect single molecules....
 

 Open Access DOI:10.23937/2572-3987.1510009

Levothyroxine for Hypothyroidism: Current Status of Biowaiver and Bioequivalence Studies

Nunez-Guzman NA, Munoz-Ibarra AI, Ruiz-Molina D, Figueroa-Nunez B and Garcia-Perez ME

Article Type: Review Article | First Published: January 24, 2017

Hypothyroidism is a common disease that needs to be closely treated, in order to reduce adverse symptoms and pathophysiological effects. For thyroid hormone replacement is preferred a therapy with a synthetic form of thyroxine (levothyroxine), a drug recognized by its Narrow Therapeutic Index. Generic levothyroxine can be an economic alternative for Hypothyroidism treatment....
 

 Open Access DOI:10.23937/2572-3987.1510008

Increase in Carbamazepine Serum Levels in Patient Treated with Voriconazole

Alberto Sanchez-Romero, Ana Valladolid-Walsh, Rafael Garcia-Delgado and Esperanza Lopez-Rubio

Article Type: Case Report | First Published: December 05, 2016

The addition of voriconazole to chronic treatment with carbamazepine 400 mg twice a day was associated with increased carbamazepine serum levels (14.1 mg/l) and serum concentration dose ratios. Three days after the voriconazole was started, this ratio doubled its value to 1. Carbamazepine concentration as well as serum concentration dose ratio gradually decreased after treatment with voriconazole was discontinued, suggesting a probable interactio...
 

 Open Access DOI:10.23937/2572-3987.1510007

Insight from 'Calcium Paradox' due to Ca2+ / cAMP Interaction: Novel Pharmacological Strategies for the Treatment of Depression

Leandro Bueno Bergantin and Afonso Caricati-Neto

Article Type: Review Article | First Published: September 12, 2016

Depression is a psychiatric disease resulting mainly by dysfunction of monoaminergic neurotransmission in central nervous system. Depression is a severe global illness, becoming more and more common each decade. Because of specific symptoms, it is considered as a leading cause of disability all over the world with a high death factor due to suicides. There are many antidepressants used in the therapy, but still more than one-third of patients do ...
 

 Open Access DOI:10.23937/2572-3987.1510006

Unacceptable Intravenous Administration of Chloral Hydrate Oral Solution

Turgay Cokyaman, Omer Ertugrul, Haydar Ali Tasdemir and Ayhan Dagdemir

Article Type: Case Report | First Published: August 04, 2016

Chloral hydrate is very frequently used in medical procedures with the purpose of sedation. After oral or rectal administration, central nervous system (CNS) and respiratory depression, cardiac arrhythmia and gastric irritation are known as classical adverse effects. Although the adverse effects developing after enteral usage are well known, there are limited data in literature about the misuse of chloral hydrate oral solution intravenously and t...
 

 Open Access DOI:10.23937/2572-3987.1510005

Mass Dose Effects of Carfentanil and Raclopride on Venous Plasma Cortisol and Prolactin after Tobacco Smoking during PET Scanning

Edward F Domino, Lisong Ni and Mika Hirasawa-Fujita

Article Type: Original Article | First Published: May 09, 2016

Peak cortisol levels after average nicotine (avnic) tobacco smoking were decreased with greater carfentanil doses (p = 0.03). The change in plasma cortisol levels after avnic smoking compared to before avnic smoking was also decreased with greater carfentanil doses (p = 0.003). Unexpectedly the changes in cortisol levels after denicitinized (denic) tobacco smoking compared to before denic smoking were increased with greater carfentanil doses (p =...
 

 Open Access DOI:10.23937/2572-3987.1510004

Case Report: Addition of Naltrexone and Bupropion to Lorcaserin to Manage Olanzapine-induced Weight Gain

Kevin Bera, Eric Tran and Charles T. Nguyen

Article Type: Case Report | First Published: January 25, 2016

Antipsychotic medications, both typical and atypical, share the potential side effect of weight gain with atypical agents carrying a greater risk. Atypical antipsychotics, such as clozapine and olanzapine, which antagonize the 5-hydroxytryptamine (serotonin) subtype 5-HT2C receptor, have been associated with a higher likelihood to induce weight gain....
 

 Open Access DOI:10.23937/2572-3987.1510003

A Review: Are All Inhaled Fibres, Such as Asbestos, Toxic?

Sumayah Abdul-Jabbar and Luigi G Martini

Article Type: Review Article | First Published: August 05, 2015

Exposure to asbestos is well known to have a causal relationship with the development of lung cancer. In order to understand the mechanism of this toxicity an extensive review was undertaken. Findings were able to show that the morphology of the asbestos (which is fibrous) has a marked correlation with its toxicity. It is this morphology that mutually contributes to enhanced aerodynamic properties making asbestos ideal for deposition in the lungs...
 

 Open Access DOI:10.23937/2572-3987.1510002

Evaluation of Empirical Antibiotic Therapy for the Treatment of Community-Acquired Urinary Tract Infections (CA-UTI)

Joao Pedro Aguiar, Filipa Alves da Costa and Patricia Cavaco Silva

Article Type: Research Article | First Published: July 28, 2015

Objectives: To characterize the pattern of indication of antibiotic regimens for CA-UTI; to evaluate the adequacy of antibiotic empirical therapy in CA-UTI and the resistance profile of the bacterial isolates. Methods: An observational study was conducted, where the prevalence and resistance profiles of the microorganisms involved and the pattern of antibiotic indication were investigated through a cross-sectional approach. Patients presenting wi...
 

 Open Access DOI:10.23937/2572-3987.1510001

Amitriptyline Therapy in Chronic Pain

Min Su, Liang Liang and Shengyuan Yu

Article Type: Review Article | First Published: June 26, 2015

Rodent evidence has confirmed the analgesic effect of tricyclic antidepressants in the treatment of chronic pain, which amitriptyline is rigorously verified. The analgesic effect of amitriptyline, whose mechanisms are complex and unclear, is different from its antidepressant effect. This article reviewed the mechanisms behind amitriptyline's analgesic properties to further understanding of this drug. Additionally, this article reviewed the clinic...

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