International Journal of Blood Research and Disorders is a peer-reviewed publication in the field of blood research. It focuses on all aspects of hematology including blood cells, hematologic diseases, blood hemostatic mechanisms, hemato-oncology, immunology, and transfusion medicine. It also focuses on all aspects of the prevention and therapy of blood disorders.
International Journal of Blood Research and Disorders aims to publish original articles, research, reviews, case reports, short communications, commentaries etc., layering the spectrum of clinical and laboratory hematological practice and research. The classification terms include but not limited to Anemia, Platelet disorders, Eosinophilic disorders, Leukemia, Myeloma, Coagulation disorders, blood Transfusion, sepsis.
International Journal of Blood Research and Disorders ensures the faster publication of high-quality articles with the support of its eminent Editorial board members. Two independent review comments followed by editor's decision will be considered to publish the article. IJBRD is a permanent archive of information on Blood research, disorders and therapeutics which under open access category provides its global readers with free access to its content, thus serving the scientific community.
Journal Information
Title: International Journal of Blood Research and Disorders
ISSN: 2469-5696
Editor-in-chief: Preet M Chaudhary
NLM title abbreviation: Int J Blood Res Disord
ICV: 88.22
ISO abbreviation: Int J Blood Res Disord
Other titles: IJBRD
Category: Human Physiology
DOI: 10.23937/2469-5696
Peer review: Double blind
Review speed: 3 weeks
Fast-track review: 10 days
Publication format (s): Electronic and print
Publication policy: Open Access; COPE guide
Publication type(s): Periodicals
Publisher: ClinMed International Library
Country of publication: USA
Language: English
Contact email: contact@clinmedjournals.org
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2469-5696/1410046 First Observation of Two TMPRSS6 Gene Mutations (G603R and K636AFSX17) in Turkish Population Yasemin Ardicoglu Akisin, Gulnaz Kurt, Hüseyin Onay, Ferda Ozkinay and Nejat Akar Article Type: Case Report | First Published: December 20, 2019 Iron is one of the elements that participate numerous reaction on the body and the structure of hemoglobin to the purpose of carrying oxygen to the tissues. Thus, iron deficiency causes different problems in the body. Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder that has some signs of iron deficiency anemia (IDA) but refractory to oral iron and partially refractory to intravenous iron. The mutation in TMPRSS6 gene causes matriptase-2 protein deficiency that negatively reg...
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Open Access DOI:10.23937/2469-5696/1410045 Prevalence of Antiphospholipid Antibodies in HIV-Infected Children in Ile-Ife, South-Western Nigeria Oyelese AT, Salawu L, Adejuyigbe EA and Olasanmi O Article Type: Review Article | First Published: December 12, 2019 Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and this has been documented in Nigerian adult patients but not in the pediatric age group. To determine the prevalence of antiphospholipid antibodies in HIV-infected children and its associatio...
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Open Access DOI:10.23937/2469-5696/1410044 Repeat Ultrasonographic Examinations Reveal Accessory Spleen in a Case with Relapse ITP Ahmet Sarici, Ayshe Slocum, Hilal Er Ulubaba, Mehmet Hanifi Kandemir, Mehmet Ali Erkurt, Emin Kaya and Irfan Kuku Article Type: Original Article | First Published: August 09, 2019 The aim of treatment in patients with primary immune thrombocytopenia (ITP) is to obtain a safe platelet count to prevent clinically significant bleeding (major bleeding) rather than normalizing the platelet count. In light of this information, treatment indications for newly diagnosed ITP patients include, I) Thrombocyte counts below 30,000/microL and II) Platelet counts above 30,000/microL in correlation with clinically significant bleeding. Corticosteroids make-up the first-line treatment of ...
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Open Access DOI:10.23937/2469-5696/1410043 Is There Any Relationship between ABO Blood Groups and Coronary Ectasia? Hakan Kaya Article Type: Research Article | First Published: July 17, 2019 Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 201...
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Open Access DOI:10.23937/2469-5696/1410042 Christian Cajavilca, Tina Yaqing Cai Lam, Alexandra Vaio Sykes, Shannon Wheeler and Rajan R Gadhia Article Type: Case Report | First Published: July 04, 2019 81-year-old female presented to an outside emergency room with subacute onset of left facial weakness and right hemiparesis for 12 hours. A non-contrast CT scan of the head and CTA head and neck showed no acute findings. Laboratory results were remarkable for a leukocyte count of 245.75 k/uL. She was diagnosed with acute leukemia and transferred to a comprehensive stroke center where she was treated with leukapheresis and hydroxyurea. The patients focal deficits somewhat improved, but in the fol...
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Open Access DOI:10.23937/2469-5696/1410041 Michael Tarasev, Marina Muchnik and Sumita Chakraborty Article Type: Original Article | First Published: June 27, 2019 While in circulation, red blood cells (RBC) need to elastically undergo large deformations without lysing, an ability that may be compromised by cell membrane damage. Such can be tested in vitro by subjecting an RBC sample to external mechanical stress, e.g. through bead milling or oscillation of an object in a sample. In addition to controlling frequency and duration of oscillations, this approach can be further tailored by bead selection/design....
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Open Access DOI:10.23937/2469-5696/1410040 Asafa MA, Ogunlade O, Bolarinwa RA, Bisiriyu LA and Asafa ST Article Type: Research Article | First Published: June 17, 2019 It had been established that ABO blood group system associated with some diseases or disorders. The objective of this study was to determine the effect of ABO blood group on anthropometric indices among apparently healthy young adults of Yoruba ethnicity. Eighty apparently healthy young adults who were purposely selected participated in the study after screening for the ABO blood groups following the standard protocol. They were divided into four equal groups; 20 in each of blood groups A, B, AB...
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Open Access DOI:10.23937/2469-5696/1410039 Haruko Tashiro MD, PhD, Yasutoshi Oshima, Ritsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kensuke Matsumoto, Jun Ooi, Naohisa Matsunaga, Yoshinao Kikuchi and Naoki Shirafuji Article Type: Case Report | First Published: May 16, 2019 Survival rates for patients with severe aplastic anemia have greatly improved with the development of better supportive care including transfusion strategies and the availability of anti-fungal agents. However, invasive fungal infection remains the main cause of death and increases mortality in severe aplastic anemia patients. Among invasive fungal infections, mucormycosis is one of the fatal diseases in immunocompromised patients. We report the case of a 72-year-old man with severe aplastic ane...
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Open Access DOI:10.23937/2469-5696/1410038 MEK1/2 as a Therapeutic Target in Sickle Cell Disease Rahima Zennadi Article Type: Short review | First Published: April 04, 2019 Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...
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Open Access DOI:10.23937/2469-5696/1410037 Sinem Namdaroglu, MD and Gizem Yıldırım Article Type: Research Article | First Published: March 06, 2019 Even though a single high dose administration of intravenous ferric carboxymaltose (FC) is supposed to be effective, it is unknown whether the second dose of FC given one week after the initial dose provides additional benefits. The aim of the present study was to investigate whether two doses of intravenous ferric carboxymaltose is more effective than a single dose of intravenous FC for replenishing iron stores and correction of anemia in patients with iron deficiency....
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Open Access DOI:10.23937/2469-5696/1410036 Kodai Kuriyama, Hiroki Hosoi, Masaya Shimanuku, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Nobuyoshi Hanaoka and Takashi Sonoki Article Type: Case Report | First Published: January 25, 2019 In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the ...
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Open Access DOI:10.23937/2469-5696/1410035 Angeli Ambayya, Andrew Octavian Sasmita, Subramanian Yegappan and Jameela Sathar Article Type: Research Article | First Published: January 20, 2019 The full blood count (FBC) analyzers, Sysmex XE-5000 and Unicel DxH 800, are equipped to perform routine and extended parameters tests; thus, this study considered extended red blood cell (eRBC) parameters to distinguish iron-deficient erythropoiesis related disorders. Malaysian female subjects comprising three main ethnic groups (Malay, Chinese and Indian) were included. Three groups of findings were distinguished based on FBC, morphology, and iron status of the subjects: normal, latent iron de...
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Open Access DOI:10.23937/2469-5696/1410034 Mingjun He, Xiaoli Zhu, Wei Niu, Lingming Kong, Gaofeng Yao and Li-yi Zhang Article Type: Research Article | First Published: December 12, 2018 Based on the prior studies, altered lncRNAs in peripheral blood Molecular Cells (PBMC) from depression patients were chosen to perform informatics analysis for lncRNA target gene prediction and functional annotation. Microarray was first used to screen dys regulated lncRNAs in the PBMCs of MDD patients, of which 10 lncRNAs were selected for quantitative real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR) study, as well as bioinformatics analysis....
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Open Access DOI:10.23937/2469-5696/1410033 Gennadiy Galstyan, Polina Makarova, Elena Parovichnikova, Larisa Kuzmina, Vera Troitskaya, Eduard Gemdzhian and Valeriy Savchenko Article Type: Original Article | First Published: October 12, 2018 To investigate the safety of the of bone marrow-derived human multipotent mesenchymal stromal cells (MMSCs) administration in neutropenic patients with septic shock. Mesenchymal stromal cells (MMSCs) may represent a promising cell-based therapy of sepsis. MMSCs, activated by lipopolysaccharide or tumor necrosis factor-α, reprogram macrophages by releasing prostaglandin E2. Prostaglandin E2 acts on the macrophages through the EP2 and EP4 receptors and stimulates the production and release of an ...
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Open Access DOI:10.23937/2469-5696/1410032 Camila Marca de Veiga Cabral, Walter Moises Tobias Braga, Adriano de Moraes Arantes, Jose Salvador Rodrigues de Oliveira, Gisele Wally Braga Colleoni and Fabio Rodrigues Kerbauy Article Type: ORIGINAL ARTICLE | First Published: September 07, 2018 The aim of this study is to characterize Treg (FOXP3) and Th17 (RORC)-related genes in patients who underwent hematopoietic cell transplantation (HCT) and correlate them with graft-versus-host disease (GVHD) onset and patients' outcome. Fifty-one patients undergoing allogeneic HCT from matched related donors (MRD) were studied. Samples were collected before HCT, at acute (aGVHD) or chronic GVHD (cGVHD) onset, and 90 days post-HCT for those who did not have signs of aGVHD. FOXP3 and RORC gene exp...
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Open Access DOI:10.23937/2469-5696/1410031 Giuseppe Mele and Domenico Pastore Article Type: Case Reports & Case Series | First Published: July 12, 2018 Patients with relapsed/refractory Multiple Myeloma (rrMM) and End Stage Renal Disease (ESRD) requiring hemodialysis must receive lenalidomide at a dosage of 5 mg daily on days 1-21 of repeated 28-day cycles, due to substantial elimination via the kidneys. Unfortunately, despite dose reduction, severe adverse events occur with a high frequency. Therefore, lenalidomide is recommended mainly in patients with mild-to-moderate renal impairment....
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Open Access DOI:10.23937/2469-5696/1410030 Md Serajul Islam and Pavel Kotoucek Article Type: Case Report | First Published: June 30, 2018 Proteinaceous lymphadenopathy is a rare non-specific lymph node changes incidence of which increases with age. This condition is usually associated with hypergammaglobulinemia or rheumatological conditions. However, this condition can also be due to unknown aetiology as we are presenting a case where no underlying case was found. It may affect nodal function, and rarely may it calcify. Histopathologist needs to be vigilant of this condition as lymphoma with lymph node sclerosis should be conside...
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Open Access DOI:10.23937/2469-5696/1410029 Multiple Myeloma Associated with Dermatomyositis: A Short Report and Mini-Review Md Serajul Islam and Pavel Kotoucek Article Type: Research Article | First Published: June 20, 2018 Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cell clones that produce monoclonal immunoglobulin. Dermatomyositis (DM), and to a lesser extent polymyositis (PM), carry a higher risk of cancer than that of the general population as demonstrated by several studies with the prevalence being 32% and 15% for DM and PM respectively. The mechanism underlying the association between idiopathic inflammatory myopathies (IIM) and malignancies remains unclear....
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Open Access DOI:10.23937/2469-5696/1410028 Zika Induced Meningoencephalitis in a Ruxolitinib Treated Patient with Secondary Myelofibrosis Ahmad Al Ghoche, Jean Pegliasco, Jessica Anne-Marie-Sainte, Julien Cuziat, Lucas Meyer, Fatiha Najioullah, Jean Côme Meniane and Samy Chraïbi Article Type: Case Report | First Published: October 28, 2017 We describe here the first case of a patient with post-ET myelofibrosis treated with ruxolitinib at French West Indies complicated with zika induced meningoencephalitis. Patient presented with fever, confusion along with conjunctivitis, diffuse joints pain and skin rash. PCR was positive for Zika virus in blood, urine and cerebrospinal fluid. Diagnosis of Zika induced meningoencephalitis was confirmed....
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Open Access DOI:10.23937/2469-5696/1410027 Poorva Bindal, Heenam Goel, Alexei Shimanovsky, Joseph M Ryan, Jeffrey S Wasser and Enrique Ballesteros Article Type: Case Report | First Published: September 29, 2017 The incidence of therapy-related Acute Promyelocytic Leukemia (t-APL) has been steadily rising. Radioactive Iodine (RAI) has emerged as a potential leukemogenic insult. Translocation involving the Retinoic Acid Receptor-alpha (RAR-alpha, RARa) gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15....
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Open Access DOI:10.23937/2469-5696/1410026 Bone Marrow Necrosis: An Unusual Misdiagnosed Serious Complication Georges El Hachem Article Type: Literature Review | First Published: July 31, 2017 Bone Marrow Necrosis (BMN) is an uncommon syndrome characterized by destruction of hematopoietic tissue with preservation of the bone. It presents as localized or diffuse generalized process. Many underlying diseases can lead to marrow necrosis: most commonly malignancies and rarely sickle cell disease....
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Open Access DOI:10.23937/2469-5696/1410025 Polycomb Proteins in Hematopoiesis and Hematologic Malignancie Jie Li Article Type: Review Article | First Published: March 20, 2017 In recent years, the Polycomb group (PcG) of proteins has been revealed to be involved in the regulation of hematologic stem cell function and differentiation and have been broadly linked to hematologic malignancies. Polycomb proteins are histone modifiers that contain two multi-protein complexes: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2)....
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Open Access DOI:10.23937/2469-5696/1410024 Diaz De-La-Noval B, Hernandez Gutierrez A, Zapardiel I, De-Santiago Garcia J and Diestro Tejeda Article Type: Case Report | First Published: August 30, 2016 The incidence of Non-Hodgkin's Lymphoma (NHL) has been increasing in recent decades, the prevalence of extranodal-NHL is about 30 to 50% of all NHL patients. Primary Large B-cell extranodal lymphoma of the cervix is a very rare disease, 0.008% of all cervical tumors. The Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal lymphoid neoplasm in around 25% of all NHL....
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Open Access DOI:10.23937/2469-5696/1410023 Polycythemia Vera with High Erythropoietin Level: Case Report Rami Nassabein, Mariam al khatib, Marie Helen Abbas, Marie youssef, Daniel Amer and Jaafar Wazni Article Type: Case Report | First Published: August 30, 2016 Polycythemia Vera (PV) is a myeloproliferative disorder of bone marrow stem cells characterized by erythrocytosis. Elevated erythropoietin level strongly indicates secondary erythrocytosis and excludes PV diagnosis. However, patients with PV who co-present with Budd-Chiari syndrome (BCS) have been documented with elevated serum erythropoietin levels provided that JAK2 mutation is positive....
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Open Access DOI:10.23937/2469-5696/1410022 First Haploidentical Transplant in Peru in Pediatric Patient with Bilineal Leukemia Mariela Del Carmen Moreno, Cinthia Palacios and Yessenia Cruz Article Type: Case Report | First Published: August 01, 2016 Bilineal leukemia is a very rare health condition, especially in pediatric patients; it is associated with poor prognosis, even without uniformity therapeutic criteria. Hereby, we present a 4-year-old boy, who debuted as T-cell lymphoblastic lymphoma, he initially received treatment induction, which was unanswered, further studies showed evidence of being bilinear leukemia (T-AML M5). He continued the AML induction therapy followed by four consolidations, achieving CR....
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Open Access DOI:10.23937/2469-5696/1410021 Significance of sCD86 Levels in Acute Myelogenous Leukemia Patients: An Egyptian Study Naglaa M Hassan, Nevin M Al-azhary and Marwa M Hussein Article Type: Research Article | First Published: May 28, 2016 The aim of the study is to assess the level of soluble CD86 (sCD86) in patients with de novo AML and to compare them with a normal control group to determine any possible role with prognosis and clinical outcome, as the significance of sCD86 in hematologic malignancies is still controversial....
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Open Access DOI:10.23937/2469-5696/1410020 Viviane Chaves Pereira, Karoline Honorato Costa and Leonardo Rodrigues de Oliveira Article Type: Case Report | First Published: May 28, 2016 Although they are rare, severe hematologic adverse effects are described and may be fatal. The current study describes the case of a patient presenting psoriatic arthritis, and under prolonged treatment with adalimumab. His condition worsened due to severe acute thrombocytopenia and severe hemorrhagic manifestations. Adalimumab was considered to be the probable cause of the thrombocytopenia and, therefore, its use was discontinued. The treatment consisted of corticosteroids, human immunoglobulin...
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Open Access DOI:10.23937/2469-5696/1410019 DA Ammon, H Andruszkow, L Sieg, M Wilhelmi, CF Weber, N Rahe-Meyer and AA Hanke Article Type: Research Article | First Published: November 27, 2015 Hypothermia and acidosis are risk factors for coagulopathy during trauma. We investigated influence of fibrinogen and factor XIII on whole blood coagulation under hypothermia and acidosis in an In vitro model. Fibrinogen, but not FXIII improved coagulation significantly. Furthermore, combined administration of fibrinogen and FXIII did not show differences to administration of fibrinogen alone....
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Open Access DOI:10.23937/2469-5696/1410018 The Management of Mucositis of Pediatric Hematopoietic Stem-Cell Transplantation CIFTCIOGLU Sule and EFE Emine Article Type: Perspective | First Published: September 23, 2015 Hematopoietic stem-cell transplantation (HSCT) is used primarily for hematologic and lymphoid cancers but also for many other disorders. Autologous HSCT (in which stem cells are derived from the patient) is mainly used to treat chemosensitive malignancies. Allogeneic HSCT (in which the stem cells are derived from a donor) is often the preferred treatment option, particularly in patients with acute leukaemia. Oral complications are a significant cause of morbidity and potential mortality for chil...
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Open Access DOI:10.23937/2469-5696/1410017 Koksal Deveci, Serdal Korkmaz, Enver Sancakdar, Duygu Acibucu, Filiz Alkan, Hatice Terzi and Mehmet Sencan Article Type: Research Article | First Published: September 17, 2015 A monoclonal gammopathy is defined as the electrophoretically and antigenically homogeneous protein product of a single clone of B lymphocytes and/or plasma cells that has proliferated beyond the constraints of normal control mechanisms. Monoclonal gammopathies are detected in serum and/or urine from individuals with a wide variety of neoplastic, potentially neoplastic, neurological and infectious conditions....
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Open Access DOI:10.23937/2469-5696/1410016 The Levels of PAI-1, Urokinase uPA, Thrombomodulin and TFPI in Essential Thrombocythemia Oktay Bilgir, Ferda Bilgir, Mehmet Calan and Giray Bozkaya Article Type: Research Article | First Published: September 05, 2015 Generally, ET is a myeloproliferative disorder characterized by persistent peripheral thrombocytosis and abnormal megakaryocytic proliferation in the bone marrow. ET is a rare cause of thrombocytosis and may be associated with both venous and arterial thrombosis in 10-75% of cases, depending largely on the study and whether vasomotor symptoms are included in thrombotic manifestations....
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Open Access DOI:10.23937/2469-5696/1410015 Tom Rider, John Jones, John Brewin, Gillian Horne, Jack Wills, Hannah Barton, Kevin Boyd, Timothy Corbett, Sabina Dizdarevic and Timothy Chevassut Article Type: Research Article | First Published: July 09, 2015 Early stage Hodgkin's Lymphoma (HL) has excellent outcomes and recent research has focused on minimising treatment-related toxicities. However, the role of 18F-florodeoxyglucose positron emission tomography (FDG PET) imaging in this setting is not fully determined. We retrospectively calculated overall survival (OS) and relapse free survival (RFS) in stage I-II HL when radiotherapy was omitted if post-chemotherapy FDG PET imaging was negative....
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Open Access DOI:10.23937/2469-5696/1410014 Apostolos Pourtsidis, Marina Servitzoglou, Margarita Baka, Despina Bouhoutsou, Maria Varvoutsi, Dimitrios Doganis, Katherine Strantzia-Michail and Helen Kosmidis Article Type: Research Article | First Published: May 10, 2015 Aims and background: Our objective was to analyze the clinical and demographic characteristics of children with B-cell lymphoma treated in a single center over the last two decades. Methods: Data was collected by a retrospective review of the charts of all 76 patients treated to our unit, from 1990 to 2010, with FAB LMB 89, 96 protocols and 2003 modifications....
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Open Access DOI:10.23937/2469-5696/1410013 Fetal and Neonatal Alloimmune Thrombocytopenia: Advances in Laboratory Diagnosis and Management Hacene Brouk and Hanifa Ouelaa Article Type: Review Article | First Published: April 30, 2015 Fetal and neonatal alloimmune thrombocytopenia (F/NAIT), caused by fetomaternal mismatch for human platelet (PLT) alloantigens (HPAs), is the commonest cause of severe thrombocytopenia in term neonates and is analogous to the fetal/neonatal anaemia caused by haemolytic disease of the newborn (HDN). The most feared complication of this syndrome is the occurrence of intracranial hemorrhage leading to death or neurological sequels....
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Open Access DOI:10.23937/2469-5696/1410012 The Comparison between Microhematocrit and Automated Methods for Hematocrit Determination Gebrewahd Gebretsadkan, Kebede Tessema, Henock Ambachew and Misganaw Birhaneselassie Article Type: Research Article | First Published: April 01, 2015 Hematocrit is a test that measures a percentage of blood that is comprised of red blood cell. This is often referred to as packed cell volume (PCV) or erythrocyte volume fraction. It is considered as an integral part of a person's complete blood count, along with hemoglobin concentration, white blood cell count and platelet counts....
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Open Access DOI:10.23937/2469-5696/1410011 Hemolytic Anemia in Alcohol-Induced Liver Disease: A Case Report on Zieve's Syndrome Shefali Nath and Joshua R Peck Article Type: Case Report | First Published: March 26, 2015 We report a case of Zieve's syndrome in a patient with a longstanding history of alcohol abuse admitted for acute alcoholic hepatitis. Zieve's syndrome is defied as the triad of hemolytic anemia, hypertriglyceridemia, and jaundice in patients with known liver disease. It is an uncommon diagnosis, but is an important one to consider in patients with known liver disease admitted with these constellation of signs and symptoms....
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Open Access DOI:10.23937/2469-5696/1410010 Adrienne A. Phillips, Jalanni Giddings, Shing M. Lee and Steven M. Horwitz Article Type: Case Report | First Published: March 21, 2015 Adult T-cell Leukemia/Lymphoma (ATLL) is resistant to chemotherapy and the acute and lymphomatous subtypes of disease have a dismal prognosis. There is no standard therapy for relapsed or refractory disease in Western countries and new agents are being explored. Lenalidomide is an immunomodulatory agent with promising activity in hematologic malignancies, including non-Hodgkin's lymphoma and represents a novel therapeutic option. ...
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Open Access DOI:10.23937/2469-5696/1410009 Kee Kiat Yeo, Jonathan G. Murnick, Marijean M. Miller and Anne L. Angiolillo Article Type: Case Report | First Published: February 23, 2015 Intraocular relapse of Acute Lymphoblastic Leukemia (ALL) is rare. Prompt diagnosis and treatment can minimize vision loss. We report a case of a young girl diagnosed with pre-B ALL who was initially treated successfully with chemotherapy....
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Open Access DOI:10.23937/2469-5696/1410008 Thrombophilia: Demographics and Clinical Presentation in United Arab Emirates Fatma H Sajwani and Moza A Khuzam Article Type: Research Article | First Published: February 20, 2015 Thrombophilia is a group of disorders that increases the patient's risk of thrombosis. Inherited causes of thrombophilia are challenging to diagnose and once diagnosed may subject the patient to prolonged treatment. The extent of the condition is not well established in UAE and data on prevalence and demographics are lacking. This study aimed at setting a baseline data on the prevalence, demographics and clinical presentation of thrombophilia in UAE....
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Open Access DOI:10.23937/2469-5696/1410007 Michael Bursey, Kane Curtis, Robert Gibson, Hongyan Xu and Matthew Lyon Article Type: Research Article | First Published: February 17, 2015 Hemoglobin (Hgb) measurement is an important risk-stratification tool for patients presenting to the Emergency Department with vaso-occlusive crisis (VOC) from sickle cell disease (SCD). Point-of- care (POC) Hgb testing such as the HemoCue device decreases time to identification of significant anemia. However, there are no studies evaluating the accuracy of HemoCue testing in patients with SCD and VOC. The purpose of this study was to evaluate the correlation of Hgb measurements from HemoCue com...
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Open Access DOI:10.23937/2469-5696/1410006 Starkova AV, Syropyatov B Ya, Sobin FV and Pulina NA Article Type: Case Report | First Published: February 08, 2015 The aim of this research is to study the mechanism of action of the newly synthesized substance - Thiazoline Ammonium 4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate (FS-169), which possesses the direct anticoagulant activity. The research was conducted with the use of 'АPG4-02-P' coagulometer. For the purposes of the study the rabbit plasma was used. The results show that FS-169 effectively changes Partial thromboplastin time and prothrombin time indicators. However, FS-169 has no influence on...
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Open Access DOI:10.23937/2469-5696/1410005 A Case of Localized Neuroblastoma in Caffey Disease, with Early and Uncommon Progression Manuela Pagano, Chiara Galletto, Maurizio Bianchi and Franca Fagioli Article Type: Case Report | First Published: January 21, 2015 Background: Caffey disease is a rare syndrome caused by mutation in the alpha-1 collagen type I gene, not described in literature as a predisposing condition to cancer development. Observation: We report a case of a 6-years-old female diagnosed with Caffey disease that developed a localized neuroblastoma. The patient had a poor clinical and radiological response with unusual disease dissemination and progression until death. Conclusion: The case is a rare example of rapid progression of localize...
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Open Access DOI:10.23937/2469-5696/1410004 Nabeel Al Moamen, Fawzia Mahdi, Ahmed Thabet, Rugaya Abbas, Ebtihal Salman and Ahmed Al Alawi Article Type: Letter to Editor | First Published: January 15, 2015 A total of 1187 patients with α-thalassemia phenotype presentation have been recruited for this investigation. Preliminary diagnosis of α-thalassemia was based on low hematological indices (MCV and MCH) of the red blood cells and/or persistently low hemoglobin levels, along with low or normal levels of HbA2 and absence of iron deficiency. Th molecular diagnosis of α-thalassemia was established by using a commercially available α-thalassemia strip assay (α-Globin StripAss...
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Open Access DOI:10.23937/2469-5696/1410003 Chakra P Chaulagain and Kenneth B Miller Article Type: Case Report | First Published: December 22, 2014 Malignancy associated Sweet syndrome (acute febrile neutrophilic dermatosis) accounts for approximately 20% of all cases of Sweet syndrome and is characterized by painful, erythematous inflammatory papules and nodules that can precede, coincide or follow malignancies with predilection for hematologic malignancies. Corticosteroids are the cornerstone of treatment with exquisite response which has made many clinicians to include steroid responsiveness as one of the diagnostic criteria. However, re...
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Open Access DOI:10.23937/2469-5696/1410002 Pharmacological Treatment may Impair Mineral Status in Blood Joanna Suliburska Article Type: Editorial | First Published: July 31, 2014 Some medicines may interact with mineral, with the result that changes occur in the concentration of minerals and other blood parameters that are associated with mineral status. Interpretation of the results of morphological and biochemical blood analyses therefore needs to take into account the drugs used by patients....
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Open Access DOI:10.23937/2469-5696/1410001 Jun Gong Article Type: Editorial | First Published: July 30, 2014 Oncolytic reovirus continues to pick up momentum as a novel agent in the treatment of cancer. Since the initial discovery of the virus' tendency to preferentially replicate in transformed cell lines from studies in the late 1970s, reovirus has rapidly progressed from preclinical to clinical trials evaluating its efficacy across a spectrum of malignancies, including hematologic....
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