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Journal of Musculoskeletal Disorders and Treatment




Improved Walking Capabilities after Eight Weeks of Hal® Exoskeleton-Supported Treadmill Therapy in a Patient with Limb-Girdle Muscular Dystrophy Type 2I

Matthias Sczesny-Kaiser1*, Rebecca Kowalewski1, Mirko Aach2, Dennis Grasmücke2, Thomas A Schildhauer3, Matthias Vorgerd1 and Martin Tegenthoff1


1Department of Neurology, BG-University Hospital Bergmannsheil Bochum, Germany
2Department of Spinal Cord Injury, BG-University Hospital Bergmannsheil Bochum, Germany
3Department of General and Trauma Surgery, BG-University Hospital Bergmannsheil Bochum, Germany


*Corresponding author: Matthias Sczesny-Kaiser, MD, Department of Neurology, BG-University Hospital Bergmannsheil Bochum, Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany, Tel: +49 234 3023258, E-mail: matthias.sczesny-kaiser@rub.de
J Musculoskelet Disord Treat, JMDT-2-016, (Volume 2, Issue 3), Video Case Report
Received: March 14, 2016: Accepted: June 29, 2016: Published: July 02, 2016
Citation: Sczesny-Kaiser M, Kowalewski R, Aach M, Grasmücke D, Schildhauer TA, et al. (2016) Improved Walking Capabilities after Eight Weeks of Hal® Exoskeleton-Supported Treadmill Therapy in a Patient with Limb-Girdle Muscular Dystrophy Type 2I. J Musculoskelet Disord Treat 2:016.
Copyright: © 2016 Sczesny-Kaiser M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract

Objective:HAL® robot suit is a new voluntary driven exoskeleton for the lower limbs. It has already been demonstrated to improve walking functions in spinal cord injury and stroke patients. So far, it is not known if HAL® training may be beneficial in patients with limb girdle muscular dystrophy, too.

Design/methods:In this short report, HAL® exoskeleton assisted body-weight supported treadmill training has been applied in a patient with limb-girdle muscular dystrophy type 2I for eight weeks (3 times × 8 weeks = 24 sessions). For training success, standardized walking tests were assessed prior and after training session, and after 6 weeks serving as follow-up measurement (10-meter-walk test, 6-minute-walk test, timed-up-and-go test).

Results:The patient improved in all walking functions. Follow-up measurements showed outlasting effects after 6 weeks without HAL® training. No adverse events occurred.

Conclusions: HAL®-supported treadmill training canto be a promising new rehabilitation approach also for patients with muscular dystrophy. Systematic clinical trials with respect to genetic LGMD subtype should prove beneficial effects in a larger cohort.


Keywords

Myopathy, Muscular dystrophy, Rehabilitation


Introduction

Over the last 15 years, a lot of robotic technology has been developed to improve effects of rehabilitation therapy especially for walking functions in spinal cord injury and stroke patients [1,2]. Different driven gait orthosis, end-effector machines and exoskeletons are available on the market. The hybrid-assistive limb (HAL®, Cyberdyne Inc., Japan) is the first exoskeleton that can be driven voluntary by the patient [3]. In contrast to other exoskeletons, it offers the possibility of monitoring muscle contractions via surface EMG-electrodes at the extensor-flexor muscle region of the upper leg. This allows for voluntary robot-supported motion using EMG-signals recorded from hip and knee flexors and extensors. Pilot studies showed the feasibility, safety and efficiency of HAL® training on patients with acute and chronic spinal cord injury, and stroke [4-7]. HAL®-supported locomotor training in neuromuscular diseases, esp. myopathies, are only described in a large cohort of 38 patients with a widespread spectrum of diseases causing limited mobility [8]. Beneficial effects of HAL® training have not been documented for every different entity or disease. Because there are very limited therapeutic approaches for patients with muscular dystrophies, innovative rehabilitation techniques are very attractive. In this short report, we describe the effect of HAL®-supported BWSTT in a single patient with limb-girdle-muscular dystrophy type 2I.


Case Report

A 57-year-old woman suffering from limb-girdle muscular dystrophy type 2I (LGMD, fukutin-related protein gene mutation) took part in body-weight supported treadmill therapy with the voluntary driven exoskeleton HAL® [4,8]. First clinical signs were evident 11 years ago. The diagnosis has been determined genetically in 2009. Clinical examination showed floppy quadriparesis with typical proximal pronouncement (MRC 3-4/5), positive trendelenburg sign bilateral and lumbar hyperlordosis. Due to the muscular dystrophy, the patient is retired. She needs a wheeled walker to deal with longer distances, e.g shopping. Her muscle weakness causes falls regularly. The patient gave written informed consent to participate in a clinical application observation.


Methods and Treatment

The patient performed HAL® exoskeleton-supported and body-weight supported treadmill therapy over a period of eight weeks (three days/week, see first part of the First part of the video). Improvement of walking function and balance were defined as an aim of therapy in order to reduce the risk of falling. The 10-meter walk test (10 MWT) was done before and after each training session. It detected the time to walk a 10 m distance [9]. The timed-up-and-go test (TUG) describes the time and assistance required for standing up from the chair, walk 3 meters, turn around, walk back and sit down [10]. The 6-minute walk test (6 MWT) and TUG test were done at the beginning, at half time and at the end if possible, depending on the patient. The 6 MWT evaluates the distance while walking for 6 minutes [11]. At least, the Berg Balance Scale (BBS) assessed dynamic and static balance abilities [12].


Results

The patient reported no adverse events, especially no myalgia or muscular weakness after the training. The 10 MWT showed an increase in time from 24.97 s to 18.49 s (see second part of the Second part of the video). The patient also improved in the 6MWT (265 m to 296 m), in the TUG test (32.84 s to 23.88 s) as well as in the BBS (39 to 44 points). In the follow-up assessments, we obtained 20.19 s in the 10 MWT, 252 m in the 6 MWT and 25.17 s in the TUG test.


Discussion

These result simply that the HAL® exoskeleton-supported treadmill therapy can improve walking capabilities and balance abilities in patients suffering from LGMD and that these effects can persist for several weeks. Therefore, HAL® training can be considered a novel and innovative symptomatic therapy which can be repeated on a regular basis without side effects. It may be even more important to stabilize disease progression particularly before more causative oriented therapeutic options become available in the future. Further controlled clinical trials have to be performed in the future to assess valid and reliable training effects in LGMD or different types of myopathy. In these studies, an intensive supervision of HAL training should be performed including serum creatinkinase, serum lactate, spiroergometry with VO2max and heart rate analysis. In this single case, these parameters were not assessed.


Ethics

Ethic Committee of the Medical Faculty, Ruhr University Bochum, reg. No. 4733-13.


Acknowledgements

There was no funding source. None of the authors have been paid to write this article. The corresponding author (MSK) had full access to all data and had final responsibility for the decision to submit for publication.


Competing Interests

MSK, RK, MA, DG, MV and MT have no conflicting interests. TAS reports personal fees from Cyberdyne, Inc. outside the submitted work.


Author's Contribution

MSK: patient recruitment, clinical examination, data collection, data analysis, data interpretation, writing; RK: patient recruitment, data collection, data analysis, data interpretation, writing; TAS, DG, MA: study concept, writing, data interpretation, critical revision; MV: study concept, writing, data interpretation, critical revision; MT: study concept, writing, data interpretation, critical revision.


References
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  2. Wirz M, Zemon DH, Rupp R, Scheel A, Colombo G, et al. (2004) Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. Arch Phys Med Rehabil 86: 672-680.

  3. Kawamoto H, Taal S, Niniss H, Hayashi T, Kamibayashi K, et al. (2010) Voluntary motion support control of Robot Suit HAL triggered by bioelectrical signal for hemiplegia. Conf Proc IEEE Eng Med Biol Soc 2010: 462-466.

  4. Aach M, Cruciger O, Sczesny-Kaiser M, Höffken O, Meindl RCh, et al. (2014) Voluntary driven exoskeleton as a new tool for rehabilitation in chronic spinal cord injury: a pilot study. Spine J 14: 2847-2853.

  5. Cruciger O, Schildhauer TA, Meindl RC, Tegenthoff M, Schwenkreis P, et al. (2014) Impact of locomotion training with a neurologic controlled hybrid assistive limb (HAL) exoskeleton on neuropathic pain and health related quality of life (HRQoL) in chronic SCI: a case study. Disabil Rehabil Assist Technol: 1-6.

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  7. Anneli Wall, Jörgen Borg, Susanne Palmcrantz (2015) Clinical application of the Hybrid Assistive Limb (HAL) for gait training-a systematic review. Front Syst Neurosci 9: 48.

  8. Kubota S, Nakata Y, Eguchi K, Kawamoto H, Kamibayashi K, et al. (2013) Feasibility of rehabilitation training with a newly developed wearable robot for patients with limited mobility. Arch Phys Med Rehabil 94: 1080-1087.

  9. Bohannon RW, Andrews AW, Thomas MW (1996) Walking speed: reference values and correlates for older adults. J Orthop Sports Phys Ther 24: 86-90.

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