Older Persons with HIV in Canada
Article Type: Review Article | First Published: July 18, 2019
Thanks to the widespread use of antiretroviral therapy, the number of older patients living with HIV, usually defined as individuals over 50 years of age, has markedly increased everywhere in the world. The aim of this review is to describe the epidemiology and special needs of older persons with HIV in Canada now and in the near future. It is estimated that, by 2025 in Canada, one in six of all HIV-infected adults will be over 50 years of age. Most will reside in Ontario, Quebec, and British Columbia and will require a number of specialized health services. These three provinces need to trai...
In silico Characterization of Rad51a Interactions with Cancer-Related Proteins
Kleber Santiago Freitas e Silva
Article Type: Research Article | First Published: June 28, 2019
RAD51a is a highly conserved protein and its major role is the repair of DNA double strand breaks. Endogenous species are generated during normal cell metabolic activities and can cause damage to DNA, as well as several environmental factors. The interactions RAD51a perform with other proteins help the maintenance of oncogenetic metabolism within cells. RAD51a interacts with PCNA, FANCD2 and ABL1, among many other cancer-related proteins. PCNA acts as a DNA clamp and is related to the replication process, FANCD2 arrests DNA replication fork progression in response to DNA damage and ABL1 is a p...
Paraquat Poisoning: Survival after Oral Ingestion
Sarah Allen, MD, Mario Gomez, MD, Alice M. Boylan, MD, Kristin B. Highland, MD, Anthony Germinario, MD, Michelle McCauley, MD and Michael Malone, MD
Article Type: Case Report | First Published: July 20, 2019
A 52-year-old caucasian male farmer from Walterboro, South Carolina presented to the Medical University of South Carolina Health-University Medical Center in August, one hour after ingestion of 20 oz of a 50/50 water/paraquat preparation, with suicidal intent, complaining of nausea and emesis of blue colored fluid. His vital signs were normal on admission other than an increased blood pressure of 159/92 mmHg. Upon presentation, physical examination was within normal limits. Plasma levels of paraquat were obtained and the patient underwent gastrointestinal evacuation via nasogastric tube and wa...
Osteoporosis: Bisphosphonate Therapy in Postmenopausal Women
Amber Rowe, Erin Zamora and Tamera Pearson
Article Type: Case Report | First Published: July 19, 2019
Osteoporosis is the deterioration of bone tissue and strength, which leads to an increased risk of fractures. Postmenopausal women are at increased risk for osteoporosis. Bisphosphonates have long been the mainstay of osteoporosis treatment to prevent fractures, especially hip fractures by increasing bone mineral density. Extending treatment to up to 10 years is currently recommended. In lieu of possible adverse events such as atypical fractures and osteonecrosis of the jaw, drug holidays are an important consideration although research is currently inconclusive. Providers need to consider ind...
Histological Modifications of Postmenopausal Vaginal Mucosa after Regenerative Solid State Laser Treatment: A Multicenter Study
D Dodero, F Frascani, M Angelucci, G Bernabei, E Merlo, F Locatelli, D Recalcati and F Murina
Article Type: Research Article | First Published: July 17, 2019
Vulvovaginal atrophy (VVA) is a condition afflicting more than 50% of women and nowadays has changed his name in Genitourinary syndrome of menopause (GSM) due to the multiple aspects involved having an adverse impact on quality of life. Many treatment are now available and laser represent a new powerful option. The aim of this work is assess the histological effect of a new type of non-ablative laser, Solid State Vaginal Laser (SSVL), on vaginal tissue in women treated for GSM....
Complex Hip Spine Syndrome in Young Athlete: A Diagnosis Dilemma
Mohamad Azwan Aziz and Redzal Abu Hanifah
Article Type: Case Report | First Published: July 20, 2019
This is a case of Mr. D, a 32 Chinese gentleman. He is an active in recreational body building exercise for 10 years with an athletic physique. He was diagnosed with prolapse intervertebral disc in the past 7 years however his condition worsening for the past 3 years with multiple episode of severe back pain requiring admission and he develops reduces sensation over left lower limb at L3 and L4 dermatomes associated with reduced motor power in dorsiflexion of ankle and extension of big toe over left lower limb. His first Magnetic Resonance Imaging (MRI) Spine in 2015 showed left lateral disc p...
Diagnostic Yield of Fiberoptic Bronchoscopy for the Evaluation of Chronic Cough in Patients with Normal Chest X-Ray
Zainab Syed, Ro- Jay Reid and Roberto Solis
Article Type: Research Article | First Published: July 25, 2019
Approximately 30 million annual clinic visits are attributed to cough in the United States. Moreover, evaluation and management of persistent cough in pulmonary clinics account for roughly 40% of patient volume. The most common etiologies are: Upper airway cough syndrome (UACS), asthma, non-asthmatic eosinophilic bronchitis (NAEB) and gastro-esophageal reflux disease (GERD) - all of which are treatable. However, despite avoidance of triggers and medical therapy, there remains an elusive diagnosis for some individuals with persistent cough. Further investigation warrants bronchoscopy, which is ...
Use of the Electrical Stimulation Therapy in the Lower Esophageal Sphincter for the Treatment of Gastroesophageal Reflux Disease in Paediatric Patients, Two First Cases Reported
Rodrigo Hipolito Cifuentes, Rene Carmona Barba, Antonio Vega Valdes and Placido Espinosa Rosas
Article Type: Research Article | First Published: July 18, 2019
One female patient, on chronic acid-suppressive therapy who underwent successful laparoscopic implantation of the LES stimulation system, surgery time 1 hour, trans surgical endoscopy with absence of perforation, closure of pillars; measured by GERD daily symptom diaries the patient symptoms improved soon. Two weeks after the surgery, the patient reported better symptom control without the intake of PPI, and the absence of heartburn and regurgitation. One month follow-up with esophageal ph shows decrease of the Demeester score to 20.2, and 3 months esophageal ph shows decrease to 3.9 (Normal D...
Influence of Image Manipulation Restricted to Global Alterations on Diagnosis by an Oral Cytologist
Aman Chowdhry, Keya Sircar and Deepika Bablani Popli
Article Type: Original Research | First Published: July 24, 2019
Cytology has always proudly been in forefront to absorb new technologic advances for practical use. The extensive and passionate implementation of digital imaging in telecytology, automated screening, education, training and certification, research, and publications is an appropriate example. Digitalization cytology records make its manipulation very simple. Several such manipulations, however, correspond to inappropriate changes and can affect final diagnosis of digital slides....